Aliases for MOB1B Gene
External Ids for MOB1B Gene
Previous HGNC Symbols for MOB1B Gene
Previous GeneCards Identifiers for MOB1B Gene
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for MOB1B Gene
MOB1B (MOB Kinase Activator 1B) is a Protein Coding gene. Diseases associated with MOB1B include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient. Among its related pathways are Hippo signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include kinase binding and kinase activator activity. An important paralog of this gene is MOB1A.
UniProtKB/Swiss-Prot Summary for MOB1B Gene
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.