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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular prot... See more...
Aliases for MMP9 Gene
Aliases for MMP9 Gene
External Ids for MMP9 Gene
- HGNC: 7176
- Entrez Gene: 4318
- Ensembl: ENSG00000100985
- OMIM: 120361
- UniProtKB: P14780
Previous HGNC Symbols for MMP9 Gene
- CLG4B
Previous GeneCards Identifiers for MMP9 Gene
- GC20P044366
- GC20P045275
- GC20P045322
- GC20P044070
- GC20P044637
- GC20P041378
Summaries for MMP9 Gene
-
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP9 Gene
MMP9 (Matrix Metallopeptidase 9) is a Protein Coding gene. Diseases associated with MMP9 include Metaphyseal Anadysplasia 2 and Metaphyseal Anadysplasia. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include identical protein binding and metalloendopeptidase activity. An important paralog of this gene is MMP2.
UniProtKB/Swiss-Prot Summary for MMP9 Gene
-
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
-
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.
Additional gene information for MMP9 Gene
- HGNC(7176)
- Entrez Gene(4318)
- Ensembl(ENSG00000100985)
- OMIM(120361)
- UniProtKB(P14780)
- Open Targets Platform(ENSG00000100985)
- Monarch Initiative
- Search for MMP9 at DataMed
- Search for MMP9 at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP9 Gene
Genomics for MMP9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MMP9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MMP9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP9
- Top Transcription factor binding sites by QIAGEN in the MMP9 gene promoter:
-
- c-Myc
- Max
- NRSF form 1
- NRSF form 2
- USF-1
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for MMP9 Gene
Genomic Locations for MMP9 Gene
- chr20:46,008,908-46,016,561
- (GRCh38/hg38)
- Size:
- 7,654 bases
- Orientation:
- Plus strand
- chr20:44,637,547-44,645,200
- (GRCh37/hg19)
- Size:
- 7,654 bases
- Orientation:
- Plus strand
Genomic View for MMP9 Gene
Genes around MMP9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
MMP9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MMP9 Gene
Proteins for MMP9 Gene
-
Protein details for MMP9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14780-MMP9_HUMAN
- Recommended name:
- Matrix metalloproteinase-9
- Protein Accession:
- P14780
- B2R7V9
- Q3LR70
- Q8N725
- Q9H4Z1
- Q9UCJ9
- Q9UCL1
- Q9UDK2
Protein attributes for MMP9 Gene
- Size:
- 707 amino acids
- Molecular mass:
- 78458 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Exists as monomer or homodimer; disulfide-linked (PubMed:1281792, PubMed:7683678). Exists also as heterodimer with LCN2 (PubMed:1281792, PubMed:7683678). Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1 (PubMed:16512877).
- (Microbial infection) Interacts with Staphylococcus aureus protein SSL5; this interaction inhibits MMP9 activity.
- Miscellaneous:
-
- In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.
Protein Expression for MMP9 Gene
Selected DME Specific Peptides for MMP9 Gene
- P14780:
-
- PRCGVPD
- LWCATTSN
- GLLAHAFPPG
- LFLVAAHE
- VAAHEFGHALGL
- FFFSGRQ
- DGYPFDG
- VAAHEFGH
- LDKLGLG
- IGNQLYL
- GLLAHAF
- GGNSAGE
- KWGFCPD
Post-translational modifications for MMP9 Gene
- Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
- N- and O-glycosylated.
