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This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]
MMP17 (Matrix Metallopeptidase 17) is a Protein Coding gene. Diseases associated with MMP17 include Arthritis and Breast Cancer. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004222 | metalloendopeptidase activity | IEA,IBA | 21873635 |
GO:0008047 | enzyme activator activity | TAS | 8640782 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031012 | extracellular matrix | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
|
|
2 | Degradation of the extracellular matrix | ||
3 | Parathyroid hormone synthesis, secretion and action |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0006508 | proteolysis | IEA,TAS | 14645246 |
GO:0030198 | extracellular matrix organization | IBA | 21873635 |
GO:0030574 | collagen catabolic process | IBA | 21873635 |
GO:0042756 | drinking behavior | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Marimastat | Investigational | Pharma | Target, inhibitor | MMPs inhibitor,board spectrum | 4 | |
Calcium | Nutra | 6556 | ||||
ARP 100 | Pharma | Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 | 0 | |||
ARP 101 | Pharma | MMP inhibitor,potent and selective, Inhibitor of MMP-2 | 0 | |||
PD 166793 | Pharma | MMP inhibitor, Broad spectrum MMP inhibitor | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MMP17 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MMP17 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MMP17 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mmp17 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mmp17 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MMP17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MMP17 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MMP17 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mmp17 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mmp17a 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011870 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mmp2 30 32 |
|
||
Mmp1 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | zmp-1 30 |
|
||
C31B8.8 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711465 | Benign: not provided | 131,841,736(+) | G/A | SYNONYMOUS_VARIANT | |
715457 | Benign: not provided | 131,849,915(+) | A/G | MISSENSE_VARIANT | |
776779 | Benign: not provided | 131,840,747(+) | C/A | SYNONYMOUS_VARIANT | |
777691 | Benign: not provided | 131,841,661(+) | C/T | SYNONYMOUS_VARIANT | |
782132 | Likely Benign: not provided | 131,838,267(+) | C/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2746901 | CNV | deletion | 23290073 |
esv2746902 | CNV | deletion | 23290073 |
esv2751042 | CNV | gain | 17911159 |
esv3631278 | CNV | loss | 21293372 |
nsv1052544 | CNV | gain | 25217958 |
nsv1070152 | CNV | deletion | 25765185 |
nsv1071075 | CNV | deletion | 25765185 |
nsv1143716 | CNV | deletion | 24896259 |
nsv455803 | CNV | gain | 19166990 |
nsv455804 | CNV | loss | 19166990 |
nsv560927 | CNV | gain | 21841781 |
nsv560928 | CNV | gain | 21841781 |
nsv560929 | CNV | loss | 21841781 |
nsv560930 | CNV | loss | 21841781 |
nsv560931 | CNV | loss | 21841781 |
nsv560932 | CNV | loss | 21841781 |
nsv826561 | CNV | gain | 20364138 |
nsv832555 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
arthritis |
|
|
breast cancer |
|