Free for academic non-profit institutions. Other users need a Commercial license
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. Diseases associated with MNDA include Nodal Marginal Zone Lymphoma and Parkinson Disease 4, Autosomal Dominant. Among its related pathways are Innate Immune System and Apoptosis and Autophagy. An important paralog of this gene is PYHIN1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 23455924 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IBA,IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Apoptosis and Autophagy | ||
3 | NF-kappaB Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002218 | activation of innate immune response | IEA,IBA | 21873635 |
GO:0006968 | cellular defense response | TAS | 1644857 |
GO:0006974 | cellular response to DNA damage stimulus | IMP | 17875758 |
GO:0030889 | negative regulation of B cell proliferation | IMP | 17875758 |
GO:0032731 | positive regulation of interleukin-1 beta production | IBA | 21873635 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MNDA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MNDA 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ifi205 31 |
|
OneToMany | |
Mnda 31 |
|
OneToMany | |||
Mndal 31 |
|
OneToMany | |||
Ifi204 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
745938 | Likely Benign: not provided | 158,847,807(+) | G/A | NONSENSE | |
762401 | Likely Benign: not provided | 158,843,364(+) | C/T | SYNONYMOUS_VARIANT | |
767713 | Benign: not provided | 158,842,330(+) | T/C | SYNONYMOUS_VARIANT | |
rs1056771 | - | p.Val286Leu | |||
rs2276403 | - | p.His357Tyr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv589n54 | CNV | loss | 21841781 |
esv2669506 | CNV | deletion | 23128226 |
esv3587685 | CNV | loss | 21293372 |
nsv1002401 | CNV | loss | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nodal marginal zone lymphoma |
|
|
parkinson disease 4, autosomal dominant |
|
|
methotrexate-associated lymphoproliferation |
|
|
myeloid leukemia |
|
|
burkitt lymphoma |
|