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Aliases for MOB2 Gene

Aliases for MOB2 Gene

  • MOB Kinase Activator 2 2 3 5
  • Mps One Binder Kinase Activator-Like 2 3 4
  • HCCA2 3 4
  • MOB2 Mps One Binder Homolog (Yeast) 2
  • MOB2 Mps One Binder Homolog 3
  • Mob2 Homolog 4

External Ids for MOB2 Gene

Previous GeneCards Identifiers for MOB2 Gene

  • GC11M001278

Summaries for MOB2 Gene

GeneCards Summary for MOB2 Gene

MOB2 (MOB Kinase Activator 2) is a Protein Coding gene. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot for MOB2 Gene

  • Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Additional gene information for MOB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MOB2 Gene

Genomics for MOB2 Gene

GeneHancer (GH) Regulatory Elements for MOB2 Gene

Promoters and enhancers for MOB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I001485 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 559.4 +14.5 14461 3.2 SCRT1 ESRRA NR2F1 ZSCAN4 EBF1 ZIC2 ZFHX2 EGR1 SCRT2 STAT2 MOB2 KRTAP5-AS1 GC11P001473
GH11I001502 Enhancer 0.5 FANTOM5 ENCODE 550.8 -1.8 -1808 1 ZFHX2 MOB2 KRTAP5-AS1 GC11P001506
GH11I001556 Enhancer 1.2 Ensembl ENCODE dbSUPER 19.9 -57.5 -57484 4.5 NFIB KLF17 SIN3A YY1 GLIS2 RCOR1 FOS EGR2 USF2 CEBPB GC11M001556 KRTAP5-AS1 MOB2 KRTAP5-1 KRTAP5-2 GC11M001565 DUSP8
GH11I001458 Enhancer 1 Ensembl ENCODE dbSUPER 20.2 +42.0 41958 2.1 CTCF KLF1 MAZ RAD21 HIC1 ZFHX2 ZNF316 EGR1 GLIS1 VEZF1 MOB2 KRTAP5-AS1 LOC105376514 PIR38157 GC11M001469 BRSK2
GH11I001567 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 9.3 -69.8 -69755 8 PKNOX1 ATF1 ZFP64 SIN3A ZNF2 ZNF766 GLIS2 ZNF143 FOS ATF7 KRTAP5-AS1 DUSP8 KRTAP5-2 KRTAP5-5 MOB2 GC11M001565
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MOB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MOB2 Gene

Genomic Locations for MOB2 Gene
chr11:1,469,448-1,501,247
(GRCh38/hg38)
Size:
31,800 bases
Orientation:
Minus strand
chr11:1,490,685-1,522,477
(GRCh37/hg19)

Genomic View for MOB2 Gene

Genes around MOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB2 Gene

Proteins for MOB2 Gene

  • Protein details for MOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70IA6-MOB2_HUMAN
    Recommended name:
    MOB kinase activator 2
    Protein Accession:
    Q70IA6
    Secondary Accessions:
    • B4DKP3
    • Q96M67

    Protein attributes for MOB2 Gene

    Size:
    237 amino acids
    Molecular mass:
    26927 Da
    Quaternary structure:
    • Binds STK38 and STK38L.

    Alternative splice isoforms for MOB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB2 Gene

Post-translational modifications for MOB2 Gene

Other Protein References for MOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MOB2 Gene

Domains & Families for MOB2 Gene

Gene Families for MOB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOB2 Gene

Suggested Antigen Peptide Sequences for MOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70IA6

UniProtKB/Swiss-Prot:

MOB2_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB2: view

Function for MOB2 Gene

Molecular function for MOB2 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Phenotypes From GWAS Catalog for MOB2 Gene

Gene Ontology (GO) - Molecular Function for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24366813
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB2: view

Phenotypes for MOB2 Gene

genes like me logo Genes that share phenotypes with MOB2: view

Animal Models for MOB2 Gene

MGI Knock Outs for MOB2:
  • Mob2 tm1b(KOMP)Wtsi

miRNA for MOB2 Gene

miRTarBase miRNAs that target MOB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB2 Gene

Localization for MOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB2 Gene

Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0044306 neuron projection terminus IEA --
genes like me logo Genes that share ontologies with MOB2: view

Pathways & Interactions for MOB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with MOB2: view

No data available for Pathways by source and SIGNOR curated interactions for MOB2 Gene

Drugs & Compounds for MOB2 Gene

No Compound Related Data Available

Transcripts for MOB2 Gene

Unigene Clusters for MOB2 Gene

MOB kinase activator 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6:
SP7: -

Relevant External Links for MOB2 Gene

GeneLoc Exon Structure for
MOB2
ECgene alternative splicing isoforms for
MOB2

Expression for MOB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MOB2 Gene

Protein differential expression in normal tissues from HIPED for MOB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5), Esophagus (6.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MOB2 Gene



Protein tissue co-expression partners for MOB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MOB2 Gene:

MOB2

SOURCE GeneReport for Unigene cluster for MOB2 Gene:

Hs.370360

Evidence on tissue expression from TISSUES for MOB2 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MOB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB2 Gene

Orthologs for MOB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MOB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB2 33 34
  • 99 (n)
rat
(Rattus norvegicus)
Mammalia Mob2 33
  • 87.21 (n)
cow
(Bos Taurus)
Mammalia MOB2 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob2 33 16 34
  • 86.93 (n)
dog
(Canis familiaris)
Mammalia MOB2 33 34
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia MOB2 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves MOB2 33 34
  • 77.82 (n)
lizard
(Anolis carolinensis)
Reptilia MOB2 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob2.1 33
  • 79.6 (n)
MGC76042 33
zebrafish
(Danio rerio)
Actinopterygii mob2a 33 34
  • 74.3 (n)
mob2b 34
  • 74 (a)
OneToMany
MOB2 (3 of 3) 34
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010841 33
  • 57.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mob2 34
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F38H4.10 34
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2588 33
Species where no ortholog for MOB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MOB2 Gene

ENSEMBL:
Gene Tree for MOB2 (if available)
TreeFam:
Gene Tree for MOB2 (if available)

Paralogs for MOB2 Gene

Paralogs for MOB2 Gene

(7) SIMAP similar genes for MOB2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MOB2: view

Variants for MOB2 Gene

Sequence variations from dbSNP and Humsavar for MOB2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000403535 -- 1,484,117(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000447345 -- 1,470,606(-) C/T intron_variant
rs1000487310 -- 1,485,687(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000612841 -- 1,481,413(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000676990 -- 1,475,570(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MOB2 Gene

Variant ID Type Subtype PubMed ID
nsv951279 CNV deletion 24416366
esv2743878 CNV deletion 23290073
esv2669189 CNV deletion 23128226
dgv10n68 CNV loss 17160897

Variation tolerance for MOB2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB2 Gene

Disorders for MOB2 Gene

Additional Disease Information for MOB2

No disorders were found for MOB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MOB2 Gene

Publications for MOB2 Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E … Silver PA (The Journal of biological chemistry 2004) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Gene expression profile in Alzheimer's brain screened by molecular indexing. (PMID: 11223154) Doyu M … Kato K (Brain research. Molecular brain research 2001) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MOB2 Gene

Sources for MOB2 Gene

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