-
Glycosylation at Asn38, Asn120, and Asn127
- NX_P14780 (NX_P14780-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- MMP9_HUMAN (6)
Other Protein References for MMP9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences MMP9 / Gelatinase B Antibody and MMP9 / Gelatinase B Monoclonal Antibody
- G Biosciences Immunotagâ„¢ MMP9 Antibody and Immunotagâ„¢ MMP-9 Antibody
- SouthernBiotech Mouse Anti-Human MMP-9-HRP and Mouse Anti-Human MMP-9-UNLB
- NSJ Bioreagents MMP9 Antibody
- Creative Diagnostics Anti-matrix metallopeptidase 9 (full length) polyclonal antibody
-
Creative Biolabs
- Recombinant Mouse Anti-Human MMP9 Antibody Fab Fragment
- Anti-Human MMP9 Therapeutic Antibody (GS-5745)
- Anti-Human MMP9 Therapeutic Antibody Fab Fragment (G03)
- Anti-Human MMP9 Therapeutic Antibody (G06)
- Mouse Anti-MMP9 (C-terminus) Recombinant Antibody (CBFYM-2423)
- Anti-Human MMP9 Therapeutic Antibody (Andecaliximab)
- Hi-Affiâ„¢ Recombinant Rabbit Anti-MMP9 Monoclonal Antibody (DS2263AB)
- Mouse Anti-MMP9 (C-terminus) Recombinant Antibody (CBFYM-0443)
- Rat Anti-MMP9 Recombinant Antibody (7S41)
- Mouse Anti-MMP9 Recombinant Antibody (CBFYM-0700)
- Recombinant Human Anti-MMP9 Antibody (G03-VH-GL-V1/ G06-VL-GL1)
- Recombinant Mouse anti-Human MMP9 Monoclonal antibody (26X3)
- Recombinant Human Anti-MMP9 Antibody (DX-2802)
- Afucoâ„¢ Anti-MMP9 ADCC Theraputic Antibody (Andecaliximab), ADCC Enhanced
- Mouse Anti-MMP9 Antibody Fab Fragment (M4)
- BioLegend MMP9 Antibody and MMP-9 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MMP9
- 73-100
- 75-100
- AM05379PU-N
- AM05380PU-N
- AM06662SU-N
- AM06664SU-N
- AM08200HR-N
- AM08200PU-N
- AM10115SU-N
- AP06236PU-N
- AP13187PU-N
- AP22745PU-N
- AP52713PU-N
- TA312179
- TA319098
- TA325695
- TA326571
- TA326652
- TA327267
- TA336901
- TA341163
- TA341164
- TA347924
- TA349222
- TA351481
- TA351482
- TA353338L
- TA353339L
- TA354280
- TA590194
- Novus Biologicals Antibodies for MMP9
-
Abcam antibodies for MMP9
- Invitrogen Antibodies for MMP9 (AFLGC-MMP9)
- antibodies-online: Show 197 available MMP 9 Antibodies ranked by validation data
- Compare Top MMP 9 Antibodies
-
Recommended
- 418 WB Antibodies (anti-human)
- 50 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 162 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 186 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IF Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MMP9
- Sino Biological Antibodies for MMP9
Protein Products
- G Biosciences Human MMP-9/metalloproteinase-9/CLG4B, Liquid
-
BioLegend
- Recombinant Human MMP-9 (dimer, carrier-free) (551104)
- Recombinant Human MMP-9 (dimer, carrier-free) (551106)
- Recombinant Human MMP-9 (carrier-free) (550504)
- Recombinant Human MMP-9 (dimer, carrier-free) (551102)
- Recombinant Human MMP-9 (carrier-free) (550506)
- Recombinant Human MMP-9 (carrier-free) (550502)
- Recombinant Human MMP-9 (ELISA Std.)
- Search Origene for MassSpec and Protein Over-expression Lysates for MMP9
- Origene Custom Protein Services for MMP9
- Sino Biological Recombinant Proteins for MMP9
- Sino Biological Cell Lysates for MMP9
-
Abcam proteins for MMP9
Assay Products
- RayBiotech Human MMP-9 ELISA
- Novus Biologicals ELISA Kits for MMP9
- antibodies-online: Show 174 available MMP 9 Elisa Kits ranked by validation data
- Compare Top MMP 9 Elisa Kits
-
Quality Products:
- ABIN415059
- ABIN818177
- ABIN6574164
- ABIN625060
- ABIN411333
- ABIN1115942
- ABIN2506950
- ABIN1029258
- ABIN492069
- ABIN1379995
- ABIN6730931
- ABIN6720461
- ABIN411334
- ABIN415640
- ABIN1115944
- ABIN365501
- ABIN1979379
- ABIN5524753
- ABIN492070
- ABIN1029259
- ABIN6730943
- ABIN416391
- ABIN365564
- ABIN1115943
- ABIN5524756
- ABIN1571297
- ABIN5510644
- ABIN578882
- ABIN5670915
- ABIN5594727
- ABIN431284
- ABIN1571296
- ABIN365674
- ABIN5524754
- ABIN779371
- ABIN1564029
- ABIN2544032
- ABIN6229485
- ABIN5656797
- ABIN2949383
-
Abcam assays for MMP9
- Sino Biological Assays for MMP9
Domains & Families for MMP9 Gene
Gene Families for MMP9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted secreted proteins
Protein Domains for MMP9 Gene
- InterPro:
- Blocks:
-
- Type II fibronectin collagen-binding domain
- Hemopexin repeat
- Matrixin
- Putative peptidoglycan binding domain 1
- ProtoNet:
Suggested Antigen Peptide Sequences for MMP9 Gene
- GenScript: Design optimal peptide antigens:
-
- Gelatinase B (MMP9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14780UniProtKB/Swiss-Prot:
MMP9_HUMAN :- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- Belongs to the peptidase M10A family.
- Domain:
-
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- Family:
-
- Belongs to the peptidase M10A family.
Function for MMP9 Gene
Molecular function for MMP9 Gene
- UniProtKB/Swiss-Prot Function:
- May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Cleavage of gelatin types I and V and collagen types IV and V.; EC=3.4.24.35; Evidence={ECO:0000269|PubMed:1480034};.
- UniProtKB/Swiss-Prot Induction:
- Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells.
- UniProtKB/Swiss-Prot Induction:
- (Microbial infection) Expression induced by M.bovis MPB83 (at protein level) (PubMed:20800577).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1.
- GENATLAS Biochemistry:
- matrix metalloproteinase 9,regulator of matrix remodeling,expressed in alveolar macrophages,granulocytes and mast cells,generating angiostatin fragments by hydrolyzing plasminogen,key regulator of grow plate angiogenesis and apoptosis of hypertrophic chondrocytes in mice,playing a control role of keratinocyte growth,also involved in the migratory process (acute and chronic inflammation of tumoral metastatic process and in injury processus of myofibers),overexpressed in colorectal adenomas and in inflammatory bowel diseases,significantly diminished in diffuse type gastric carcinoma,involved in pathophysiology of malignant gliomas by acting in the remodeling,associated with neovascularization),may be also involved in the severity of coronary atherosclerosis
Enzyme Numbers (IUBMB) for MMP9 Gene
Phenotypes From GWAS Catalog for MMP9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IDA | 19022250 |
| GO:0004222 | metalloendopeptidase activity | TAS | -- |
| GO:0004252 | serine-type endopeptidase activity | EXP | 17428795 |
| GO:0005515 | protein binding | IPI | 2251898 |
| GO:0005518 | collagen binding | TAS | 2551898 |
Phenotypes for MMP9 Gene
- MGI mutant phenotypes for MMP9:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for MMP9:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Increased gamma-H2AX phosphorylation
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased shRNA abundance
- Increased Nanog expression
- Increased NF-kappaB reporter expression
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Models for MMP9 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for MMP9
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MMP9 - Select products 50% OFF >
- * MMP9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MMP9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMP9
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMP9
miRNA for MMP9 Gene
- miRTarBase miRNAs that target MMP9
-
- rno-miR-338-3p (MIRT002190)
- rno-miR-290 (MIRT002191)
- rno-miR-132-3p (MIRT002192)
- rno-miR-664-3p (MIRT002193)
- rno-miR-125a-5p (MIRT002194)
- mmu-miR-204-5p (MIRT004704)
- hsa-miR-451a (MIRT005743)
- mmu-miR-212-3p (MIRT005939)
- mmu-miR-132-3p (MIRT005940)
- hsa-miR-491-5p (MIRT006134)
- mmu-miR-320-3p (MIRT006296)
- hsa-miR-338-3p (MIRT019229)
- hsa-miR-204-5p (MIRT024984)
- hsa-miR-21-5p (MIRT030871)
- hsa-miR-9-5p (MIRT053482)
- hsa-miR-211-5p (MIRT053791)
- hsa-let-7e-5p (MIRT054561)
- hsa-miR-133b (MIRT438251)
- mmu-miR-21a-5p (MIRT438889)
- hsa-miR-29b-3p (MIRT438916)
- hsa-miR-320a (MIRT732492)
- hsa-miR-9-3p (MIRT732888)
- hsa-miR-524-5p (MIRT733144)
- hsa-miR-302a-5p (MIRT733417)
- hsa-miR-132-3p (MIRT733764)
- hsa-miR-15b-5p (MIRT734151)
- hsa-miR-942-3p (MIRT734269)
- hsa-miR-203a-5p (MIRT734406)
- hsa-miR-133a-5p (MIRT734741)
- hsa-miR-143-3p (MIRT734785)
- hsa-miR-892b (MIRT735505)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMP9
- Browse OriGene Inhibitory RNA Products For MMP9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP9
Clone Products
- Applied Biological Materials (abm): Clones for MMP9 - Select products 50% OFF >
- * MMP9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MMP9
- Addgene plasmids for MMP9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMP9
Cell Line Products
-
Horizon Cell Lines for MMP9
No data available for Transcription Factor Targets and HOMER Transcription for MMP9 Gene
Localization for MMP9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MMP9 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 2551898 |
| GO:0031012 | extracellular matrix | IEA | -- |
| GO:0062023 | collagen-containing extracellular matrix | HDA | 28344315 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for MMP9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
|
Transendothelial Migration of Leukocytes
.38
|
| 2 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
| 3 | Degradation of the extracellular matrix | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Relaxin signaling pathway | ||
Pathways by source for MMP9 Gene
21 BioSystems pathways for MMP9 Gene
18 Reactome pathways for MMP9 Gene
1 PharmGKB pathway for MMP9 Gene
14 KEGG pathways for MMP9 Gene
3 GeneGo (Thomson Reuters) pathways for MMP9 Gene
- Cell adhesion_Cell-matrix glycoconjugates
- Cell adhesion_ECM remodeling
- Development EGFR signaling pathway
3 R&D Systems pathways for MMP9 Gene
8 Qiagen pathways for MMP9 Gene
- Colorectal Cancer Metastasis
- Glioma Invasiveness
- Inhibition of Angiogenesis by TSP1
- Inhibition of Matrix Metalloproteinases
- Pancreatic Adenocarcinoma
2 Cell Signaling Technology pathways for MMP9 Gene
1 GeneTex pathway for MMP9 Gene
Interacting Proteins for MMP9 Gene
Selected Interacting proteins:
P14780-MMP9_HUMAN
ENSP00000361405
for MMP9 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MMP9
SIGNOR curated interactions for MMP9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 22984561 |
| GO:0006508 | proteolysis | IDA | 2551898 |
| GO:0007566 | embryo implantation | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Drugs & Compounds for MMP9 Gene
(117) Drugs for MMP9 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
| Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
| Captopril | Approved | Pharma | Inhibitor, Inhibition, Target, inhibitor | ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase | 50 | |
| Simvastatin | Approved | Pharma | Inhibitor, Competitive | HMG-CoA reductase inhibitor | 582 | |
| Glucosamine | Approved, Investigational | Pharma | Target, antagonist | 88 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) Tocris Compounds for MMP9 Gene
(6) ApexBio Compounds for MMP9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide | Substrate of matrix metalloproteinases assay | 140430-53-1 |
| Batimastat (BB-94) | MMP inhibitor | 130370-60-4 |
| GM 6001 | Broad spectrum MMP inhibitor | 142880-36-2 |
| Marimastat | MMPs inhibitor,board spectrum | 154039-60-8 |
| Phosphoramidon Disodium Salt | 164204-38-0 | |
| SB-3CT | gelatinases inhibitor, potent and selective | 292605-14-2 |
Drug Products
- G Biosciences Human MMP-9/metalloproteinase-9/CLG4B, Liquid
-
BioLegend
- Recombinant Human MMP-9 (dimer, carrier-free) (551104)
- Recombinant Human MMP-9 (dimer, carrier-free) (551106)
- Recombinant Human MMP-9 (carrier-free) (550504)
- Recombinant Human MMP-9 (dimer, carrier-free) (551102)
- Recombinant Human MMP-9 (carrier-free) (550506)
- Recombinant Human MMP-9 (carrier-free) (550502)
- Recombinant Human MMP-9 (ELISA Std.)
- ApexBio compounds for MMP9
Transcripts for MMP9 Gene
mRNA/cDNA for MMP9 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000372330 2336 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MMP9 - Select products 50% OFF >
- * MMP9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MMP9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMP9
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMP9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMP9
- Browse OriGene Inhibitory RNA Products For MMP9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP9
Clone Products
- Applied Biological Materials (abm): Clones for MMP9 - Select products 50% OFF >
- * MMP9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MMP9
- Addgene plasmids for MMP9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMP9
Relevant External Links for MMP9 Gene
- GeneLoc Exon Structure for
- MMP9
Expression for MMP9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
-
Somite (Muscoskeletal System)
- Mononuclear Myocytes Sacral Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Hypaxial Myotome
- Mononuclear Myocytes Thoracic Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Primary Epaxial Myotome
- Mononuclear Myocytes Cervical Epaxial Myotome
-
Bone (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Mononucleated Osteoclasts Bone Marrow
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Terminal Chondrocytes Rib
- Hypertrophic Chondrocytes Zeugopod Growth Plate
-
Limb (Muscoskeletal System)
- Mononuclear Myocytes Hindlimb Ventral Muscle
- Mononuclear Myocytes Forelimb Dorsal Muscles
- Mononuclear Myocytes Hindlimb Dorsal Muscle
- Mononuclear Myocytes Forelimb Ventral Muscles
- Interzone Cells Stylopod Synovial Joint
-
Cartilage (Muscoskeletal System)
- Hypertrophic Chondrocytes Vertebrae
- Hypertrophic Chondrocytes Stylopod Growth Plate
- Terminal Chondrocytes Rib
- Hypertrophic Chondrocytes Zeugopod Growth Plate
- Hypertrophic Chondrocytes Autopod Growth Plate
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Outer Enamel Epithelial Cells Dental Enamel
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Conventional Dendritic Cells II Spleen
- Hematopoietic Bone Marrow
-
Epithelial Cells
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Spleen (Hematopoietic System)
- Liver (Hepatobiliary System)
- NULL (Integumentary System)
- Uncategorized
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for MMP9 Gene
This gene is overexpressed in Whole Blood (x46.3).
This gene is overexpressed in Neutrophil (45.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP9
SOURCE GeneReport for Unigene cluster for MMP9 Gene:
Hs.297413mRNA Expression by UniProt/SwissProt for MMP9 Gene:
P14780-MMP9_HUMAN
Tissue specificity:
Detected in neutrophils (at protein level) (PubMed:7683678). Produced by normal alveolar macrophages and granulocytes.
Evidence on tissue expression from TISSUES for MMP9 Gene
- Blood(5)
- Bone marrow(3.8)
- Intestine(3.8)
- Lymph node(3.7)
- Heart(3.6)
- Nervous system(3.5)
- Spleen(3.5)
- Lung(3.5)
- Liver(3.5)
- Muscle(3.3)
- Skin(3.2)
- Kidney(3.1)
- Bone(3.1)
- Stomach(2.9)
- Pancreas(2.9)
- Eye(2.8)
- Urine(2.5)
- Adrenal gland(2.4)
- Gall bladder(2.4)
- Saliva(2.3)
- Thyroid gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP9 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for MMP9
-
OriGene qPCR primer pairs and template standards for MMP9
Gene Expression Assay Products
Orthologs for MMP9 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MMP9 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MMP9 30 |
|
||
| MMP-9 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | MMP9 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mmp9 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mmp9 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MMP9 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | MMP9 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100494738 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC69080 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mmp9 30 31 |
|
OneToOne | |
| wufb02g06 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10476 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | H19M22.3 31 |
|
ManyToMany | |
| zmp-1 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G45040 30 |
|
- Species where no ortholog for MMP9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MMP9 Gene
- ENSEMBL:
- Gene Tree for MMP9 (if available)
- TreeFam:
- Gene Tree for MMP9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MMP9: view image
Paralogs for MMP9 Gene
Paralogs for MMP9 Gene
(1) SIMAP similar genes for MMP9 Gene using alignment to 1 proteins:
- MMP9_HUMAN
Variants for MMP9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP9 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 707836 | Benign/Likely Benign: Metaphyseal anadysplasia 2; not provided | 46,008,996(+) | C/T | MISSENSE_VARIANT | |
| 708035 | Benign: Metaphyseal anadysplasia 2; not provided | 46,009,039(+) | A/G | MISSENSE_VARIANT | |
| 708644 | Likely Benign: not provided | 46,010,093(+) | C/A | SYNONYMOUS_VARIANT | |
| 713798 | Likely Benign: not provided | 46,010,495(+) | C/T | SYNONYMOUS_VARIANT | |
| 719765 | Conflicting Interpretations: Metaphyseal anadysplasia 2; not provided | 46,009,007(+) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.70;
97.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MMP9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP9 Gene
Disorders for MMP9 Gene
(276) MalaCards diseases for MMP9 Gene - From: OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| metaphyseal anadysplasia 2 |
|
|
| metaphyseal anadysplasia |
|
|
| central nervous system tuberculosis |
|
|
| hemorrhoid |
|
|
| adamantinous craniopharyngioma |
|
|
Search MMP9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MMP9_HUMAN- Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. {ECO:0000269 PubMed:19615667}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MMP9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MMP9 Gene
Publications for MMP9 Gene
- Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals. (PMID: 20184534) Wu S … Ko YL (Clinical chemistry and laboratory medicine 2010) 3 23 41
- The genotypes of IL-1 beta and MMP-3 are associated with the prognosis of HCV-related hepatocellular carcinoma. (PMID: 20467172) Okamoto K … Yuasa I (Internal medicine (Tokyo, Japan) 2010) 3 23 41
- MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan. (PMID: 20392358) Wang CH … Kuo HP (The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2010) 3 23 41
- Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. (PMID: 19643940) Scherf DB … Risch A (The European respiratory journal 2010) 3 23 41
- Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population. (PMID: 20110530) Wipff J … Allanore Y (The Journal of rheumatology 2010) 3 23 41
ExternalLinks
Products for MMP9 Gene
- View all 33 R&D Systems MMP9 (MMP-9) Products
- View all 2 R&D Systems MMP9 (MMP-9) Proteins and Enzymes
- View all 13 R&D Systems MMP9 (MMP-9) Primary Antibodies
- View all 6 R&D Systems MMP9 (MMP-9) ELISAs
- View all R&D Systems MMP9 (MMP-9) Simple Plex Assays
- View all 2 R&D Systems MMP9 (MMP-9) Luminex Assays
- View all 7 R&D Systems MMP9 (MMP-9) Proteome Profiler Antibody Arrays
- View all R&D Systems MMP9 (MMP-9) Activity Assays
- View all R&D Systems MMP9 (MMP-9) ELISpot and FluoroSpot Kits
- Learn more about R&D Systems custom MMP9 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MMP9
- 73-100
- 75-100
- AM05379PU-N
- AM05380PU-N
- AM06662SU-N
- AM06664SU-N
- AM08200HR-N
- AM08200PU-N
- AM10115SU-N
- AP06236PU-N
- AP13187PU-N
- AP22745PU-N
- AP52713PU-N
- TA312179
- TA319098
- TA325695
- TA326571
- TA326652
- TA327267
- TA336901
- TA341163
- TA341164
- TA347924
- TA349222
- TA351481
- TA351482
- TA353338L
- TA353339L
- TA354280
- TA590194
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MMP9
- Origene Custom Protein Services for MMP9
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMP9
- Browse OriGene Inhibitory RNA Products For MMP9
- OriGene qPCR primer pairs for MMP9
- OriGene qPCR primer pairs and template standards for MMP9
- OriGene CRISPR knockouts for MMP9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MMP9
- Sino Biological Human cDNA Clone for MMP9
- Sino Biological Recombinant Proteins for MMP9
- Sino Biological Cell Lysates for MMP9
- Sino Biological Antibodies for MMP9
- Sino Biological Assays for MMP9
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MMP9
- Novus Biologicals proteins and lysates for MMP9
- Novus Biologicals ELISA Kits for MMP9
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MMP9
- Abcam proteins for MMP9
- Abcam assays for MMP9
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for MMP9
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for MMP9 (AFLGC-MMP9)
- ApexBio compounds for MMP9
- VectorBuilder Custom and pre-made DNA vectors for MMP9 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MMP9 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MMP9 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MMP9 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MMP9
- Addgene plasmids for MMP9
- antibodies-online: Show 197 available MMP 9 Antibodies ranked by validation data
- Compare Top MMP 9 Antibodies
- Recommended
- 418 WB Antibodies (anti-human)
- 50 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 13 IHC Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 3 IF Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 162 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IF Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 186 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IF Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 174 available MMP 9 Elisa Kits ranked by validation data
- Compare Top MMP 9 Elisa Kits
- Quality Products:
- ABIN415059
- ABIN818177
- ABIN6574164
- ABIN625060
- ABIN411333
- ABIN1115942
- ABIN2506950
- ABIN1029258
- ABIN492069
- ABIN1379995
- ABIN6730931
- ABIN6720461
- ABIN411334
- ABIN415640
- ABIN1115944
- ABIN365501
- ABIN1979379
- ABIN5524753
- ABIN492070
- ABIN1029259
- ABIN6730943
- ABIN416391
- ABIN365564
- ABIN1115943
- ABIN5524756
- ABIN1571297
- ABIN5510644
- ABIN578882
- ABIN5670915
- ABIN5594727
- ABIN431284
- ABIN1571296
- ABIN365674
- ABIN5524754
- ABIN779371
- ABIN1564029
- ABIN2544032
- ABIN6229485
- ABIN5656797
- ABIN2949383
- antibodies-online: Show 66 available MMP 9 Proteins ranked by validation data
- Compare Top MMP 9 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for MMP9
- Search Santa Cruz Biotechnology (SCBT) for MMP9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MMP9
- Horizon Cell Lines for MMP9
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMP9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMP9
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MMP9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP9
Sources for MMP9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116)