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Aliases for MMP3 Gene

Aliases for MMP3 Gene

  • Matrix Metallopeptidase 3 2 3 5
  • Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase) 2 3
  • Transin-1 3 4
  • STMY1 3 4
  • MMP-3 3 4
  • SL-1 3 4
  • Matrix Metalloproteinase-3 4
  • Proteoglycanase 3
  • Stromelysin-1 3
  • Stromelysin 1 2
  • EC 3.4.24.17 4
  • CHDS6 3
  • STR1 3
  • STMY 3

External Ids for MMP3 Gene

Previous HGNC Symbols for MMP3 Gene

  • STMY1
  • STMY

Previous GeneCards Identifiers for MMP3 Gene

  • GC11M104900
  • GC11M104063
  • GC11M102695
  • GC11M102199
  • GC11M102200
  • GC11M102211
  • GC11M102706
  • GC11M098634

Summaries for MMP3 Gene

Entrez Gene Summary for MMP3 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP3 Gene

MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include Coronary Heart Disease 6 and Arthritis. Among its related pathways are Rheumatoid arthritis and Cell adhesion_ECM remodeling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.

UniProtKB/Swiss-Prot for MMP3 Gene

  • Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Tocris Summary for MMP3 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP3 Gene

Additional gene information for MMP3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP3 Gene

Genomics for MMP3 Gene

GeneHancer (GH) Regulatory Elements for MMP3 Gene

Promoters and enhancers for MMP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J102843 Promoter/Enhancer 0.8 EPDnew Ensembl 650.7 +0.1 109 0.6 EP300 MMP3 MMP1 PIR58757
GH11J102780 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 9.7 +63.0 62989 1 CTCF JUND FOXA2 JUN SMC3 FOSL2 RAD21 TRIM28 MMP10 MMP3 MMP1 WTAPP1
GH11J102759 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.8 +81.8 81810 4.1 HDAC1 NFIB PLRG1 RFX5 ZNF366 ZNF350 RCOR1 ATF7 FOS CEBPB DYNC2H1 CFAP300 MMP1 MMP8 MMP3 MMP27 MMP7 BIRC2 ENSG00000225678 LOC100421658
GH11J102727 Enhancer 0.9 FANTOM5 Ensembl ENCODE 9.9 +115.7 115677 1.5 JUND JUN FOS MMP8 MMP27 MMP10 MMP1 MMP3 RNU7-159P BIRC2 TMEM123 BIRC3 WTAPP1
GH11J103035 Enhancer 0.9 Ensembl ENCODE 9.4 -192.3 -192337 1.1 CTCF NFATC3 JUN MAX CEBPG RAD21 FOSL1 ZNF316 EGR1 NFATC1 RNU7-159P MMP3 RPL21P96 ENSG00000276521
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP3 gene promoter:
  • STAT3
  • SRF (504 AA)
  • SRF
  • SRY
  • AP-1
  • HNF-1A
  • HNF-1
  • Sox5

Genomic Locations for MMP3 Gene

Genomic Locations for MMP3 Gene
chr11:102,835,797-102,843,803
(GRCh38/hg38)
Size:
8,007 bases
Orientation:
Minus strand
chr11:102,706,528-102,714,534
(GRCh37/hg19)
Size:
8,007 bases
Orientation:
Minus strand

Genomic View for MMP3 Gene

Genes around MMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP3 Gene

Proteins for MMP3 Gene

  • Protein details for MMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08254-MMP3_HUMAN
    Recommended name:
    Stromelysin-1
    Protein Accession:
    P08254
    Secondary Accessions:
    • B2R8B8
    • Q3B7S0
    • Q6GRF8

    Protein attributes for MMP3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP3 Gene

neXtProt entry for MMP3 Gene

Post-translational modifications for MMP3 Gene

  • Glycosylation at isoforms=120
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMP3 Gene

Domains & Families for MMP3 Gene

Gene Families for MMP3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08254

UniProtKB/Swiss-Prot:

MMP3_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP3: view

Function for MMP3 Gene

Molecular function for MMP3 Gene

UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage where P1, P2 and P3 are hydrophobic residues.
GENATLAS Biochemistry:
matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing bone,interacting with ZBP89,playing a role in tumor metastasis

Enzyme Numbers (IUBMB) for MMP3 Gene

Phenotypes From GWAS Catalog for MMP3 Gene

Gene Ontology (GO) - Molecular Function for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 15863497
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 9573338
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MMP3: view
genes like me logo Genes that share phenotypes with MMP3: view

Animal Models for MMP3 Gene

MGI Knock Outs for MMP3:

Animal Model Products

CRISPR Products

miRNA for MMP3 Gene

miRTarBase miRNAs that target MMP3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP3 Gene

Localization for MMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 3360803
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP3: view

Pathways & Interactions for MMP3 Gene

genes like me logo Genes that share pathways with MMP3: view

SIGNOR curated interactions for MMP3 Gene

Activates:

