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Aliases for MOGAT1 Gene

Aliases for MOGAT1 Gene

  • Monoacylglycerol O-Acyltransferase 1 2 3 4 5
  • Diacylglycerol Acyltransferase 2-Like Protein 1 3 4
  • Diacylglycerol O-Acyltransferase Candidate 2 3 4
  • Acyl-CoA:Monoacylglycerol Acyltransferase 1 3 4
  • Diacylglycerol O-Acyltransferase 2 Like 1 2 3
  • 2-Acylglycerol O-Acyltransferase 1 3 4
  • EC 2.3.1.22 4 56
  • DGAT2L1 3 4
  • MGAT1 3 4
  • HDC2 3 4
  • EC 2.3.1 56
  • DGAT2L 3
  • DC2 4

External Ids for MOGAT1 Gene

Previous HGNC Symbols for MOGAT1 Gene

  • DGAT2L1

Previous GeneCards Identifiers for MOGAT1 Gene

  • GC02P223739
  • GC02P223361
  • GC02P223244
  • GC02P223536
  • GC02P215389

Summaries for MOGAT1 Gene

Entrez Gene Summary for MOGAT1 Gene

  • Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MOGAT1 Gene

MOGAT1 (Monoacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Among its related pathways are triacylglycerol biosynthesis and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and diacylglycerol O-acyltransferase activity. An important paralog of this gene is MOGAT2.

UniProtKB/Swiss-Prot for MOGAT1 Gene

  • Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).

Additional gene information for MOGAT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOGAT1 Gene

Genomics for MOGAT1 Gene

GeneHancer (GH) Regulatory Elements for MOGAT1 Gene

Promoters and enhancers for MOGAT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J222671 Promoter/Enhancer 1.4 Ensembl ENCODE 600.7 +1.2 1163 3.4 ZNF652 SP1 ELF3 MNT POLR2A RERE AHR ZNF24 TFE3 PPARG MOGAT1 ENSG00000203531 ACSL3 ENSG00000234193 FARSB LOC100384885
GH02J222707 Enhancer 1.1 ENCODE 11.3 +37.0 37026 3.3 ELF3 CC2D1A CTCF MNT CBFA2T2 MLLT1 CEBPG RERE ZSCAN21 AHR ACSL3 MOGAT1 ENSG00000234193 FARSB ENSG00000235225 ENSG00000203531 RPL31P17
GH02J222848 Enhancer 0.4 Ensembl 10.5 +178.0 177963 2.2 MAFK ZBTB33 MOGAT1 ENSG00000234193 ACSL3 GC02M222847 LOC105373903
GH02J222706 Enhancer 0.3 ENCODE 11.3 +35.1 35069 0.2 NANOG ACSL3 MOGAT1 ENSG00000234193 FARSB ENSG00000203531 RPL31P17
GH02J222690 Enhancer 1.2 Ensembl ENCODE 0.4 +18.2 18163 2.6 ZNF652 CC2D1A CTCF ELF3 CEBPG ZNF24 MAFK TFE3 SP7 ELF1 FARSB ACSL3 ENSG00000234193 ENSG00000203531 ENSG00000233751 MOGAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOGAT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOGAT1 gene promoter:
  • Cdc5
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • NF-1
  • NF-1/L
  • POU2F1
  • POU2F1a

Genomic Locations for MOGAT1 Gene

Genomic Locations for MOGAT1 Gene
chr2:222,671,738-222,709,930
(GRCh38/hg38)
Size:
38,193 bases
Orientation:
Plus strand
chr2:223,536,457-223,574,649
(GRCh37/hg19)
Size:
38,193 bases
Orientation:
Plus strand

Genomic View for MOGAT1 Gene

Genes around MOGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOGAT1 Gene

Proteins for MOGAT1 Gene

  • Protein details for MOGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD6-MOGT1_HUMAN
    Recommended name:
    2-acylglycerol O-acyltransferase 1
    Protein Accession:
    Q96PD6
    Secondary Accessions:
    • Q6IEE5

    Protein attributes for MOGAT1 Gene

    Size:
    335 amino acids
    Molecular mass:
    38812 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX81987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MOGAT1 Gene

Selected DME Specific Peptides for MOGAT1 Gene

Q96PD6:
  • LARRLQT
  • VLQWVLSFL

Post-translational modifications for MOGAT1 Gene

  • Glycosylation at isoforms=180, posLast=125125, and isoforms=121
  • Modification sites at PhosphoSitePlus

Other Protein References for MOGAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MOGAT1 Gene

Gene Families for MOGAT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for MOGAT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOGAT1 Gene

GenScript: Design optimal peptide antigens:
  • Monoacylglycerol O-acyltransferase 1 (MOGT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96PD6

UniProtKB/Swiss-Prot:

MOGT1_HUMAN :
  • Belongs to the diacylglycerol acyltransferase family.
Family:
  • Belongs to the diacylglycerol acyltransferase family.
genes like me logo Genes that share domains with MOGAT1: view

Function for MOGAT1 Gene

Molecular function for MOGAT1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA; Xref=Rhea:RHEA:32947, ChEBI:CHEBI:17389, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.22;.

Enzyme Numbers (IUBMB) for MOGAT1 Gene

Phenotypes From GWAS Catalog for MOGAT1 Gene

Gene Ontology (GO) - Molecular Function for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003846 2-acylglycerol O-acyltransferase activity IEA --
GO:0004144 diacylglycerol O-acyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA --
genes like me logo Genes that share ontologies with MOGAT1: view
genes like me logo Genes that share phenotypes with MOGAT1: view

Animal Models for MOGAT1 Gene

MGI Knock Outs for MOGAT1:

Animal Model Products

CRISPR Products

miRNA for MOGAT1 Gene

miRTarBase miRNAs that target MOGAT1

Clone Products

  • Applied Biological Materials (abm): Clones for MOGAT1 - Now 50% OFF >
  • * MOGAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MOGAT1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOGAT1 Gene

Localization for MOGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOGAT1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 2
mitochondrion 1
extracellular 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOGAT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MOGAT1 Gene

Pathways & Interactions for MOGAT1 Gene

genes like me logo Genes that share pathways with MOGAT1: view

Pathways by source for MOGAT1 Gene

UniProtKB/Swiss-Prot Q96PD6-MOGT1_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol biosynthesis.

Interacting Proteins for MOGAT1 Gene

Gene Ontology (GO) - Biological Process for MOGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006651 diacylglycerol biosynthetic process IEA --
GO:0019432 triglyceride biosynthetic process TAS --
genes like me logo Genes that share ontologies with MOGAT1: view

No data available for SIGNOR curated interactions for MOGAT1 Gene

Drugs & Compounds for MOGAT1 Gene

(5) Drugs for MOGAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Glyceryl Trioleate Investigational Pharma 0
Tricaprylin Investigational Pharma 0
Coenzyme A Investigational Nutra 0

(100) Additional Compounds for MOGAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with MOGAT1: view

Transcripts for MOGAT1 Gene

mRNA/cDNA for MOGAT1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for MOGAT1 Gene

Monoacylglycerol O-acyltransferase 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for MOGAT1 - Now 50% OFF >
  • * MOGAT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * MOGAT1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for MOGAT1 Gene

No ASD Table

Relevant External Links for MOGAT1 Gene

GeneLoc Exon Structure for
MOGAT1
ECgene alternative splicing isoforms for
MOGAT1

Expression for MOGAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOGAT1 Gene

mRNA differential expression in normal tissues according to GTEx for MOGAT1 Gene

This gene is overexpressed in Liver (x13.2) and Adipose - Visceral (Omentum) (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of MOGAT1 Gene:

MOGAT1

SOURCE GeneReport for Unigene cluster for MOGAT1 Gene:

Hs.344090

Evidence on tissue expression from TISSUES for MOGAT1 Gene

  • Kidney(4.1)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with MOGAT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOGAT1 Gene

Orthologs for MOGAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOGAT1 35 34
  • 98.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MOGAT1 35 34
  • 84.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MOGAT1 35 34
  • 83.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mogat1 17 35 34
  • 77.41 (n)
oppossum
(Monodelphis domestica)
Mammalia MOGAT1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MOGAT1 35 34
  • 69.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MOGAT1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mogat1 34
  • 65.77 (n)
Str.8301 34
African clawed frog
(Xenopus laevis)
Amphibia dgat2l1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii mogat3a 35 34
  • 60.33 (n)
OneToOne
Dr.12962 34
fruit fly
(Drosophila melanogaster)
Insecta CG1942 35
  • 34 (a)
ManyToMany
CG1946 35
  • 33 (a)
ManyToMany
CG1941 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K07B1.4 35
  • 42 (a)
ManyToMany
Y53G8B.2 35
  • 41 (a)
ManyToMany
dgtr-1 35
  • 40 (a)
ManyToMany
dgat-2 35
  • 39 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11165g 34
  • 48.95 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR140C 34
  • 48.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DGA1 35 34
  • 47.84 (n)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dga1 34
  • 50.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02665 34
  • 49.34 (n)
Species where no ortholog for MOGAT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOGAT1 Gene

ENSEMBL:
Gene Tree for MOGAT1 (if available)
TreeFam:
Gene Tree for MOGAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOGAT1: view image

Paralogs for MOGAT1 Gene

Paralogs for MOGAT1 Gene

(7) SIMAP similar genes for MOGAT1 Gene using alignment to 1 proteins:

  • MOGT1_HUMAN
genes like me logo Genes that share paralogs with MOGAT1: view

Variants for MOGAT1 Gene

Sequence variations from dbSNP and Humsavar for MOGAT1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000019983 -- 222,684,629(+) T/C intron_variant
rs1000069404 -- 222,684,413(+) A/G intron_variant
rs1000228601 -- 222,705,729(+) G/A intron_variant
rs1000329341 -- 222,686,204(+) T/C intron_variant
rs1000364465 -- 222,678,207(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOGAT1 Gene

Variant ID Type Subtype PubMed ID
esv3305579 CNV mobile element insertion 20981092
esv3413359 CNV insertion 20981092
esv3594427 CNV loss 21293372
nsv1001083 CNV gain 25217958
nsv1011830 CNV gain 25217958
nsv834551 CNV gain+loss 17160897

Variation tolerance for MOGAT1 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.26; 85.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOGAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOGAT1
Human Gene Mutation Database (HGMD)
MOGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOGAT1 Gene

Disorders for MOGAT1 Gene

Additional Disease Information for MOGAT1

No disorders were found for MOGAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOGAT1 Gene

Publications for MOGAT1 Gene

  1. Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals. (PMID: 14970677) Winter A … Fries R (Cytogenetic and genome research 2003) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. (PMID: 11481335) Cases S … Farese RV (The Journal of biological chemistry 2001) 3 4 58
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  5. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. (PMID: 12077311) Yen CL … Farese RV (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for MOGAT1 Gene

Sources for MOGAT1 Gene

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