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Aliases for MMRN2 Gene

Aliases for MMRN2 Gene

  • Multimerin 2 2 3 5
  • Elastin Microfibril Interfacer 3 2 3 4
  • Elastin Microfibril Interface Located Protein 3 3 4
  • EndoGlyx-1 P125/P140 Subunit 3 4
  • EMILIN-3 3 4
  • EMILIN3 3 4
  • EMILIN-Like Protein EndoGlyx-1 3
  • Multimerin-2 3
  • ENDOGLYX-1 3

External Ids for MMRN2 Gene

Previous HGNC Symbols for MMRN2 Gene


Previous GeneCards Identifiers for MMRN2 Gene

  • GC10M088361
  • GC10M088685
  • GC10M082549

Summaries for MMRN2 Gene

Entrez Gene Summary for MMRN2 Gene

  • This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

GeneCards Summary for MMRN2 Gene

MMRN2 (Multimerin 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is MMRN1.

UniProtKB/Swiss-Prot for MMRN2 Gene

  • Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Additional gene information for MMRN2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMRN2 Gene

Genomics for MMRN2 Gene

GeneHancer (GH) Regulatory Elements for MMRN2 Gene

Promoters and enhancers for MMRN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I086965 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 122 7.8 HDGF CLOCK ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF143 ATF7 FOS ADIRF-AS1 AGAP11 ENSG00000273413 MMRN2 ADIRF SNCG ENSG00000261011 BMS1P3 BMPR1A GRID1
GH10I086953 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.4 +12.5 12492 8 PKNOX1 ARID4B SIN3A IRF4 POLR2B ZNF143 FOS KLF13 ZNF263 SP3 SNCG MMRN2 LINC00863 NUTM2A-AS1 ADIRF-AS1 GC10P086949
GH10I086939 Enhancer 1.1 Ensembl ENCODE 13.3 +30.4 30423 1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF207 ZNF143 ADIRF MMRN2 ENSG00000151303 SNCG ENSG00000281974 GC10P086921
GH10I087081 Enhancer 1 Ensembl ENCODE 10.9 -113.6 -113568 4.2 FOXA2 BMI1 RARA ZNF121 ATF7 FOS IKZF2 ZNF362 JUNB ELF1 MMRN2 ADIRF SNCG FAM35A NUTM2A-AS1 OPN4 NUTM2D GLUD1 GC10M087058
GH10I086747 Enhancer 0.8 ENCODE dbSUPER 10.4 +221.9 221892 0.9 ZNF362 FOXA2 JUN USF2 MAX ZNF384 NR2F2 FOXA1 PRDM6 BMPR1A ADIRF MMRN2 SNCG ENSG00000272631 GC10M086714
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MMRN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMRN2 gene promoter:

Genomic Locations for MMRN2 Gene

Genomic Locations for MMRN2 Gene
34,414 bases
Minus strand

Genomic View for MMRN2 Gene

Genes around MMRN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMRN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMRN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMRN2 Gene

Proteins for MMRN2 Gene

  • Protein details for MMRN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q504V7
    • Q6P2N2

    Protein attributes for MMRN2 Gene

    949 amino acids
    Molecular mass:
    104409 Da
    Quaternary structure:
    • Heteromer of p110, p125, p140 and p200 subunits; disulfide-linked. Interacts with VEGFA.

neXtProt entry for MMRN2 Gene

Post-translational modifications for MMRN2 Gene

  • N- and O-glycosylated.
  • Glycosylation at Asn205, Asn214, isoforms=249, Asn261, Asn350, isoforms=379, Asn439, Asn472, Asn727, isoforms=765, and isoforms=845
  • Modification sites at PhosphoSitePlus

Other Protein References for MMRN2 Gene

No data available for DME Specific Peptides for MMRN2 Gene

Domains & Families for MMRN2 Gene

Gene Families for MMRN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MMRN2 Gene

Suggested Antigen Peptide Sequences for MMRN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MMRN2: view

No data available for UniProtKB/Swiss-Prot for MMRN2 Gene

Function for MMRN2 Gene

Molecular function for MMRN2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.

Gene Ontology (GO) - Molecular Function for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22020326
genes like me logo Genes that share ontologies with MMRN2: view

Phenotypes for MMRN2 Gene

GenomeRNAi human phenotypes for MMRN2:
genes like me logo Genes that share phenotypes with MMRN2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMRN2

CRISPR Products

miRNA for MMRN2 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMRN2 Gene

Localization for MMRN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMRN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMRN2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 11559704
GO:0031012 extracellular matrix IDA 23979707
genes like me logo Genes that share ontologies with MMRN2: view

Pathways & Interactions for MMRN2 Gene

genes like me logo Genes that share pathways with MMRN2: view

Pathways by source for MMRN2 Gene

Interacting Proteins for MMRN2 Gene

Selected Interacting proteins: Q9H8L6-MMRN2_HUMAN for MMRN2 Gene via IID

Gene Ontology (GO) - Biological Process for MMRN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA 22020326
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IDA 22020326
genes like me logo Genes that share ontologies with MMRN2: view

No data available for SIGNOR curated interactions for MMRN2 Gene

Drugs & Compounds for MMRN2 Gene

No Compound Related Data Available

Transcripts for MMRN2 Gene

Unigene Clusters for MMRN2 Gene

Multimerin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMRN2 Gene

No ASD Table

Relevant External Links for MMRN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMRN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMRN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMRN2 Gene

This gene is overexpressed in Serum (30.0) and Urine (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMRN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMRN2 Gene:


SOURCE GeneReport for Unigene cluster for MMRN2 Gene:


mRNA Expression by UniProt/SwissProt for MMRN2 Gene:

Tissue specificity: Endothelium.

Evidence on tissue expression from TISSUES for MMRN2 Gene

  • Bone marrow(4)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with MMRN2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMRN2 Gene

Orthologs for MMRN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMRN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MMRN2 33 34
  • 99.37 (n)
(Bos Taurus)
Mammalia MMRN2 33 34
  • 83.06 (n)
(Canis familiaris)
Mammalia MMRN2 33 34
  • 76.4 (n)
(Rattus norvegicus)
Mammalia Mmrn2 33
  • 75.37 (n)
(Mus musculus)
Mammalia Mmrn2 33 16 34
  • 75.12 (n)
(Monodelphis domestica)
Mammalia MMRN2 34
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia MMRN2 34
  • 43 (a)
(Gallus gallus)
Aves MMRN2 33 34
  • 51.03 (n)
(Anolis carolinensis)
Reptilia MMRN2 34
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmrn2 33
  • 47.23 (n)
(Danio rerio)
Actinopterygii mmrn2a 33 34
  • 41.67 (n)
mmrn2b 34
  • 19 (a)
Species where no ortholog for MMRN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMRN2 Gene

Gene Tree for MMRN2 (if available)
Gene Tree for MMRN2 (if available)

Paralogs for MMRN2 Gene

Paralogs for MMRN2 Gene Pseudogenes for MMRN2 Gene

genes like me logo Genes that share paralogs with MMRN2: view

Variants for MMRN2 Gene

Sequence variations from dbSNP and Humsavar for MMRN2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs748531029 A colorectal cancer sample 86,943,442(-) C/G/T coding_sequence_variant, missense_variant
rs1000069376 -- 86,958,989(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000113071 -- 86,943,322(-) A/G coding_sequence_variant, missense_variant
rs1000213699 -- 86,935,449(-) C/T downstream_transcript_variant
rs1000350462 -- 86,970,264(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMRN2 Gene

Variant ID Type Subtype PubMed ID
dgv1324n54 CNV loss 21841781
dgv1325n54 CNV loss 21841781
dgv1326n54 CNV gain+loss 21841781
dgv1327n54 CNV gain 21841781
esv24935 CNV loss 19812545
esv2759774 CNV gain+loss 17122850
esv33376 CNV loss 17666407
nsv1141879 OTHER inversion 24896259
nsv428236 CNV loss 18775914
nsv470969 CNV loss 18288195
nsv517487 CNV gain+loss 19592680
nsv551806 CNV gain+loss 21841781
nsv551810 CNV gain 21841781
nsv7482 CNV insertion 18451855

Variation tolerance for MMRN2 Gene

Residual Variation Intolerance Score: 7.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.97; 84.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMRN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMRN2 Gene

Disorders for MMRN2 Gene

Additional Disease Information for MMRN2

No disorders were found for MMRN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMRN2 Gene

Publications for MMRN2 Gene

  1. Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. (PMID: 11559704) Christian S … Lenter MC (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway. (PMID: 22020326) Lorenzon E … Mongiat M (Oncogene 2012) 3 4 58
  3. N-glycoprotein profiling of lung adenocarcinoma pleural effusions by shotgun proteomics. (PMID: 18327805) Soltermann A … Moch H (Cancer 2008) 3 22 58
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MMRN2 Gene

Sources for MMRN2 Gene

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