Aliases for MMS22L Gene
External Ids for MMS22L Gene
Previous HGNC Symbols for MMS22L Gene
Previous GeneCards Identifiers for MMS22L Gene
The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
GeneCards Summary for MMS22L Gene
MMS22L (MMS22 Like, DNA Repair Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for MMS22L Gene
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.