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The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcri... See more...
Aliases for MOG Gene
Aliases for MOG Gene
External Ids for MOG Gene
- HGNC: 7197
- Entrez Gene: 4340
- Ensembl: ENSG00000204655
- OMIM: 159465
- UniProtKB: Q16653
Previous GeneCards Identifiers for MOG Gene
- GC06P029682
- GC06P029395
- GC06P029732
- GC06P029624
- GC06P029431
- GC06P029808
- GC06P030070
- GC06P032158
- GC06P032405
- GC06P032481
- GC06P030321
- GC06P030473
- GC06P030668
- GC06P030835
- GC06P030994
- GC06P031154
- GC06P031320
- GC06P031564
Summaries for MOG Gene
-
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for MOG Gene
MOG (Myelin Oligodendrocyte Glycoprotein) is a Protein Coding gene. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is BTN1A1.
UniProtKB/Swiss-Prot Summary for MOG Gene
-
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
-
(Microbial infection) Acts as a receptor for rubella virus.
Additional gene information for MOG Gene
- Monarch Initiative
- Search for MOG at DataMed
- Search for MOG at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOG Gene
Genomics for MOG Gene
GeneHancer (GH) Regulatory Elements for MOG Gene
Promoters and enhancers for MOG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MOG on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOG
- Top Transcription factor binding sites by QIAGEN in the MOG gene promoter:
-
- CREB
- deltaCREB
- MRF-2
- RSRFC4
Genomic Locations for MOG Gene
Genomic Locations for MOG Gene
- chr6:29,656,981-29,672,372
- (GRCh38/hg38)
- Size:
- 15,392 bases
- Orientation:
- Plus strand
- chr6:29,624,758-29,640,149
- (GRCh37/hg19)
- Size:
- 15,392 bases
- Orientation:
- Plus strand
Genomic View for MOG Gene
Genes around MOG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
MOG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MOG Gene
Proteins for MOG Gene
-
Protein details for MOG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16653-MOG_HUMAN
- Recommended name:
- Myelin-oligodendrocyte glycoprotein
- Protein Accession:
- Q16653
- A6NDR4
- A6NNJ9
- A8MY31
- B0UZR9
- E9PGF0
- F8W9D5
- O00713
- O00714
- O00715
- Q13054
- Q13055
- Q14855
- Q29ZN8
- Q56UY0
- Q5JNX7
- Q5JNY1
- Q5JNY2
- Q5JNY4
- Q5SSB5
- Q5SSB6
- Q5STL9
- Q5STM0
- Q5STM1
- Q5STM2
- Q5STM5
- Q5SUK5
- Q5SUK7
- Q5SUK8
- Q5SUK9
- Q5SUL0
- Q5SUL1
- Q8IYG5
- Q92891
- Q92892
- Q92893
- Q92894
- Q92895
- Q93053
- Q96KU9
- Q96KV0
- Q96KV1
- Q99605
Protein attributes for MOG Gene
- Size:
- 247 amino acids
- Molecular mass:
- 28193 Da
- Quaternary structure:
-
- Homodimer (By similarity). May form heterodimers between the different isoforms (By similarity).
- (Microbial infection) Interacts with rubella virus E2 glycoprotein.
- Miscellaneous:
-
- [Isoform 9]: Not functionally active. May be expressed at low level in the adult.
- [Isoform 10]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for MOG Gene
Post-translational modifications for MOG Gene
Other Protein References for MOG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MOG Antibody
- NSJ Bioreagents MOG Antibody / Myelin Oligodendrocyte Glycoprotein
- Creative Diagnostics Anti-MOG monoclonal antibody, clone OZSNPH
- Creative Biolabs Recombinant Anti-human MOG Antibody and Mouse Anti-MOG Recombinant Antibody (CBFYM-2467)
- GeneTex Anti-MOG antibody [C2C3], C-term
- Novus Biologicals Antibodies for MOG
-
Abcam antibodies for MOG
- Invitrogen Antibodies for MOG (AFLGC-MOG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MOG
- Sino Biological Antibodies for MOG
Protein Products
- G Biosciences Human MOG, Lyophilized (BAN0143) and Human MOG, Lyophilized (BAN0595)
-
OriGene Purified Proteins for MOG
- Search Origene for MassSpec and Protein Over-expression Lysates for MOG
- Origene Custom Protein Services for MOG
- Sino Biological Recombinant Proteins for MOG
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for MOG
-
ProSci Proteins for MOG
-
Abcam proteins for MOG
Assay Products
- RayBiotech Custom Human MOG ELISA
- Creative Diagnostics Anti-MOG (35-55) IgG ELISA Kit
- Aviva Systems Biology MOG ELISA Kit (Human) : 96 Wells (OKEH00438) and MOG ELISA Kit (Human) (OKCD06330)
No data available for DME Specific Peptides for MOG Gene
Domains & Families for MOG Gene
Gene Families for MOG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Protein Domains for MOG Gene
- Blocks:
-
- Immunoglobulin V-type
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MOG Gene
- GenScript: Design optimal peptide antigens:
-
- Myelin oligodendrocyte glycoprotein (A2AAS0_HUMAN)
- Myelin oligodendrocyte glycoprotein (B0UZS4_HUMAN)
- Myelin oligodendrocyte glycoprotein (B0UZS5_HUMAN)
- cDNA FLJ51848, highly similar to Myelin-oligodendrocyte glycoprotein (B7Z2X8_HUMAN)
- Myelin-oligodendrocyte glycoprotein (MOG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16653- Family:
-
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
Function for MOG Gene
Molecular function for MOG Gene
- UniProtKB/Swiss-Prot Function:
- Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for rubella virus.
- GENATLAS Biochemistry:
- myelin oligodendrocyte glycoprotein,26-28kDa,associated with multiple sclerosis susceptibility
Phenotypes From GWAS Catalog for MOG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005102 | signaling receptor binding | IBA | 21873635 |
Phenotypes for MOG Gene
- MGI mutant phenotypes for MOG:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for MOG:
Animal Model Products
-
Taconic Biosciences Mouse Models for MOG
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MOG - Select products 50% OFF >
- * MOG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MOG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOG
- genomics-online: gRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOG
miRNA for MOG Gene
- miRTarBase miRNAs that target MOG
-
- hsa-mir-3185 (MIRT445536)
- hsa-mir-5197-3p (MIRT445537)
- hsa-mir-4428 (MIRT445538)
- hsa-mir-498 (MIRT684166)
- hsa-mir-6836-3p (MIRT684167)
- hsa-mir-5001-3p (MIRT684168)
- hsa-mir-6783-3p (MIRT684169)
- hsa-mir-1343-3p (MIRT684170)
- hsa-mir-23b-5p (MIRT684171)
- hsa-mir-23a-5p (MIRT684172)
- hsa-mir-6829-3p (MIRT684173)
- hsa-mir-6791-3p (MIRT684174)
- hsa-mir-6778-3p (MIRT684175)
- hsa-mir-4695-3p (MIRT684176)
- hsa-mir-4772-3p (MIRT684177)
- hsa-mir-6787-3p (MIRT684178)
- hsa-mir-1304-3p (MIRT684179)
- hsa-mir-6742-3p (MIRT684180)
- hsa-mir-6852-5p (MIRT684181)
- hsa-mir-939-3p (MIRT684182)
- hsa-mir-660-3p (MIRT684183)
- hsa-mir-6736-3p (MIRT684184)
- hsa-mir-6890-3p (MIRT684185)
- hsa-mir-200c-5p (MIRT784127)
- hsa-mir-3664-5p (MIRT785084)
- hsa-mir-3672 (MIRT785142)
- hsa-mir-4524a-3p (MIRT786122)
- hsa-mir-4714-5p (MIRT786507)
- hsa-mir-4797-5p (MIRT786832)
- hsa-mir-5007-5p (MIRT786954)
- hsa-mir-514a-5p (MIRT787167)
- hsa-mir-550a-3p (MIRT787606)
- hsa-mir-550b-3p (MIRT787611)
- hsa-mir-6864-3p (MIRT789147)
- hsa-mir-8055 (MIRT789702)
- hsa-mir-924 (MIRT789944)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOG
- Browse OriGene Inhibitory RNA Products For MOG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOG
- genomics-online: shRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MOG - Select products 50% OFF >
- * MOG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203093
- MR203093
- MR203093L3
- MR203093L4
- RC213662
- RC213662L3
- RC213662L4
- RC214382
- RC214382L3
- RC214382L4
- RC216498
- RC216498L3
- RC216498L4
- RC222455
- RC222455L3
- RC222455L4
- RC222910
- RC222910L3
- RC222910L4
- RC223054
- RC223054L3
- RC223054L4
- RC223107
- RC223107L3
- RC223107L4
- RC225170
- RC225170L3
- RC225170L4
- RC229538
- RC229538L3
- RC229538L4
- RG213662
- RG214382
- RG216498
- RG222455
- RG222910
- RG223054
- RG223107
- RG225170
- RG229538
- RR208826
- RR208826L1
- RR208826L2
- RR208826L3
- RR208826L4
- MR203093L3V
- MR203093L4V
- RC213662L3V
- RC213662L4V
- RC214382L3V
- RC214382L4V
- RC216498L3V
- RC216498L4V
- RC222455L3V
- RC222455L4V
- RC222910L3V
- RC222910L4V
- RC223054L3V
- RC223054L4V
- RC223107L3V
- RC223107L4V
- RC225170L3V
- RC225170L4V
- RC229538L3V
- RC229538L4V
- RR208826L1V
- RR208826L2V
- RR208826L3V
- RR208826L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MOG
- Addgene plasmids for MOG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOG
Cell Line Products
-
Horizon Cell Lines for MOG
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MOG Gene
Localization for MOG Gene
Subcellular locations from UniProtKB/Swiss-Prot for MOG Gene
- [Isoform 1]: Cell membrane; Multi-pass membrane protein.
- [Isoform 5]: Cell membrane; Multi-pass membrane protein.
- [Isoform 2]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 3]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 6]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 7]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 8]: Cell membrane; Single-pass type I membrane protein.
- [Isoform 9]: Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | NAS | 8530032 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MOG Gene
Pathways & Interactions for MOG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Neural Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
Pathways by source for MOG Gene
1 R&D Systems pathway for MOG Gene
Interacting Proteins for MOG Gene
GPS-Prot Interaction Network for MOG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007417 | central nervous system development | TAS | 1373175 |
| GO:0016032 | viral process | IEA | -- |
| GO:0046718 | viral entry into host cell | IEA | -- |
| GO:0050776 | regulation of immune response | IBA | 21873635 |
No data available for SIGNOR curated interactions for MOG Gene
Drugs & Compounds for MOG Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| MOG (35-55) | Pharma | Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| B2 |
|
115687-05-3 |
|
|
||
| Nogo-66 (1-40) |
|
475221-20-6 |
|
|
||
| PLP (139-151) |
|
122018-58-0 |
|
|
||
| TCS PrP Inhibitor 13 |
|
34320-83-7 |
|
|
(5) Tocris Compounds for MOG Gene
| Compound | Action | Cas Number |
|---|---|---|
| B2 | Promotes inclusion formation in Huntington's and Parkinson's diseases | 115687-05-3 |
| MOG (35-55) | Encephalitogenic myelin oligodendrocyte glycoprotein fragment | 149635-73-4 |
| Nogo-66 (1-40) | Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration | 475221-20-6 |
| PLP (139-151) | Encephalitogenic myelin proteolipid fragment | 122018-58-0 |
| TCS PrP Inhibitor 13 | Antiprion agent; potently inhibits PrP-res accumulation | 34320-83-7 |
(1) ApexBio Compounds for MOG Gene
| Compound | Action | Cas Number |
|---|---|---|
| MOG (35-55) | Minor component of CNS myelin | 149635-73-4 |
Drug Products
- G Biosciences Human MOG, Lyophilized (BAN0143) and Human MOG, Lyophilized (BAN0595)
- ApexBio compounds for MOG
Transcripts for MOG Gene
mRNA/cDNA for MOG Gene
- 11 REFSEQ mRNAs :
- 39 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376888 1529 bps (ENST00000376888.6)
- ENST00000376889 1981 bps (ENST00000376889.3)
- ENST00000376891 889 bps (ENST00000376891.8)
- ENST00000376894 2499 bps (ENST00000376894.8)
- ENST00000376898 1027 bps (ENST00000376898.7)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MOG - Select products 50% OFF >
- * MOG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MOG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOG
- genomics-online: gRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOG
- Browse OriGene Inhibitory RNA Products For MOG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOG
- genomics-online: shRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
Clone Products
- Applied Biological Materials (abm): Clones for MOG - Select products 50% OFF >
- * MOG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203093
- MR203093
- MR203093L3
- MR203093L4
- RC213662
- RC213662L3
- RC213662L4
- RC214382
- RC214382L3
- RC214382L4
- RC216498
- RC216498L3
- RC216498L4
- RC222455
- RC222455L3
- RC222455L4
- RC222910
- RC222910L3
- RC222910L4
- RC223054
- RC223054L3
- RC223054L4
- RC223107
- RC223107L3
- RC223107L4
- RC225170
- RC225170L3
- RC225170L4
- RC229538
- RC229538L3
- RC229538L4
- RG213662
- RG214382
- RG216498
- RG222455
- RG222910
- RG223054
- RG223107
- RG225170
- RG229538
- RR208826
- RR208826L1
- RR208826L2
- RR208826L3
- RR208826L4
- MR203093L3V
- MR203093L4V
- RC213662L3V
- RC213662L4V
- RC214382L3V
- RC214382L4V
- RC216498L3V
- RC216498L4V
- RC222455L3V
- RC222455L4V
- RC222910L3V
- RC222910L4V
- RC223054L3V
- RC223054L4V
- RC223107L3V
- RC223107L4V
- RC225170L3V
- RC225170L4V
- RC229538L3V
- RC229538L4V
- RR208826L1V
- RR208826L2V
- RR208826L3V
- RR208826L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MOG
- Addgene plasmids for MOG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOG
Relevant External Links for MOG Gene
- GeneLoc Exon Structure for
- MOG
Expression for MOG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Spinal Cord (Nervous System)
- Myelinating Oligodendrocyte Cells Spinal Cord White Matter
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
mRNA differential expression in normal tissues according to GTEx for MOG Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.2), Brain - Substantia nigra (x8.3), and Brain - Hippocampus (x5.2).
This gene is overexpressed in Spinal cord (46.5) and Frontal cortex (20.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOG Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOG
SOURCE GeneReport for Unigene cluster for MOG Gene:
Hs.141308mRNA Expression by UniProt/SwissProt for MOG Gene:
Q16653-MOG_HUMAN
Tissue specificity:
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
Evidence on tissue expression from TISSUES for MOG Gene
- Nervous system(5)
- Blood(2.7)
- Spleen(2.4)
- Eye(2.3)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MOG Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- ear
- eye
- head
- mouth
- pharynx
Thorax:
- heart
General:
- blood vessel
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for MOG
-
OriGene qPCR primer pairs and template standards for MOG
- genomics-online: primer clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
Gene Expression Assay Products
Orthologs for MOG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MOG 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MOG 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MOG 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mog 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Mog 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MOG 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MOG 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858529 30 |
|
- Species where no ortholog for MOG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for MOG Gene
- ENSEMBL:
- Gene Tree for MOG (if available)
- TreeFam:
- Gene Tree for MOG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MOG: view image
Paralogs for MOG Gene
Paralogs for MOG Gene
(11) SIMAP similar genes for MOG Gene using alignment to 8 proteins:
- MOG_HUMAN
- C9JTE0_HUMAN
- E9PG44_HUMAN
- H0Y8A0_HUMAN
- H7BYC0_HUMAN
- Q5SSB8_HUMAN
- Q5SUK5_HUMAN
- Q8IYG5_HUMAN
Pseudogenes.org Pseudogenes for MOG Gene
Variants for MOG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOG Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs387906655 | Pathogenic: Narcolepsy 7. Narcolepsy 7 (NRCLP7) [MIM:614250] | 29,659,628(+) | C/Gp.Ser133Cys | MISSENSE_VARIANT,INTRON_VARIANT | |
| rs2857766 | - | p.Val171Leu | |||
| rs3130253 | - | p.Ile174Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759411 | CNV | gain+loss | 17122850 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1145096 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.10;
75.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MOG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOG Gene
Disorders for MOG Gene
(46) MalaCards diseases for MOG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| narcolepsy 7 |
|
|
| rubella |
|
|
| primary progressive multiple sclerosis |
|
|
| optic neuritis |
|
|
| acute disseminated encephalomyelitis |
|
|
Search MOG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MOG_HUMAN- Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:21907016}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MOG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MOG Gene
Publications for MOG Gene
- SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot RK … Rubio JP (Tissue antigens 2008) 3 23 41 54
- A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. (PMID: 17928868) D'Alfonso S … Momigliano-Richiardi P (Genes and immunity 2008) 3 23 41 54
- Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia. (PMID: 15660663) Zai G … Kennedy JL (Genes, brain, and behavior 2005) 3 23 41 54
- Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis. (PMID: 12149493) Ohlenbusch A … Hanefeld F (Pediatric research 2002) 3 23 41 54
- A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PMID: 9210466) Albouz-Abo S … von Itzstein M (European journal of biochemistry 1997) 3 4 23 54
ExternalLinks
Products for MOG Gene
- View all 7 R&D Systems MOG (MOG) Products
- View all R&D Systems MOG (MOG) Proteins and Enzymes
- View all 5 R&D Systems MOG (MOG) Primary Antibodies
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- MG203093
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- RC229538L3V
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- RR208826L1V
- RR208826L2V
- RR208826L3V
- RR208826L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MOG
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for MOG (AFLGC-MOG)
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- VectorBuilder Custom and pre-made DNA vectors for MOG (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MOG (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for MOG
- Addgene plasmids for MOG
- antibodies-online: Show 36 available Myelin Oligodendrocyte Glycoprotein (MOG) Antibodies ranked by validation data
- antibodies-online: Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) related products ranked by validation data
- antibodies-online: Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for MOG
- Search Santa Cruz Biotechnology (SCBT) for MOG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MOG
- Horizon Cell Lines for MOG
- genomics-online: cdna clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
- orf clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
- genomics-online: gRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
- genomics-online: primer clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
- genomics-online: shRNA clones - Search results for available Myelin Oligodendrocyte Glycoprotein (MOG) gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MOG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOG
Sources for MOG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody