MMP17 Gene (Protein Coding)

Matrix Metallopeptidase 17

GC12P131828
GIFtS:
44
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of t... See more...

Aliases for MMP17 Gene

Aliases for MMP17 Gene

  • Matrix Metallopeptidase 17 2 3 5
  • Matrix Metalloproteinase 17 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 17 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 4 3 4
  • Membrane-Type-4 Matrix Metalloproteinase 3 4
  • Matrix Metalloproteinase-17 3 4
  • MT-MMP 4 3 4
  • MT4-MMP 3 4
  • MMP-17 3 4
  • MT4MMP 3 4
  • MTMMP4 3 4
  • EC 3.4.24.- 4

External Ids for MMP17 Gene

Previous GeneCards Identifiers for MMP17 Gene

  • GC12U990053
  • GC12P131752
  • GC12P132193
  • GC12P130807
  • GC12P130979
  • GC12P130878
  • GC12P132312
  • GC12P129198

Summaries for MMP17 Gene

Entrez Gene Summary for MMP17 Gene

  • This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP17 Gene

MMP17 (Matrix Metallopeptidase 17) is a Protein Coding gene. Diseases associated with MMP17 include Aortic Aneurysm, Familial Thoracic 1. Among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.

UniProtKB/Swiss-Prot Summary for MMP17 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala- -Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Tocris Summary for MMP17 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP17 Gene

Additional gene information for MMP17 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP17 Gene

Genomics for MMP17 Gene

GeneHancer (GH) Regulatory Elements for MMP17 Gene

Promoters and enhancers for MMP17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP17 gene promoter:
  • AP-1
  • C/EBPalpha
  • CHOP-10
  • HSF1short
  • RFX1
  • Sp1
  • Zic1

Genomic Locations for MMP17 Gene

Genomic Locations for MMP17 Gene
chr12:131,828,393-131,851,783
(GRCh38/hg38)
Size:
23,391 bases
Orientation:
Plus strand
chr12:132,312,938-132,336,328
(GRCh37/hg19)
Size:
23,391 bases
Orientation:
Plus strand

Genomic View for MMP17 Gene

Genes around MMP17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MMP17 Gene

Proteins for MMP17 Gene

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  3. Assay

  • Protein details for MMP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULZ9-MMP17_HUMAN
    Recommended name:
    Matrix metalloproteinase-17
    Protein Accession:
    Q9ULZ9
    Secondary Accessions:
    • Q14850

    Protein attributes for MMP17 Gene

    Size:
    603 amino acids
    Molecular mass:
    66653 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP17 Gene

Protein Expression for MMP17 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MMP17 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn137 and Asn318
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMP17 Gene

Domains & Families for MMP17 Gene

Gene Families for MMP17 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MMP17 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MMP17 Gene

GenScript: Design optimal peptide antigens:
  • Membrane-type-4 matrix metalloproteinase (MMP17_HUMAN)
  • MMP17 protein (Q5U5M0_HUMAN)
  • MMP17 protein (Q8IWC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULZ9

UniProtKB/Swiss-Prot:

MMP17_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP17: view

Function for MMP17 Gene

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  1. Animal Model
  2. CRISPR
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  6. Cell Line

Molecular function for MMP17 Gene

UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala- -Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.
GENATLAS Biochemistry:
membrane type 4-matrix metalloproteinase 17,mainly predominantly expressed in brain and leukocytes,colon,ovary,testis,linked to D12S367,with one minor non expressed transcript and a major alternatively spliced,involved in neurogenesis

Enzyme Numbers (IUBMB) for MMP17 Gene

Phenotypes From GWAS Catalog for MMP17 Gene

Gene Ontology (GO) - Molecular Function for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,IBA 21873635
GO:0008047 enzyme activator activity TAS 8640782
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP17: view
genes like me logo Genes that share phenotypes with MMP17: view

Animal Models for MMP17 Gene

MGI Knock Outs for MMP17:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP17

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP17

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP17 Gene

Localization for MMP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP17 Gene

Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP17 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP17 Gene

Pathways & Interactions for MMP17 Gene

genes like me logo Genes that share pathways with MMP17: view

Pathways by source for MMP17 Gene

1 BioSystems pathway for MMP17 Gene
1 Qiagen pathway for MMP17 Gene
  • Inhibition of Matrix Metalloproteinases
1 GeneTex pathway for MMP17 Gene

Gene Ontology (GO) - Biological Process for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006508 proteolysis IEA,TAS 14645246
GO:0030198 extracellular matrix organization IBA 21873635
GO:0030574 collagen catabolic process IBA 21873635
GO:0042756 drinking behavior IEA --
genes like me logo Genes that share ontologies with MMP17: view

No data available for SIGNOR curated interactions for MMP17 Gene

Drugs & Compounds for MMP17 Gene

Products:

