Aliases for MMP27 Gene
External Ids for MMP27 Gene
Previous GeneCards Identifiers for MMP27 Gene
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP27 Gene
MMP27 (Matrix Metallopeptidase 27) is a Protein Coding gene. Diseases associated with MMP27 include Inflammatory Bowel Disease 13. Among its related pathways are Integrin Pathway and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP10.
UniProtKB/Swiss-Prot Summary for MMP27 Gene
Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.