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The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimeriza... See more...
Aliases for MNT Gene
Aliases for MNT Gene
External Ids for MNT Gene
- HGNC: 7188
- Entrez Gene: 4335
- Ensembl: ENSG00000070444
- OMIM: 603039
- UniProtKB: Q99583
Previous GeneCards Identifiers for MNT Gene
- GC17M002594
- GC17M002238
- GC17M002493
- GC17M002234
- GC17M002183
- GC17M002287
Summaries for MNT Gene
-
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for MNT Gene
MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include Tetanus Neonatorum and Mixed Type Thymoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is MXI1.
UniProtKB/Swiss-Prot Summary for MNT Gene
-
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Additional gene information for MNT Gene
- HGNC(7188)
- Entrez Gene(4335)
- Ensembl(ENSG00000070444)
- OMIM(603039)
- UniProtKB(Q99583)
- Open Targets Platform(ENSG00000070444)
- Search for MNT at DataMed
- Search for MNT at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MNT Gene
Genomics for MNT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MNT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MNT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MNT
- Top Transcription factor binding sites by QIAGEN in the MNT gene promoter:
-
- c-Myc
- GR
- GR-alpha
- GR-beta
- Max
- Max1
- MyoD
- p53
Genomic Locations for MNT Gene
Genomic Locations for MNT Gene
- chr17:2,384,073-2,401,104
- (GRCh38/hg38)
- Size:
- 17,032 bases
- Orientation:
- Minus strand
- chr17:2,287,354-2,304,412
- (GRCh37/hg19)
- Size:
- 17,059 bases
- Orientation:
- Minus strand
Genomic View for MNT Gene
Genes around MNT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
MNT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MNT Gene
Proteins for MNT Gene
-
Protein details for MNT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99583-MNT_HUMAN
- Recommended name:
- Max-binding protein MNT
- Protein Accession:
- Q99583
- A8K6D1
- D3DTI7
- Q1ED38
Protein attributes for MNT Gene
- Size:
- 582 amino acids
- Molecular mass:
- 62300 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.
Protein Expression for MNT Gene
Post-translational modifications for MNT Gene
Other Protein References for MNT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MNT Antibody
- GeneTex Anti-MNT antibody [N1C1]
- Novus Biologicals Antibodies for MNT
- Invitrogen Antibodies for MNT (AFLGC-MNT)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MNT
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MNT
- Origene Custom Protein Services for MNT
- Novus Biologicals proteins for MNT
- antibodies-online: Show 3 available MNT Proteins ranked by validation data
- Compare Top MNT Proteins
-
Abcam proteins for MNT
Assay Products
- antibodies-online: Show 3 available MNT Elisa Kits ranked by validation data
- Compare Top MNT Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MNT
No data available for DME Specific Peptides for MNT Gene
Domains & Families for MNT Gene
Gene Families for MNT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MNT Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- ProtoNet:
Suggested Antigen Peptide Sequences for MNT Gene
- GenScript: Design optimal peptide antigens:
-
- Protein ROX (MNT_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MNT Gene
Function for MNT Gene
Molecular function for MNT Gene
- UniProtKB/Swiss-Prot Function:
- Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
- GENATLAS Biochemistry:
- Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer
Phenotypes From GWAS Catalog for MNT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 9184233 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 9184233 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for MNT Gene
- MGI mutant phenotypes for MNT:
-
inferred from 4 alleles
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for MNT:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Polylobed nuclei, large nuclei
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MNT - Select products 50% OFF >
- * MNT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MNT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNT
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNT
miRNA for MNT Gene
- miRTarBase miRNAs that target MNT
-
- hsa-miR-210-3p (MIRT004672)
- mmu-let-7b-5p (MIRT012180)
- mmu-miR-297a-5p (MIRT013141)
- hsa-miR-331-3p (MIRT043556)
- hsa-miR-17-5p (MIRT050948)
- hsa-miR-218-5p (MIRT440223)
- hsa-miR-3691-5p (MIRT491676)
- hsa-miR-3165 (MIRT491677)
- hsa-miR-6745 (MIRT491678)
- hsa-miR-363-5p (MIRT491679)
