This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytic... See more...

Aliases for MMP24 Gene

Aliases for MMP24 Gene

  • Matrix Metallopeptidase 24 2 3 5
  • MT5-MMP 2 3 4
  • Matrix Metalloproteinase 24 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 24 (Membrane-Inserted) 2 3
  • Membrane-Type 5 Matrix Metalloproteinase 2 3
  • Membrane-Type Matrix Metalloproteinase 5 3 4
  • Matrix Metalloproteinase-24 3 4
  • MT-MMP 5 3 4
  • MMP-24 3 4
  • MT5MMP 3 4
  • MTMMP5 3 4
  • Membrane-Type-5 Matrix Metalloproteinase 4
  • EC 3.4.24.80 51
  • EC 3.4.24.- 4
  • EC 3.4.24 51
  • MT-MMP5 3
  • MMP25 3
  • MMP24 5

External Ids for MMP24 Gene

Previous GeneCards Identifiers for MMP24 Gene

  • GC20P033573
  • GC20P034483
  • GC20P034530
  • GC20P033278
  • GC20P033814
  • GC20P030592

Summaries for MMP24 Gene

Entrez Gene Summary for MMP24 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

GeneCards Summary for MMP24 Gene

MMP24 (Matrix Metallopeptidase 24) is a Protein Coding gene. Diseases associated with MMP24 include Asymptomatic Dengue. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP16.

UniProtKB/Swiss-Prot Summary for MMP24 Gene

  • Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).

Tocris Summary for MMP24 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP24 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP24 Gene

Genomics for MMP24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MMP24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP24

Top Transcription factor binding sites by QIAGEN in the MMP24 gene promoter:
  • AML1a
  • AREB6
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • Sp1
  • YY1

Genomic Locations for MMP24 Gene

Genomic Locations for MMP24 Gene
chr20:35,226,690-35,276,998
(GRCh38/hg38)
Size:
50,309 bases
Orientation:
Plus strand
chr20:33,814,457-33,864,804
(GRCh37/hg19)
Size:
50,348 bases
Orientation:
Plus strand

Genomic View for MMP24 Gene

Genes around MMP24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP24 Gene

Proteins for MMP24 Gene

  • Protein details for MMP24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5R2-MMP24_HUMAN
    Recommended name:
    Matrix metalloproteinase-24
    Protein Accession:
    Q9Y5R2
    Secondary Accessions:
    • B7ZBG8
    • Q9H440

    Protein attributes for MMP24 Gene

    Size:
    645 amino acids
    Molecular mass:
    73231 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with APBA3 (via PDZ domain). Interacts with GRIP1 and GRIP2 (By similarity).

neXtProt entry for MMP24 Gene

Selected DME Specific Peptides for MMP24 Gene

Q9Y5R2:
  • GGFLAHAYFPGP
  • NYTPKVGE
  • PRCGVPD
  • AIMAPFYQ
  • FVFFKGD
  • PGPGIGGD
  • FYGIPVTGVLD
  • YWKFDNQKL
  • LRDWMGC
  • GHALGLEHS
  • RGEMFVFK
  • FASGFHGDSSPFDG
  • DPGYPKPI

Post-translational modifications for MMP24 Gene

  • Cleaved by a furin endopeptidase in the trans-Golgi network.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP24 Gene

Domains & Families for MMP24 Gene

Gene Families for MMP24 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP24 Gene

GenScript: Design optimal peptide antigens:
  • Membrane-type-5 matrix metalloproteinase (MMP24_HUMAN)
  • MMP24 protein (Q86VV6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5R2

UniProtKB/Swiss-Prot:

MMP24_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • The PDZ-binding motif (also named EWV motif) is required for interaction with PDZ domains of APBA3 and recycling through the trans-Golgi network.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP24: view

Function for MMP24 Gene

Molecular function for MMP24 Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
GENATLAS Biochemistry:
matrix metalloproteinase 24,membrane type (MT),expressed in brain,kidney,pancreas and lung activator of progelalinase,overexpressed in brain tumor,involved in neurogenesis

Enzyme Numbers (IUBMB) for MMP24 Gene

Phenotypes From GWAS Catalog for MMP24 Gene

Gene Ontology (GO) - Molecular Function for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS,ISS --
GO:0008047 enzyme activator activity TAS 10363975
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP24: view
genes like me logo Genes that share phenotypes with MMP24: view

Animal Models for MMP24 Gene

MGI Knock Outs for MMP24:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP24

