Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role... See more...

Aliases for MMP28 Gene

Aliases for MMP28 Gene

  • Matrix Metallopeptidase 28 2 3 5
  • Matrix Metalloproteinase-28 3 4
  • MMP-28 3 4
  • MMP25 3 4
  • Matrix Metalloprotease MMP25 3
  • Matrix Metalloproteinase 28 2
  • EC 3.4.24.- 4
  • EPILYSIN 3
  • Epilysin 4
  • MMP-25 3
  • MM28 3

External Ids for MMP28 Gene

Previous GeneCards Identifiers for MMP28 Gene

  • GC17M033862
  • GC17M036128
  • GC17M034238
  • GC17M031116
  • GC17M034092
  • GC17M030278

Summaries for MMP28 Gene

Entrez Gene Summary for MMP28 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for MMP28 Gene

MMP28 (Matrix Metallopeptidase 28) is a Protein Coding gene. Among its related pathways are Matrix Metalloproteinases and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP15.

UniProtKB/Swiss-Prot Summary for MMP28 Gene

  • Can degrade casein. Could play a role in tissues homeostasis and repair.

Tocris Summary for MMP28 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP28 Gene

Additional gene information for MMP28 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP28 Gene

Genomics for MMP28 Gene

GeneHancer (GH) Regulatory Elements for MMP28 Gene

Promoters and enhancers for MMP28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035794 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 750.6 +0.5 506 2 ZNF121 POLR2A SP7 ZNF548 EGR1 GLIS2 ZIC2 ZBTB8A PRDM10 ZEB2 MMP28 ZNF830 LIG3 C17orf50 HEATR9 lnc-C17orf50-4 TAF15
GH17J035807 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9 -13.9 -13889 4.4 SIN3A SP1 CTCF SREBF1 SIX5 MLX RBPJ POLR2A TCF7L2 ATF1 ENSG00000270829 TAF15 SLFN14 SLFN12 LIG3 C17orf50 ENSG00000267102 GAS2L2 ENSG00000267648 SLFN11
GH17J035559 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 9.6 +235.4 235406 3.4 SMARCE1 RUNX1 CC2D1A ELF1 L3MBTL2 DACH1 TEAD4 ZKSCAN8 ZNF148 GTF2F1 ENSG00000267625 SLFN14 piR-43325-040 RASL10B LIG3 ZNF830 SLFN5 SLFN12L TAF15 SLFN13
GH17J035742 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 11.2 +54.3 54306 0.8 CTCF L3MBTL2 GMEB1 MGA USF1 NRF1 BHLHE40 SIN3A POLR2A SMARCA4 RASL10B MMP28 TAF15 NLE1 GAS2L2
GH17J035725 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 10.8 +69.2 69174 2.5 ZBTB6 NFIB SP7 PKNOX1 ZIC2 ZBTB8A PRDM10 ZNF544 ZEB2 CEBPB AP2B1 C17orf50 MMP28 GAS2L2 RPL17P42 RASL10B TAF15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP28 gene promoter:
  • AP-1
  • AP-4
  • c-Fos
  • C/EBPalpha
  • CHOP-10
  • Chx10
  • Egr-3
  • HOXA3
  • JunD
  • Pax-5

Genomic Locations for MMP28 Gene

Genomic Locations for MMP28 Gene
chr17:35,756,249-35,795,707
(GRCh38/hg38)
Size:
39,459 bases
Orientation:
Minus strand
chr17:34,083,268-34,122,711
(GRCh37/hg19)
Size:
39,444 bases
Orientation:
Minus strand

Genomic View for MMP28 Gene

Genes around MMP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP28 Gene

Proteins for MMP28 Gene

  • Protein details for MMP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H239-MMP28_HUMAN
    Recommended name:
    Matrix metalloproteinase-28
    Protein Accession:
    Q9H239
    Secondary Accessions:
    • Q96F04
    • Q96TE2

    Protein attributes for MMP28 Gene

    Size:
    520 amino acids
    Molecular mass:
    58939 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP28 Gene

Post-translational modifications for MMP28 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn164 and Asn355
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MMP28 Gene

Domains & Families for MMP28 Gene

Gene Families for MMP28 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP28 Gene

GenScript: Design optimal peptide antigens:
  • Matrix metallopeptidase 28, isoform CRA_b (C0H5X0_HUMAN)
  • Epilysin (MMP28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H239

UniProtKB/Swiss-Prot:

MMP28_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP28: view

Function for MMP28 Gene

Molecular function for MMP28 Gene

UniProtKB/Swiss-Prot Function:
Can degrade casein. Could play a role in tissues homeostasis and repair.