  1. Drug

(5) Drugs for MMP17 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
Marimastat Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0
PD 166793 Pharma MMP inhibitor, Broad spectrum MMP inhibitor 0

(3) Tocris Compounds for MMP17 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP17: view

Transcripts for MMP17 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MMP17 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP17

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MMP17 Gene

GeneLoc Exon Structure for
MMP17
ECgene alternative splicing isoforms for
MMP17

Expression for MMP17 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP17 Gene

mRNA expression in normal human tissues for MMP17 Gene
mRNA expression by BioGPS for MMP17 GenemRNA expression by GTEx for MMP17 Gene

mRNA differential expression in normal tissues according to GTEx for MMP17 Gene

This gene is overexpressed in Brain - Cortex (x4.8) and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for MMP17 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP17 Gene



Protein tissue co-expression partners for MMP17 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP17 Gene:

MMP17

SOURCE GeneReport for Unigene cluster for MMP17 Gene:

Hs.709245

mRNA Expression by UniProt/SwissProt for MMP17 Gene:

Q9ULZ9-MMP17_HUMAN
Tissue specificity: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
genes like me logo Genes that share expression patterns with MMP17: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP17 Gene

Orthologs for MMP17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MMP17 33 32
  • 98.87 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MMP17 33 32
  • 85.78 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MMP17 33 32
  • 84.22 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mmp17 17 33 32
  • 83.66 (n)
rat
(Rattus norvegicus)
 Mammalia Mmp17 32
  • 83.4 (n)
oppossum
(Monodelphis domestica)
 Mammalia MMP17 33
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MMP17 33 32
  • 76.72 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MMP17 33
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mmp17 32
  • 66.92 (n)
zebrafish
(Danio rerio)
 Actinopterygii mmp17a 33 32
  • 69.28 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011870 32
  • 54.44 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Mmp2 34 32
  • 51.39 (n)
Mmp1 34
  • 33 (a)
worm
(Caenorhabditis elegans)
 Secernentea zmp-1 32
  • 40.98 (n)
C31B8.8 34
  • 38 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 37 (a)
 OneToMany
Species where no ortholog for MMP17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP17 Gene

ENSEMBL:
Gene Tree for MMP17 (if available)
TreeFam:
Gene Tree for MMP17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP17: view image

Paralogs for MMP17 Gene

Paralogs for MMP17 Gene

(18) SIMAP similar genes for MMP17 Gene using alignment to 9 proteins:

  • MMP17_HUMAN
  • F5GWR3_HUMAN
  • F5GZA7_HUMAN
  • F5H209_HUMAN
  • F5H249_HUMAN
  • F5H846_HUMAN
  • F5H881_HUMAN
  • Q5U5M0_HUMAN
  • Q8IWC3_HUMAN
genes like me logo Genes that share paralogs with MMP17: view

Variants for MMP17 Gene

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Sequence variations from dbSNP and Humsavar for MMP17 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000281762 -- 131,851,145(+) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000523412 -- 131,847,279(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000617440 -- 131,844,593(+) G/A intron_variant, non_coding_transcript_variant
rs1000671446 -- 131,829,457(+) CCCCCCC/CCCCCC/CCCCCCCC genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000855605 -- 131,848,959(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP17 Gene

Variant ID Type Subtype PubMed ID
esv2746901 CNV deletion 23290073
esv2746902 CNV deletion 23290073
esv2751042 CNV gain 17911159
esv3631278 CNV loss 21293372
nsv1052544 CNV gain 25217958
nsv1070152 CNV deletion 25765185
nsv1071075 CNV deletion 25765185
nsv1143716 CNV deletion 24896259
nsv455803 CNV gain 19166990
nsv455804 CNV loss 19166990
nsv560927 CNV gain 21841781
nsv560928 CNV gain 21841781
nsv560929 CNV loss 21841781
nsv560930 CNV loss 21841781
nsv560931 CNV loss 21841781
nsv560932 CNV loss 21841781
nsv826561 CNV gain 20364138
nsv832555 CNV loss 17160897

Variation tolerance for MMP17 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.50; 88.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP17 Gene

Disorders for MMP17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MMP17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aortic aneurysm, familial thoracic 1
  • aat1
- elite association - COSMIC cancer census association via MalaCards
Search MMP17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP17 Gene

Publications for MMP17 Gene

  1. Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. (PMID: 10471807) Kajita M … Seiki M (FEBS letters 1999) 3 4 23 56
  2. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. (PMID: 10567400) Itoh Y … Seiki M (The Journal of biological chemistry 1999) 3 4 23 56
  3. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. (PMID: 9878265) Puente XS … López-Otín C (Genomics 1998) 2 3 23 56
  4. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. (PMID: 8640782) Puente XS … López-Otín C (Cancer research 1996) 3 4 23 56
  5. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 43 56

ExternalLinks

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