CRISPR Products

miRNA for MMP24 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP24

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP24 Gene

Localization for MMP24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP24 Gene

[Matrix metalloproteinase-24]: Cell membrane. Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.
[Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP24 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 4
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS,ISS --
genes like me logo Genes that share ontologies with MMP24: view

Pathways & Interactions for MMP24 Gene

genes like me logo Genes that share pathways with MMP24: view

Pathways by source for MMP24 Gene

1 Qiagen pathway for MMP24 Gene
  • Inhibition of Matrix Metalloproteinases

Gene Ontology (GO) - Biological Process for MMP24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS,ISS --
GO:0007155 cell adhesion IEA --
GO:0010001 glial cell differentiation IEA,ISS --
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
genes like me logo Genes that share ontologies with MMP24: view

No data available for SIGNOR curated interactions for MMP24 Gene

Drugs & Compounds for MMP24 Gene

(5) Drugs for MMP24 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Calcium Nutra 6556
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(1) Additional Compounds for MMP24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dermatan
  • b-Heparin
  • beta-Heparin
  • Chondroitin sulfate b
  • Chondroitin sulfate type b
  • Chondroitin sulphate b
24967-94-0

(3) Tocris Compounds for MMP24 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP24: view

Transcripts for MMP24 Gene

mRNA/cDNA for MMP24 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP24

Alternative Splicing Database (ASD) splice patterns (SP) for MMP24 Gene

No ASD Table

Relevant External Links for MMP24 Gene

GeneLoc Exon Structure for
MMP24

Expression for MMP24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP24 Gene

This gene is overexpressed in Brain - Cerebellum (x8.4) and Brain - Cerebellar Hemisphere (x7.0).

Protein differential expression in normal tissues from HIPED for MMP24 Gene

This gene is overexpressed in Placenta (34.4), Liver (14.6), Pancreas (12.4), and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP24 Gene



Protein tissue co-expression partners for MMP24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP24

SOURCE GeneReport for Unigene cluster for MMP24 Gene:

Hs.715494

mRNA Expression by UniProt/SwissProt for MMP24 Gene:

Q9Y5R2-MMP24_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.

Evidence on tissue expression from TISSUES for MMP24 Gene

  • Nervous system(4.8)
  • Kidney(2.1)
  • Bone marrow(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with MMP24: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP24 Gene

Orthologs for MMP24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MMP24 30 31
  • 99.74 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MMP24 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MMP24 30 31
  • 93.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MMP24 30 31
  • 93.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mmp24 30 17 31
  • 91.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mmp24 30
  • 90.48 (n)
Chicken
(Gallus gallus)
Aves MMP24 30 31
  • 78.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MMP24 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mmp24 30
  • 74.85 (n)
Zebrafish
(Danio rerio)
Actinopterygii mmp24 30 31
  • 75.96 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Mmp1 32
  • 37 (a)
Mmp2 31
  • 25 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C31B8.8 32
  • 41 (a)
H19M22.3a 32
  • 33 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7631 30
Species where no ortholog for MMP24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MMP24 Gene

ENSEMBL:
Gene Tree for MMP24 (if available)
TreeFam:
Gene Tree for MMP24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP24: view image

Paralogs for MMP24 Gene

(18) SIMAP similar genes for MMP24 Gene using alignment to 3 proteins:

  • MMP24_HUMAN
  • L8E8C1_HUMAN
  • Q86VV6_HUMAN
genes like me logo Genes that share paralogs with MMP24: view

Variants for MMP24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP24 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
769997 Benign: not provided 35,254,705(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
rs751887 - p.Arg564His

Additional dbSNP identifiers (rs#s) for MMP24 Gene

Structural Variations from Database of Genomic Variants (DGV) for MMP24 Gene

Variant ID Type Subtype PubMed ID
esv3645713 CNV loss 21293372
nsv1059168 CNV loss 25217958
nsv1073056 CNV deletion 25765185
nsv1136327 CNV deletion 24896259
nsv585943 CNV loss 21841781
nsv954028 CNV deletion 24416366

Variation tolerance for MMP24 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP24 Gene

Disorders for MMP24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
asymptomatic dengue
- elite association - COSMIC cancer census association via MalaCards
Search MMP24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MMP24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP24 Gene

Publications for MMP24 Gene

  1. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. (PMID: 10363975) Llano E … López-Otin C (Cancer research 1999) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 41
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 41
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41

Products for MMP24 Gene

  • Signalway ELISA kits for MMP24
  • Signalway Proteins for MMP24

Sources for MMP24 Gene