Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MOB3B Gene

Aliases for MOB3B Gene

  • MOB Kinase Activator 3B 2 3 5
  • Monopolar Spindle 1 Binding, MOB1, Domain Containing 2 3
  • Mps One Binder Kinase Activator-Like 2B 3 4
  • MOB Kinase Activator-Like 2B 3 4
  • Mob1 Homolog 2b 3 4
  • C9orf35 3 4
  • MOBKL2B 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2B (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 2B 3
  • Chromosome 9 Open Reading Frame 35 2
  • MOB1D 3

External Ids for MOB3B Gene

Previous HGNC Symbols for MOB3B Gene

  • C9orf35

Summaries for MOB3B Gene

Entrez Gene Summary for MOB3B Gene

  • The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MOB3B Gene

MOB3B (MOB Kinase Activator 3B) is a Protein Coding gene. An important paralog of this gene is MOB3A.

UniProtKB/Swiss-Prot for MOB3B Gene

  • May regulate the activity of kinases.

Additional gene information for MOB3B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3B Gene

Genomics for MOB3B Gene

GeneHancer (GH) Regulatory Elements for MOB3B Gene

Promoters and enhancers for MOB3B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I027527 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 556.1 +1.1 1097 3.4 PKNOX1 RB1 ZNF76 SIN3A ZNF48 RAD21 ZNF335 GLIS2 ZNF207 ZNF143 MOB3B C9orf72 EQTN IFNK
GH09I027524 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.4 +5.3 5287 0.1 IFNK MOB3B
GH09I027365 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +160.6 160579 8.5 HDGF PKNOX1 ZSCAN4 FEZF1 BATF IRF4 RCOR1 ATF7 ETV6 FOS MOB3B IFT74 ENSG00000237734 EQTN IFNK C9orf72 PLAA GC09M027375
GH09I027538 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.3 -10.1 -10061 2.8 ELF3 PKNOX1 FOXA2 SMAD1 RARA RFX5 YY1 RCOR1 FOS CREM MOB3B C9orf72 EQTN
GH09I027332 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 14 +196.4 196431 1.3 CTCF FOXA2 ZNF384 ZNF2 RAD21 GATA3 ZNF143 SMC3 DEK ZNF362 MOB3B IFNK EQTN IFT74 C9orf72 GC09M027375
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOB3B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOB3B Gene

Genomic Locations for MOB3B Gene
204,644 bases
Minus strand

Genomic View for MOB3B Gene

Genes around MOB3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3B Gene

Proteins for MOB3B Gene

  • Protein details for MOB3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MOB kinase activator 3B
    Protein Accession:
    Secondary Accessions:
    • Q8NEB4
    • Q9H8V4

    Protein attributes for MOB3B Gene

    216 amino acids
    Molecular mass:
    25464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MOB3B Gene

Post-translational modifications for MOB3B Gene

No Post-translational modifications

Other Protein References for MOB3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB3B Gene

Domains & Families for MOB3B Gene

Gene Families for MOB3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOB3B Gene

Suggested Antigen Peptide Sequences for MOB3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOB1/phocein family.
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3B: view

Function for MOB3B Gene

Molecular function for MOB3B Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Phenotypes From GWAS Catalog for MOB3B Gene

Gene Ontology (GO) - Molecular Function for MOB3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB3B: view
genes like me logo Genes that share phenotypes with MOB3B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3B Gene

Localization for MOB3B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB3B gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Intermediate filaments (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MOB3B Gene

Pathways & Interactions for MOB3B Gene

SuperPathways for MOB3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB3B Gene


No data available for Pathways by source and SIGNOR curated interactions for MOB3B Gene

Drugs & Compounds for MOB3B Gene

(1) Drugs for MOB3B Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with MOB3B: view

Transcripts for MOB3B Gene

mRNA/cDNA for MOB3B Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3B Gene

No ASD Table

Relevant External Links for MOB3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MOB3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB3B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9).

Protein differential expression in normal tissues from HIPED for MOB3B Gene

This gene is overexpressed in Ovary (22.2), Retina (20.0), Fetal gut (9.5), and Lymph node (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MOB3B Gene

NURSA nuclear receptor signaling pathways regulating expression of MOB3B Gene:


SOURCE GeneReport for Unigene cluster for MOB3B Gene:


Evidence on tissue expression from TISSUES for MOB3B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MOB3B: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB3B Gene

Orthologs for MOB3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MOB3B 34
  • 100 (a)
  • 99.85 (n)
(Monodelphis domestica)
Mammalia MOB3B 34
  • 99 (a)
(Canis familiaris)
Mammalia MOB3B 33 34
  • 95.52 (n)
(Bos Taurus)
Mammalia MOB3B 33 34
  • 92.28 (n)
(Rattus norvegicus)
Mammalia Mob3b 33
  • 91.51 (n)
(Mus musculus)
Mammalia Mob3b 33 16 34
  • 90.59 (n)
(Ornithorhynchus anatinus)
Mammalia MOB3B 34
  • 85 (a)
(Gallus gallus)
Aves MOB3B 34
  • 94 (a)
  • 82.87 (n)
(Anolis carolinensis)
Reptilia MOB3B 34
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14298 33
(Danio rerio)
Actinopterygii mob1bb 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mob3 34
  • 66 (a)
(Caenorhabditis elegans)
Secernentea T12B3.4 34
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 34
  • 68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9757 33
Species where no ortholog for MOB3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MOB3B Gene

Gene Tree for MOB3B (if available)
Gene Tree for MOB3B (if available)

Paralogs for MOB3B Gene

Paralogs for MOB3B Gene

(8) SIMAP similar genes for MOB3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB3B: view

Variants for MOB3B Gene

Sequence variations from dbSNP and Humsavar for MOB3B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000014305 -- 27,473,564(-) G/A intron_variant
rs1000015435 -- 27,369,123(-) C/A/T intron_variant
rs1000034664 -- 27,474,269(-) C/G intron_variant
rs1000059670 -- 27,424,700(-) T/C intron_variant
rs1000073314 -- 27,332,751(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOB3B Gene

Variant ID Type Subtype PubMed ID
nsv613949 CNV loss 21841781
nsv473199 CNV novel sequence insertion 20440878
nsv466337 CNV loss 19166990
nsv1019688 CNV loss 25217958
nsv1015259 CNV gain 25217958
esv3620130 CNV loss 21293372
esv3620129 CNV loss 21293372
esv3573190 CNV loss 25503493
esv3428618 CNV insertion 20981092
esv2738323 CNV deletion 23290073
esv2738322 CNV deletion 23290073
esv2664439 CNV deletion 23128226
esv2131938 CNV deletion 18987734
esv1113815 CNV insertion 17803354
dgv480e215 CNV deletion 23714750

Variation tolerance for MOB3B Gene

Residual Variation Intolerance Score: 30.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB3B Gene

Disorders for MOB3B Gene

Additional Disease Information for MOB3B

No disorders were found for MOB3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3B Gene

Publications for MOB3B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics. (PMID: 26130958) Kim EA … Kim WJ (Journal of Korean medical science 2015) 3 58
  5. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. (PMID: 23376709) Kerns SL … Rosenstein BS (The Journal of urology 2013) 3 58

Products for MOB3B Gene

Sources for MOB3B Gene

Loading form....