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Aliases for MMP7 Gene

Aliases for MMP7 Gene

  • Matrix Metallopeptidase 7 2 3 5
  • Matrix Metalloproteinase 7 (Matrilysin, Uterine) 2 3
  • Matrix Metalloproteinase-7 3 4
  • Uterine Metalloproteinase 3 4
  • Pump-1 Protease 3 4
  • Matrilysin 2 3
  • Matrin 3 4
  • MPSL1 3 4
  • MMP-7 3 4
  • Matrix Metallopeptidase 7 (Matrilysin, Uterine) 3
  • Uterine Matrilysin 3
  • EC 4
  • PUMP-1 3
  • PUMP1 4

External Ids for MMP7 Gene

Previous HGNC Symbols for MMP7 Gene

  • MPSL1

Previous GeneCards Identifiers for MMP7 Gene

  • GC11M104584
  • GC11M103748
  • GC11M101928
  • GC11M101896
  • GC11M098318

Summaries for MMP7 Gene

Entrez Gene Summary for MMP7 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP7 Gene

MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Brain Glioblastoma Multiforme and Light Chain Deposition Disease. Among its related pathways are Cell adhesion_ECM remodeling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP20.

UniProtKB/Swiss-Prot for MMP7 Gene

  • Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Tocris Summary for MMP7 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP7 Gene

Additional gene information for MMP7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP7 Gene

Genomics for MMP7 Gene

GeneHancer (GH) Regulatory Elements for MMP7 Gene

Promoters and enhancers for MMP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J102530 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 661.5 -0.2 -167 1 SMARCA5 ZNF335 JUN ZBTB33 ATF7 ELF1 MLLT1 MMP7 ENSG00000256916
GH11J102445 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +79.2 79197 11.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 TMEM123 LOC101928424 BIRC2 MMP7 ENSG00000256916 MMP20 BIRC3 GC11P102396
GH11J102558 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -29.8 -29831 3.4 HDGF PKNOX1 SMAD1 STAT5A ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM MMP7 MMP20 ENSG00000256916 BIRC2 MMP10 ANGPTL5 BIRC3
GH11J102311 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +213.1 213091 13.2 HDGF PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF207 ZNF143 BIRC3 BIRC2 ENSG00000256916 MMP20 MMP7 TMEM123 RNU6-952P
GH11J102563 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.6 -33.6 -33620 2 JUN BACH1 BATF FOSL1 ZNF316 STAT2 ATF7 FOSL2 NFE2 FOS MMP7 ENSG00000256916 MMP20 ANGPTL5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP7 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • STAT1
  • p53
  • ATF
  • STAT5A
  • Tal-1beta
  • ITF-2

Genomic Locations for MMP7 Gene

Genomic Locations for MMP7 Gene
10,246 bases
Minus strand
10,246 bases
Minus strand

Genomic View for MMP7 Gene

Genes around MMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP7 Gene

Proteins for MMP7 Gene

  • Protein details for MMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BTK9

    Protein attributes for MMP7 Gene

    267 amino acids
    Molecular mass:
    29677 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP7 Gene

neXtProt entry for MMP7 Gene

Post-translational modifications for MMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MMP7

No data available for DME Specific Peptides for MMP7 Gene

Domains & Families for MMP7 Gene

Gene Families for MMP7 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP7: view

Function for MMP7 Gene

Molecular function for MMP7 Gene

UniProtKB/Swiss-Prot Function:
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
GENATLAS Biochemistry:
matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta catenin/CF4 and important factor in early tumor growth progression and metastasis

Enzyme Numbers (IUBMB) for MMP7 Gene

Phenotypes From GWAS Catalog for MMP7 Gene

Gene Ontology (GO) - Molecular Function for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 20812334
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MMP7: view
genes like me logo Genes that share phenotypes with MMP7: view

Animal Models for MMP7 Gene

MGI Knock Outs for MMP7:

Animal Model Products

Clone Products

  • Addgene plasmids for MMP7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP7 Gene

Localization for MMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,TAS 1497627
GO:0009986 cell surface IEA --
GO:0031012 extracellular matrix IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MMP7: view

Pathways & Interactions for MMP7 Gene

genes like me logo Genes that share pathways with MMP7: view

Gene Ontology (GO) - Biological Process for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS,IDA 15297466
GO:0007568 aging IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process TAS,IEA --
GO:0031667 response to nutrient levels IEA --
genes like me logo Genes that share ontologies with MMP7: view

