Aliases for MMP7 Gene
External Ids for MMP7 Gene
Previous HGNC Symbols for MMP7 Gene
Previous GeneCards Identifiers for MMP7 Gene
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]
GeneCards Summary for MMP7 Gene
MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Brain Glioblastoma Multiforme and Stomach Disease. Among its related pathways are Cell adhesion_ECM remodeling and AGE/RAGE pathway. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP3.
UniProtKB/Swiss-Prot Summary for MMP7 Gene
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.