This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008] See more...

Aliases for MMP23A Gene

Aliases for MMP23A Gene

  • Matrix Metallopeptidase 23A (Pseudogene) 2 3 5
  • Matrix Metalloproteinase 23A 2 3
  • Matrix Metalloproteinase In The Female Reproductive Tract 3
  • Matrix Metalloproteinase 23 Pseudogene 3
  • Matrix Metalloproteinase 21 3
  • Matrix Metallopeptidase 23A 2
  • Femalysin 3
  • MIFR-1 3
  • MMP21 3
  • MIFR 3

External Ids for MMP23A Gene

Previous HGNC Symbols for MMP23A Gene

  • MMP21

Previous GeneCards Identifiers for MMP23A Gene

  • GC01U990215
  • GC01P001436
  • GC01P001579
  • GC01P000048
  • GC01P9N0059
  • GC01P001557
  • GC01P001619
  • GC01P000908

Summaries for MMP23A Gene

Entrez Gene Summary for MMP23A Gene

  • This locus represents the partially duplicated copy of the MMP23B gene, and therefore considered a pseudogene. This pseudogene is part of a duplicated region of chromosome 1p36.3. It belongs to the more centromeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP23A Gene

MMP23A (Matrix Metallopeptidase 23A (Pseudogene)) is a Pseudogene.

Additional gene information for MMP23A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP23A Gene

Genomics for MMP23A Gene

GeneHancer (GH) Regulatory Elements for MMP23A Gene

Promoters and enhancers for MMP23A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001698 Promoter/Enhancer 0.5 Ensembl dbSUPER 750.6 +0.4 362 1.8 HSALNG0000186-002 MMP23A HSALNG0000191
GH01J001696 Enhancer 0.7 Ensembl dbSUPER 0.6 -2.6 -2638 1.4 MCM2 CDC5L MCM7 LARP7 YY2 ZNF280C HSALNG0000191 FAM87B INTS11 UBE2J2 CDK11B NOC2L ENSG00000234396 FAAP20 ATAD3B LINC01409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP23A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP23A gene promoter:
  • AML1a
  • C/EBPalpha
  • E47
  • ER-alpha
  • ITF-2
  • Nkx5-1
  • Tal-1
  • Tal-1beta
  • USF1
  • Zic3

Genomic Locations for MMP23A Gene

Genomic Locations for MMP23A Gene
chr1:1,699,939-1,701,808
(GRCh38/hg38)
Size:
1,870 bases
Orientation:
Plus strand
chr1:1,631,369-1,633,249
(GRCh37/hg19)
Size:
1,881 bases
Orientation:
Plus strand

Genomic View for MMP23A Gene

Genes around MMP23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP23A Gene

Proteins for MMP23A Gene

Post-translational modifications for MMP23A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MMP23A Gene

Domains & Families for MMP23A Gene

genes like me logo Genes that share domains with MMP23A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MMP23A Gene

Function for MMP23A Gene

Molecular function for MMP23A Gene

GENATLAS Biochemistry:
matrix metalloproteinase 23A,regulator in matrix remodeling,with three alternatively spliced isoforms A,B,C,expressed in ovary,testis,prostate

Phenotypes From GWAS Catalog for MMP23A Gene

genes like me logo Genes that share phenotypes with MMP23A: view

Animal Model Products

CRISPR Products

miRNA for MMP23A Gene

miRTarBase miRNAs that target MMP23A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MMP23A Gene

Localization for MMP23A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MMP23A Gene

Pathways & Interactions for MMP23A Gene

PathCards logo

SuperPathways for MMP23A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MMP23A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MMP23A Gene

Drugs & Compounds for MMP23A Gene

(1) Drugs for MMP23A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
genes like me logo Genes that share compounds with MMP23A: view

Transcripts for MMP23A Gene

mRNA/cDNA for MMP23A Gene

(3) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP23A Gene

No ASD Table

Relevant External Links for MMP23A Gene

GeneLoc Exon Structure for
MMP23A
ECgene alternative splicing isoforms for
MMP23A

Expression for MMP23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP23A Gene

mRNA differential expression in normal tissues according to GTEx for MMP23A Gene

This gene is overexpressed in Ovary (x5.7).

Protein differential expression in normal tissues from HIPED for MMP23A Gene

This gene is overexpressed in Testis (35.6), Lung (11.5), Prostate (9.2), and Ovary (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for MMP23A Gene



Protein tissue co-expression partners for MMP23A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MMP23A Gene:

MMP23A

SOURCE GeneReport for Unigene cluster for MMP23A Gene:

Hs.671760
genes like me logo Genes that share expression patterns with MMP23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP23A Gene

Orthologs for MMP23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP23A Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4264 32
Species where no ortholog for MMP23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP23A Gene

ENSEMBL:
Gene Tree for MMP23A (if available)
TreeFam:
Gene Tree for MMP23A (if available)

Paralogs for MMP23A Gene

(2) SIMAP similar genes for MMP23A Gene using alignment to 1 proteins:

  • MMP23_HUMAN
genes like me logo Genes that share paralogs with MMP23A: view

No data available for Paralogs for MMP23A Gene

Variants for MMP23A Gene

Sequence variations from dbSNP and Humsavar for MMP23A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001223299 -- 1,702,242(+) C/G/T downstream_transcript_variant
rs1002604896 -- 1,698,440(+) G/T upstream_transcript_variant
rs1004263891 -- 1,698,699(+) A/C upstream_transcript_variant
rs1004658658 -- 1,699,490(+) A/T upstream_transcript_variant
rs1008851456 -- 1,699,913(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP23A Gene

Variant ID Type Subtype PubMed ID
dgv2e199 CNV deletion 23128226
dgv2e214 CNV loss 21293372
dgv38n54 CNV gain 21841781
dgv39n54 CNV loss 21841781
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv4e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
dgv9n100 CNV loss 25217958
esv2659399 CNV deletion 23128226
esv2661270 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv2764265 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3577686 CNV loss 25503493
esv3585007 CNV loss 21293372
esv3585010 CNV loss 21293372
esv3585015 CNV gain 21293372
esv3891747 CNV loss 25118596
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv1160864 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv436343 CNV deletion 17901297
nsv442858 CNV gain+loss 18776908
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545026 CNV loss 21841781
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv834091 CNV loss 17160897
nsv950452 CNV deletion 24416366
nsv950516 CNV deletion 24416366

Additional Variant Information for MMP23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MMP23A Gene

Disorders for MMP23A Gene

Additional Disease Information for MMP23A

No disorders were found for MMP23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP23A Gene

Publications for MMP23A Gene

  1. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3. (PMID: 9740677) Gururajan R … Kidd VJ (Genomics 1998) 2 3 23 56
  2. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R … Kidd VJ (Genome research 1998) 2 3 56
  3. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. (PMID: 19965868) Rangaraju S … Chandy KG (The Journal of biological chemistry 2010) 3 56
  4. Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness. (PMID: 18286480) Hegedüs L … Eliceiri GL (Journal of cellular physiology 2008) 23 56
  5. Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure. (PMID: 15483646) Gajecka M … Shaffer LG (European journal of human genetics : EJHG 2005) 3 56

Products for MMP23A Gene

Sources for MMP23A Gene