Aliases for MOB2 Gene

Aliases for MOB2 Gene

  • MOB Kinase Activator 2 2 3 4 5
  • HCCA2 2 3 4
  • Mps One Binder Kinase Activator-Like 2 3 4
  • MOB2 Mps One Binder Homolog (Yeast) 2
  • MOB2 Mps One Binder Homolog 3
  • Mob2 Homolog 4
  • MOB2 5

External Ids for MOB2 Gene

Previous GeneCards Identifiers for MOB2 Gene

  • GC11M001490
  • GC11M001278

Summaries for MOB2 Gene

GeneCards Summary for MOB2 Gene

MOB2 (MOB Kinase Activator 2) is a Protein Coding gene. Diseases associated with MOB2 include Van Maldergem Syndrome and Periventricular Nodular Heterotopia. An important paralog of this gene is MOB1B.

UniProtKB/Swiss-Prot Summary for MOB2 Gene

  • Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOB2 Gene

Genomics for MOB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MOB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J001530 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 621.2 -31.0 -31010 3.1 ZIC2 CTCF POLR2A ZNF687 MNT MOB2 KRTAP5-AS1 TOLLIP TOLLIP-AS1 KRTAP5-5 KRTAP5-4 GATD1 piR-42694-025 DUSP8
GH11J001501 Enhancer 0.4 Ensembl 600.7 -0.1 -54 0.2 ZNF316 MAFF MAFK EMSY MOB2 lnc-MOB2-1 HSALNG0082116 DUSP8
GH11J001500 Enhancer 0.2 Ensembl 600.7 +0.3 346 0.2 MOB2 lnc-MOB2-1 KRTAP5-AS1 piR-45158 BRSK2
GH11J002376 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.3 -883.4 -883399 16.2 CTCF PRDM10 ZNF629 REST POLR2A BACH1 JUND LARP7 ZNF143 RELA CD81 CD81-AS1 MOB2 ENSG00000199550 KCNQ1 lnc-TSSC4-2 NONHSAG007426.2 TSSC4
GH11J001301 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.4 +194.4 194431 10.7 HNRNPL GATAD2A CTCF TFE3 NFKBIZ ZNF692 POLR2A BACH1 LARP7 ZNF143 TOLLIP TOLLIP-AS1 TSPAN4 MOB2 TMEM80 SNORA52 PHRF1 ENSG00000255237 PIDD1 CD151
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOB2

Genomic Locations for MOB2 Gene

Genomic Locations for MOB2 Gene
chr11:1,469,448-1,501,247
(GRCh38/hg38)
Size:
31,800 bases
Orientation:
Minus strand
chr11:1,490,685-1,522,477
(GRCh37/hg19)
Size:
31,793 bases
Orientation:
Minus strand

Genomic View for MOB2 Gene

Genes around MOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB2 Gene

Proteins for MOB2 Gene

  • Protein details for MOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA6-MOB2_HUMAN
    Recommended name:
    MOB kinase activator 2
    Protein Accession:
    Q70IA6
    Secondary Accessions:
    • B4DKP3
    • Q96M67

    Protein attributes for MOB2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26927 Da
    Quaternary structure:
    • Binds STK38 and STK38L.

    Alternative splice isoforms for MOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB2 Gene

Post-translational modifications for MOB2 Gene

Other Protein References for MOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MOB2
  • Boster Bio Antibodies for MOB2

No data available for DME Specific Peptides for MOB2 Gene

Domains & Families for MOB2 Gene

Gene Families for MOB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOB2 Gene

InterPro:
Blocks:
  • Mob1/phocein family
ProtoNet:

Suggested Antigen Peptide Sequences for MOB2 Gene

GenScript: Design optimal peptide antigens:
  • Mob2 homolog (MOB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q70IA6

UniProtKB/Swiss-Prot:

MOB2_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB2: view

Function for MOB2 Gene

Molecular function for MOB2 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Phenotypes From GWAS Catalog for MOB2 Gene

Gene Ontology (GO) - Molecular Function for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24366813
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB2: view
genes like me logo Genes that share phenotypes with MOB2: view

Animal Models for MOB2 Gene

MGI Knock Outs for MOB2:
  • Mob2 Mob2<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for MOB2 Gene

miRTarBase miRNAs that target MOB2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB2 Gene

Localization for MOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MOB2: view

Pathways & Interactions for MOB2 Gene

PathCards logo

SuperPathways for MOB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with MOB2: view

No data available for Pathways by source and SIGNOR curated interactions for MOB2 Gene

Drugs & Compounds for MOB2 Gene

No Compound Related Data Available

Transcripts for MOB2 Gene

mRNA/cDNA for MOB2 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB2

Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for MOB2 Gene

GeneLoc Exon Structure for
MOB2

Expression for MOB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOB2 Gene

Protein differential expression in normal tissues from HIPED for MOB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5), Esophagus (6.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOB2 Gene



Protein tissue co-expression partners for MOB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOB2

SOURCE GeneReport for Unigene cluster for MOB2 Gene:

Hs.370360

Evidence on tissue expression from TISSUES for MOB2 Gene

  • Nervous system(4.7)
  • Intestine(4.3)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with MOB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB2 Gene

Orthologs for MOB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MOB2 30 31
  • 99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mob2 30
  • 87.21 (n)
Cow
(Bos Taurus)
Mammalia MOB2 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mob2 30 17 31
  • 86.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MOB2 30 31
  • 85.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MOB2 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MOB2 30 31
  • 77.82 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MOB2 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mob2.1 30
  • 79.6 (n)
MGC76042 30
Zebrafish
(Danio rerio)
Actinopterygii mob2a 30 31
  • 74.3 (n)
OneToMany
mob2b 31
  • 74 (a)
OneToMany
MOB2 (3 of 3) 31
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010841 30
  • 57.92 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Mob2 31
  • 16 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea F38H4.10 31
  • 33 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 31
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2588 30
Species where no ortholog for MOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MOB2 Gene

ENSEMBL:
Gene Tree for MOB2 (if available)
TreeFam:
Gene Tree for MOB2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOB2: view image

Paralogs for MOB2 Gene

Paralogs for MOB2 Gene

(7) SIMAP similar genes for MOB2 Gene using alignment to 1 proteins:

  • MOB2_HUMAN
genes like me logo Genes that share paralogs with MOB2: view

Variants for MOB2 Gene

Additional dbSNP identifiers (rs#s) for MOB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MOB2 Gene

Variant ID Type Subtype PubMed ID
dgv10n68 CNV loss 17160897
esv2669189 CNV deletion 23128226
esv2743878 CNV deletion 23290073
nsv951279 CNV deletion 24416366

Variation tolerance for MOB2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOB2 Gene

Disorders for MOB2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MOB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
van maldergem syndrome
  • cerebrofacioarticular syndrome
periventricular nodular heterotopia
  • periventricular heterotopia
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search MOB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOB2

genes like me logo Genes that share disorders with MOB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOB2 Gene

Publications for MOB2 Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E … Silver PA (The Journal of biological chemistry 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Gene expression profile in Alzheimer's brain screened by molecular indexing. (PMID: 11223154) Doyu M … Kato K (Brain research. Molecular brain research 2001) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for MOB2 Gene

Sources for MOB2 Gene