This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme wi... See more...

Aliases for MMP8 Gene

Aliases for MMP8 Gene

  • Matrix Metallopeptidase 8 2 3 5
  • Matrix Metalloproteinase 8 (Neutrophil Collagenase) 2 3
  • Matrix Metalloproteinase-8 3 4
  • Neutrophil Collagenase 3 4
  • PMNL Collagenase 3 4
  • PMNL-CL 3 4
  • MMP-8 3 4
  • CLG1 3 4
  • PMN Leukocyte Collagenase 3
  • Collagenase 2 3
  • EC 3.4.24.34 4
  • EC 3.4.24 52
  • HNC 3

External Ids for MMP8 Gene

Previous HGNC Symbols for MMP8 Gene

  • CLG1

Previous GeneCards Identifiers for MMP8 Gene

  • GC11M104777
  • GC11M103940
  • GC11M102121
  • GC11M102088
  • GC11M098509

Summaries for MMP8 Gene

Entrez Gene Summary for MMP8 Gene

  • This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MMP8 Gene

MMP8 (Matrix Metallopeptidase 8) is a Protein Coding gene. Diseases associated with MMP8 include Preterm Premature Rupture Of The Membranes and Gingivitis. Among its related pathways are Innate Immune System and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP1.

UniProtKB/Swiss-Prot Summary for MMP8 Gene

Tocris Summary for MMP8 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP8 Gene

Additional gene information for MMP8 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP8 Gene

Genomics for MMP8 Gene

GeneHancer (GH) Regulatory Elements for MMP8 Gene

Promoters and enhancers for MMP8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J102719 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 500.7 +1.7 1749 12.2 ZBTB40 NONO FOS SPI1 JUND ZNF18 ATF4 JUN HLF POLR2A MMP8 MMP10 MMP1 MMP3 RNU7-159P MMP27 BIRC2 TMEM123 BIRC3
GH11J102757 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.1 -33.9 -33850 7 TCF12 JUND TEAD4 FOS TRIM28 EP300 ATF2 NFIC ZBTB17 GABPA DYNC2H1 CFAP300 MMP1 MMP8 MMP3 MMP27 MMP7 BIRC2 ENSG00000225678 LOC100421658
GH11J102589 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.1 +136.6 136649 6 RXRA CTCF SP1 EP300 RELA MEF2C RCOR1 NFYB BCL11A TCF12 BIRC2 MMP20 TMEM123 MMP7 ENSG00000255337 MMP8 BIRC3 MMP27 lnc-MMP7-1 ENSG00000256916
GH11J102746 Promoter 0.9 Ensembl 11.8 -20.3 -20251 1.4 ZIC2 ZBTB10 ZNF423 ZBTB26 KLF7 ZNF341 KLF9 WT1 ZBTB17 ZNF76 WTAPP1 lnc-DYNC2H1-3 piR-32461-040 piR-45358-001 MMP8 MMP27 ENSG00000225678
GH11J103043 Enhancer 0.8 Ensembl ENCODE 9.6 -317.0 -316975 1.2 ZNF316 MAFG MITF RXRA MAFK GABPB1 MAFF USF2 L3MBTL2 RAD51 ENSG00000239861 RPL21P96 lnc-DYNC2H1-1 RNU7-159P MMP13 MMP8 piR-37895-037
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP8

Top Transcription factor binding sites by QIAGEN in the MMP8 gene promoter:
  • aMEF-2
  • c-Rel
  • FOXO4
  • MEF-2A
  • p300
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for MMP8 Gene

Genomic Locations for MMP8 Gene
chr11:102,711,795-102,727,050
(GRCh38/hg38)
Size:
15,256 bases
Orientation:
Minus strand
chr11:102,582,526-102,597,781
(GRCh37/hg19)
Size:
15,256 bases
Orientation:
Minus strand

Genomic View for MMP8 Gene

Genes around MMP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP8 Gene

Proteins for MMP8 Gene

  • Protein details for MMP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22894-MMP8_HUMAN
    Recommended name:
    Neutrophil collagenase
    Protein Accession:
    P22894
    Secondary Accessions:
    • Q45F99

    Protein attributes for MMP8 Gene

    Size:
    467 amino acids
    Molecular mass:
    53412 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP8 Gene

neXtProt entry for MMP8 Gene

Selected DME Specific Peptides for MMP8 Gene

P22894:
  • DNSPFDG
  • PRCGVPD
  • LFLVAAHE
  • LAHAFQPG
  • VAAHEFGH
  • LTFDAIT

Post-translational modifications for MMP8 Gene

  • Glycosylation at Asn54, Asn73, Asn112, Asn204, and Asn246
  • Modification sites at PhosphoSitePlus

Domains & Families for MMP8 Gene

Gene Families for MMP8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP8 Gene

GenScript: Design optimal peptide antigens:
  • PMNL collagenase (MMP8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22894

UniProtKB/Swiss-Prot:

MMP8_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP8: view

Function for MMP8 Gene

Molecular function for MMP8 Gene

UniProtKB/Swiss-Prot Function:
Can degrade fibrillar type I, II, and III collagens.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.; EC=3.4.24.34;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Cannot be activated without removal of the activation peptide.
GENATLAS Biochemistry:
matrix metalloproteinase 8,regulator in matrix remodeling,MMP cluster

Enzyme Numbers (IUBMB) for MMP8 Gene

Phenotypes From GWAS Catalog for MMP8 Gene

Gene Ontology (GO) - Molecular Function for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IMP 25049354
GO:0004222 metalloendopeptidase activity IEA,IBA 21873635
GO:0004252 serine-type endopeptidase activity IDA 2164002
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP8: view
genes like me logo Genes that share phenotypes with MMP8: view

Animal Models for MMP8 Gene

MGI Knock Outs for MMP8:
  • Mmp8 Mmp8<tm1.1(KOMP)Vlcg>
  • Mmp8 Mmp8<tm1Otin>

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP8

miRNA for MMP8 Gene

miRTarBase miRNAs that target MMP8

Clone Products

  • Addgene plasmids for MMP8

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP8 Gene

Localization for MMP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP8 Gene

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP8 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 2164002
GO:0031012 extracellular matrix IEA --
GO:0035580 specific granule lumen TAS --
GO:0062023 collagen-containing extracellular matrix HDA 28344315
genes like me logo Genes that share ontologies with MMP8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP8 Gene

Pathways & Interactions for MMP8 Gene

PathCards logo

SuperPathways for MMP8 Gene

SuperPathway Contained pathways
1 Matrix Metalloproteinases
.69
2 Degradation of the extracellular matrix
3 Innate Immune System
4 Integrin Pathway
.56
.38
5 GPCR Pathway
.59
genes like me logo Genes that share pathways with MMP8: view

Pathways by source for MMP8 Gene

4 Qiagen pathways for MMP8 Gene
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway

Gene Ontology (GO) - Biological Process for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 2164002
GO:0010628 positive regulation of gene expression IEA,ISS 25049354
GO:0010629 negative regulation of gene expression ISS,IEA 25049354
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization IBA 21873635
genes like me logo Genes that share ontologies with MMP8: view

No data available for SIGNOR curated interactions for MMP8 Gene

Drugs & Compounds for MMP8 Gene

(43) Drugs for MMP8 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxycycline Approved, Investigational, Vet_approved Pharma inhibitor 305
Calcium Approved Nutra 7884
Collagenase Approved, Investigational Pharma 0
Batimastat Experimental Pharma Target 0
(1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid Experimental Pharma Target 0

(23) Additional Compounds for MMP8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP8 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4

(2) ApexBio Compounds for MMP8 Gene

Compound Action Cas Number
GM 6001 Broad spectrum MMP inhibitor 142880-36-2
Ro 32-3555 MMP inhibitor 190648-49-8
genes like me logo Genes that share compounds with MMP8: view

Transcripts for MMP8 Gene

mRNA/cDNA for MMP8 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for MMP8

Alternative Splicing Database (ASD) splice patterns (SP) for MMP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for MMP8 Gene

GeneLoc Exon Structure for
MMP8

Expression for MMP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP8 Gene

This gene is overexpressed in Whole Blood (x48.9).

Protein differential expression in normal tissues from HIPED for MMP8 Gene

This gene is overexpressed in Neutrophil (47.7) and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP8 Gene



Protein tissue co-expression partners for MMP8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP8

SOURCE GeneReport for Unigene cluster for MMP8 Gene:

Hs.161839

mRNA Expression by UniProt/SwissProt for MMP8 Gene:

P22894-MMP8_HUMAN
Tissue specificity: Neutrophils.

Evidence on tissue expression from TISSUES for MMP8 Gene

  • Blood(4.6)
  • Lung(4.5)
  • Bone marrow(2.9)
  • Saliva(2.6)
  • Heart(2.2)
  • Spleen(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with MMP8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP8 Gene

Orthologs for MMP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP8 31 30
  • 99.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MMP8 31 30
  • 83.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MMP8 31 30
  • 83.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp8 17 31 30
  • 80.01 (n)
rat
(Rattus norvegicus)
Mammalia Mmp8 30
  • 79.81 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP8 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP8 31
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mmp13a 30
  • 57.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 32
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 32
  • 39 (a)
Species where no ortholog for MMP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMP8 Gene

ENSEMBL:
Gene Tree for MMP8 (if available)
TreeFam:
Gene Tree for MMP8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP8: view image

Paralogs for MMP8 Gene

(16) SIMAP similar genes for MMP8 Gene using alignment to 5 proteins:

  • MMP8_HUMAN
  • E9PIY7_HUMAN
  • E9PJB3_HUMAN
  • E9PL87_HUMAN
  • H7C1M3_HUMAN
genes like me logo Genes that share paralogs with MMP8: view

Variants for MMP8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP8 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
708208 Benign: not provided 102,715,443(-) G/A INTRON_VARIANT
714053 Benign: not provided 102,713,365(-) T/C MISSENSE_VARIANT
724355 Likely Benign: not provided 102,716,423(-) G/A INTRON_VARIANT
726250 Benign: not provided 102,724,778(-) T/C SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
742574 Likely Benign: not provided 102,716,306(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MMP8 Gene

Structural Variations from Database of Genomic Variants (DGV) for MMP8 Gene

Variant ID Type Subtype PubMed ID
esv3579884 CNV loss 25503493
nsv832252 CNV gain 17160897

Variation tolerance for MMP8 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP8 Gene

Human Gene Mutation Database (HGMD)
MMP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP8 Gene

Disorders for MMP8 Gene

MalaCards: The human disease database

(66) MalaCards diseases for MMP8 Gene - From: ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
preterm premature rupture of the membranes
  • pprom
gingivitis
  • acute gingivitis
periodontitis, chronic
  • periodontitis, adult
bronchiolitis obliterans
  • bronchiolitis exudativa
blepharoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search MMP8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP8 Gene

Publications for MMP8 Gene

  1. Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM). (PMID: 15367487) Wang H … Strauss JF (Human molecular genetics 2004) 3 23 41 54
  2. Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase. (PMID: 2176876) Mallya SK … Van Wart HE (Biochemistry 1990) 3 4 23 54
  3. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 41 54

Products for MMP8 Gene

Sources for MMP8 Gene