- hsa-miR-486-3p (MIRT491680)
- hsa-miR-6883-5p (MIRT491681)
- hsa-miR-6825-5p (MIRT491682)
- hsa-miR-6785-5p (MIRT491683)
- hsa-miR-4728-5p (MIRT491684)
- hsa-miR-149-3p (MIRT491685)
- hsa-miR-885-3p (MIRT491686)
- hsa-miR-1255b-5p (MIRT491687)
- hsa-miR-1255a (MIRT491688)
- hsa-miR-6744-5p (MIRT491689)
- hsa-miR-3656 (MIRT491690)
- hsa-miR-423-5p (MIRT491691)
- hsa-miR-3184-5p (MIRT491692)
- hsa-miR-6889-5p (MIRT491693)
- hsa-miR-6777-5p (MIRT491694)
- hsa-miR-211-3p (MIRT491695)
- hsa-miR-1272 (MIRT491696)
- hsa-miR-4688 (MIRT491697)
- hsa-miR-6743-5p (MIRT491698)
- hsa-miR-92b-5p (MIRT570320)
- mmu-miR-3057-3p (MIRT594637)
- mmu-miR-188-3p (MIRT594638)
- hsa-miR-3674 (MIRT612260)
- hsa-miR-3692-3p (MIRT612261)
- hsa-miR-4703-3p (MIRT612262)
- hsa-miR-922 (MIRT636027)
- hsa-miR-3118 (MIRT701887)
- hsa-miR-134-5p (MIRT701888)
- hsa-miR-4483 (MIRT701889)
- hsa-miR-1293 (MIRT701890)
- hsa-miR-6766-5p (MIRT701891)
- hsa-miR-6756-5p (MIRT701892)
- hsa-miR-5787 (MIRT701893)
- hsa-miR-4505 (MIRT701894)
- hsa-miR-5589-5p (MIRT701895)
- hsa-miR-7112-3p (MIRT701896)
- hsa-miR-6774-5p (MIRT701897)
- hsa-miR-5002-3p (MIRT701898)
- hsa-miR-635 (MIRT701899)
- hsa-miR-6776-5p (MIRT701900)
- hsa-miR-3614-5p (MIRT701901)
- hsa-miR-4446-3p (MIRT701902)
- hsa-miR-6807-5p (MIRT712026)
- hsa-miR-4539 (MIRT712027)
- hsa-miR-146a-3p (MIRT712028)
- hsa-miR-6777-3p (MIRT712029)
- hsa-miR-4714-5p (MIRT712030)
- hsa-miR-1343-5p (MIRT737474)
- hsa-miR-187-3p (MIRT738281)
- hsa-miR-198 (MIRT738723)
- hsa-miR-3150a-3p (MIRT740271)
- hsa-miR-3175 (MIRT740668)
- hsa-miR-3657 (MIRT741936)
- hsa-miR-3660 (MIRT741984)
- hsa-miR-4526 (MIRT745945)
- hsa-miR-4537 (MIRT746093)
- hsa-miR-4669 (MIRT746835)
- hsa-miR-491-5p (MIRT749216)
- hsa-miR-6719-3p (MIRT753737)
- hsa-miR-6730-3p (MIRT753968)
- hsa-miR-6763-5p (MIRT755013)
- hsa-miR-6827-5p (MIRT757060)
- hsa-miR-92a-2-5p (MIRT760569)
- hsa-miR-939-5p (MIRT760765)
- hsa-miR-1207-5p (MIRT761262)
- hsa-miR-1908-5p (MIRT763236)
- hsa-miR-3141 (MIRT764986)
- hsa-miR-4270 (MIRT768248)
- hsa-miR-4434 (MIRT769095)
- hsa-miR-4441 (MIRT769151)
- hsa-miR-4516 (MIRT769928)
- hsa-miR-4723-5p (MIRT771613)
- hsa-miR-4763-3p (MIRT772018)
- hsa-miR-5090 (MIRT773254)
- hsa-miR-5698 (MIRT775154)
- hsa-miR-5703 (MIRT775222)
- hsa-miR-6090 (MIRT775771)
- hsa-miR-6132 (MIRT775902)
- hsa-miR-663a (MIRT777497)
- hsa-miR-6721-5p (MIRT777827)
- hsa-miR-6754-5p (MIRT778380)
- hsa-miR-6775-5p (MIRT778732)
- hsa-miR-6787-5p (MIRT779218)
- hsa-miR-6816-5p (MIRT779819)
- hsa-miR-6836-5p (MIRT780067)
- hsa-miR-6870-5p (MIRT780689)
- hsa-miR-6878-5p (MIRT780773)
- hsa-miR-7111-5p (MIRT781444)
- hsa-miR-744-5p (MIRT781731)
- hsa-miR-1915-3p (MIRT784033)
- hsa-miR-4426 (MIRT785826)
- hsa-miR-4433a-5p (MIRT785855)
- hsa-miR-4433b-5p (MIRT785861)
- hsa-miR-4647 (MIRT786289)
- hsa-miR-4662b (MIRT786344)
- hsa-miR-4726-3p (MIRT786533)
- hsa-miR-574-5p (MIRT787869)
- hsa-miR-576-3p (MIRT787897)
- hsa-miR-6764-5p (MIRT788611)
- hsa-miR-6840-3p (MIRT789037)
- hsa-miR-6867-5p (MIRT789209)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MNT
- Browse OriGene Inhibitory RNA Products For MNT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNT
Clone Products
- Applied Biological Materials (abm): Clones for MNT - Select products 50% OFF >
- * MNT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MNT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNT
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MNT Gene
Localization for MNT Gene
Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for MNT Gene
Interacting Proteins for MNT Gene
Selected Interacting proteins:
Q99583-MNT_HUMAN
ENSP00000174618
for MNT Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MNT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9184233 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 9184233 |
| GO:0007275 | multicellular organism development | TAS | 9184233 |
| GO:0007569 | cell aging | IEA | -- |
No data available for Pathways by source for MNT Gene
Transcripts for MNT Gene
mRNA/cDNA for MNT Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000174618 4925 nts (view in UCSC)
- ENST00000571232 508 nts (view in UCSC)
- ENST00000571836 529 nts (view in UCSC)
- ENST00000572892 556 nts (view in UCSC)
- ENST00000573384 528 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MNT - Select products 50% OFF >
- * MNT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MNT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNT
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MNT
- Browse OriGene Inhibitory RNA Products For MNT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNT
Clone Products
- Applied Biological Materials (abm): Clones for MNT - Select products 50% OFF >
- * MNT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MNT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNT
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for MNT Gene
- GeneLoc Exon Structure for
- MNT
Expression for MNT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MNT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MNT
SOURCE GeneReport for Unigene cluster for MNT Gene:
Hs.632239Evidence on tissue expression from TISSUES for MNT Gene
- Nervous system(4.7)
- Pancreas(4.3)
- Blood(2.6)
- Skin(2.5)
- Bone marrow(2.3)
- Kidney(2.1)
- Liver(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for MNT
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MNT Gene
Orthologs for MNT Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MNT 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mnt 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MNT 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MNT 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MNT 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MNT 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MNT 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MNT 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mnt 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10853 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mntb 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Mnt 31 |
|
OneToOne |
- Species where no ortholog for MNT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MNT Gene
- ENSEMBL:
- Gene Tree for MNT (if available)
- TreeFam:
- Gene Tree for MNT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MNT: view image
Paralogs for MNT Gene
Variants for MNT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MNT Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 730317 | Benign: not provided | 2,387,111(-) | C/T | SYNONYMOUS_VARIANT | |
| 744718 | Likely Benign: not provided | 2,387,405(-) | T/C | SYNONYMOUS_VARIANT | |
| 759878 | Likely Benign: not provided | 2,387,216(-) | C/G | SYNONYMOUS_VARIANT | |
| 770261 | Benign: not provided | 2,388,029(-) | C/T | SYNONYMOUS_VARIANT | |
| rs7207965 | - | p.Ala109Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3083n100 | CNV | gain | 25217958 |
| nsv1055225 | CNV | loss | 25217958 |
| nsv1063109 | CNV | gain | 25217958 |
| nsv1066475 | CNV | loss | 25217958 |
| nsv1070377 | CNV | deletion | 25765185 |
| nsv1160443 | CNV | deletion | 26073780 |
| nsv1160444 | CNV | deletion | 26073780 |
| nsv1160445 | CNV | duplication | 26073780 |
| nsv469765 | CNV | loss | 16826518 |
| nsv470569 | CNV | loss | 18288195 |
| nsv517489 | CNV | loss | 19592680 |
| nsv574224 | CNV | gain | 21841781 |
| nsv833336 | CNV | loss | 17160897 |
| nsv833338 | CNV | loss | 17160897 |
| nsv952104 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.80;
58.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MNT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MNT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene
Disorders for MNT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tetanus neonatorum |
|
|
| mixed type thymoma |
|
|
| wolfram syndrome 2 |
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| baritosis |
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| patellar tendinitis |
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Search MNT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MNT
No data available for UniProtKB/Swiss-Prot and Genatlas for MNT Gene
Publications for MNT Gene
- The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PMID: 9598315) Lo Nigro C … Carrozzo R (Genomics 1998) 2 3 4
- Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H … Lu SC (Hepatology (Baltimore, Md.) 2009) 3 23
- Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo XL … Ohno R (Leukemia & lymphoma 2007) 3 23
- Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) Wahlström T … Henriksson M (Advances in cancer research 2007) 3 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
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Products for MNT Gene
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- antibodies-online: Show 13 available MNT Antibodies ranked by validation data
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- antibodies-online: Show 3 available MNT Proteins ranked by validation data
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Sources for MNT Gene
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