The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms ... See more...

Aliases for MOB1A Gene

Aliases for MOB1A Gene

  • MOB Kinase Activator 1A 2 3 4 5
  • Mps One Binder Kinase Activator-Like 1B 3 4
  • Mob1 Homolog 1B 3 4
  • Mob1 Alpha 3 4
  • MOBKL1B 3 4
  • C2orf6 3 4
  • MOBK1B 3 4
  • Mob4B 2 3
  • MOB1 2 3
  • MOB1, Mps One Binder Kinase Activator-Like 1B (Yeast) 2
  • MOB1, Mps One Binder Kinase Activator-Like 1B 3
  • MOB1 Mps One Binder Homolog A (Yeast) 2
  • Chromosome 2 Open Reading Frame 6 2
  • MOB1 Mps One Binder Homolog A 3
  • FLJ10788 2
  • FLJ11595 2
  • MATS1 3
  • MOB1A 5
  • Mats1 2
  • MOB4B 4
  • Mob1A 4

External Ids for MOB1A Gene

Previous HGNC Symbols for MOB1A Gene

  • C2orf6
  • MOBK1B
  • MOBKL1B

Previous GeneCards Identifiers for MOB1A Gene

  • GC02M074382

Summaries for MOB1A Gene

Entrez Gene Summary for MOB1A Gene

  • The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for MOB1A Gene

MOB1A (MOB Kinase Activator 1A) is a Protein Coding gene. Diseases associated with MOB1A include Wilson-Turner X-Linked Mental Retardation Syndrome and Syndromic X-Linked Intellectual Disability. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. An important paralog of this gene is MOB1B.

UniProtKB/Swiss-Prot Summary for MOB1A Gene

  • Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Gene Wiki entry for MOB1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MOB1A Gene

Genomics for MOB1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MOB1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MOB1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MOB1A

Genomic Locations for MOB1A Gene

Latest Assembly
chr2:74,152,528-74,178,898
(GRCh38/hg38)
Size:
26,371 bases
Orientation:
Minus strand

Previous Assembly
chr2:74,379,655-74,406,006
(GRCh37/hg19 by Entrez Gene)
Size:
26,352 bases
Orientation:
Minus strand

chr2:74,379,655-74,406,025
(GRCh37/hg19 by Ensembl)
Size:
26,371 bases
Orientation:
Minus strand

Genomic View for MOB1A Gene

Genes around MOB1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MOB1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MOB1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MOB1A Gene

Proteins for MOB1A Gene

  • Protein details for MOB1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8S9-MOB1A_HUMAN
    Recommended name:
    MOB kinase activator 1A
    Protein Accession:
    Q9H8S9
    Secondary Accessions:
    • Q53S34
    • Q9H3T5
    • Q9HAI0
    • Q9NVE2

    Protein attributes for MOB1A Gene

    Size:
    216 amino acids
    Molecular mass:
    25080 Da
    Quaternary structure:
    • Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.
    Miscellaneous:
    • [Isoform 2]: May be due to an intron retention.

    Three dimensional structures from OCA and Proteopedia for MOB1A Gene

    Alternative splice isoforms for MOB1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MOB1A Gene

Post-translational modifications for MOB1A Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MOB1A Gene

Antibodies for research

  • Abcam antibodies for MOB1A
  • Boster Bio Antibodies for MOB1A
  • Santa Cruz Biotechnology (SCBT) Antibodies for MOB1A

No data available for DME Specific Peptides for MOB1A Gene

Domains & Families for MOB1A Gene

Gene Families for MOB1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MOB1A Gene

InterPro:
Blocks:
  • Mob1/phocein family

Suggested Antigen Peptide Sequences for MOB1A Gene

GenScript: Design optimal peptide antigens:
  • Protein Mob4B (MOL1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H8S9

UniProtKB/Swiss-Prot:

MOB1A_HUMAN :
  • Belongs to the MOB1/phocein family.
Family:
  • Belongs to the MOB1/phocein family.
genes like me logo Genes that share domains with MOB1A: view

Function for MOB1A Gene

Molecular function for MOB1A Gene

UniProtKB/Swiss-Prot Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Phenotypes From GWAS Catalog for MOB1A Gene

Gene Ontology (GO) - Molecular Function for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15197186
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MOB1A: view
genes like me logo Genes that share phenotypes with MOB1A: view

Animal Models for MOB1A Gene

MGI Knock Outs for MOB1A:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MOB1A Gene

Localization for MOB1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MOB1A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 20458337
genes like me logo Genes that share ontologies with MOB1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MOB1A Gene

Pathways & Interactions for MOB1A Gene

genes like me logo Genes that share pathways with MOB1A: view

Pathways by source for MOB1A Gene

2 Reactome pathways for MOB1A Gene
2 Cell Signaling Technology pathways for MOB1A Gene

SIGNOR curated interactions for MOB1A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MOB1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035329 hippo signaling TAS --
genes like me logo Genes that share ontologies with MOB1A: view

Drugs & Compounds for MOB1A Gene

No Compound Related Data Available

Transcripts for MOB1A Gene

mRNA/cDNA for MOB1A Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MOB1A

Alternative Splicing Database (ASD) splice patterns (SP) for MOB1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8: -

Relevant External Links for MOB1A Gene

GeneLoc Exon Structure for
MOB1A

Expression for MOB1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MOB1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MOB1A Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for MOB1A Gene

This gene is overexpressed in Spleen (15.9), Ovary (15.7), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MOB1A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MOB1A

SOURCE GeneReport for Unigene cluster for MOB1A Gene:

Hs.602092

mRNA Expression by UniProt/SwissProt for MOB1A Gene:

Q9H8S9-MOB1A_HUMAN
Tissue specificity: Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.

Evidence on tissue expression from TISSUES for MOB1A Gene

  • Blood(4.5)
  • Intestine(2.7)
  • Liver(2.4)
  • Skin(2.4)
  • Lymph node(2.3)
  • Kidney(2.2)
  • Spleen(2.1)
  • Heart(2.1)
  • Lung(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MOB1A: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MOB1A Gene

Orthologs for MOB1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MOB1A Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia MOBKL1B 30
  • 100 (a)
OneToOne
MOB1A 29
  • 95.68 (n)
Chimpanzee
(Pan troglodytes)
Mammalia MOBKL1B 29 30
  • 99.85 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 98 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia MOB1A 29 30
  • 96.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mob1a 29 16 30
  • 93.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mob1a 29
  • 92.75 (n)
Chicken
(Gallus gallus)
Aves MOB1A 30
  • 93 (a)
OneToOne
LOC429657 29
  • 82.87 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mob1a 29
  • 81.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia MOB1 29
Zebrafish
(Danio rerio)
Actinopterygii mob1a 30
  • 96 (a)
OneToOne
LOC100331697 29
  • 79.63 (n)
wufv69d04 29
Fruit Fly
(Drosophila melanogaster)
Insecta mats 30
  • 85 (a)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03795g 29
  • 57.37 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL236W 29
  • 55.12 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOB1 29 30
  • 55.08 (n)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os10g0396300 29
  • 65.09 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 81 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mob1 29
  • 59.94 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01605 29
  • 53.12 (n)
Species where no ortholog for MOB1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MOB1A Gene

ENSEMBL:
Gene Tree for MOB1A (if available)
TreeFam:
Gene Tree for MOB1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MOB1A: view image
Alliance of Genome Resources:
Additional Orthologs for MOB1A

Paralogs for MOB1A Gene

Paralogs for MOB1A Gene

(8) SIMAP similar genes for MOB1A Gene using alignment to 2 proteins:

  • MOB1A_HUMAN
  • H7BZ12_HUMAN

Pseudogenes.org Pseudogenes for MOB1A Gene

genes like me logo Genes that share paralogs with MOB1A: view

Variants for MOB1A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MOB1A Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1558830933 Uncertain Significance: not provided 74,159,231(-) TAA/T
NM_018221.5(MOB1A):c.431_432del (p.Phe144fs)
FRAMESHIFT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MOB1A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MOB1A Gene

Variant ID Type Subtype PubMed ID
esv3364261 CNV insertion 20981092
nsv834261 CNV loss 17160897

Variation tolerance for MOB1A Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MOB1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MOB1A
Leiden Open Variation Database (LOVD)
MOB1A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MOB1A Gene

Disorders for MOB1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for MOB1A Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search MOB1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MOB1A

genes like me logo Genes that share disorders with MOB1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MOB1A Gene

Publications for MOB1A Gene

  1. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A … Yang X (International journal of cancer 2010) 3 4
  2. Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. (PMID: 20624913) Kohler RS … Hergovich A (Molecular and cellular biology 2010) 2 3
  3. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. (PMID: 18328708) Praskova M … Avruch J (Current biology : CB 2008) 3 4
  4. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. (PMID: 18362890) Hirabayashi S … Hata Y (Oncogene 2008) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4

Products for MOB1A Gene

Sources for MOB1A Gene