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Aliases for MOB3A Gene

Aliases for MOB3A Gene

  • MOB Kinase Activator 3A 2 3 3 5
  • Mps One Binder Kinase Activator-Like 2A 3 4
  • Mob1 Homolog 2A 3 4
  • MOB LAK 2 3
  • MOBKL2A 3 4
  • MOB-LAK 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 2A (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 2A 3
  • Moblak 3
  • MOB1C 3

External Ids for MOB3A Gene

Previous HGNC Symbols for MOB3A Gene

  • MOBKL2A

Summaries for MOB3A Gene

GeneCards Summary for MOB3A Gene

MOB3A (MOB Kinase Activator 3A) is a Protein Coding gene. An important paralog of this gene is MOB3B.

UniProtKB/Swiss-Prot for MOB3A Gene

  • May regulate the activity of kinases.

Gene Wiki entry for MOB3A Gene

Additional gene information for MOB3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB3A Gene

Genomics for MOB3A Gene

GeneHancer (GH) Regulatory Elements for MOB3A Gene

Promoters and enhancers for MOB3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002079 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.1 +7.8 7820 18.9 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MOB3A IZUMO4 ZNF77 LMNB2 ZNF555 BTBD2 SF3A2 CIRBP MKNK2 DOT1L
GH19J002038 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 +45.6 45648 24.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 NFYC MKNK2 SF3A2 ZNF77 TCF3 DAZAP1 LOC100288123 CIRBP LMNB2 ENSG00000267317 MUM1
GH19J001872 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +222.0 221958 5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ENSG00000261526 ENSG00000267232 GC19M001875 KLF16 SF3A2 TMEM259 LOC100288123 DAZAP1 GRIN3B TCF3
GH19J002781 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -687.7 -687657 4.9 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC THOP1 SGTA ZNF554 SF3A2 CACTIN-AS1 APBA3 LOC100288123 ENSG00000267139 MOB3A DOT1L
GH19J002234 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 -142.8 -142842 10.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SF3A2 PLEKHJ1 DAZAP1 ZNF77 AMH LOC100288123 TCF3 ENSG00000267317 DOT1L GNA11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOB3A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOB3A Gene

Genomic Locations for MOB3A Gene
chr19:2,071,032-2,096,673
(GRCh38/hg38)
Size:
25,642 bases
Orientation:
Minus strand
chr19:2,071,035-2,096,672
(GRCh37/hg19)
Size:
25,638 bases
Orientation:
Minus strand

Genomic View for MOB3A Gene

Genes around MOB3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB3A Gene

Proteins for MOB3A Gene

  • Protein details for MOB3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BX8-MOB3A_HUMAN
    Recommended name:
    MOB kinase activator 3A
    Protein Accession:
    Q96BX8
    Secondary Accessions:
    • B3KTF1
    • O75249
    • Q8TF69

    Protein attributes for MOB3A Gene

    Size:
    217 amino acids
    Molecular mass:
    25464 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB84554.1; Type=Miscellaneous discrepancy; Note=Chimera. There is an inclusion of DNA from another gene in position 141.; Evidence={ECO:0000305};

neXtProt entry for MOB3A Gene

Post-translational modifications for MOB3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MOB3A Gene

Domains & Families for MOB3A Gene

Gene Families for MOB3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOB3A Gene

Suggested Antigen Peptide Sequences for MOB3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BX8

UniProtKB/Swiss-Prot:

MOB3A_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB3A: view

Function for MOB3A Gene

Molecular function for MOB3A Gene

UniProtKB/Swiss-Prot Function:
May regulate the activity of kinases.

