Aliases for MMP19 Gene
External Ids for MMP19 Gene
Previous HGNC Symbols for MMP19 Gene
Previous GeneCards Identifiers for MMP19 Gene
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
GeneCards Summary for MMP19 Gene
MMP19 (Matrix Metallopeptidase 19) is a Protein Coding gene. Diseases associated with MMP19 include Cavitary Optic Disc Anomalies and Multiple Sclerosis. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP15.
UniProtKB/Swiss-Prot Summary for MMP19 Gene
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.