The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] See more...

Aliases for MOB1B Gene

Aliases for MOB1B Gene

  • MOB Kinase Activator 1B 2 3 4 5
  • Mps One Binder Kinase Activator-Like 1A 3 4
  • Mob1 Homolog 1A 3 4
  • MOBKL1A 3 4
  • Mob1A 3 4
  • MOB4A 3 4
  • MOB1, Mps One Binder Kinase Activator-Like 1A (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1A 3
  • MOB1 Mps One Binder Homolog B (Yeast) 2
  • MOB1 Mps One Binder Homolog B 3
  • Mob4A Protein 2
  • MATS2 3
  • Mob1B 4

External Ids for MOB1B Gene

Previous HGNC Symbols for MOB1B Gene

  • MOBKL1A

Previous GeneCards Identifiers for MOB1B Gene

  • GC04P071769

Summaries for MOB1B Gene

Entrez Gene Summary for MOB1B Gene

  • The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MOB1B Gene

MOB1B (MOB Kinase Activator 1B) is a Protein Coding gene. Diseases associated with MOB1B include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Hippo signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include kinase binding and kinase activator activity. An important paralog of this gene is MOB1A.

UniProtKB/Swiss-Prot Summary for MOB1B Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Gene Wiki entry for MOB1B Gene

Additional gene information for MOB1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOB1B Gene

Genomics for MOB1B Gene

GeneHancer (GH) Regulatory Elements for MOB1B Gene

Promoters and enhancers for MOB1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J070901 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 517.5 +0.9 927 3.4 CTCF NRF1 POLR2G PHF8 PHB2 ZFX ZNF639 ZIC2 POLR2A ZBTB11 MOB1B lnc-GRSF1-2 DCK GRSF1 UTP3 JCHAIN piR-59760
GH04J070923 Enhancer 0.9 Ensembl ENCODE 18.7 +23.5 23527 5.8 POLR2A ZNF341 ZBTB17 SPI1 ZFHX2 BATF ELF1 POU2F2 IKZF1 ZNF189 MOB1B DCK GRSF1 UTP3 JCHAIN piR-59760 MF281472
GH04J070992 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.8 +93.3 93265 6.2 RXRA HNRNPK ZBTB40 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 PHF8 DCK RUFY3 MOB1B JCHAIN piR-35967-007 piR-39341-277
GH04J071186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.1 +286.3 286327 4.6 ZSCAN5C FOS CTCF ZBTB10 ZBTB26 EZH2 HDAC2 ZNF341 POLR2A ZBTB17 SLC4A4 MOB1B piR-57195-160 RF00994-738
GH04J070891 Enhancer 1 Ensembl ENCODE 5.5 -9.6 -9574 2 AFF1 TOE1 CTBP1 PBX2 TRIM24 CEBPG MAX POLR2H FOSL1 BCOR MOB1B DCK lnc-MOB1B-1 lnc-MOB1B-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOB1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOB1B

Genomic Locations for MOB1B Gene

Genomic Locations for MOB1B Gene
chr4:70,901,974-71,022,449
(GRCh38/hg38)
Size:
120,476 bases
Orientation:
Plus strand
chr4:71,768,043-71,888,166
(GRCh37/hg19)
Size:
120,124 bases
Orientation:
Plus strand

Genomic View for MOB1B Gene

Genes around MOB1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1B Gene

Proteins for MOB1B Gene

  • Protein details for MOB1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L9L4-MOB1B_HUMAN
    Recommended name:
    MOB kinase activator 1B
    Protein Accession:
    Q7L9L4
    Secondary Accessions:
    • B2R8U6
    • B4DRY3
    • Q8IY23

    Protein attributes for MOB1B Gene

    Size:
    216 amino acids
    Molecular mass:
    25091 Da
    Quaternary structure:
    • Binds STK38L. Interacts with LATS1 and LATS2.

    Alternative splice isoforms for MOB1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1B Gene

Post-translational modifications for MOB1B Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB1B Gene

No data available for DME Specific Peptides for MOB1B Gene

Domains & Families for MOB1B Gene

Gene Families for MOB1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MOB1B Gene

Blocks:
  • Mob1/phocein family
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MOB1B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ36226 fis, clone THYMU2001018, highly similar to Mps one binder kinase activator-like 1A (B3KSH6_HUMAN)
  • cDNA FLJ52228, highly similar to Mps one binder kinase activator-like 1A (B4DRY3_HUMAN)
  • Protein Mob4A (MOL1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L9L4

UniProtKB/Swiss-Prot:

MOB1B_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1B: view

Function for MOB1B Gene

Molecular function for MOB1B Gene

UniProtKB/Swiss-Prot Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Phenotypes From GWAS Catalog for MOB1B Gene

Gene Ontology (GO) - Molecular Function for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19739119
GO:0019209 kinase activator activity IDA 15197186
GO:0019900 kinase binding IPI 15197186
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB1B: view
genes like me logo Genes that share phenotypes with MOB1B: view

Animal Model Products

CRISPR Products

miRNA for MOB1B Gene

miRTarBase miRNAs that target MOB1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB1B

Clone Products

  • Addgene plasmids for MOB1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MOB1B Gene

Localization for MOB1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MOB1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB1B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15067004
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 15067004
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MOB1B: view

Pathways & Interactions for MOB1B Gene

genes like me logo Genes that share pathways with MOB1B: view

Pathways by source for MOB1B Gene

2 Reactome pathways for MOB1B Gene
2 Cell Signaling Technology pathways for MOB1B Gene

SIGNOR curated interactions for MOB1B Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MOB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031952 regulation of protein autophosphorylation IDA 15197186
GO:0033674 positive regulation of kinase activity IEA --
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with MOB1B: view

Drugs & Compounds for MOB1B Gene

No Compound Related Data Available

Transcripts for MOB1B Gene

mRNA/cDNA for MOB1B Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB1B

Clone Products

  • Addgene plasmids for MOB1B

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1B Gene

No ASD Table

Relevant External Links for MOB1B Gene

GeneLoc Exon Structure for
MOB1B

Expression for MOB1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOB1B Gene

Protein differential expression in normal tissues from HIPED for MOB1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5), Monocytes (12.1), Tlymphocyte (12.1), and Blymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOB1B Gene



Protein tissue co-expression partners for MOB1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOB1B

SOURCE GeneReport for Unigene cluster for MOB1B Gene:

Hs.691454

mRNA Expression by UniProt/SwissProt for MOB1B Gene:

Q7L9L4-MOB1B_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.

Evidence on tissue expression from TISSUES for MOB1B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MOB1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB1B Gene

Orthologs for MOB1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MOB1B 31
  • 100 (a)
OneToOne
MOBKL1A 30
  • 99.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MOB1B 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MOB1B 31 30
  • 95.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MOB1B 31 30
  • 94.79 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MOB1B 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mob1b 17 31 30
  • 91.63 (n)
rat
(Rattus norvegicus)
Mammalia Mob1b 30
  • 91.47 (n)
chicken
(Gallus gallus)
Aves MOB1B 31
  • 97 (a)
OneToOne
MOBKL1A 30
  • 87.2 (n)
lizard
(Anolis carolinensis)
Reptilia MOB1B 31
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mob1b 30
  • 81.52 (n)
zebrafish
(Danio rerio)
Actinopterygii mob1ba 31 30
  • 79.62 (n)
OneToOne
-- 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002066 30
  • 71.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta mats 31 30
  • 70.79 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 31
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45550 30
  • 64.9 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3019 30
rice
(Oryza sativa)
Liliopsida Os03g0577200 30
  • 64.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 79 (a)
OneToMany
Species where no ortholog for MOB1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MOB1B Gene

ENSEMBL:
Gene Tree for MOB1B (if available)
TreeFam:
Gene Tree for MOB1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOB1B: view image

Paralogs for MOB1B Gene

Paralogs for MOB1B Gene

(8) SIMAP similar genes for MOB1B Gene using alignment to 2 proteins:

  • MOB1B_HUMAN
  • D6RCK3_HUMAN
genes like me logo Genes that share paralogs with MOB1B: view

Variants for MOB1B Gene

Additional dbSNP identifiers (rs#s) for MOB1B Gene

Structural Variations from Database of Genomic Variants (DGV) for MOB1B Gene

Variant ID Type Subtype PubMed ID
esv2727796 CNV deletion 23290073
esv3600942 CNV loss 21293372
esv3600943 CNV loss 21293372
nsv1012495 CNV gain 25217958
nsv1109615 CNV deletion 24896259
nsv1136873 CNV deletion 24896259
nsv594651 CNV loss 21841781
nsv594652 CNV loss 21841781
nsv829966 CNV loss 17160897

Variation tolerance for MOB1B Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOB1B Gene

Disorders for MOB1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MOB1B Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search MOB1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOB1B

genes like me logo Genes that share disorders with MOB1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOB1B Gene

Publications for MOB1B Gene

  1. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. (PMID: 15067004) Devroe E … Silver PA (The Journal of biological chemistry 2004) 2 3 4 54
  2. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A … Yang X (International journal of cancer 2010) 3 4 54
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M … Avruch J (Current biology : CB 2008) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for MOB1B Gene

  • Signalway ELISA kits for MOB1B
  • Signalway Proteins for MOB1B

Sources for MOB1B Gene