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The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimeriza... See more...
Aliases for MNT Gene
Aliases for MNT Gene
External Ids for MNT Gene
- HGNC: 7188
- Entrez Gene: 4335
- Ensembl: ENSG00000070444
- OMIM: 603039
- UniProtKB: Q99583
Previous GeneCards Identifiers for MNT Gene
- GC17M002594
- GC17M002238
- GC17M002493
- GC17M002234
- GC17M002183
- GC17M002287
Summaries for MNT Gene
-
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for MNT Gene
MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include Tetanus Neonatorum and Retinitis Pigmentosa, Y-Linked. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is MXD3.
UniProtKB/Swiss-Prot Summary for MNT Gene
-
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MNT Gene
Genomics for MNT Gene
GeneHancer (GH) Regulatory Elements for MNT Gene
Promoters and enhancers for MNT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MNT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MNT gene promoter:
-
- c-Myc
- GR
- GR-alpha
- GR-beta
- Max
- Max1
- MyoD
- p53
Genomic Locations for MNT Gene
Genomic Locations for MNT Gene
- chr17:2,384,060-2,401,104
- (GRCh38/hg38)
- Size:
- 17,045 bases
- Orientation:
- Minus strand
- chr17:2,287,354-2,304,412
- (GRCh37/hg19)
- Size:
- 17,059 bases
- Orientation:
- Minus strand
Genomic View for MNT Gene
Genes around MNT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.3 by HGNC
- 17p13.3 by Entrez Gene
- 17p13.3 by Ensembl
MNT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MNT Gene
Proteins for MNT Gene
-
Protein details for MNT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99583-MNT_HUMAN
- Recommended name:
- Max-binding protein MNT
- Protein Accession:
- Q99583
- A8K6D1
- D3DTI7
- Q1ED38
Protein attributes for MNT Gene
- Size:
- 582 amino acids
- Molecular mass:
- 62300 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.
Protein Expression for MNT Gene
Post-translational modifications for MNT Gene
Other Protein References for MNT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ MNT Antibody
- Atlas Antibodies Anti-MNT Antibody (HPA067578) and Anti-MNT Antibody (HPA059532)
- GeneTex Anti-MNT antibody [N1C1]
- Novus Biologicals Antibodies for MNT
- Invitrogen Antibodies for MNT (AFLGC-MNT)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MNT
Protein Products
- Atlas Antibodies PrEST Antigen MNT (APrEST92011) and PrEST Antigen MNT (APrEST92739)
- Creative Biomart Recombinant Human MNT lysate
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MNT
- Origene Custom Protein Services for MNT
- Novus Biologicals proteins for MNT
- antibodies-online: Show 3 available MNT Proteins ranked by validation data
- Compare Top MNT Proteins
-
Abcam proteins for MNT
Assay Products
- antibodies-online: Show 3 available MNT Elisa Kits ranked by validation data
- Compare Top MNT Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MNT Gene
Domains & Families for MNT Gene
Gene Families for MNT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MNT Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MNT Gene
- GenScript: Design optimal peptide antigens:
-
- Protein ROX (MNT_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MNT Gene
Function for MNT Gene
Molecular function for MNT Gene
- UniProtKB/Swiss-Prot Function:
- Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
- GENATLAS Biochemistry:
- Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer
Phenotypes From GWAS Catalog for MNT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 9184233 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 9184233 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for MNT Gene
- MGI mutant phenotypes for MNT:
-
inferred from 4 alleles
- digestive/alimentary phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MNT:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for MNT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNT
- genomics-online: gRNA clones - Search for available MNT gRNA products
- Overview of 198 available MNT gene related products
- Applied Biological Materials (abm): CRISPR Clones for MNT - Select products 50% OFF >
- * MNT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MNT CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNT
miRNA for MNT Gene
- miRTarBase miRNAs that target MNT
-
- hsa-mir-210-3p (MIRT004672)
- hsa-mir-331-3p (MIRT043556)
- hsa-mir-17-5p (MIRT050948)
- hsa-mir-218-5p (MIRT440223)
- hsa-mir-3691-5p (MIRT491676)
- hsa-mir-3165 (MIRT491677)
- hsa-mir-6745 (MIRT491678)
- hsa-mir-363-5p (MIRT491679)
- hsa-mir-486-3p (MIRT491680)
- hsa-mir-6883-5p (MIRT491681)
- hsa-mir-6825-5p (MIRT491682)
- hsa-mir-6785-5p (MIRT491683)
- hsa-mir-4728-5p (MIRT491684)
- hsa-mir-149-3p (MIRT491685)
- hsa-mir-885-3p (MIRT491686)
- hsa-mir-1255b-5p (MIRT491687)
- hsa-mir-1255a (MIRT491688)
- hsa-mir-6744-5p (MIRT491689)
- hsa-mir-3656 (MIRT491690)
- hsa-mir-423-5p (MIRT491691)
- hsa-mir-3184-5p (MIRT491692)
- hsa-mir-6889-5p (MIRT491693)
- hsa-mir-6777-5p (MIRT491694)
- hsa-mir-211-3p (MIRT491695)
- hsa-mir-1272 (MIRT491696)
- hsa-mir-4688 (MIRT491697)
- hsa-mir-6743-5p (MIRT491698)
- hsa-mir-92b-5p (MIRT570320)
- hsa-mir-3674 (MIRT612260)
- hsa-mir-3692-3p (MIRT612261)
- hsa-mir-4703-3p (MIRT612262)
- hsa-mir-922 (MIRT636027)
- hsa-mir-3118 (MIRT701887)
- hsa-mir-134-5p (MIRT701888)
- hsa-mir-4483 (MIRT701889)
- hsa-mir-1293 (MIRT701890)
- hsa-mir-6766-5p (MIRT701891)
- hsa-mir-6756-5p (MIRT701892)
- hsa-mir-5787 (MIRT701893)
- hsa-mir-4505 (MIRT701894)
- hsa-mir-5589-5p (MIRT701895)
- hsa-mir-7112-3p (MIRT701896)
- hsa-mir-6774-5p (MIRT701897)
- hsa-mir-5002-3p (MIRT701898)
- hsa-mir-635 (MIRT701899)
- hsa-mir-6776-5p (MIRT701900)
- hsa-mir-3614-5p (MIRT701901)
- hsa-mir-4446-3p (MIRT701902)
- hsa-mir-6807-5p (MIRT712026)
- hsa-mir-4539 (MIRT712027)
- hsa-mir-146a-3p (MIRT712028)
- hsa-mir-6777-3p (MIRT712029)
- hsa-mir-4714-5p (MIRT712030)
- hsa-mir-1343-5p (MIRT737474)
- hsa-mir-187-3p (MIRT738281)
- hsa-mir-198 (MIRT738723)
- hsa-mir-3150a-3p (MIRT740271)
- hsa-mir-3175 (MIRT740668)
- hsa-mir-3657 (MIRT741936)
- hsa-mir-3660 (MIRT741984)
- hsa-mir-4526 (MIRT745945)
- hsa-mir-4537 (MIRT746093)
- hsa-mir-4669 (MIRT746835)
- hsa-mir-491-5p (MIRT749216)
- hsa-mir-6719-3p (MIRT753737)
- hsa-mir-6730-3p (MIRT753968)
- hsa-mir-6763-5p (MIRT755013)
- hsa-mir-6827-5p (MIRT757060)
- hsa-mir-92a-2-5p (MIRT760569)
- hsa-mir-939-5p (MIRT760765)
- hsa-mir-1207-5p (MIRT761262)
- hsa-mir-1908-5p (MIRT763236)
- hsa-mir-3141 (MIRT764986)
- hsa-mir-4270 (MIRT768248)
- hsa-mir-4434 (MIRT769095)
- hsa-mir-4441 (MIRT769151)
- hsa-mir-4516 (MIRT769928)
- hsa-mir-4723-5p (MIRT771613)
- hsa-mir-4763-3p (MIRT772018)
- hsa-mir-5090 (MIRT773254)
- hsa-mir-5698 (MIRT775154)
- hsa-mir-5703 (MIRT775222)
- hsa-mir-6090 (MIRT775771)
- hsa-mir-6132 (MIRT775902)
- hsa-mir-663a (MIRT777497)
- hsa-mir-6721-5p (MIRT777827)
- hsa-mir-6754-5p (MIRT778380)
- hsa-mir-6775-5p (MIRT778732)
- hsa-mir-6787-5p (MIRT779218)
- hsa-mir-6816-5p (MIRT779819)
- hsa-mir-6836-5p (MIRT780067)
- hsa-mir-6870-5p (MIRT780689)
- hsa-mir-6878-5p (MIRT780773)
- hsa-mir-7111-5p (MIRT781444)
- hsa-mir-744-5p (MIRT781731)
- hsa-mir-1915-3p (MIRT784033)
- hsa-mir-4426 (MIRT785826)
- hsa-mir-4433a-5p (MIRT785855)
- hsa-mir-4433b-5p (MIRT785861)
- hsa-mir-4647 (MIRT786289)
- hsa-mir-4662b (MIRT786344)
- hsa-mir-4726-3p (MIRT786533)
- hsa-mir-574-5p (MIRT787869)
- hsa-mir-576-3p (MIRT787897)
- hsa-mir-6764-5p (MIRT788611)
- hsa-mir-6840-3p (MIRT789037)
- hsa-mir-6867-5p (MIRT789209)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MNT
- Browse OriGene Inhibitory RNA Products For MNT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNT
- genomics-online: shRNA clones - Search for available MNT shRNA products
- Overview of 198 available MNT gene related products
Clone Products
- Sino Biological Human cDNA Clone for MNT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNT
- genomics-online: cdna clones - Search for available MNT CDNA products
- Overview of 198 available MNT gene related products
- orf clones - Search for available MNT ORF products
- Overview of 198 available MNT gene related products
- Applied Biological Materials (abm): Clones for MNT - Select products 50% OFF >
- * MNT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MNT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for MNT
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MNT Gene
Localization for MNT Gene
Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| extracellular | 0 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for MNT Gene
Interacting Proteins for MNT Gene
GPS-Prot Interaction Network for MNT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 9184233 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 9184233 |
| GO:0007275 | multicellular organism development | TAS | 9184233 |
| GO:0007569 | cell aging | IEA | -- |
No data available for Pathways by source for MNT Gene
Drugs & Compounds for MNT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen MNT (APrEST92011) and PrEST Antigen MNT (APrEST92739)
- Creative Biomart Recombinant Human MNT lysate
Transcripts for MNT Gene
mRNA/cDNA for MNT Gene
- (1) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (139) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000174618 4925 bps (ENST00000174618.4)
- ENST00000575374 936 bps (ENST00000575374.5)
- ENST00000572892 556 bps (ENST00000572892.5)
- ENST00000571232 508 bps (ENST00000571232.1)
- ENST00000573384 528 bps (ENST00000573384.1)
CRISPR Products
-
OriGene CRISPR knockouts for MNT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MNT
- genomics-online: gRNA clones - Search for available MNT gRNA products
- Overview of 198 available MNT gene related products
- Applied Biological Materials (abm): CRISPR Clones for MNT - Select products 50% OFF >
