Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular prote... See more...

Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3 5
  • MT6-MMP 2 3 4
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Matrix Metalloproteinase-25 3 4
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MMP-25 3 4
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Membrane-Type-6 Matrix Metalloproteinase 4
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 25 2
  • Matrix Metalloproteinase 20 3
  • EC 3.4.24.- 4
  • MT-MMP6 3
  • MMP20A 3
  • MMP25 5

External Ids for MMP25 Gene

Previous HGNC Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Previous GeneCards Identifiers for MMP25 Gene

  • GC16U990147
  • GC16P003130
  • GC16P003097
  • GC16P003100
  • GC16P003102
  • GC16P003037
  • GC16P003038
  • GC16P003106
  • GC16P003108
  • GC16P003068
  • GC16P003109
  • GC16P003111
  • GC16P003127
  • GC16P003151
  • GC16P003139
  • GC16P003149
  • GC16P003745
  • GC16P003830
  • GC16P003881
  • GC16P004057
  • GC16P003235
  • GC16P003291
  • GC16P003330
  • GC16P003383
  • GC16P003423
  • GC16P003467
  • GC16P003447
  • GC16P003597

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Diseases associated with MMP25 include Jalili Syndrome and Dentin Dysplasia. Among its related pathways are Degradation of the extracellular matrix and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP17.

UniProtKB/Swiss-Prot Summary for MMP25 Gene

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP25 Gene

Additional gene information for MMP25 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MMP25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003045 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +0.4 438 2.8 ZBTB33 KDM1A FOXA1 ZIC2 POLR2A PATZ1 IKZF2 EZH2 ZNF239 GTF2F1 MMP25 BICDL2 E4F1 CREBBP ZNF263 SRRM2 ENSG00000262482 ZNF597 THOC6 TSC2
GH16J003044 Promoter 0.4 Ensembl 600.7 -1.3 -1262 0.2 EZH2 MMP25 BICDL2 MMP25-AS1
GH16J003003 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 49.3 -38.2 -38246 8.6 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 REST TFE3 LOC105371056 lnc-CLDN6-1 MMP25 CREBBP ENSG00000272079 ZNF597 SRRM2 AMDHD2 ZNF263 ZNF598
GH16J003069 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +28.4 28417 9.8 SP1 YBX1 LEF1 JUND LARP7 ZNF143 ZIC2 TCF12 IKZF2 POLR2A LOC107984896 MMP25-AS1 ZNF205 ENSG00000262370 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 HCFC1R1
GH16J003063 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 +20.1 20094 5.8 HNRNPL GATAD2A ATF7 ZNF629 REST TFE3 NFKBIZ ZNF692 POLR2A PRDM1 IL32 NONHSAG018389.2 MMP25 ENSG00000262370 E4F1 ZNF75A BICDL2 ZSCAN10 LOC100128770 ENSG00000272079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP25

Top Transcription factor binding sites by QIAGEN in the MMP25 gene promoter:
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT3

Genomic Locations for MMP25 Gene

Genomic Locations for MMP25 Gene
chr16:3,045,963-3,060,729
(GRCh38/hg38)
Size:
14,767 bases
Orientation:
Plus strand
chr16:3,096,682-3,110,727
(GRCh37/hg19)
Size:
14,046 bases
Orientation:
Plus strand

Genomic View for MMP25 Gene

Genes around MMP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA2-MMP25_HUMAN
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Q9NPA2
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    Size:
    562 amino acids
    Molecular mass:
    62554 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

No data available for DME Specific Peptides for MMP25 Gene

Domains & Families for MMP25 Gene

Gene Families for MMP25 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MMP25 Gene

Suggested Antigen Peptide Sequences for MMP25 Gene

GenScript: Design optimal peptide antigens:
  • Membrane-type-6 matrix metalloproteinase (MMP25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPA2

UniProtKB/Swiss-Prot:

MMP25_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function:
May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP25 Gene

Phenotypes From GWAS Catalog for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP25: view
genes like me logo Genes that share phenotypes with MMP25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP25

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP25

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
endoplasmic reticulum 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MMP25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP25 Gene

Pathways & Interactions for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

Pathways by source for MMP25 Gene

1 Qiagen pathway for MMP25 Gene
  • Inhibition of Matrix Metalloproteinases

SIGNOR curated interactions for MMP25 Gene

Activates:

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 10706098
GO:0006954 inflammatory response NAS 10628838
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MMP25: view

Drugs & Compounds for MMP25 Gene

(7) Drugs for MMP25 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenofibrate Approved Pharma Target, inhibitor PPARalpha agonist 185
Fenofibric acid Approved Pharma Channel blocker, Agonist, Target, unknown 33
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Calcium Nutra 6556
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0

(3) Tocris Compounds for MMP25 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

mRNA/cDNA for MMP25 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP25

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
MMP25

Expression for MMP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (x46.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP25

SOURCE GeneReport for Unigene cluster for MMP25 Gene:

Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene:

Q9NPA2-MMP25_HUMAN
Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.

Evidence on tissue expression from TISSUES for MMP25 Gene

  • Bone marrow(2.4)
  • Blood(2.3)
  • Intestine(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with MMP25: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP25 Gene

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MMP25 30 31
  • 99.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MMP25 30 31
  • 85.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MMP25 30 31
  • 83.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mmp25 30 17 31
  • 79.43 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MMP25 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MMP25 31
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MMP25 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mmp25 30
  • 56.21 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100333601 30
  • 52.71 (n)
CABZ01030094.1 31
  • 44 (a)
OneToMany
MMP25 (2 of 2) 31
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 30
  • 51.31 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Mmp2 32
  • 36 (a)
Mmp1 32
  • 34 (a)
Worm
(Caenorhabditis elegans)
Secernentea C31B8.8 32
  • 38 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for MMP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MMP25 Gene

ENSEMBL:
Gene Tree for MMP25 (if available)
TreeFam:
Gene Tree for MMP25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP25: view image

Paralogs for MMP25 Gene

(11) SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

  • MMP25_HUMAN
  • L8ECJ7_HUMAN
genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Additional dbSNP identifiers (rs#s) for MMP25 Gene

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
dgv323e201 CNV deletion 23290073
esv2750390 CNV deletion 23290073
esv2750392 CNV deletion 23290073
esv2763127 CNV loss 21179565
esv3581939 CNV loss 25503493
esv3637645 CNV gain 21293372
esv3637646 CNV loss 21293372
esv3637647 CNV gain 21293372
nsv1115893 CNV deletion 24896259
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897
nsv952907 CNV deletion 24416366

Variation tolerance for MMP25 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP25 Gene

Disorders for MMP25 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MMP25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
jalili syndrome
  • cone-rod dystrophy and amelogenesis imperfecta
dentin dysplasia
  • dd
trichodentoosseous syndrome
  • tdo
teeth hard tissue disease
amelogenesis imperfecta
  • ai
- elite association - COSMIC cancer census association via MalaCards
Search MMP25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MMP25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D (Cell research 1999) 2 3 4 23
  2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PMID: 10706098) Velasco G … López-Otín C (Cancer research 2000) 2 3 4
  3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PMID: 11034316) Kojima S … Seiki M (FEBS letters 2000) 3 4 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 41

Products for MMP25 Gene

Sources for MMP25 Gene