Aliases for MNX1 Gene
Aliases for MNX1 Gene
External Ids for MNX1 Gene
- HGNC: 4979
- Entrez Gene: 3110
- Ensembl: ENSG00000130675
- OMIM: 142994
- UniProtKB: P50219
Previous HGNC Symbols for MNX1 Gene
- HLXB9
Previous GeneCards Identifiers for MNX1 Gene
- GC07M156491
- GC07M156786
- GC07M150530
Summaries for MNX1 Gene
-
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for MNX1 Gene
MNX1 (Motor Neuron And Pancreas Homeobox 1) is a Protein Coding gene. Diseases associated with MNX1 include Currarino Syndrome and Anorectal Anomalies. Among its related pathways are Regulation of beta-cell development and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is GBX1.
UniProtKB/Swiss-Prot for MNX1 Gene
-
Putative transcription factor involved in pancreas development and function.
Additional gene information for MNX1 Gene
- Monarch Initiative
- Search for MNX1 at DataMed
- Search for MNX1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNX1 Gene
Genomics for MNX1 Gene
GeneHancer (GH) Regulatory Elements for MNX1 Gene
Promoters and enhancers for MNX1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MNX1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MNX1 gene promoter:
-
- FOXF2
- Nkx2-5
- GATA-3
- GATA-1
- POU2F1
- POU2F1a
- STAT3
- AML1a
Regulatory Element Products
Genomic Locations for MNX1 Gene
Genomic Locations for MNX1 Gene
- chr7:156,994,051-157,010,653
- (GRCh38/hg38)
- Size:
- 16,603 bases
- Orientation:
- Minus strand
- chr7:156,786,745-156,803,347
- (GRCh37/hg19)
- Size:
- 16,603 bases
- Orientation:
- Minus strand
Genomic View for MNX1 Gene
Genes around MNX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q36.3 by Entrez Gene
- 7q36.3 by HGNC
- 7q36.3 by Ensembl
MNX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MNX1 Gene
Proteins for MNX1 Gene
-
Protein details for MNX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50219-MNX1_HUMAN
- Recommended name:
- Motor neuron and pancreas homeobox protein 1
- Protein Accession:
- P50219
- F5H401
- Q9Y648
Protein attributes for MNX1 Gene
- Size:
- 401 amino acids
- Molecular mass:
- 40569 Da
- Quaternary structure:
- No Data Available
Protein Expression for MNX1 Gene
Post-translational modifications for MNX1 Gene
Other Protein References for MNX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MNX1
- Novus Biologicals Antibodies for MNX1
-
Abcam antibodies for MNX1
- Invitrogen Antibodies for MNX1
- GeneTex MNX1 Antibody for MNX1
-
Boster Bio Antibodies for MNX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MNX1
- Sino Biological Antibodies for MNX1
Protein Products
-
OriGene Purified Proteins for MNX1
- Search Origene for MassSpec and Protein Over-expression Lysates for MNX1
- Origene Custom Protein Services for MNX1
- antibodies-online: Search results for 3 available MNX1 Proteins ranked by validation data
- Compare Top MNX1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for MNX1
Assay Products
- antibodies-online: Search results for 6 available MNX1 Elisa Kits ranked by validation data
- Compare Top MNX1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MNX1 Gene
Domains & Families for MNX1 Gene
Gene Families for MNX1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MNX1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MNX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MNX1 Gene
Function for MNX1 Gene
Molecular function for MNX1 Gene
- UniProtKB/Swiss-Prot Function:
- Putative transcription factor involved in pancreas development and function.