Phenotypes From GWAS Catalog for MOB3A Gene

Gene Ontology (GO) - Molecular Function for MOB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB3A: view
genes like me logo Genes that share phenotypes with MOB3A: view

Animal Model Products

CRISPR Products

miRNA for MOB3A Gene

miRTarBase miRNAs that target MOB3A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB3A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB3A Gene

Localization for MOB3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB3A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Intermediate filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOB3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with MOB3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOB3A Gene

Pathways & Interactions for MOB3A Gene

SuperPathways for MOB3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MOB3A Gene

Drugs & Compounds for MOB3A Gene

No Compound Related Data Available

Transcripts for MOB3A Gene

mRNA/cDNA for MOB3A Gene

Unigene Clusters for MOB3A Gene

MOB kinase activator 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB3A

Alternative Splicing Database (ASD) splice patterns (SP) for MOB3A Gene

No ASD Table

Relevant External Links for MOB3A Gene

GeneLoc Exon Structure for
MOB3A
ECgene alternative splicing isoforms for
MOB3A

Expression for MOB3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB3A Gene

mRNA differential expression in normal tissues according to GTEx for MOB3A Gene

This gene is overexpressed in Whole Blood (x14.4).

Protein differential expression in normal tissues from HIPED for MOB3A Gene

This gene is overexpressed in Tlymphocyte (13.2), Lymph node (8.6), and Bone (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOB3A Gene



Protein tissue co-expression partners for MOB3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB3A Gene:

MOB3A

SOURCE GeneReport for Unigene cluster for MOB3A Gene:

Hs.744938

Evidence on tissue expression from TISSUES for MOB3A Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with MOB3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB3A Gene

Orthologs for MOB3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB3A 34 33
  • 99.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MOB3A 34 33
  • 92.17 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOB3A 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MOB3A 34 33
  • 89.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mob3a 33
  • 88.02 (n)
mouse
(Mus musculus)
Mammalia Mob3a 16 34 33
  • 85.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOB3A 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB3A 34
  • 90 (a)
OneToOne
LOC100857182 33
  • 87.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mob3a 33
  • 75.15 (n)
zebrafish
(Danio rerio)
Actinopterygii mob3a 34 33
  • 80.19 (n)
OneToOne
wufc69e01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3035 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007872 33
  • 65.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob3 34 33
  • 63.38 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T12B3.4 34 33
  • 60.81 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2077 34
  • 69 (a)
OneToMany
Species where no ortholog for MOB3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB3A Gene

ENSEMBL:
Gene Tree for MOB3A (if available)
TreeFam:
Gene Tree for MOB3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOB3A: view image

Paralogs for MOB3A Gene

Paralogs for MOB3A Gene

(8) SIMAP similar genes for MOB3A Gene using alignment to 7 proteins:

  • MOB3A_HUMAN
  • K7EKK6_HUMAN
  • K7ELH3_HUMAN
  • K7ELS3_HUMAN
  • K7EPX7_HUMAN
  • K7ESA9_HUMAN
  • K7ESI3_HUMAN
genes like me logo Genes that share paralogs with MOB3A: view

Variants for MOB3A Gene

Sequence variations from dbSNP and Humsavar for MOB3A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000054568 -- 2,079,369(-) G/T intron_variant
rs1000231388 -- 2,089,112(-) G/A intron_variant
rs1000393 -- 2,075,667(-) A/T intron_variant
rs1000570680 -- 2,074,910(-) G/T intron_variant
rs1000700208 -- 2,092,249(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOB3A Gene

Variant ID Type Subtype PubMed ID
esv26236 CNV gain 19812545
esv2663238 CNV deletion 23128226
esv2672429 CNV deletion 23128226
esv3583203 CNV loss 25503493
esv3643418 CNV loss 21293372
esv3893156 CNV loss 25118596
nsv458325 CNV loss 19166990
nsv470107 CNV loss 18288195
nsv578380 CNV loss 21841781

Variation tolerance for MOB3A Gene

Residual Variation Intolerance Score: 53.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB3A Gene

Disorders for MOB3A Gene

Additional Disease Information for MOB3A

No disorders were found for MOB3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB3A Gene

Publications for MOB3A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for MOB3A Gene

Sources for MOB3A Gene

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