Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular prot... See more...

Aliases for MMP27 Gene

Aliases for MMP27 Gene

  • Matrix Metallopeptidase 27 2 3 5
  • Matrix Metalloproteinase-27 3 4
  • Matrix Metalloprotease 27 2 3
  • MMP-27 3 4
  • Matrix Metalloproteinase 27 2
  • EC 3.4.24.35 51
  • EC 3.4.24.- 4
  • EC 3.4.24 51
  • MMP27 5

External Ids for MMP27 Gene

Previous GeneCards Identifiers for MMP27 Gene

  • GC11M104756
  • GC11M103919
  • GC11M102100
  • GC11M102067
  • GC11M098489

Summaries for MMP27 Gene

Entrez Gene Summary for MMP27 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP27 Gene

MMP27 (Matrix Metallopeptidase 27) is a Protein Coding gene. Diseases associated with MMP27 include Inflammatory Bowel Disease 13. Among its related pathways are Integrin Pathway and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.

UniProtKB/Swiss-Prot Summary for MMP27 Gene

  • Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Tocris Summary for MMP27 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP27 Gene

Additional gene information for MMP27 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP27 Gene

Genomics for MMP27 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MMP27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J102705 Promoter/Enhancer 0.5 EPDnew Ensembl 609.8 -0.2 -238 0.8 MMP27 MMP8
GH11J102733 Enhancer 0.8 Ensembl ENCODE 17.7 -27.2 -27216 1.6 CTCF ZNF143 PKNOX1 REST RAD21 TRIM22 PBX2 SCRT2 RUNX3 SMC3 MMP27 MMP10 MMP1 MMP3 RNU7-159P MMP8 piR-45358-001
GH11J102719 Promoter/Enhancer 1.3 EPDnew FANTOM5 Ensembl ENCODE 9 -19.5 -19516 12.2 CEBPB ZBTB40 FOS NONO SPI1 ZNF18 ATF4 JUND JUN HLF MMP8 MMP10 MMP1 MMP3 RNU7-159P MMP27 BIRC2 TMEM123 BIRC3
GH11J102678 Enhancer 0.5 Ensembl 18 +24.7 24684 5 CTCF SPI1 GABPA REST POLR2A RAD21 MMP27 piR-33614-045 ENSG00000281655 MMP20 LOC101928477
GH11J102797 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 5.5 -94.4 -94422 5.6 JUND CEBPB USF1 FOS BHLHE40 MAX POLR2A NFE2L2 MMP1 MMP27 JA662190 lnc-MMP10-3 ENSG00000256035 lnc-MMP1-1 lnc-DYNC2H1-4 MMP3 WTAPP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP27 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP27

Top Transcription factor binding sites by QIAGEN in the MMP27 gene promoter:
  • CUTL1
  • FOXI1
  • HFH-3
  • Lmo2
  • p300
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • XBP-1

Genomic Locations for MMP27 Gene

Genomic Locations for MMP27 Gene
chr11:102,690,943-102,705,785
(GRCh38/hg38)
Size:
14,843 bases
Orientation:
Minus strand
chr11:102,562,218-102,576,537
(GRCh37/hg19)
Size:
14,320 bases
Orientation:
Minus strand

Genomic View for MMP27 Gene

Genes around MMP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP27 Gene

Proteins for MMP27 Gene

  • Protein details for MMP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H306-MMP27_HUMAN
    Recommended name:
    Matrix metalloproteinase-27
    Protein Accession:
    Q9H306
    Secondary Accessions:
    • Q6UWK6

    Protein attributes for MMP27 Gene

    Size:
    513 amino acids
    Molecular mass:
    59026 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP27 Gene

Selected DME Specific Peptides for MMP27 Gene

Q9H306:
  • PGPGLGGD
  • PRCGVPD
  • LFLVAAHE
  • VAAHEFGHALGL
  • IHTLGFP
  • VAAHEFGH
  • LTFDAIT
  • QDDINGIQ
  • VKKIDAA
  • TGKLDSNT

Post-translational modifications for MMP27 Gene

Other Protein References for MMP27 Gene

Domains & Families for MMP27 Gene

Gene Families for MMP27 Gene

Suggested Antigen Peptide Sequences for MMP27 Gene

GenScript: Design optimal peptide antigens:
  • Matrix metalloproteinase-27 (MMP27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H306

UniProtKB/Swiss-Prot:

MMP27_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP27: view

Function for MMP27 Gene

Molecular function for MMP27 Gene

UniProtKB/Swiss-Prot Function:
Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Enzyme Numbers (IUBMB) for MMP27 Gene

Phenotypes From GWAS Catalog for MMP27 Gene

Gene Ontology (GO) - Molecular Function for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP27: view
genes like me logo Genes that share phenotypes with MMP27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP27