No data available for SIGNOR curated interactions for MMP7 Gene

Drugs & Compounds for MMP7 Gene

(23) Drugs for MMP7 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
calcium Approved Nutra 0
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID Experimental Pharma Target 0
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE Experimental Pharma Target 0

(20) Additional Compounds for MMP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP7 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP7: view

Transcripts for MMP7 Gene

mRNA/cDNA for MMP7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP7 Gene

Matrix metallopeptidase 7 (matrilysin, uterine):
Representative Sequences:

Clone Products

  • Addgene plasmids for MMP7

Alternative Splicing Database (ASD) splice patterns (SP) for MMP7 Gene

No ASD Table

Relevant External Links for MMP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP7 Gene

mRNA differential expression in normal tissues according to GTEx for MMP7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.0), Kidney - Cortex (x8.1), Pancreas (x5.7), and Breast - Mammary Tissue (x4.4).

Protein differential expression in normal tissues from HIPED for MMP7 Gene

This gene is overexpressed in Cervix (29.4), Stomach (13.7), and Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP7 Gene:


SOURCE GeneReport for Unigene cluster for MMP7 Gene:


Evidence on tissue expression from TISSUES for MMP7 Gene

  • Kidney(4.6)
  • Intestine(4.5)
  • Lung(2.7)
  • Blood(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with MMP7: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP7 Gene

Orthologs for MMP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MMP7 34 33
  • 98.75 (n)
(Canis familiaris)
Mammalia MMP7 34 33
  • 81.12 (n)
(Bos Taurus)
Mammalia MMP7 34 33
  • 80.52 (n)
(Mus musculus)
Mammalia Mmp7 16 34 33
  • 74.4 (n)
(Rattus norvegicus)
Mammalia Mmp7 33
  • 73.89 (n)
(Monodelphis domestica)
Mammalia MMP7 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia MMP7 34
  • 56 (a)
(Gallus gallus)
Aves MMP7 34 33
  • 59.62 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
(Danio rerio)
Actinopterygii mmp30 34
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16640 33
  • 49.42 (n)
(Oryza sativa)
Liliopsida Os10g0557900 33
  • 44.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for MMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP7 Gene

Gene Tree for MMP7 (if available)
Gene Tree for MMP7 (if available)
Evolutionary constrained regions (ECRs) for MMP7: view image

Paralogs for MMP7 Gene

(18) SIMAP similar genes for MMP7 Gene using alignment to 2 proteins:

  • A5GZ72_HUMAN
genes like me logo Genes that share paralogs with MMP7: view

Variants for MMP7 Gene

Sequence variations from dbSNP and Humsavar for MMP7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000079990 -- 102,529,973(-) C/A/T intron_variant
rs1000302078 -- 102,520,285(-) G/T downstream_transcript_variant
rs1000381022 -- 102,531,716(-) T/C upstream_transcript_variant
rs1000909777 -- 102,528,823(-) C/T intron_variant
rs1000962032 -- 102,522,937(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP7 Gene

Variant ID Type Subtype PubMed ID
dgv2136n54 CNV gain 21841781
nsv468854 CNV gain 19166990
nsv469990 CNV gain 18288195
nsv972953 CNV duplication 23825009

Variation tolerance for MMP7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP7 Gene

Disorders for MMP7 Gene

MalaCards: The human disease database

(24) MalaCards diseases for MMP7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
light chain deposition disease
  • lcdd
spastic entropion
focal myositis
  • focal nodular myositis
biliary atresia
  • atresia of bile duct
- elite association - COSMIC cancer census association via MalaCards
Search MMP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP7 Gene

Publications for MMP7 Gene

  1. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PMID: 18648013) Beeghly-Fadiel A … Zheng W (Cancer research 2008) 3 22 44 58
  2. Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis. (PMID: 19643940) Scherf DB … Risch A (The European respiratory journal 2010) 3 44 58
  3. Matrix metalloproteinase-7 (MMP-7) polymorphism is a risk factor for endometrial cancer susceptibility. (PMID: 20113256) Yi YC … Yang SF (Clinical chemistry and laboratory medicine 2010) 3 44 58
  4. Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population. (PMID: 20230842) Ban JY … Chung JH (Life sciences 2010) 3 44 58
  5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 44 58

Products for MMP7 Gene

  • Addgene plasmids for MMP7

Sources for MMP7 Gene

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