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Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3 5
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MT6-MMP 3 4
  • MMP-25 3 4
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Membrane-Type-6 Matrix Metalloproteinase 4
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 20 3
  • Matrix Metalloproteinase-25 3
  • Matrix Metalloproteinase 25 2
  • EC 3.4.24.- 4
  • MT-MMP6 3
  • MMP20A 3

External Ids for MMP25 Gene

Previous HGNC Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Previous GeneCards Identifiers for MMP25 Gene

  • GC16U990147
  • GC16P003130
  • GC16P003097
  • GC16P003100
  • GC16P003102
  • GC16P003037
  • GC16P003038
  • GC16P003106
  • GC16P003108
  • GC16P003068
  • GC16P003109
  • GC16P003111
  • GC16P003127
  • GC16P003151
  • GC16P003139
  • GC16P003149
  • GC16P003235
  • GC16P003291
  • GC16P003330
  • GC16P003383
  • GC16P003423
  • GC16P003467

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Diseases associated with MMP25 include Teeth Hard Tissue Disease. Among its related pathways are Innate Immune System and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP17.

UniProtKB/Swiss-Prot for MMP25 Gene

  • May activate progelatinase A.

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP25 Gene

Additional gene information for MMP25 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

GeneHancer (GH) Regulatory Elements for MMP25 Gene

Promoters and enhancers for MMP25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003045 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.1 129 1.4 FOXA2 SIN3A ZNF335 GLIS2 ZNF548 IKZF2 EGR2 SP3 ZBTB11 ZNF398 MMP25 E4F1 CREBBP ZNF263 SRRM2 LOC105371055 ZNF597 THOC6 TSC2 ENSG00000261938
GH16J003003 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 49.3 -38.1 -38147 8.4 CLOCK MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 ENSG00000272079 LOC105371056 CREBBP ZNF597 MMP25 AMDHD2 SRRM2 ZNF598 ZNF263 ZNF200
GH16J003255 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.6 +211.9 211934 5.8 SAP130 MAX CEBPG ZNF384 ZNF7 POLR2A FOS THAP11 GATAD2A SMARCC1 MEFV MMP25 ZNF200 ZNF263 OR2C1 TIGD7 ZNF75A PRSS33 NAA60 ZNF597
GH16J003063 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.7 +20.1 20094 5.8 HDGF PKNOX1 MLX ARID4B DMAP1 IRF4 YY1 ZNF143 SP5 MXD4 IL32 MMP25 LOC105371058 ZNF597 E4F1 CREBBP ZNF75A BICDL2 ZSCAN10 LOC100128770
GH16J003069 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.3 +28.4 28417 9.8 HDGF PKNOX1 YBX1 IRF4 ZNF207 ZNF143 ZFP91 ATF7 RUNX3 PAF1 GC16P003606 ZNF205 LOC105371058 MMP25 ZNF597 IL32 FLYWCH2 ZNF200 ZNF174 ZSCAN32
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP25 gene promoter:
  • STAT3
  • HNF-4alpha2
  • HNF-4alpha1

Genomic Locations for MMP25 Gene

Genomic Locations for MMP25 Gene
chr16:3,045,963-3,060,729
(GRCh38/hg38)
Size:
14,767 bases
Orientation:
Plus strand
chr16:3,096,682-3,110,727
(GRCh37/hg19)
Size:
14,046 bases
Orientation:
Plus strand

Genomic View for MMP25 Gene

Genes around MMP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA2-MMP25_HUMAN
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Q9NPA2
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    Size:
    562 amino acids
    Molecular mass:
    62554 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

No data available for DME Specific Peptides for MMP25 Gene

Domains & Families for MMP25 Gene

Gene Families for MMP25 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA2

UniProtKB/Swiss-Prot:

MMP25_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function:
May activate progelatinase A.

Enzyme Numbers (IUBMB) for MMP25 Gene

Phenotypes From GWAS Catalog for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP25: view
genes like me logo Genes that share phenotypes with MMP25: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP25

miRNA for MMP25 Gene

miRTarBase miRNAs that target MMP25

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP25 Gene

Pathways & Interactions for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

Pathways by source for MMP25 Gene

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS,IEA 10706098
GO:0006954 inflammatory response NAS,IEA 10628838
GO:0043312 neutrophil degranulation TAS --
GO:0060022 hard palate development IEA --
genes like me logo Genes that share ontologies with MMP25: view

No data available for SIGNOR curated interactions for MMP25 Gene

Drugs & Compounds for MMP25 Gene

(5) Drugs for MMP25 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
calcium Approved Nutra 0
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(3) Tocris Compounds for MMP25 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

mRNA/cDNA for MMP25 Gene

Unigene Clusters for MMP25 Gene

Matrix metallopeptidase 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
MMP25
ECgene alternative splicing isoforms for
MMP25

Expression for MMP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (x46.5).

NURSA nuclear receptor signaling pathways regulating expression of MMP25 Gene:

MMP25

SOURCE GeneReport for Unigene cluster for MMP25 Gene:

Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene:

Q9NPA2-MMP25_HUMAN
Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas.
genes like me logo Genes that share expression patterns with MMP25: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP25 Gene

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP25 34 33
  • 99.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MMP25 34 33
  • 85.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MMP25 34 33
  • 83.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp25 16 34 33
  • 79.43 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP25 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP25 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP25 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp25 33
  • 56.21 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333601 33
  • 52.71 (n)
CABZ01030094.1 34
  • 44 (a)
OneToMany
MMP25 (2 of 2) 34
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 33
  • 51.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 36 (a)
Mmp1 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 35
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for MMP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP25 Gene

ENSEMBL:
Gene Tree for MMP25 (if available)
TreeFam:
Gene Tree for MMP25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP25: view image

Paralogs for MMP25 Gene

(11) SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

  • MMP25_HUMAN
  • L8ECJ7_HUMAN
genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Sequence variations from dbSNP and Humsavar for MMP25 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000020951 -- 3,045,319(+) G/A upstream_transcript_variant
rs1000310751 -- 3,059,135(+) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000333071 -- 3,046,663(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000506108 -- 3,050,775(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000809057 -- 3,059,826(+) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
dgv323e201 CNV deletion 23290073
esv2750390 CNV deletion 23290073
esv2750392 CNV deletion 23290073
esv2763127 CNV loss 21179565
esv3581939 CNV loss 25503493
esv3637645 CNV gain 21293372
esv3637646 CNV loss 21293372
esv3637647 CNV gain 21293372
nsv1115893 CNV deletion 24896259
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv833125 CNV loss 17160897
nsv952907 CNV deletion 24416366

Variation tolerance for MMP25 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP25

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP25 Gene

Disorders for MMP25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
teeth hard tissue disease
- elite association - COSMIC cancer census association via MalaCards
Search MMP25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D (Cell research 1999) 2 3 4 22 58
  2. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PMID: 10706098) Velasco G … López-Otín C (Cancer research 2000) 2 3 4 58
  3. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PMID: 11034316) Kojima S … Seiki M (FEBS letters 2000) 3 4 22 58
  4. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for MMP25 Gene

Sources for MMP25 Gene

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