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The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
MOG (Myelin Oligodendrocyte Glycoprotein) is a Protein Coding gene. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cells and Lineage-specific Markers. An important paralog of this gene is BTN1A1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | NAS | 8530032 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Neural Stem Cells and Lineage-specific Markers |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001817 | regulation of cytokine production | IBA | 21873635 |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007417 | central nervous system development | TAS | 1373175 |
GO:0016032 | viral process | IEA | -- |
GO:0046718 | viral entry into host cell | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
MOG (35-55) | Pharma | Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
B2 |
|
115687-05-3 |
|
|
||
Nogo-66 (1-40) |
|
475221-20-6 |
|
|
||
PLP (139-151) |
|
122018-58-0 |
|
|
||
TCS PrP Inhibitor 13 |
|
34320-83-7 |
|
|
Compound | Action | Cas Number |
---|---|---|
B2 | Promotes inclusion formation in Huntington's and Parkinson's diseases | 115687-05-3 |
MOG (35-55) | Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 149635-73-4 |
Nogo-66 (1-40) | Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration | 475221-20-6 |
PLP (139-151) | Encephalitogenic myelin proteolipid fragment | 122018-58-0 |
TCS PrP Inhibitor 13 | Antiprion agent; potently inhibits PrP-res accumulation | 34320-83-7 |
Compound | Action | Cas Number |
---|---|---|
MOG (35-55) | Minor component of CNS myelin | 149635-73-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MOG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MOG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MOG 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mog 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mog 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MOG 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MOG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100858529 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs387906655 | Pathogenic: Narcolepsy 7. Narcolepsy 7 (NRCLP7) [MIM:614250] | 29,659,628(+) | C/Gp.Ser133Cys | MISSENSE_VARIANT,INTRON_VARIANT | |
rs2857766 | - | p.Val171Leu | |||
rs3130253 | - | p.Ile174Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759411 | CNV | gain+loss | 17122850 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1145096 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
narcolepsy 7 |
|
|
rubella |
|
|
primary progressive multiple sclerosis |
|
|
optic neuritis |
|
|
narcolepsy 1 |
|
|