Enzyme Numbers (IUBMB) for MMP28 Gene

Phenotypes From GWAS Catalog for MMP28 Gene

Gene Ontology (GO) - Molecular Function for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS 11121398
GO:0005515 protein binding IPI 21152186
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP28: view
genes like me logo Genes that share phenotypes with MMP28: view

Animal Models for MMP28 Gene

MGI Knock Outs for MMP28:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP28

CRISPR Products

miRNA for MMP28 Gene

miRTarBase miRNAs that target MMP28

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP28 Gene

Localization for MMP28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP28 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP28 gene
Compartment Confidence
extracellular 5
peroxisome 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0031012 extracellular matrix NAS 11121398
GO:0062023 collagen-containing extracellular matrix HDA 27068509
genes like me logo Genes that share ontologies with MMP28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP28 Gene

Pathways & Interactions for MMP28 Gene

PathCards logo

SuperPathways for MMP28 Gene

SuperPathway Contained pathways
1 Matrix Metalloproteinases
.69
2 Integrin Pathway
.56
.38
3 GPCR Pathway
.59
genes like me logo Genes that share pathways with MMP28: view

Pathways by source for MMP28 Gene

1 BioSystems pathway for MMP28 Gene
4 Qiagen pathways for MMP28 Gene
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway

Gene Ontology (GO) - Biological Process for MMP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0010760 negative regulation of macrophage chemotaxis IEA --
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
genes like me logo Genes that share ontologies with MMP28: view

No data available for SIGNOR curated interactions for MMP28 Gene

Drugs & Compounds for MMP28 Gene

(5) Drugs for MMP28 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(3) Tocris Compounds for MMP28 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP28: view

Transcripts for MMP28 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP28 Gene

No ASD Table

Relevant External Links for MMP28 Gene

GeneLoc Exon Structure for
MMP28
ECgene alternative splicing isoforms for
MMP28

Expression for MMP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP28 Gene

This gene is overexpressed in Testis (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP28 Gene



Protein tissue co-expression partners for MMP28 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP28 Gene:

MMP28

SOURCE GeneReport for Unigene cluster for MMP28 Gene:

Hs.380710

mRNA Expression by UniProt/SwissProt for MMP28 Gene:

Q9H239-MMP28_HUMAN
Tissue specificity: Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.

Evidence on tissue expression from TISSUES for MMP28 Gene

  • Lung(4.4)
  • Pancreas(4)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with MMP28: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP28 Gene

Orthologs for MMP28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP28 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MMP28 32
  • 87.82 (n)
mouse
(Mus musculus)
Mammalia Mmp28 17 32
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia Mmp28 32
  • 84 (n)
cow
(Bos Taurus)
Mammalia MMP28 32
  • 78.61 (n)
chicken
(Gallus gallus)
Aves MMP28 32
  • 65.89 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp28 32
  • 58.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68506 32
zebrafish
(Danio rerio)
Actinopterygii LOC100005670 32
  • 59.53 (n)
Species where no ortholog for MMP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP28 Gene

ENSEMBL:
Gene Tree for MMP28 (if available)
TreeFam:
Gene Tree for MMP28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP28: view image

Paralogs for MMP28 Gene

(1) SIMAP similar genes for MMP28 Gene using alignment to 6 proteins:

  • MMP28_HUMAN
  • C0H5X0_HUMAN
  • K7ELN8_HUMAN
  • K7EMV8_HUMAN
  • K7ENP0_HUMAN
  • K7ERF8_HUMAN
genes like me logo Genes that share paralogs with MMP28: view

Variants for MMP28 Gene

Sequence variations from dbSNP and Humsavar for MMP28 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000026322 -- 35,770,282(-) C/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000041298 -- 35,785,733(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000231544 -- 35,768,768(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000355399 -- 35,782,263(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000431161 -- 35,782,655(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP28 Gene

Variant ID Type Subtype PubMed ID
esv3640457 CNV gain 21293372
esv3892999 CNV loss 25118596

Variation tolerance for MMP28 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP28 Gene

Disorders for MMP28 Gene

Additional Disease Information for MMP28

No disorders were found for MMP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP28 Gene

Publications for MMP28 Gene

  1. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. (PMID: 11121398) Lohi J … Parks WC (The Journal of biological chemistry 2001) 2 3 4 23 56
  2. MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. (PMID: 11255011) Marchenko GN … Strongin AY (Gene 2001) 2 3 4 23 56
  3. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PMID: 20144149) Swingler TE … Clark IM (The Biochemical journal 2010) 3 23 56
  4. Expression and function of matrix metalloproteinase (MMP)-28. (PMID: 19375502) Rodgers UR … Clark IM (Matrix biology : journal of the International Society for Matrix Biology 2009) 3 23 56
  5. Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs. (PMID: 20003223) Gruber HE … Hanley EN (Arthritis research & therapy 2009) 3 23 56

Products for MMP28 Gene

Sources for MMP28 Gene