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This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the met... See more...
Aliases for MOCOS Gene
Aliases for MOCOS Gene
External Ids for MOCOS Gene
- HGNC: 18234
- Entrez Gene: 55034
- Ensembl: ENSG00000075643
- OMIM: 613274
- UniProtKB: Q96EN8
Previous GeneCards Identifiers for MOCOS Gene
- GC18P032019
- GC18P032021
- GC18P033767
- GC18P030626
Summaries for MOCOS Gene
-
This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]
GeneCards Summary for MOCOS Gene
MOCOS (Molybdenum Cofactor Sulfurase) is a Protein Coding gene. Diseases associated with MOCOS include Xanthinuria, Type Ii and Xanthinuria. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity and lyase activity. An important paralog of this gene is MTARC1.
UniProtKB/Swiss-Prot Summary for MOCOS Gene
-
Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.
Additional gene information for MOCOS Gene
- HGNC(18234)
- Entrez Gene(55034)
- Ensembl(ENSG00000075643)
- OMIM(613274)
- UniProtKB(Q96EN8)
- Open Targets Platform(ENSG00000075643)
- Monarch Initiative
- Search for MOCOS at DataMed
- Search for MOCOS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOCOS Gene
Genomics for MOCOS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MOCOS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MOCOS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOCOS
- Top Transcription factor binding sites by QIAGEN in the MOCOS gene promoter:
-
- AP-1
- ARP-1
- c-Fos
- c-Jun
- Ik-2
- Lmo2
- NRSF form 1
- NRSF form 2
- POU2F1
- POU2F1a
Genomic Locations for MOCOS Gene
Genomic Locations for MOCOS Gene
- chr18:36,187,497-36,272,157
- (GRCh38/hg38)
- Size:
- 84,661 bases
- Orientation:
- Plus strand
- chr18:33,767,480-33,852,120
- (GRCh37/hg19)
- Size:
- 84,641 bases
- Orientation:
- Plus strand
Genomic View for MOCOS Gene
Genes around MOCOS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q12.2 by HGNC
- 18q12.2 by Entrez Gene
- 18q12.2 by Ensembl
MOCOS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MOCOS Gene
Proteins for MOCOS Gene
-
Protein details for MOCOS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96EN8-MOCOS_HUMAN
- Recommended name:
- Molybdenum cofactor sulfurase
- Protein Accession:
- Q96EN8
- Q53GP5
- Q8N3A4
- Q9NWM7
Protein attributes for MOCOS Gene
- Size:
- 888 amino acids
- Molecular mass:
- 98120 Da
- Cofactor:
- Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
- No Data Available
Protein Expression for MOCOS Gene
Post-translational modifications for MOCOS Gene
Other Protein References for MOCOS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for MOCOS
- Invitrogen Antibodies for MOCOS (AFLGC-MOCOS)
-
Biorbyt antibodies for MOCOS
-
Santa Cruz Biotechnology (SCBT) Antibodies for MOCOS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MOCOS
- Origene Custom Protein Services for MOCOS
-
Signalway Proteins for MOCOS
-
Abcam proteins for MOCOS
Assay Products
- antibodies-online: Show 9 available MOCOS Elisa Kits ranked by validation data
- Compare Top MOCOS Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MOCOS
No data available for DME Specific Peptides for MOCOS Gene
Domains & Families for MOCOS Gene
Gene Families for MOCOS Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for MOCOS Gene
- InterPro:
- Blocks:
-
- Aminotransferase, class V
- MOSC domain
- ProtoNet:
Suggested Antigen Peptide Sequences for MOCOS Gene
- GenScript: Design optimal peptide antigens:
-
- Molybdenum cofactor sulfurase (MOCOS_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96EN8UniProtKB/Swiss-Prot:
MOCOS_HUMAN :- Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
- Family:
-
- Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
Function for MOCOS Gene
Molecular function for MOCOS Gene
- UniProtKB/Swiss-Prot Function:
- Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin; Xref=Rhea:RHEA:42636, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:35235, ChEBI:CHEBI:57972, ChEBI:CHEBI:71302, ChEBI:CHEBI:82685; EC=2.8.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_03050};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=15 uM for benzamidoxime {ECO:0000269|PubMed:16973608}; Vmax=0.24 nmol/min/mg enzyme {ECO:0000269|PubMed:16973608};