Phenotypes From GWAS Catalog for MNX1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 9843207 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for MNX1 Gene
- MGI mutant phenotypes for MNX1:
-
inferred from 6 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- skeleton phenotype
- normal phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MNX1:
-
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability with paclitaxel
- Increased viability
Animal Models for MNX1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MNX1
-
CRISPR Products
-
OriGene CRISPR knockouts for MNX1
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- genomics-online: gRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- Applied Biological Materials CRISPR for MNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNX1
- GenScript: Design CRISPR guide RNA sequences for MNX1
miRNA for MNX1 Gene
- miRTarBase miRNAs that target MNX1
-
- hsa-mir-101-3p (MIRT027276)
- hsa-mir-8055 (MIRT506559)
- hsa-mir-3180-5p (MIRT506560)
- hsa-mir-887-3p (MIRT506561)
- hsa-mir-6720-5p (MIRT506562)
- hsa-mir-6512-3p (MIRT506563)
- hsa-mir-582-5p (MIRT506564)
- hsa-mir-2052 (MIRT506565)
- hsa-mir-5186 (MIRT506566)
- hsa-mir-4645-3p (MIRT506567)
- hsa-mir-4530 (MIRT506568)
- hsa-mir-4328 (MIRT506569)
- hsa-mir-7161-5p (MIRT506570)
- hsa-mir-548u (MIRT506571)
- hsa-mir-338-3p (MIRT506572)
- hsa-mir-200a-3p (MIRT735389)
- mmu-mir-141-3p (MIRT735390)
- mmu-mir-200a-3p (MIRT735391)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MNX1
- Browse OriGene Inhibitory RNA Products For MNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNX1
- genomics-online: shRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MNX1
- VectorBuilder custom plasmid, inducible vectors for MNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNX1
- Applied Biological Materials Clones for MNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MNX1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MNX1 Gene
Localization for MNX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MNX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MNX1 Gene
Pathways by source for MNX1 Gene
1 KEGG pathway for MNX1 Gene
1 R&D Systems pathway for MNX1 Gene
Interacting Proteins for MNX1 Gene
GPS-Prot Interaction Network for MNX1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 9843207 |
| GO:0006959 | humoral immune response | TAS | 7914194 |
| GO:0009653 | anatomical structure morphogenesis | TAS | 9843207 |
Transcripts for MNX1 Gene
mRNA/cDNA for MNX1 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (16) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000469500 209 bps (uc064jri.1)
- ENST00000479817 169 bps (uc064jrj.1)
- ENST00000252971 2174 bps (uc003wnd.2)
- ENST00000425745 322 bps (uc064jrk.1)
- ENST00000428439 631 bps (uc064jrl.1)
Unigene Clusters for MNX1 Gene
- Motor neuron and pancreas homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MNX1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNX1
- genomics-online: gRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- Applied Biological Materials CRISPR for MNX1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNX1
- GenScript: Design CRISPR guide RNA sequences for MNX1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MNX1
- Browse OriGene Inhibitory RNA Products For MNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNX1
- genomics-online: shRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MNX1
- VectorBuilder custom plasmid, inducible vectors for MNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MNX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNX1
- Applied Biological Materials Clones for MNX1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MNX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Spinal Cord (Nervous System)
- Motor Neural Progenitor Cells Motor Neural Progenitor Domain
- Motor Neurons Motor Neural Progenitor Domain
- Motor neuron-like cells(Hester ME et. al. 2011)
- Precursor lateral motor column neuron EBs(Amoroso MW et. al. 2013)
- Motor neuron progenitors(Di Giorgio FP et. al. 2008)
-
Neurons
- Motor Neural Progenitor Cells Motor Neural Progenitor Domain
- Motor Neurons Motor Neural Progenitor Domain
- Motor neuron-like cells(Hester ME et. al. 2011)
- Precursor lateral motor column neuron EBs(Amoroso MW et. al. 2013)
- Motor neuron-like cells(Corti S et. al. 2009)
- Motor Neurons (Nervous System)
-
Pancreas (Endocrine System)
- Immature Beta Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Beta/Delta Progenitor Cells Dorsal Pancreatic Bud
- Pancreatic Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Pancreatic Progenitor Cells Ventral Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Prepancreatic Foregut Endoderm Cells Prepancreatic Dorsal Foregut Endoderm
- Brain (Nervous System)
- NULL (Uncategorized)
-
Neural Tube (Nervous System)
- Motor Neural Progenitor Cells Motor Neural Progenitor Domain
- Motor Neurons Motor Neural Progenitor Domain
- Neuronal progenitor cells(Wichterle H et. al. 2002)
-
Gut Tube (Gastrointestinal Tract)
- Prepancreatic Foregut Endoderm Cells Prepancreatic Dorsal Foregut Endoderm
- Dorsal Foregut Endoderm Cells Dorsal Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for MNX1 Gene
This gene is overexpressed in Pancreas (x24.8), Colon - Transverse (x6.1), and Small Intestine - Terminal Ileum (x4.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MNX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of MNX1 Gene:
MNX1SOURCE GeneReport for Unigene cluster for MNX1 Gene:
Hs.37035mRNA Expression by UniProt/SwissProt for MNX1 Gene:
P50219-MNX1_HUMAN
Tissue specificity:
Expressed in lymphoid and pancreatic tissues.
Evidence on tissue expression from TISSUES for MNX1 Gene
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MNX1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- head
- meninges
- neck
Thorax:
- esophagus
Abdomen:
- intestine
- kidney
- large intestine
- small intestine
- stomach
Pelvis:
- anus
- pelvis
- prostate
- rectum
- ureter
- urethra
- urinary bladder
- uterus
- vagina
General:
- blood
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for MNX1
-
OriGene qPCR primer pairs for MNX1
- genomics-online: primer clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for MNX1 Gene
Orthologs for MNX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MNX1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MNX1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MNX1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mnx1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mnx1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MNX1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MNX1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MNX1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MNX1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mnx1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hlxb9-A 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mnx1 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | exex 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MNX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MNX1 Gene
- ENSEMBL:
- Gene Tree for MNX1 (if available)
- TreeFam:
- Gene Tree for MNX1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MNX1: view image
Paralogs for MNX1 Gene
(29) SIMAP similar genes for MNX1 Gene using alignment to 6 proteins:
- MNX1_HUMAN
- C9JFT4_HUMAN
- C9K088_HUMAN
- S4R364_HUMAN
- S4R3G1_HUMAN
- S4R464_HUMAN
Variants for MNX1 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121912546 | pathogenic, Currarino triad | 157,006,556(-) | G/A | coding_sequence_variant, stop_gained | |
| rs121912547 | pathogenic, Currarino triad | 157,009,859(-) | G/A/T | coding_sequence_variant, genic_upstream_transcript_variant, stop_gained, synonymous_variant, upstream_transcript_variant | |
| rs121912548 | pathogenic, Currarino triad, Currarino syndrome (CURRAS) [MIM:176450] | 157,006,595(-) | T/A | coding_sequence_variant, missense_variant | |
| rs121912549 | pathogenic, Currarino triad | 157,006,487(-) | C/A | coding_sequence_variant, stop_gained | |
| VAR_017874 | Currarino syndrome (CURRAS) [MIM:176450] | p.Arg245Gly |
Gene Damage Index Score:
0.65;
13.80% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MNX1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNX1 Gene
Disorders for MNX1 Gene
(23) MalaCards diseases for MNX1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| currarino syndrome |
|
|
| anorectal anomalies |
|
|
| meningocele |
|
|
| sacrococcygeal teratoma |
|
|
| oeis complex |
|
|
Search MNX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MNX1_HUMAN- Currarino syndrome (CURRAS) [MIM:176450]: The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. {ECO:0000269 PubMed:10631160, ECO:0000269 PubMed:10749657, ECO:0000269 PubMed:19853743, ECO:0000269 PubMed:22820079}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MNX1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MNX1 Gene
Publications for MNX1 Gene
- MNX1 (HLXB9) mutations in Currarino patients. (PMID: 19853743) Garcia-Barceló MM … Tam PK (Journal of pediatric surgery 2009) 3 4 22 58
- Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. (PMID: 10749657) Hagan DM … Homfray T (American journal of human genetics 2000) 3 4 22 58
- A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. (PMID: 9843207) Ross AJ … Strachan T (Nature genetics 1998) 2 3 22 58
- A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. (PMID: 7914194) Harrison KA … Kehrl JH (The Journal of biological chemistry 1994) 3 4 22 58
- Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype. (PMID: 22820079) Markljung E … Nordenskjöld A (Gene 2012) 3 4 58
Products for MNX1 Gene
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- Novus Biologicals Antibodies for MNX1
- Novus Biologicals lysates and proteins for MNX1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for MNX1
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- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MNX1
- VectorBuilder custom plasmid, inducible vectors for MNX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MNX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 54 available MNX1 Antibodies ranked by validation data
- Compare Top MNX1 Antibodies
- antibodies-online: Search results for 6 available MNX1 Elisa Kits ranked by validation data
- Compare Top MNX1 Elisa Kits
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- antibodies-online: Search results for 3 available MNX1 Proteins ranked by validation data
- Compare Top MNX1 Proteins
- Quality Products:
- GeneTex MNX1 Antibody for MNX1
- Search GeneTex for Proteins for MNX1
- Santa Cruz Biotechnology (SCBT) Antibodies for MNX1
- Search Santa Cruz Biotechnology (SCBT) for MNX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MNX1
- Horizon Cell Lines for MNX1
- genomics-online: cdna clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- orf clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- genomics-online: gRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- genomics-online: primer clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- genomics-online: shRNA clones - Search results for 56 available MNX1 gene related products
- Overview of 56 available MNX1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNX1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNX1
- GeneCopoeia miRNA 3'UTR Target clone products for MNX1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNX1
- Boster Bio Antibodies for MNX1
- Browse Boster Bio ELISA Kits
Sources for MNX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt