This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytic... See more...

Aliases for MMP7 Gene

Aliases for MMP7 Gene

  • Matrix Metallopeptidase 7 2 3 5
  • Matrilysin 2 3 4
  • Matrix Metalloproteinase 7 (Matrilysin, Uterine) 2 3
  • Matrix Metalloproteinase-7 3 4
  • Uterine Metalloproteinase 3 4
  • Pump-1 Protease 3 4
  • PUMP-1 2 3
  • Matrin 3 4
  • MMP-7 3 4
  • MPSL1 3 4
  • Matrix Metallopeptidase 7 (Matrilysin, Uterine) 3
  • Uterine Matrilysin 3
  • EC 3.4.24.23 4
  • EC 3.4.24 50
  • PUMP1 4
  • MMP7 5

External Ids for MMP7 Gene

Previous HGNC Symbols for MMP7 Gene

  • MPSL1

Previous GeneCards Identifiers for MMP7 Gene

  • GC11M104584
  • GC11M103748
  • GC11M101928
  • GC11M101896
  • GC11M098318

Summaries for MMP7 Gene

Entrez Gene Summary for MMP7 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP7 Gene

MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Brain Glioblastoma Multiforme and Stomach Disease. Among its related pathways are Cell adhesion_ECM remodeling and AGE/RAGE pathway. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP3.

UniProtKB/Swiss-Prot Summary for MMP7 Gene

  • Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Tocris Summary for MMP7 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP7 Gene

Genomics for MMP7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MMP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP7

Top Transcription factor binding sites by QIAGEN in the MMP7 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • ITF-2
  • p53
  • STAT1
  • STAT5A
  • Tal-1beta

Genomic Locations for MMP7 Gene

Latest Assembly
chr11:102,520,508-102,530,750
(GRCh38/hg38)
Size:
10,243 bases
Orientation:
Minus strand

Previous Assembly
chr11:102,391,239-102,401,478
(GRCh37/hg19 by Entrez Gene)
Size:
10,240 bases
Orientation:
Minus strand

chr11:102,391,239-102,401,484
(GRCh37/hg19 by Ensembl)
Size:
10,246 bases
Orientation:
Minus strand

Genomic View for MMP7 Gene

Genes around MMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP7 Gene

Proteins for MMP7 Gene

  • Protein details for MMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09237-MMP7_HUMAN
    Recommended name:
    Matrilysin
    Protein Accession:
    P09237
    Secondary Accessions:
    • Q9BTK9

    Protein attributes for MMP7 Gene

    Size:
    267 amino acids
    Molecular mass:
    29677 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP7 Gene

neXtProt entry for MMP7 Gene

Selected DME Specific Peptides for MMP7 Gene

P09237:
  • PRCGVPD
  • LAHAFAPG
  • MQKFFGL

Post-translational modifications for MMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for MMP7

Domains & Families for MMP7 Gene

Gene Families for MMP7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for MMP7 Gene

Suggested Antigen Peptide Sequences for MMP7 Gene

GenScript: Design optimal peptide antigens:
  • Matrix metalloproteinase 7 (A5GZ72_HUMAN)
  • Uterine metalloproteinase (MMP7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09237

UniProtKB/Swiss-Prot:

MMP7_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP7: view

Function for MMP7 Gene

Molecular function for MMP7 Gene

UniProtKB/Swiss-Prot Function:
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).; EC=3.4.24.23;.
GENATLAS Biochemistry:
matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta catenin/CF4 and important factor in early tumor growth progression and metastasis

Enzyme Numbers (IUBMB) for MMP7 Gene

Phenotypes From GWAS Catalog for MMP7 Gene

Gene Ontology (GO) - Molecular Function for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 23845380
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 20812334
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with MMP7: view
genes like me logo Genes that share phenotypes with MMP7: view

Animal Models for MMP7 Gene

MGI Knock Outs for MMP7:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP7 Gene

Localization for MMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0009986 cell surface IEA --
GO:0031012 extracellular matrix IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MMP7: view

Pathways & Interactions for MMP7 Gene

genes like me logo Genes that share pathways with MMP7: view

Pathways by source for MMP7 Gene

1 GeneGo (Thomson Reuters) pathway for MMP7 Gene
  • Cell adhesion_ECM remodeling
6 Qiagen pathways for MMP7 Gene
  • Colorectal Cancer Metastasis
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway
1 Cell Signaling Technology pathway for MMP7 Gene

SIGNOR curated interactions for MMP7 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS,IDA 15297466
GO:0006509 membrane protein ectodomain proteolysis IMP 23437250
GO:0007568 aging IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization IBA 21873635
genes like me logo Genes that share ontologies with MMP7: view

Drugs & Compounds for MMP7 Gene

(25) Drugs for MMP7 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE Experimental Pharma Target 0
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID Experimental Pharma Target 0
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE Experimental Pharma Target 0
Batimastat Experimental Pharma inhibitor 0
Marimastat Investigational Pharma Target, antagonist, inhibitor MMPs inhibitor,board spectrum 4

(21) Additional Compounds for MMP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP7 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4

(3) ApexBio Compounds for MMP7 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor 130370-60-4
Marimastat MMPs inhibitor,board spectrum 154039-60-8
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
genes like me logo Genes that share compounds with MMP7: view

Transcripts for MMP7 Gene

mRNA/cDNA for MMP7 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP7

Alternative Splicing Database (ASD) splice patterns (SP) for MMP7 Gene

No ASD Table

Relevant External Links for MMP7 Gene

GeneLoc Exon Structure for
MMP7

Expression for MMP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP7 Gene

mRNA differential expression in normal tissues according to GTEx for MMP7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.0), Kidney - Cortex (x8.1), Pancreas (x5.7), and Breast - Mammary Tissue (x4.4).

Protein differential expression in normal tissues from HIPED for MMP7 Gene

This gene is overexpressed in Cervix (29.4), Stomach (13.7), and Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP7

SOURCE GeneReport for Unigene cluster for MMP7 Gene:

Hs.2256

Evidence on tissue expression from TISSUES for MMP7 Gene

  • Kidney(4.7)
  • Intestine(4.5)
  • Gall bladder(3)
  • Blood(2.8)
  • Lung(2.8)
  • Pancreas(2.6)
  • Stomach(2.5)
  • Skin(2.3)
  • Liver(2.3)
  • Heart(2.3)
  • Lymph node(2.3)
  • Muscle(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with MMP7: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP7 Gene

Orthologs for MMP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MMP7 29 30
  • 98.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MMP7 29 30
  • 81.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MMP7 29 30
  • 80.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mmp7 29 16 30
  • 74.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mmp7 29
  • 73.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MMP7 30
  • 56 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MMP7 30
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MMP7 29 30
  • 59.62 (n)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 45 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii mmp30 30
  • 24 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Mmp2 31
  • 53 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT4G16640 29
  • 49.42 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0557900 29
  • 44.66 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 20 (a)
OneToMany
Species where no ortholog for MMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MMP7 Gene

ENSEMBL:
Gene Tree for MMP7 (if available)
TreeFam:
Gene Tree for MMP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP7: view image
Alliance of Genome Resources:
Additional Orthologs for MMP7

Paralogs for MMP7 Gene

(18) SIMAP similar genes for MMP7 Gene using alignment to 2 proteins:

  • MMP7_HUMAN
  • A5GZ72_HUMAN
genes like me logo Genes that share paralogs with MMP7: view

Variants for MMP7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP7 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs138970782 Benign: not provided 102,527,669(-) G/A
NM_002423.5(MMP7):c.339C>T (p.Ile113=)
SYNONYMOUS
rs17879235 Benign: not provided 102,527,807(-) G/A
NM_002423.5(MMP7):c.285C>T (p.Tyr95=)
SYNONYMOUS
rs17879417 Benign: not provided 102,527,861(-) G/A
NM_002423.5(MMP7):c.231C>T (p.Arg77=)
SYNONYMOUS
rs17886506 Benign: not provided 102,523,293(-) G/Ap.Pro241Leu
NM_002423.5(MMP7):c.722C>T (p.Pro241Leu)
MISSENSE
rs61753777 Benign: not provided 102,527,941(-) T/G
NM_002423.5(MMP7):c.151A>C (p.Asn51His)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MMP7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MMP7 Gene

Variant ID Type Subtype PubMed ID
dgv2136n54 CNV gain 21841781
nsv468854 CNV gain 19166990
nsv469990 CNV gain 18288195
nsv972953 CNV duplication 23825009

Variation tolerance for MMP7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP7 Gene

Human Gene Mutation Database (HGMD)
MMP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP7
Leiden Open Variation Database (LOVD)
MMP7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP7 Gene

Disorders for MMP7 Gene

MalaCards: The human disease database

(44) MalaCards diseases for MMP7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
stomach disease
  • gastric disease
rectum cancer
  • cancer of rectum
biliary atresia
  • atresia of bile duct
spastic entropion
- elite association - COSMIC cancer census association via MalaCards
Search MMP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP7 Gene

Publications for MMP7 Gene

  1. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PMID: 20113256) Yi YC … Yang SF (Clinical chemistry and laboratory medicine 2010) 3 22 40
  2. Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. (PMID: 19643940) Scherf DB … Risch A (The European respiratory journal 2010) 3 22 40
  3. Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population. (PMID: 19132754) Jin G … Shen H (International journal of cancer 2009) 3 22 40
  4. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PMID: 18648013) Beeghly-Fadiel A … Zheng W (Cancer research 2008) 3 22 40
  5. No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population. (PMID: 18768525) Qiu W … He F (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 22 40

Products for MMP7 Gene

  • Addgene plasmids for MMP7

Sources for MMP7 Gene