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MNDA Gene(Protein Coding)

Myeloid Cell Nuclear Differentiation Antigen

GCID:
GC01P158801
GIFtS:
47
Genes Participants
UDN Logo

Aliases for MNDA Gene

Aliases for MNDA Gene

  • Myeloid Cell Nuclear Differentiation Antigen 2 3 3 5
  • PYHIN3 3

External Ids for MNDA Gene

Previous GeneCards Identifiers for MNDA Gene

  • GC01P156593
  • GC01P154533
  • GC01P155579
  • GC01P156017
  • GC01P155614
  • GC01P157067
  • GC01P130158

Summaries for MNDA Gene

Entrez Gene Summary for MNDA Gene

  • The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNDA Gene

MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. Diseases associated with MNDA include Nodal Marginal Zone Lymphoma and Diffuse Scleroderma. Among its related pathways are Apoptosis and Autophagy and Innate Immune System. An important paralog of this gene is PYHIN1.

UniProtKB/Swiss-Prot for MNDA Gene

  • May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Gene Wiki entry for MNDA Gene

Additional gene information for MNDA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNDA Gene

Genomics for MNDA Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MNDA Gene

Promoters and enhancers for MNDA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J158829 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 532 3.8 PKNOX1 REST ATF2 IRF4 YY1 POLR2A IKZF1 NBN ATF7 MLLT1 MNDA OR6N2 PYHIN5P
GH01J158818 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -11.9 -11882 2.1 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ZFP91 MNDA CD1D PYHIN1 IFI16 OR10AA1P
GH01J158800 Enhancer 1 FANTOM5 Ensembl dbSUPER 25.3 -29.0 -29016 4.2 ZNF316 MAFF MAFG REST EMSY MAFK ZNF592 MNDA OR6N1 OR6N2 PYHIN1 IFI16 OR2AQ1P OR10AA1P
GH01J159084 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 24.1 +253.5 253529 0.9 POLR2A GABPA MNDA AIM2 IFI16 RAD1P2 GC01M159143 TRR-TCT4-1
GH01J158808 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 14.8 -21.4 -21416 2.6 CEBPB OR10AA1P MNDA OR6N2 OR6N1 OR6K2 PYHIN1 IFI16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MNDA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MNDA gene promoter:
  • ATF-2
  • S8
  • FOXJ2 (long isoform)
  • FOXJ2
  • Cart-1
  • Chx10

Genomic Locations for MNDA Gene

Genomic Locations for MNDA Gene
chr1:158,831,317-158,849,506
(GRCh38/hg38)
Size:
18,190 bases
Orientation:
Plus strand
chr1:158,801,107-158,819,296
(GRCh37/hg19)
Size:
18,190 bases
Orientation:
Plus strand

Genomic View for MNDA Gene

Genes around MNDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNDA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MNDA Gene

Proteins for MNDA Gene

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  • Protein details for MNDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41218-MNDA_HUMAN
    Recommended name:
    Myeloid cell nuclear differentiation antigen
    Protein Accession:
    P41218

    Protein attributes for MNDA Gene

    Size:
    407 amino acids
    Molecular mass:
    45836 Da
    Quaternary structure:
    • Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

    Three dimensional structures from OCA and Proteopedia for MNDA Gene

neXtProt entry for MNDA Gene

Protein Expression for MNDA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MNDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MNDA Gene

Domains & Families for MNDA Gene

Gene Families for MNDA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MNDA Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MNDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41218

UniProtKB/Swiss-Prot:

MNDA_HUMAN :
  • Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
Domain:
  • Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
genes like me logo Genes that share domains with MNDA: view

Function for MNDA Gene

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  2. CRISPR
  3. miRNA
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Molecular function for MNDA Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
UniProtKB/Swiss-Prot Induction:
Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.
GENATLAS Biochemistry:
myeloid nuclear differentiation antigen,interferon alpha-inducible protein

Gene Ontology (GO) - Molecular Function for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with MNDA: view
genes like me logo Genes that share phenotypes with MNDA: view

Animal Model Products

miRNA for MNDA Gene

miRTarBase miRNAs that target MNDA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MNDA Gene

Localization for MNDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNDA Gene

Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MNDA gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MNDA: view

Pathways & Interactions for MNDA Gene

genes like me logo Genes that share pathways with MNDA: view

Pathways by source for MNDA Gene

3 Reactome pathways for MNDA Gene
2 Cell Signaling Technology pathways for MNDA Gene

Gene Ontology (GO) - Biological Process for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006968 cellular defense response TAS 1644857
GO:0006974 cellular response to DNA damage stimulus IMP 17875758
GO:0030889 negative regulation of B cell proliferation IMP 17875758
genes like me logo Genes that share ontologies with MNDA: view

No data available for SIGNOR curated interactions for MNDA Gene

Drugs & Compounds for MNDA Gene

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(1) Drugs for MNDA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MNDA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MNDA: view

Transcripts for MNDA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MNDA Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MNDA Gene

Myeloid cell nuclear differentiation antigen:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNDA Gene

No ASD Table

Relevant External Links for MNDA Gene

GeneLoc Exon Structure for
MNDA
ECgene alternative splicing isoforms for
MNDA

Expression for MNDA Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MNDA Gene

mRNA expression in normal human tissues for MNDA Gene
mRNA expression by GTEx for MNDA GenemRNA expression by BioGPS for MNDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNDA Gene

This gene is overexpressed in Whole Blood (x47.0).

Protein differential expression in normal tissues from HIPED for MNDA Gene

This gene is overexpressed in Neutrophil (23.2), Monocytes (10.0), Peripheral blood mononuclear cells (9.5), and Lavage (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MNDA Gene



Protein tissue co-expression partners for MNDA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MNDA Gene:

MNDA

SOURCE GeneReport for Unigene cluster for MNDA Gene:

Hs.153837

mRNA Expression by UniProt/SwissProt for MNDA Gene:

P41218-MNDA_HUMAN
Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.

Evidence on tissue expression from TISSUES for MNDA Gene

  • Pancreas(4.2)
  • Blood(3.5)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with MNDA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MNDA Gene

Orthologs for MNDA Gene

This gene was present in the common ancestor of mammals.

Orthologs for MNDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MNDA 34 33
  • 99.34 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MNDA 34
  • 51 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ifi205 34
  • 44 (a)
 OneToMany
Mnda 34
  • 42 (a)
 OneToMany
Mndal 34
  • 35 (a)
 OneToMany
Ifi204 34
  • 30 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia -- 34
  • 33 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 30 (a)
 OneToMany
Species where no ortholog for MNDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MNDA Gene

ENSEMBL:
Gene Tree for MNDA (if available)
TreeFam:
Gene Tree for MNDA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MNDA: view image

Paralogs for MNDA Gene

Paralogs for MNDA Gene

(3) SIMAP similar genes for MNDA Gene using alignment to 4 proteins:

  • MNDA_HUMAN
  • H0Y6P3_HUMAN
  • Q05CU9_HUMAN
  • Q5VUU6_HUMAN

Pseudogenes.org Pseudogenes for MNDA Gene

genes like me logo Genes that share paralogs with MNDA: view

Variants for MNDA Gene

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Sequence variations from dbSNP and Humsavar for MNDA Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000020171 -- 158,831,854(+) G/A intron_variant
rs1000041657 -- 158,845,366(+) T/C intron_variant
rs1000104626 -- 158,847,583(+) T/A intron_variant
rs1000140086 -- 158,838,491(+) T/C intron_variant
rs1000261373 -- 158,838,779(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MNDA Gene

Variant ID Type Subtype PubMed ID
dgv589n54 CNV loss 21841781
esv2669506 CNV deletion 23128226
esv3587685 CNV loss 21293372
nsv1002401 CNV loss 25217958

Variation tolerance for MNDA Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MNDA Gene

Human Gene Mutation Database (HGMD)
MNDA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MNDA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNDA Gene

Disorders for MNDA Gene

MalaCards: The human disease database

(6) MalaCards diseases for MNDA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nodal marginal zone lymphoma
  • mucosa-associated lymphoid tissue lymphoma
diffuse scleroderma
  • systemic scleroderma
limited scleroderma
  • crest syndrome
burkitt lymphoma
  • bl
myelodysplastic syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards
Search MNDA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MNDA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MNDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MNDA Gene

Publications for MNDA Gene

  1. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. (PMID: 7512843) Briggs RC … Dessypris EN (Blood 1994) 2 3 4 22 58
  2. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (PMID: 1644857) Briggs JA … Briggs RC (Journal of cellular biochemistry 1992) 2 3 4 22 58
  3. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. (PMID: 9712147) Xie J … Briggs RC (Journal of cellular biochemistry 1998) 3 4 22 58
  4. The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. (PMID: 7806273) Dawson MJ … Baker E (Immunogenetics 1995) 3 4 22 58
  5. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. (PMID: 8175894) Briggs R … Lian J (Journal of cellular biochemistry 1994) 3 4 22 58

Products for MNDA Gene

Sources for MNDA Gene

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