This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease proce... See more...

Aliases for MMP23B Gene

Aliases for MMP23B Gene

  • Matrix Metallopeptidase 23B 2 3 5
  • Femalysin 2 3 4
  • Matrix Metalloproteinase In The Female Reproductive Tract 2 3
  • Matrix Metalloproteinase 23B 2 3
  • Matrix Metalloproteinase-21 3 4
  • Matrix Metalloproteinase-23 3 4
  • Matrix Metalloproteinase 22 2 3
  • MIFR-1 3 4
  • MMP-21 3 4
  • MMP-22 3 4
  • MMP-23 3 4
  • MMP22 3 4
  • Matrix Metalloproteinase-22 4
  • EC 3.4.24.- 4
  • MMP23A 3
  • MMP21 4
  • MIFR 3

External Ids for MMP23B Gene

Previous HGNC Symbols for MMP23B Gene

  • MMP22

Previous GeneCards Identifiers for MMP23B Gene

  • GC01P001188
  • GC01P001437
  • GC01P001500
  • GC01P001580
  • GC01P9N0048
  • GC01P001558
  • GC01P001559
  • GC01P000843
  • GC01P001567

Summaries for MMP23B Gene

Entrez Gene Summary for MMP23B Gene

  • This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23B Gene

MMP23B (Matrix Metallopeptidase 23B) is a Protein Coding gene. Diseases associated with MMP23B include Chromosome 1P36 Deletion Syndrome. Among its related pathways are Matrix Metalloproteinases and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is MMP17.

UniProtKB/Swiss-Prot Summary for MMP23B Gene

  • Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).

Tocris Summary for MMP23B Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP23B Gene

Additional gene information for MMP23B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP23B Gene

Genomics for MMP23B Gene

GeneHancer (GH) Regulatory Elements for MMP23B Gene

Promoters and enhancers for MMP23B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001626 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.6 -1.8 -1849 6.7 SP1 HCFC1 NKRF POLR2A ZNF687 ZNF143 LARP7 PATZ1 PKNOX1 ZFX HSALNG0000184 MMP23B SLC35E2B ENSG00000269737 SLC35E2A MIB2 ENSG00000272106 HSALNG0000182 HSALNG0000183
GH01J001968 Enhancer 0.6 Ensembl ENCODE 4.6 +336.7 336671 0.7 GLIS2 ZNF24 SP1 KLF1 CFAP74 ANKRD65 MMP23B piR-51077
GH01J001633 Promoter/Enhancer 0.5 Ensembl dbSUPER 0.6 +2.0 2005 0.2 HSALNG0000186-001 MMP23B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP23B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP23B gene promoter:
  • AP-1
  • ATF
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • p53
  • Roaz
  • Tal-1

Genomic Locations for MMP23B Gene

Genomic Locations for MMP23B Gene
chr1:1,632,095-1,635,263
(GRCh38/hg38)
Size:
3,169 bases
Orientation:
Plus strand
chr1:1,567,474-1,570,639
(GRCh37/hg19)
Size:
3,166 bases
Orientation:
Plus strand

Genomic View for MMP23B Gene

Genes around MMP23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23B Gene

Proteins for MMP23B Gene

  • Protein details for MMP23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75900-MMP23_HUMAN
    Recommended name:
    Matrix metalloproteinase-23
    Protein Accession:
    O75900
    Secondary Accessions:
    • A2AGN0
    • A2AGN1
    • O75894
    • O75895
    • Q5QPQ8
    • Q76P96
    • Q7LDM6
    • Q7LDM7
    • Q9UBR9
    • Q9UJK8

    Protein attributes for MMP23B Gene

    Size:
    390 amino acids
    Molecular mass:
    43935 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP23B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP23B Gene

Post-translational modifications for MMP23B Gene

No data available for DME Specific Peptides for MMP23B Gene

Domains & Families for MMP23B Gene

Gene Families for MMP23B Gene

Suggested Antigen Peptide Sequences for MMP23B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60714, highly similar to Homo sapiens matrix metallopeptidase 23B (MMP23B), mRNA (B4DMZ6_HUMAN)
  • Matrix metalloproteinase-22 (MMP23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75900

UniProtKB/Swiss-Prot:

MMP23_HUMAN :
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
  • Belongs to the peptidase M10A family.
Domain:
  • The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP23B: view

Function for MMP23B Gene

Molecular function for MMP23B Gene

UniProtKB/Swiss-Prot Function:
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by TIMP2.
GENATLAS Biochemistry:
matrix metalloproteinase 23B,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate

Enzyme Numbers (IUBMB) for MMP23B Gene

Phenotypes From GWAS Catalog for MMP23B Gene

Gene Ontology (GO) - Molecular Function for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,NAS 9740677
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,NAS 9740677
GO:0008270 zinc ion binding NAS,IEA 9988691
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP23B: view
genes like me logo Genes that share phenotypes with MMP23B: view

