Aliases for MMP8 Gene
External Ids for MMP8 Gene
Previous HGNC Symbols for MMP8 Gene
Previous GeneCards Identifiers for MMP8 Gene
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for MMP8 Gene
MMP8 (Matrix Metallopeptidase 8) is a Protein Coding gene. Diseases associated with MMP8 include Preterm Premature Rupture Of The Membranes and Gingivitis. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP1.
UniProtKB/Swiss-Prot Summary for MMP8 Gene
Can degrade fibrillar type I, II, and III collagens.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.