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MMP27 Gene

Localization for MMP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP27 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Note=Retained in the endoplasmic reticulum. {ECO:0000269 PubMed:24548619}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP27 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0031012 extracellular matrix IEA --
GO:0042406 extrinsic component of endoplasmic reticulum membrane IDA 24548619
genes like me logo Genes that share ontologies with MMP27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP27 Gene

Pathways & Interactions for MMP27 Gene

PathCards logo

SuperPathways for MMP27 Gene

SuperPathway Contained pathways
1 Matrix Metalloproteinases
.69
2 Integrin Pathway
.56
.38
3 GPCR Pathway
.59
genes like me logo Genes that share pathways with MMP27: view

Pathways by source for MMP27 Gene

1 BioSystems pathway for MMP27 Gene
4 Qiagen pathways for MMP27 Gene
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway

Gene Ontology (GO) - Biological Process for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
genes like me logo Genes that share ontologies with MMP27: view

No data available for SIGNOR curated interactions for MMP27 Gene

Drugs & Compounds for MMP27 Gene

(5) Drugs for MMP27 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Calcium Nutra 6556
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(3) Tocris Compounds for MMP27 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP27: view

Transcripts for MMP27 Gene

mRNA/cDNA for MMP27 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP27

Alternative Splicing Database (ASD) splice patterns (SP) for MMP27 Gene

No ASD Table

Relevant External Links for MMP27 Gene

GeneLoc Exon Structure for
MMP27

Expression for MMP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP27 Gene

mRNA differential expression in normal tissues according to GTEx for MMP27 Gene

This gene is overexpressed in Minor Salivary Gland (x10.9), Skin - Sun Exposed (Lower leg) (x10.6), Skin - Not Sun Exposed (Suprapubic) (x8.5), and Adipose - Subcutaneous (x6.5).

Protein differential expression in normal tissues from HIPED for MMP27 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP27 Gene



Protein tissue co-expression partners for MMP27 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP27

SOURCE GeneReport for Unigene cluster for MMP27 Gene:

Hs.534479

mRNA Expression by UniProt/SwissProt for MMP27 Gene:

Q9H306-MMP27_HUMAN
Tissue specificity: Expressed in B-cells (PubMed:14506071). Expressed in a subset of endometrial macrophages related to menstruation and in ovarian and peritoneal endometriotic lesions (at protein level)(PubMed:24810263).
genes like me logo Genes that share expression patterns with MMP27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP27 Gene

Orthologs for MMP27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP27 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MMP27 30 31
  • 99.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MMP27 30 31
  • 86.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MMP27 30 31
  • 85.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mmp27 30 17 31
  • 81.76 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mmp27 30
  • 81.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia MMP27 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MMP27 30 31
  • 65.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MMP27 31
  • 51 (a)
OneToOne
Species where no ortholog for MMP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MMP27 Gene

ENSEMBL:
Gene Tree for MMP27 (if available)
TreeFam:
Gene Tree for MMP27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP27: view image

Paralogs for MMP27 Gene

(13) SIMAP similar genes for MMP27 Gene using alignment to 1 proteins:

  • MMP27_HUMAN
genes like me logo Genes that share paralogs with MMP27: view

Variants for MMP27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP27 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12099177 - p.Arg22Trp
rs1276286 - p.Glu266Val
rs1939015 - p.Thr24Met
rs2509010 - p.Asp447Asn
rs2846707 - p.Met30Val

Additional dbSNP identifiers (rs#s) for MMP27 Gene

Structural Variations from Database of Genomic Variants (DGV) for MMP27 Gene

Variant ID Type Subtype PubMed ID
esv2660550 CNV deletion 23128226
esv3627535 CNV loss 21293372
nsv819435 CNV loss 19587683
nsv832252 CNV gain 17160897

Variation tolerance for MMP27 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.73; 93.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP27

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP27 Gene

Disorders for MMP27 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP27 Gene - From: DISEASES

Disorder Aliases PubMed IDs
inflammatory bowel disease 13
  • ibd13
- elite association - COSMIC cancer census association via MalaCards
Search MMP27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP27

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MMP27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP27 Gene

Publications for MMP27 Gene

  1. Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions. (PMID: 24810263) Cominelli A … Henriet P (Molecular human reproduction 2014) 3 4
  2. A unique C-terminal domain allows retention of matrix metalloproteinase-27 in the endoplasmic reticulum. (PMID: 24548619) Cominelli A … Henriet P (Traffic (Copenhagen, Denmark) 2014) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Matrix metalloproteinases. (PMID: 10419448) Nagase H … Woessner JF (The Journal of biological chemistry 1999) 2 3

Products for MMP27 Gene

  • Signalway ELISA kits for MMP27

Sources for MMP27 Gene