- * MNT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * MNT CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for MNT
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for MNT
- Browse OriGene Inhibitory RNA Products For MNT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MNT
- genomics-online: shRNA clones - Search for available MNT shRNA products
- Overview of 198 available MNT gene related products
Clone Products
- Sino Biological Human cDNA Clone for MNT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MNT
- genomics-online: cdna clones - Search for available MNT CDNA products
- Overview of 198 available MNT gene related products
- orf clones - Search for available MNT ORF products
- Overview of 198 available MNT gene related products
- Applied Biological Materials (abm): Clones for MNT - Select products 50% OFF >
- * MNT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * MNT tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: |
Expression for MNT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MNT Gene
NURSA nuclear receptor signaling pathways regulating expression of MNT Gene:
MNTSOURCE GeneReport for Unigene cluster for MNT Gene:
Hs.632239Evidence on tissue expression from TISSUES for MNT Gene
- Nervous system(4.6)
- Pancreas(4.1)
- Blood(2.2)
- Bone marrow(2.1)
Primer Products
-
OriGene qPCR primer pairs for MNT
- genomics-online: primer clones - Search for available MNT Primer products
- Overview of 198 available MNT gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MNT Gene
Orthologs for MNT Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MNT 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mnt 17 33 32 |
|
||
| dog (Canis familiaris) |
Mammalia | MNT 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MNT 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MNT 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MNT 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MNT 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MNT 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mnt 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10853 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mntb 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Mnt 33 |
|
OneToOne |
- Species where no ortholog for MNT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for MNT Gene
- ENSEMBL:
- Gene Tree for MNT (if available)
- TreeFam:
- Gene Tree for MNT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MNT: view image
Paralogs for MNT Gene
Variants for MNT Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000120213 | -- | 2,401,705(-) | C/G | upstream_transcript_variant | |
| rs1000171535 | -- | 2,390,744(-) | T/G | 5_prime_UTR_variant, intron_variant | |
| rs1000213502 | -- | 2,393,245(-) | G/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000214954 | -- | 2,383,834(-) | A/T | downstream_transcript_variant | |
| rs1000234548 | -- | 2,389,023(-) | G/A | 5_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3083n100 | CNV | gain | 25217958 |
| nsv1055225 | CNV | loss | 25217958 |
| nsv1063109 | CNV | gain | 25217958 |
| nsv1066475 | CNV | loss | 25217958 |
| nsv1070377 | CNV | deletion | 25765185 |
| nsv1160443 | CNV | deletion | 26073780 |
| nsv1160444 | CNV | deletion | 26073780 |
| nsv1160445 | CNV | duplication | 26073780 |
| nsv469765 | CNV | loss | 16826518 |
| nsv470569 | CNV | loss | 18288195 |
| nsv517489 | CNV | loss | 19592680 |
| nsv574224 | CNV | gain | 21841781 |
| nsv833336 | CNV | loss | 17160897 |
| nsv833338 | CNV | loss | 17160897 |
| nsv952104 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.80;
58.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MNT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MNT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene
Disorders for MNT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| tetanus neonatorum |
|
|
| retinitis pigmentosa, y-linked |
|
|
| dyschromatosis universalis hereditaria |
|
|
Search MNT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MNT
No data available for UniProtKB/Swiss-Prot and Genatlas for MNT Gene
Publications for MNT Gene
- The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PMID: 9598315) Lo Nigro C … Carrozzo R (Genomics 1998) 2 3 4 56
- Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H … Lu SC (Hepatology (Baltimore, Md.) 2009) 3 23 56
- Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo XL … Ohno R (Leukemia & lymphoma 2007) 3 23 56
- Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) Wahlström T … Henriksson M (Advances in cancer research 2007) 3 23 56
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
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Products for MNT Gene
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Sources for MNT Gene
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