Aliases for MOCS2 Gene
- Molybdenum Cofactor Synthesis 2 2 3 5
- Molybdopterin Synthase Catalytic Subunit 2 3 4
- MOCO1 2 3 4
- Molybdopterin Synthase Sulfur Carrier Subunit 3 4
- MOCS2A 2 4
- MOCS2B 2 4
- MCBPE 3 4
- Molybdenum Cofactor Synthesis Protein 2 Small Subunit 4
- Molybdenum Cofactor Synthesis Protein 2 Large Subunit 4
- Molybdenum Cofactor Biosynthesis Protein E 3
- Molybdenum Cofactor Synthesis Protein 2A 4
- Molybdenum Cofactor Synthesis Protein 2B 4
External Ids for MOCS2 Gene
Previous GeneCards Identifiers for MOCS2 Gene
Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
GeneCards Summary for MOCS2 Gene
MOCS2 (Molybdenum Cofactor Synthesis 2) is a Protein Coding gene. Diseases associated with MOCS2 include Molybdenum Cofactor Deficiency, Complementation Group B and Molybdenum Cofactor Deficiency, Complementation Group A. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Folate biosynthesis. Gene Ontology (GO) annotations related to this gene include identical protein binding and molybdopterin synthase activity. An important paralog of this gene is MBIP.
UniProtKB/Swiss-Prot Summary for MOCS2 Gene
Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.