Enzyme Numbers (IUBMB) for MOCOS Gene
Phenotypes From GWAS Catalog for MOCOS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0008265 | Mo-molybdopterin cofactor sulfurase activity | IMP | 11302742 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
Phenotypes for MOCOS Gene
- MGI mutant phenotypes for MOCOS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MOCOS:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MOCOS - Select products 50% OFF >
- * MOCOS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MOCOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOCOS
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOCOS
miRNA for MOCOS Gene
- miRTarBase miRNAs that target MOCOS
-
- hsa-miR-335-5p (MIRT018645)
- hsa-miR-526b-5p (MIRT447733)
- hsa-miR-4320 (MIRT447734)
- hsa-miR-4667-3p (MIRT447735)
- hsa-miR-541-5p (MIRT447736)
- hsa-miR-6865-3p (MIRT450467)
- hsa-miR-6086 (MIRT531964)
- hsa-miR-6854-3p (MIRT531965)
- hsa-miR-377-5p (MIRT531966)
- hsa-miR-548o-3p (MIRT531967)
- hsa-miR-1323 (MIRT531968)
- hsa-miR-5691 (MIRT641539)
- hsa-miR-6805-3p (MIRT641540)
- hsa-miR-3944-5p (MIRT641541)
- hsa-miR-143-5p (MIRT641542)
- hsa-miR-6879-3p (MIRT641543)
- hsa-miR-3194-3p (MIRT641544)
- hsa-miR-215-3p (MIRT641545)
- hsa-miR-6773-3p (MIRT641546)
- hsa-miR-4733-3p (MIRT641547)
- hsa-miR-1226-3p (MIRT641548)
- hsa-miR-1911-3p (MIRT641549)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOCOS
- Browse OriGene Inhibitory RNA Products For MOCOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOCOS
Clone Products
- Applied Biological Materials (abm): Clones for MOCOS - Select products 50% OFF >
- * MOCOS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MOCOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOCOS
Cell Line Products
-
Horizon Cell Lines for MOCOS
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MOCOS Gene
Localization for MOCOS Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 0 |
- Cytosol (2)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOCOS Gene
Pathways & Interactions for MOCOS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of water-soluble vitamins and cofactors | ||
| 2 | Folate biosynthesis | ||
| 3 | Metabolism |
.40
|
|
Pathways by source for MOCOS Gene
1 BioSystems pathway for MOCOS Gene
4 Reactome pathways for MOCOS Gene
1 KEGG pathway for MOCOS Gene
Interacting Proteins for MOCOS Gene
Selected Interacting proteins:
Q96EN8-MOCOS_HUMAN
ENSP00000261326
for MOCOS Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MOCOS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006777 | Mo-molybdopterin cofactor biosynthetic process | IEA | -- |
| GO:0032324 | molybdopterin cofactor biosynthetic process | TAS | -- |
| GO:0043545 | molybdopterin cofactor metabolic process | IMP | 11302742 |
No data available for SIGNOR curated interactions for MOCOS Gene
Drugs & Compounds for MOCOS Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Hydrogen Ion |
|
|
Transcripts for MOCOS Gene
mRNA/cDNA for MOCOS Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261326 6182 nts (view in UCSC)
- ENST00000588132 432 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MOCOS - Select products 50% OFF >
- * MOCOS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MOCOS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOCOS
-
Santa Cruz Biotechnology (SCBT) CRISPR for MOCOS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOCOS
- Browse OriGene Inhibitory RNA Products For MOCOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOCOS
Clone Products
- Applied Biological Materials (abm): Clones for MOCOS - Select products 50% OFF >
- * MOCOS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MOCOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOCOS
Relevant External Links for MOCOS Gene
- GeneLoc Exon Structure for
- MOCOS
Expression for MOCOS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Skeletal Muscle (Muscoskeletal System)
-
Hair (Integumentary System)
- Fetal Matrix Cells Hair Follicle
-
Epithelial Cells
- Fetal Matrix Cells Hair Follicle
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for MOCOS Gene
This gene is overexpressed in Liver (x10.0) and Adrenal Gland (x6.8).
