The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcri... See more...

Aliases for MOG Gene

Aliases for MOG Gene

  • Myelin Oligodendrocyte Glycoprotein 2 3 5
  • Myelin-Oligodendrocyte Glycoprotein 3 4
  • MOG Ig-AluB 3
  • MOG Alpha-5 3
  • MOG AluA 3
  • MOG AluB 3
  • BTNL11 3
  • MOGIG2 3
  • NRCLP7 3
  • BTN6 3

External Ids for MOG Gene

Previous GeneCards Identifiers for MOG Gene

  • GC06P029682
  • GC06P029395
  • GC06P029732
  • GC06P029624
  • GC06P029431
  • GC06P029808
  • GC06P030070
  • GC06P032158
  • GC06P032405
  • GC06P030321
  • GC06P030473
  • GC06P030668
  • GC06P030835
  • GC06P030994
  • GC06P031154
  • GC06P031320
  • GC06P031564

Summaries for MOG Gene

Entrez Gene Summary for MOG Gene

  • The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOG Gene

MOG (Myelin Oligodendrocyte Glycoprotein) is a Protein Coding gene. Diseases associated with MOG include Narcolepsy 7 and Rubella. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is BTN1A1.

UniProtKB/Swiss-Prot Summary for MOG Gene

  • Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
  • (Microbial infection) Acts as a receptor for rubella virus.

Tocris Summary for MOG Gene

Gene Wiki entry for MOG Gene

Additional gene information for MOG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOG Gene

Genomics for MOG Gene

GeneHancer (GH) Regulatory Elements for MOG Gene

Promoters and enhancers for MOG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029657 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 750.6 -0.8 -780 2 MEF2D MOG ZFP57 HLA-H GABBR1 ZNRD1ASP OR2H2 lnc-GABBR1-2
GH06J029676 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11.7 +22.1 22144 5 PRDM1 POLR2A CEBPB ZFP57 RPL23AP1 IFITM4P HLA-H MOG ZNRD1 SUMO2P1 GABBR1 ZNRD1ASP HLA-J
GH06J029683 Enhancer 0.2 Ensembl 11.7 +26.9 26920 1 RPL23AP1 ZFP57 MOG GABBR1 SUMO2P1 ENSG00000237669 RF00017-5396
GH06J029708 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +52.4 52407 2.6 PRDM1 IKZF1 CEBPB PKNOX1 RUNX3 CREB1 EBF1 ATF2 ZDHHC20P1 lnc-ZFP57-8 lnc-ZFP57-9 HLA-F ZFP57 HLA-J IFITM4P HLA-H ENSG00000227766 ZNRD1ASP
GH06J029600 Enhancer 0.3 FANTOM5 1.7 -56.2 -56202 0.2 NFE2 MOG GABBR1 lnc-UBD-1 OR2H2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MOG gene promoter:
  • CREB
  • deltaCREB
  • MRF-2
  • RSRFC4

Genomic Locations for MOG Gene

Genomic Locations for MOG Gene
chr6:29,656,981-29,672,372
(GRCh38/hg38)
Size:
15,392 bases
Orientation:
Plus strand
chr6:29,624,758-29,640,149
(GRCh37/hg19)
Size:
15,392 bases
Orientation:
Plus strand

Genomic View for MOG Gene

Genes around MOG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MOG Gene

  • Protein details for MOG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16653-MOG_HUMAN
    Recommended name:
    Myelin-oligodendrocyte glycoprotein
    Protein Accession:
    Q16653
    Secondary Accessions:
    • A6NDR4
    • A6NNJ9
    • A8MY31
    • B0UZR9
    • E9PGF0
    • F8W9D5
    • O00713
    • O00714
    • O00715
    • Q13054
    • Q13055
    • Q14855
    • Q29ZN8
    • Q56UY0
    • Q5JNX7
    • Q5JNY1
    • Q5JNY2
    • Q5JNY4
    • Q5SSB5
    • Q5SSB6
    • Q5STL9
    • Q5STM0
    • Q5STM1
    • Q5STM2
    • Q5STM5
    • Q5SUK5
    • Q5SUK7
    • Q5SUK8
    • Q5SUK9
    • Q5SUL0
    • Q5SUL1
    • Q8IYG5
    • Q92891
    • Q92892
    • Q92893
    • Q92894
    • Q92895
    • Q93053
    • Q96KU9
    • Q96KV0
    • Q96KV1
    • Q99605

    Protein attributes for MOG Gene

    Size:
    247 amino acids
    Molecular mass:
    28193 Da
    Quaternary structure:
    • Homodimer (By similarity). May form heterodimers between the different isoforms (By similarity).
    • (Microbial infection) Interacts with rubella virus E2 glycoprotein.

