Aliases for MMP3 Gene
External Ids for MMP3 Gene
Previous HGNC Symbols for MMP3 Gene
Previous GeneCards Identifiers for MMP3 Gene
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP3 Gene
MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include Coronary Heart Disease 6 and Arthritis. Among its related pathways are Transcriptional misregulation in cancer and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.
UniProtKB/Swiss-Prot Summary for MMP3 Gene
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.