Aliases for MMRN2 Gene
External Ids for MMRN2 Gene
Previous HGNC Symbols for MMRN2 Gene
Previous GeneCards Identifiers for MMRN2 Gene
This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
GeneCards Summary for MMRN2 Gene
MMRN2 (Multimerin 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is MMRN1.
UniProtKB/Swiss-Prot for MMRN2 Gene
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.