This gene is overexpressed in Lung (27.5), Adrenal (25.4), and Liver (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOCOS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOCOS
SOURCE GeneReport for Unigene cluster for MOCOS Gene:
Hs.405028Evidence on tissue expression from TISSUES for MOCOS Gene
- Liver(4.5)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs for MOCOS
-
OriGene qPCR primer pairs and template standards for MOCOS
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOCOS Gene
Orthologs for MOCOS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MOCOS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MOCOS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MOCOS 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mocos 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mocos 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MOCOS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MOCOS 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MOCOS 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MOCOS 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | mocos 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | MOCOS_ANOGA 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | mal 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mocs-1 30 31 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ABA3 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for MOCOS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for MOCOS Gene
- ENSEMBL:
- Gene Tree for MOCOS (if available)
- TreeFam:
- Gene Tree for MOCOS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MOCOS: view image
Paralogs for MOCOS Gene
Variants for MOCOS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOCOS Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639841 | Uncertain Significance: Xanthinuria type II | 36,199,895(+) | C/T | MISSENSE_VARIANT | |
| 644865 | Uncertain Significance: Xanthinuria type II | 36,198,734(+) | A/G | MISSENSE_VARIANT | |
| 651388 | Uncertain Significance: Xanthinuria type II | 36,215,538(+) | A/G | MISSENSE_VARIANT | |
| 651732 | Uncertain Significance: Xanthinuria type II | 36,220,150(+) | A/C | MISSENSE_VARIANT | |
| 654063 | Uncertain Significance: Xanthinuria type II | 36,187,553(+) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2667651 | CNV | deletion | 23128226 |
| esv3304219 | CNV | mobile element insertion | 20981092 |
| esv3642217 | CNV | loss | 21293372 |
| esv3642218 | CNV | loss | 21293372 |
| esv3642219 | CNV | gain | 21293372 |
| esv3642220 | CNV | loss | 21293372 |
| esv987550 | CNV | deletion | 20482838 |
| nsv1064616 | CNV | gain | 25217958 |
| nsv130568 | CNV | deletion | 16902084 |
| nsv522803 | CNV | loss | 19592680 |
| nsv576651 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.09;
93.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MOCOS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOCOS Gene
Disorders for MOCOS Gene
(6) MalaCards diseases for MOCOS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| xanthinuria, type ii |
|
|
| xanthinuria |
|
|
| purine-pyrimidine metabolic disorder |
|
|
| molybdenum cofactor deficiency, complementation group a |
|
|
| alkaptonuria |
|
|
Search MOCOS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MOCOS_HUMAN- Xanthinuria 2 (XAN2) [MIM:603592]: A disorder characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In addition, XAN2 patients cannot metabolize allopurinol into oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase. {ECO:0000269 PubMed:11302742, ECO:0000269 PubMed:14624414, ECO:0000269 PubMed:17368066, ECO:0000269 Ref.12}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MOCOS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MOCOS Gene
Publications for MOCOS Gene
- Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. (PMID: 11302742) Ichida K … Nishino T (Biochemical and biophysical research communications 2001) 2 3 4 23
- Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease. (PMID: 19500084) Smith MA … Sanderson JD (Alimentary pharmacology & therapeutics 2009) 3 23 41
- Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria. (PMID: 17368066) Peretz H … Landau D (Molecular genetics and metabolism 2007) 3 4 23
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme. (PMID: 16973608) Havemeyer A … Clement B (The Journal of biological chemistry 2006) 4 23
ExternalLinks
Products for MOCOS Gene
- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MOCOS
- Origene Custom Protein Services for MOCOS
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MOCOS
- Browse OriGene Inhibitory RNA Products For MOCOS
- OriGene qPCR primer pairs for MOCOS
- OriGene qPCR primer pairs and template standards for MOCOS
- OriGene CRISPR knockouts for MOCOS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MOCOS
- Sino Biological Human cDNA Clone for MOCOS
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for MOCOS
- Novus Biologicals proteins and lysates for MOCOS
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for MOCOS
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MOCOS (AFLGC-MOCOS)
- VectorBuilder Custom and pre-made DNA vectors for MOCOS (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MOCOS (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MOCOS (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MOCOS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MOCOS
- antibodies-online: Show 11 available MOCOS Antibodies ranked by validation data
- Compare Top MOCOS Antibodies
- antibodies-online: Show 9 available MOCOS Elisa Kits ranked by validation data
- Compare Top MOCOS Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available MOCOS Proteins ranked by validation data
- Compare Top MOCOS Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MOCOS
- Search Santa Cruz Biotechnology (SCBT) for MOCOS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MOCOS
- Horizon Cell Lines for MOCOS
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MOCOS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MOCOS
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MOCOS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOCOS
- Biorbyt antibodies for MOCOS
Sources for MOCOS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB