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Aliases for MNT Gene

Aliases for MNT Gene

  • MAX Network Transcriptional Repressor 2 3 5
  • Class D Basic Helix-Loop-Helix Protein 3 3 4
  • MNT, MAX Dimerization Protein 2 3
  • Max-Interacting Protein 2 3
  • MAX Binding Protein 2 3
  • Myc Antagonist MNT 3 4
  • BHLHd3 3 4
  • ROX 3 4
  • Max-Binding Protein MNT 3
  • Myc Antagonist 2
  • Protein ROX 4
  • BHLHD3 4
  • MAD6 3
  • MXD6 3

External Ids for MNT Gene

Previous GeneCards Identifiers for MNT Gene

  • GC17M002594
  • GC17M002238
  • GC17M002493
  • GC17M002234
  • GC17M002183
  • GC17M002287

Summaries for MNT Gene

Entrez Gene Summary for MNT Gene

  • The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNT Gene

MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include Retinitis Pigmentosa, Y-Linked. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot for MNT Gene

  • Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.

Gene Wiki entry for MNT Gene

Additional gene information for MNT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNT Gene

Genomics for MNT Gene

GeneHancer (GH) Regulatory Elements for MNT Gene

Promoters and enhancers for MNT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J002389 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 689.7 +2.1 2106 18.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 MNT GC17M002387 GC17M002400 GC17M002401 METTL16 PRPF8 SMYD4 SMG6 HNRNPA1P16 ENSG00000263345
GH17J002261 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.2 +136.0 136028 7.3 PKNOX1 SMAD1 FEZF1 ZNF2 ZNF207 ATF7 FOS RUNX3 ZNF491 ZNF592 SMG6 GC17P002267 HNRNPA1P16 SRR METTL16 DPH1 ENSG00000263345 ENSG00000263050 TSR1 MNT
GH17J001712 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +685.3 685344 7 MLX DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 WDR81 GC17M001715 MIR22 MIR22HG SMYD4 PRPF8 GEMIN4 RPA1 SERPINF2 METTL16
GH17J001624 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +773.6 773641 6.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF213 ZNF207 SLC43A2 PITPNA ENSG00000263050 SMG6 ENSG00000262869 EIF4A1P9 SAMD11P1 HNRNPA1P16 ENSG00000263345 SCARF1
GH17J002040 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 +358.1 358149 4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ENSG00000262533 ENSG00000263050 OVCA2 PRPF8 SMYD4 DPH1 SMG6 HNRNPA1P16 MNT WDR81
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MNT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MNT gene promoter:
  • c-Myc
  • Max
  • p53
  • MyoD
  • Max1
  • GR-beta
  • GR-alpha
  • GR

Genomic Locations for MNT Gene

Genomic Locations for MNT Gene
chr17:2,384,060-2,401,118
(GRCh38/hg38)
Size:
17,059 bases
Orientation:
Minus strand
chr17:2,287,354-2,304,412
(GRCh37/hg19)
Size:
17,059 bases
Orientation:
Minus strand

Genomic View for MNT Gene

Genes around MNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNT Gene

Proteins for MNT Gene

  • Protein details for MNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99583-MNT_HUMAN
    Recommended name:
    Max-binding protein MNT
    Protein Accession:
    Q99583
    Secondary Accessions:
    • A8K6D1
    • D3DTI7
    • Q1ED38

    Protein attributes for MNT Gene

    Size:
    582 amino acids
    Molecular mass:
    62300 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

neXtProt entry for MNT Gene

Post-translational modifications for MNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNT Gene

No data available for DME Specific Peptides for MNT Gene

Domains & Families for MNT Gene

Gene Families for MNT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MNT Gene

Suggested Antigen Peptide Sequences for MNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MNT: view

No data available for UniProtKB/Swiss-Prot for MNT Gene

Function for MNT Gene

Molecular function for MNT Gene

UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.
GENATLAS Biochemistry:
Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer

Phenotypes From GWAS Catalog for MNT Gene

Gene Ontology (GO) - Molecular Function for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 9184233
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 9184233
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with MNT: view
genes like me logo Genes that share phenotypes with MNT: view

Animal Models for MNT Gene

MGI Knock Outs for MNT:
  • Mnt Mnt<tm1.1Awb>
  • Mnt Mnt<tm1.1Phu>

Animal Model Products

miRNA for MNT Gene

miRTarBase miRNAs that target MNT

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MNT Gene

Localization for MNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MNT gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MNT: view

Pathways & Interactions for MNT Gene

No Data Available

Gene Ontology (GO) - Biological Process for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 9184233
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 9184233
GO:0007275 multicellular organism development TAS 9184233
genes like me logo Genes that share ontologies with MNT: view

No data available for Pathways by source and SIGNOR curated interactions for MNT Gene

Drugs & Compounds for MNT Gene

(1) Drugs for MNT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MNT: view

Transcripts for MNT Gene

Unigene Clusters for MNT Gene

MNT, MAX dimerization protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - -
SP3: - -
SP4:
SP5: - - - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MNT Gene

GeneLoc Exon Structure for
MNT
ECgene alternative splicing isoforms for
MNT

Expression for MNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MNT Gene

This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MNT Gene



Protein tissue co-expression partners for MNT Gene

NURSA nuclear receptor signaling pathways regulating expression of MNT Gene:

MNT

SOURCE GeneReport for Unigene cluster for MNT Gene:

Hs.632239

Evidence on tissue expression from TISSUES for MNT Gene

  • Nervous system(4.6)
  • Pancreas(4.1)
  • Blood(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with MNT: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MNT Gene

Orthologs for MNT Gene

This gene was present in the common ancestor of animals.

Orthologs for MNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNT 34 33
  • 98.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mnt 16 34 33
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia MNT 34 33
  • 89.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MNT 34 33
  • 89.06 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MNT 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNT 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNT 34 33
  • 69.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MNT 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mnt 33
  • 64.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10853 33
zebrafish
(Danio rerio)
Actinopterygii mntb 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mnt 34
  • 16 (a)
OneToOne
Species where no ortholog for MNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNT Gene

ENSEMBL:
Gene Tree for MNT (if available)
TreeFam:
Gene Tree for MNT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MNT: view image

Paralogs for MNT Gene

No data available for Paralogs for MNT Gene

Variants for MNT Gene

Sequence variations from dbSNP and Humsavar for MNT Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000120213 -- 2,401,705(-) C/G upstream_transcript_variant
rs1000171535 -- 2,390,744(-) T/G 5_prime_UTR_variant, intron_variant
rs1000213502 -- 2,393,245(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000214954 -- 2,383,834(-) A/T downstream_transcript_variant
rs1000234548 -- 2,389,023(-) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MNT Gene

Variant ID Type Subtype PubMed ID
nsv952104 CNV deletion 24416366
nsv833338 CNV loss 17160897
nsv833336 CNV loss 17160897
nsv574224 CNV gain 21841781
nsv517489 CNV loss 19592680
nsv470569 CNV loss 18288195
nsv469765 CNV loss 16826518
nsv1160445 CNV duplication 26073780
nsv1160444 CNV deletion 26073780
nsv1160443 CNV deletion 26073780
nsv1070377 CNV deletion 25765185
nsv1066475 CNV loss 25217958
nsv1063109 CNV gain 25217958
nsv1055225 CNV loss 25217958
dgv3083n100 CNV gain 25217958

Variation tolerance for MNT Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MNT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene

Disorders for MNT Gene

MalaCards: The human disease database

(1) MalaCards diseases for MNT Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa, y-linked
  • rpy
- elite association - COSMIC cancer census association via MalaCards
Search MNT in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with MNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MNT Gene

Publications for MNT Gene

  1. The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PMID: 9598315) Lo Nigro C … Carrozzo R (Genomics 1998) 2 3 4 58
  2. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H … Lu SC (Hepatology (Baltimore, Md.) 2009) 3 22 58
  3. Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) Wahlström T … Henriksson M (Advances in cancer research 2007) 3 22 58
  4. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo XL … Ohno R (Leukemia & lymphoma 2007) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MNT Gene

Sources for MNT Gene

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