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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include Metaphyseal Anadysplasia 2 and Metaphyseal Anadysplasia. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include identical protein binding and metalloendopeptidase activity. An important paralog of this gene is MMP2.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IDA | 19022250 |
GO:0004222 | metalloendopeptidase activity | TAS | -- |
GO:0004252 | serine-type endopeptidase activity | EXP | 17428795 |
GO:0005515 | protein binding | IPI | 2251898 |
GO:0005518 | collagen binding | TAS | 2551898 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 2551898 |
GO:0031012 | extracellular matrix | IEA | -- |
GO:0062023 | collagen-containing extracellular matrix | HDA | 28344315 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrin Pathway |
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
|
Transendothelial Migration of Leukocytes
.38
|
2 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
3 | Degradation of the extracellular matrix | ||
4 | Innate Immune System |
.61
|
|
5 | Relaxin signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IMP | 22984561 |
GO:0006508 | proteolysis | IDA | 2551898 |
GO:0007566 | embryo implantation | IEA | -- |
GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
Captopril | Approved | Pharma | Inhibitor, Inhibition, Target, inhibitor | ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase | 50 | |
Simvastatin | Approved | Pharma | Inhibitor, Competitive | HMG-CoA reductase inhibitor | 582 | |
Glucosamine | Approved, Investigational | Pharma | Target, antagonist | 88 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide | Substrate of matrix metalloproteinases assay | 140430-53-1 |
Batimastat (BB-94) | MMP inhibitor | 130370-60-4 |
GM 6001 | Broad spectrum MMP inhibitor | 142880-36-2 |
Marimastat | MMPs inhibitor,board spectrum | 154039-60-8 |
Phosphoramidon Disodium Salt | 164204-38-0 | |
SB-3CT | gelatinases inhibitor, potent and selective | 292605-14-2 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MMP9 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MMP9 30 |
|
||
MMP-9 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | MMP9 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mmp9 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mmp9 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MMP9 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | MMP9 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100494738 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC69080 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mmp9 30 31 |
|
OneToOne | |
wufb02g06 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10476 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | H19M22.3 31 |
|
ManyToMany | |
zmp-1 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G45040 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
707836 | Benign/Likely Benign: Metaphyseal anadysplasia 2; not provided | 46,008,996(+) | C/T | MISSENSE_VARIANT | |
708035 | Benign: Metaphyseal anadysplasia 2; not provided | 46,009,039(+) | A/G | MISSENSE_VARIANT | |
708644 | Likely Benign: not provided | 46,010,093(+) | C/A | SYNONYMOUS_VARIANT | |
713798 | Likely Benign: not provided | 46,010,495(+) | C/T | SYNONYMOUS_VARIANT | |
719765 | Conflicting Interpretations: Metaphyseal anadysplasia 2; not provided | 46,009,007(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
metaphyseal anadysplasia 2 |
|
|
metaphyseal anadysplasia |
|
|
central nervous system tuberculosis |
|
|
hemorrhoid |
|
|
adamantinous craniopharyngioma |
|
|