Animal Model Products

CRISPR Products

miRNA for MMP23B Gene

miRTarBase miRNAs that target MMP23B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP23B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP23B Gene

Localization for MMP23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP23B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP23B gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MMP23B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP23B Gene

Pathways & Interactions for MMP23B Gene

PathCards logo

SuperPathways for MMP23B Gene

SuperPathway Contained pathways
1 Matrix Metalloproteinases
.69
2 Integrin Pathway
.56
.38
3 GPCR Pathway
.59
genes like me logo Genes that share pathways with MMP23B: view

Pathways by source for MMP23B Gene

1 BioSystems pathway for MMP23B Gene
4 Qiagen pathways for MMP23B Gene
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway
1 GeneTex pathway for MMP23B Gene

Gene Ontology (GO) - Biological Process for MMP23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000003 reproduction IEP 9988691
GO:0006508 proteolysis IDA,IEA 9988691
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
genes like me logo Genes that share ontologies with MMP23B: view

No data available for SIGNOR curated interactions for MMP23B Gene

Drugs & Compounds for MMP23B Gene

(3) Drugs for MMP23B Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(3) Tocris Compounds for MMP23B Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP23B: view

Transcripts for MMP23B Gene

mRNA/cDNA for MMP23B Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP23B

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23B Gene

No ASD Table

Relevant External Links for MMP23B Gene

GeneLoc Exon Structure for
MMP23B
ECgene alternative splicing isoforms for
MMP23B

Expression for MMP23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP23B Gene

This gene is overexpressed in Ovary (x6.2), Artery - Aorta (x4.7), and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for MMP23B Gene

This gene is overexpressed in Testis (35.6), Lung (11.5), Prostate (9.2), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP23B Gene



Protein tissue co-expression partners for MMP23B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP23B Gene:

MMP23B

SOURCE GeneReport for Unigene cluster for MMP23B Gene:

Hs.192316

mRNA Expression by UniProt/SwissProt for MMP23B Gene:

O75900-MMP23_HUMAN
Tissue specificity: Predominantly expressed in ovary, testis and prostate.

Evidence on tissue expression from TISSUES for MMP23B Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with MMP23B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP23B Gene

Orthologs for MMP23B Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP23B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP23B 33 32
  • 98.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MMP23B 33 32
  • 87.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MMP23B 33 32
  • 85.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp23 32
  • 80.28 (n)
mouse
(Mus musculus)
Mammalia Mmp23 17 33 32
  • 80.12 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP23B 33
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP23B 33
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP23B 33 32
  • 66.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP23B 33
  • 1 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp23b 32
  • 64.09 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882601 32
  • 69.84 (n)
MMP23B 33
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea zmp-1 33
  • 14 (a)
ManyToMany
H19M22.3 33
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 19 (a)
OneToOne
Species where no ortholog for MMP23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP23B Gene

ENSEMBL:
Gene Tree for MMP23B (if available)
TreeFam:
Gene Tree for MMP23B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP23B: view image

Paralogs for MMP23B Gene

(3) SIMAP similar genes for MMP23B Gene using alignment to 7 proteins:

  • MMP23_HUMAN
  • B4DMZ6_HUMAN
  • D6REP6_HUMAN
  • H0Y6I4_HUMAN
  • H0YA69_HUMAN
  • H0YAE5_HUMAN
  • J3KRS4_HUMAN

Pseudogenes.org Pseudogenes for MMP23B Gene

genes like me logo Genes that share paralogs with MMP23B: view

Variants for MMP23B Gene

Sequence variations from dbSNP and Humsavar for MMP23B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000045042 -- 1,629,852(+) A/C upstream_transcript_variant
rs1000486332 -- 1,630,594(+) A/C upstream_transcript_variant
rs1000822115 -- 1,630,600(+) C/A/G upstream_transcript_variant
rs1000934524 -- 1,630,689(+) G/A/C/T upstream_transcript_variant
rs1001394569 -- 1,632,556(+) C/G/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP23B Gene

Variant ID Type Subtype PubMed ID
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv2659399 CNV deletion 23128226
esv2661270 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3575582 CNV gain 25503493
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for MMP23B Gene

Gene Damage Index Score: 0.07; 1.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP23B Gene

Human Gene Mutation Database (HGMD)
MMP23B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP23B Gene

Disorders for MMP23B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP23B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MMP23B

genes like me logo Genes that share disorders with MMP23B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP23B Gene

Publications for MMP23B Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R … Kidd VJ (Genomics 1998) 2 3 4 23 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. (PMID: 11328856) Ohnishi J … Takahashi T (Molecular endocrinology (Baltimore, Md.) 2001) 3 4 56
  5. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. (PMID: 9988691) Velasco G … López-Otín C (The Journal of biological chemistry 1999) 3 4 56

Products for MMP23B Gene

Sources for MMP23B Gene