Aliases for MMP21 Gene
External Ids for MMP21 Gene
Previous GeneCards Identifiers for MMP21 Gene
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
GeneCards Summary for MMP21 Gene
MMP21 (Matrix Metallopeptidase 21) is a Protein Coding gene. Diseases associated with MMP21 include Heterotaxy, Visceral, 7, Autosomal and Visceral Heterotaxy. Among its related pathways are Integrin Pathway and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP15.
UniProtKB/Swiss-Prot Summary for MMP21 Gene
Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721).
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.