Gene Ontology (GO) - Biological Process for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA,IEA 12867428
GO:0010727 negative regulation of hydrogen peroxide metabolic process IDA 20969476
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process IEA,TAS --
genes like me logo Genes that share ontologies with MMP3: view

Drugs & Compounds for MMP3 Gene

(106) Drugs for MMP3 Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma inhibitor, Target, antagonist MMPs inhibitor,board spectrum 4
Pravastatin Approved Pharma Competitive, Inhibitor 154
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 537
calcium Approved Nutra 0
Chlorthalidone Approved Pharma 66

(48) Additional Compounds for MMP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP3 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP3: view

Transcripts for MMP3 Gene

mRNA/cDNA for MMP3 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(209) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP3 Gene

Matrix metallopeptidase 3 (stromelysin 1, progelatinase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP3

Alternative Splicing Database (ASD) splice patterns (SP) for MMP3 Gene

No ASD Table

Relevant External Links for MMP3 Gene

GeneLoc Exon Structure for
MMP3
ECgene alternative splicing isoforms for
MMP3

Expression for MMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP3 Gene

This gene is overexpressed in Minor Salivary Gland (x29.0), Adipose - Subcutaneous (x6.7), and Nerve - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for MMP3 Gene

This gene is overexpressed in Synovial fluid (55.5) and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MMP3 Gene:

MMP3

SOURCE GeneReport for Unigene cluster for MMP3 Gene:

Hs.375129

Evidence on tissue expression from TISSUES for MMP3 Gene

  • Lung(4.4)
  • Blood(2.7)
  • Skin(2.5)
  • Intestine(2.3)
  • Bone(2.2)
  • Heart(2.2)
  • Muscle(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with MMP3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP3 Gene

Orthologs for MMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP3 34 33
  • 98.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MMP3 34 33
  • 84.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MMP3 34 33
  • 84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp3 16 34 33
  • 81.9 (n)
rat
(Rattus norvegicus)
Mammalia Mmp3 33
  • 81.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC428086 33
  • 62.37 (n)
-- 34
  • 53 (a)
ManyToMany
MMP10 34
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489571 33
  • 59.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 35
  • 44 (a)
Species where no ortholog for MMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP3 Gene

ENSEMBL:
Gene Tree for MMP3 (if available)
TreeFam:
Gene Tree for MMP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP3: view image

Paralogs for MMP3 Gene

(17) SIMAP similar genes for MMP3 Gene using alignment to 4 proteins:

  • MMP3_HUMAN
  • A5GZ70_HUMAN
  • E9PKX2_HUMAN
  • H7C139_HUMAN

Pseudogenes.org Pseudogenes for MMP3 Gene

genes like me logo Genes that share paralogs with MMP3: view

Variants for MMP3 Gene

Sequence variations from dbSNP and Humsavar for MMP3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs41380244 benign, not specified 102,842,716(-) G/A/C/T coding_sequence_variant, synonymous_variant
rs520540 benign, not specified 102,838,694(-) A/G coding_sequence_variant, synonymous_variant
rs591058 benign, not specified 102,840,607(-) T/C intron_variant
rs602128 benign, not specified 102,842,734(-) A/C/G coding_sequence_variant, missense_variant, synonymous_variant
rs679620 benign, not specified 102,842,889(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP3 Gene

Variant ID Type Subtype PubMed ID
esv2663139 CNV deletion 23128226
esv3627536 CNV loss 21293372

Variation tolerance for MMP3 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP3 Gene

Human Gene Mutation Database (HGMD)
MMP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP3 Gene

Disorders for MMP3 Gene

MalaCards: The human disease database

(58) MalaCards diseases for MMP3 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coronary heart disease 6
  • coronary heart disease, susceptibility to, 6
arthritis
  • inflammatory disorder of joint
conjunctivochalasis
synovitis
lymph node disease
  • disorder of lymph node
- elite association - COSMIC cancer census association via MalaCards
Search MMP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MMP3_HUMAN
  • Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:12477941, ECO:0000269 PubMed:8662692}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.

Additional Disease Information for MMP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP3: view

No data available for Genatlas for MMP3 Gene

Publications for MMP3 Gene

  1. Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration. (PMID: 20009418) Yuan HY … Xia ZL (Journal of occupational health 2010) 3 22 44 58
  2. Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth. (PMID: 19778329) Drozdzik A … Drozdzik M (Journal of periodontal research 2010) 3 22 44 58
  3. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PMID: 19479237) Song XY … Chan JC (Diabetologia 2009) 3 22 44 58
  4. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 22 44 58
  5. Haplotype analysis of the stromelysin-1 (MMP3) and gelatinase B (MMP9) genes in relation to coronary heart disease. (PMID: 19438845) Wu N … Yang Y (Annals of human genetics 2009) 3 22 44 58

Products for MMP3 Gene

Sources for MMP3 Gene

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