    Three dimensional structures from OCA and Proteopedia for MOG Gene

    Alternative splice isoforms for MOG Gene

neXtProt entry for MOG Gene

Post-translational modifications for MOG Gene

  • Glycosylation at Asn60
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MOG Gene

Domains & Families for MOG Gene

Gene Families for MOG Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MOG Gene

GenScript: Design optimal peptide antigens:
  • Myelin oligodendrocyte glycoprotein (A2AAS0_HUMAN)
  • Myelin oligodendrocyte glycoprotein (B0UZS4_HUMAN)
  • Myelin oligodendrocyte glycoprotein (B0UZS5_HUMAN)
  • cDNA FLJ51848, highly similar to Myelin-oligodendrocyte glycoprotein (B7Z2X8_HUMAN)
  • Myelin-oligodendrocyte glycoprotein (MOG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16653

UniProtKB/Swiss-Prot:

MOG_HUMAN :
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with MOG: view

Function for MOG Gene

Molecular function for MOG Gene

UniProtKB/Swiss-Prot Function:
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rubella virus.
GENATLAS Biochemistry:
myelin oligodendrocyte glycoprotein,26-28kDa,associated with multiple sclerosis susceptibility

Phenotypes From GWAS Catalog for MOG Gene

Gene Ontology (GO) - Molecular Function for MOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with MOG: view
genes like me logo Genes that share phenotypes with MOG: view

Human Phenotype Ontology for MOG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MOG Gene

MGI Knock Outs for MOG:
  • Mog Mog<tm1Dpd>
  • Mog Mog<tm1Reid>

Animal Model Products

  • Taconic Biosciences Mouse Models for MOG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOG

Clone Products

  • Addgene plasmids for MOG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MOG Gene

Localization for MOG Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOG Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 5: Cell membrane; Multi-pass membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Cell membrane; Single-pass type I membrane protein.
Isoform 7: Cell membrane; Single-pass type I membrane protein.
Isoform 8: Cell membrane; Single-pass type I membrane protein.
Isoform 9: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOG gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 8530032
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MOG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MOG Gene

Pathways & Interactions for MOG Gene

genes like me logo Genes that share pathways with MOG: view

Pathways by source for MOG Gene

Gene Ontology (GO) - Biological Process for MOG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007417 central nervous system development TAS 1373175
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
GO:0050776 regulation of immune response IBA 21873635
genes like me logo Genes that share ontologies with MOG: view

No data available for SIGNOR curated interactions for MOG Gene

Drugs & Compounds for MOG Gene

(11) Drugs for MOG Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MOG (35-55) Pharma Minor component of CNS myelin, Encephalitogenic myelin oligodendrocyte glycoprotein fragment 0

(9) Additional Compounds for MOG Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
B2
115687-05-3
Nogo-66 (1-40)
475221-20-6
PLP (139-151)
122018-58-0
TCS PrP Inhibitor 13
34320-83-7

(5) Tocris Compounds for MOG Gene

Compound Action Cas Number
B2 Promotes inclusion formation in Huntington's and Parkinson's diseases 115687-05-3
MOG (35-55) Encephalitogenic myelin oligodendrocyte glycoprotein fragment 149635-73-4
Nogo-66 (1-40) Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration 475221-20-6
PLP (139-151) Encephalitogenic myelin proteolipid fragment 122018-58-0
TCS PrP Inhibitor 13 Antiprion agent; potently inhibits PrP-res accumulation 34320-83-7

(1) ApexBio Compounds for MOG Gene

Compound Action Cas Number
MOG (35-55) Minor component of CNS myelin 149635-73-4
genes like me logo Genes that share compounds with MOG: view

Transcripts for MOG Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOG

Clone Products

  • Addgene plasmids for MOG

Alternative Splicing Database (ASD) splice patterns (SP) for MOG Gene

No ASD Table

Relevant External Links for MOG Gene

GeneLoc Exon Structure for
MOG
ECgene alternative splicing isoforms for
MOG

Expression for MOG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOG Gene

mRNA differential expression in normal tissues according to GTEx for MOG Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x16.2), Brain - Substantia nigra (x8.3), and Brain - Hippocampus (x5.2).

Protein differential expression in normal tissues from HIPED for MOG Gene

This gene is overexpressed in Spinal cord (46.5) and Frontal cortex (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MOG Gene



Protein tissue co-expression partners for MOG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOG Gene:

MOG

SOURCE GeneReport for Unigene cluster for MOG Gene:

Hs.141308

mRNA Expression by UniProt/SwissProt for MOG Gene:

Q16653-MOG_HUMAN
Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Evidence on tissue expression from TISSUES for MOG Gene

  • Nervous system(5)
  • Blood(2.7)
  • Spleen(2.4)
  • Eye(2.3)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MOG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
Thorax:
  • heart
General:
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with MOG: view

Orthologs for MOG Gene

This gene was present in the common ancestor of chordates.

Orthologs for MOG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOG 33 32
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MOG 33 32
  • 89.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MOG 33 32
  • 85.69 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mog 32
  • 83.94 (n)
mouse
(Mus musculus)
Mammalia Mog 17 33 32
  • 83.81 (n)
oppossum
(Monodelphis domestica)
Mammalia MOG 33
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MOG 33
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858529 32
  • 56.21 (n)
Species where no ortholog for MOG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MOG Gene

ENSEMBL:
Gene Tree for MOG (if available)
TreeFam:
Gene Tree for MOG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOG: view image

Paralogs for MOG Gene

(11) SIMAP similar genes for MOG Gene using alignment to 8 proteins:

  • MOG_HUMAN
  • C9JTE0_HUMAN
  • E9PG44_HUMAN
  • H0Y8A0_HUMAN
  • H7BYC0_HUMAN
  • Q5SSB8_HUMAN
  • Q5SUK5_HUMAN
  • Q8IYG5_HUMAN

Pseudogenes.org Pseudogenes for MOG Gene

genes like me logo Genes that share paralogs with MOG: view

Variants for MOG Gene

Sequence variations from dbSNP and Humsavar for MOG Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs149736421 likely-benign, Transient Neonatal Diabetes, Recessive 29,672,445(+) A/G downstream_transcript_variant
rs184974475 uncertain-significance, Transient Neonatal Diabetes, Recessive 29,672,639(+) G/A/C downstream_transcript_variant
rs387906655 pathogenic, Narcolepsy 7, Narcolepsy 7 (NRCLP7) [MIM:614250] 29,659,628(+) C/G coding_sequence_variant, intron_variant, missense_variant
rs606231122 pathogenic, Transient neonatal diabetes mellitus 1 29,672,728(+) G/ downstream_transcript_variant
rs79020217 pathogenic, Transient neonatal diabetes mellitus 1 29,672,739(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MOG Gene

Variant ID Type Subtype PubMed ID
esv2759411 CNV gain+loss 17122850
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259

Variation tolerance for MOG Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOG Gene

Human Gene Mutation Database (HGMD)
MOG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOG Gene

Disorders for MOG Gene

MalaCards: The human disease database

(36) MalaCards diseases for MOG Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
narcolepsy 7
  • nrclp7
rubella
  • german measles
primary progressive multiple sclerosis
  • ppms
optic neuritis
acute disseminated encephalomyelitis
  • acute disseminated encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search MOG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MOG_HUMAN
  • Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269 PubMed:21907016}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MOG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MOG: view

No data available for Genatlas for MOG Gene

Publications for MOG Gene

  1. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PMID: 17971048) Burfoot RK … Rubio JP (Tissue antigens 2008) 3 23 43 56
  2. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. (PMID: 17928868) D'Alfonso S … Momigliano-Richiardi P (Genes and immunity 2008) 3 23 43 56
  3. Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia. (PMID: 15660663) Zai G … Kennedy JL (Genes, brain, and behavior 2005) 3 23 43 56
  4. Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis. (PMID: 12149493) Ohlenbusch A … Hanefeld F (Pediatric research 2002) 3 23 43 56
  5. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PMID: 9210466) Albouz-Abo S … von Itzstein M (European journal of biochemistry 1997) 3 4 23 56

Products for MOG Gene

Sources for MOG Gene