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Aliases for MMP16 Gene

Aliases for MMP16 Gene

  • Matrix Metallopeptidase 16 2 3 5
  • Matrix Metallopeptidase 16 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 3 3 4
  • Membrane-Type-3 Matrix Metalloproteinase 3 4
  • MT-MMP 3 3 4
  • C8orf57 3 4
  • MT3-MMP 3 4
  • MMP-16 3 4
  • MMP-X2 3 4
  • MT3MMP 3 4
  • MTMMP3 3 4
  • Matrix Metalloproteinase 16 (Membrane-Inserted) 2
  • Putative Transmembrane Protein C8orf57 3
  • Chromosome 8 Open Reading Frame 57 2
  • Matrix Metalloproteinase-16 3
  • EC 3.4.24.- 4
  • MT-MMP2 3
  • MT-MMP3 3
  • MMPX2 4

External Ids for MMP16 Gene

Previous HGNC Symbols for MMP16 Gene

  • C8orf57

Previous GeneCards Identifiers for MMP16 Gene

  • GC08M087480
  • GC08M088781
  • GC08M089009
  • GC08M088999
  • GC08M089118
  • GC08M084259
  • GC08M089044

Summaries for MMP16 Gene

Entrez Gene Summary for MMP16 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

GeneCards Summary for MMP16 Gene

MMP16 (Matrix Metallopeptidase 16) is a Protein Coding gene. Diseases associated with MMP16 include Seminoma and Osteochondrosis. Among its related pathways are Cell adhesion_ECM remodeling and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP24.

UniProtKB/Swiss-Prot for MMP16 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Tocris Summary for MMP16 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP16 Gene

Additional gene information for MMP16 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP16 Gene

Genomics for MMP16 Gene

GeneHancer (GH) Regulatory Elements for MMP16 Gene

Promoters and enhancers for MMP16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J088325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 689.8 +1.0 1034 4.8 HDGF PKNOX1 NEUROD1 SIN3A ZNF2 ZBTB7B ETS1 ZNF143 SP3 ZNF592 MMP16 ENSG00000253553
GH08J088297 Enhancer 0.8 Ensembl ENCODE 33.4 +28.7 28746 4.5 SMARCA5 CTCF JUN EBF1 RELA ZNF217 IKZF1 NBN FOS SPI1 MMP16 ENSG00000253553 GC08M088033
GH08J088424 Enhancer 0.6 ENCODE 34.3 -97.3 -97262 1.5 CTCF PKNOX1 USF1 RFX5 SP1 SREBF1 JUND FOS FOSL2 MMP16 LOC100129100 ENSG00000253553 LOC105375629
GH08J088365 Enhancer 0.5 ENCODE 36.6 -38.6 -38600 2.1 SP1 FOXA2 NANOG POU5F1 FOXA1 MMP16 GC08P088375 PIR33898 ENSG00000253553
GH08J088590 Enhancer 0.6 ENCODE 18.6 -263.8 -263847 2.5 USF1 NANOG MAX SIN3A USF2 ATF2 SP1 POLR2A POU5F1 MMP16 LOC105375629 LOC100129100 ENSG00000253553
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP16 gene promoter:
  • ATF
  • Tal-1beta
  • E47
  • ITF-2
  • Pax-5
  • Nkx2-2

Genomic Locations for MMP16 Gene

Genomic Locations for MMP16 Gene
chr8:88,003,095-88,328,025
(GRCh38/hg38)
Size:
324,931 bases
Orientation:
Minus strand
chr8:89,044,237-89,340,254
(GRCh37/hg19)
Size:
296,018 bases
Orientation:
Minus strand

Genomic View for MMP16 Gene

Genes around MMP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP16 Gene

Proteins for MMP16 Gene

  • Protein details for MMP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51512-MMP16_HUMAN
    Recommended name:
    Matrix metalloproteinase-16
    Protein Accession:
    P51512
    Secondary Accessions:
    • B2RAN7
    • Q14824
    • Q52H48

    Protein attributes for MMP16 Gene

    Size:
    607 amino acids
    Molecular mass:
    69521 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.

    Three dimensional structures from OCA and Proteopedia for MMP16 Gene

    Alternative splice isoforms for MMP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP16 Gene

Post-translational modifications for MMP16 Gene

Other Protein References for MMP16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MMP16 Gene

Domains & Families for MMP16 Gene

Gene Families for MMP16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MMP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51512

UniProtKB/Swiss-Prot:

MMP16_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP16: view

Function for MMP16 Gene

Molecular function for MMP16 Gene

UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
UniProtKB/Swiss-Prot EnzymeRegulation:
TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
GENATLAS Biochemistry:
matrix metalloproteinase 16,membrane-type,activator of MMP2,possessing a proteolytic activity against extracellular matrix molecules,expressed in placenta,brain and lung

Enzyme Numbers (IUBMB) for MMP16 Gene

Phenotypes From GWAS Catalog for MMP16 Gene

Gene Ontology (GO) - Molecular Function for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA,IEA 27229514
GO:0008047 enzyme activator activity TAS 7559440
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA,IDA 27229514
genes like me logo Genes that share ontologies with MMP16: view
genes like me logo Genes that share phenotypes with MMP16: view

Animal Models for MMP16 Gene

MGI Knock Outs for MMP16:

Animal Model Products

Clone Products

  • Addgene plasmids for MMP16

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP16 Gene

Localization for MMP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP16 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.
Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP16 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytosol 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 7559440
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with MMP16: view

Pathways & Interactions for MMP16 Gene

genes like me logo Genes that share pathways with MMP16: view

Pathways by source for MMP16 Gene

1 GeneTex pathway for MMP16 Gene
1 BioSystems pathway for MMP16 Gene
1 GeneGo (Thomson Reuters) pathway for MMP16 Gene
1 Qiagen pathway for MMP16 Gene

Gene Ontology (GO) - Biological Process for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006508 proteolysis TAS,IEA 14645246
GO:0016485 protein processing IDA 27229514
GO:0019538 protein metabolic process TAS 21768085
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with MMP16: view

No data available for SIGNOR curated interactions for MMP16 Gene

Drugs & Compounds for MMP16 Gene

(8) Drugs for MMP16 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
calcium Approved Nutra 0
Batimastat Experimental Pharma Target 0
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0

(3) Additional Compounds for MMP16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP16 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP16: view

Transcripts for MMP16 Gene

mRNA/cDNA for MMP16 Gene

Unigene Clusters for MMP16 Gene

Matrix metallopeptidase 16 (membrane-inserted):
Representative Sequences:

Clone Products

  • Addgene plasmids for MMP16

Alternative Splicing Database (ASD) splice patterns (SP) for MMP16 Gene

No ASD Table

Relevant External Links for MMP16 Gene

GeneLoc Exon Structure for
MMP16
ECgene alternative splicing isoforms for
MMP16

Expression for MMP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP16 Gene

This gene is overexpressed in Plasma (22.2), Milk (9.6), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP16 Gene



Protein tissue co-expression partners for MMP16 Gene

NURSA nuclear receptor signaling pathways regulating expression of MMP16 Gene:

MMP16

SOURCE GeneReport for Unigene cluster for MMP16 Gene:

Hs.546267

mRNA Expression by UniProt/SwissProt for MMP16 Gene:

P51512-MMP16_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Evidence on tissue expression from TISSUES for MMP16 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with MMP16: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP16 Gene

Orthologs for MMP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP16 34 33
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MMP-16 34
  • 98 (a)
OneToOne
MMP16 33
  • 93.19 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP16 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP16 34 33
  • 94.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp16 16 34 33
  • 93.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MMP16 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp16 33
  • 92 (n)
chicken
(Gallus gallus)
Aves MMP16 34 33
  • 87.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP16 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp16 33
  • 80.61 (n)
zebrafish
(Danio rerio)
Actinopterygii mmp16a 34
  • 76 (a)
OneToMany
CABZ01029422.1 34
  • 74 (a)
OneToMany
mmp16b 34 33
  • 70.11 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2106 33
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 35
  • 36 (a)
Mmp2 34 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 35
  • 41 (a)
H19M22.3a 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
ManyToMany
Species where no ortholog for MMP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP16 Gene

ENSEMBL:
Gene Tree for MMP16 (if available)
TreeFam:
Gene Tree for MMP16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP16: view image

Paralogs for MMP16 Gene

(17) SIMAP similar genes for MMP16 Gene using alignment to 2 proteins:

  • MMP16_HUMAN
  • E5RJA7_HUMAN
genes like me logo Genes that share paralogs with MMP16: view

Variants for MMP16 Gene

Sequence variations from dbSNP and Humsavar for MMP16 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000000891 -- 88,181,277(-) T/C intron_variant
rs1000007563 -- 88,049,436(-) T/C intron_variant
rs1000018420 -- 88,051,498(-) T/A intron_variant
rs1000023598 -- 88,185,518(-) A/G intron_variant
rs1000039588 -- 88,309,064(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP16 Gene

Variant ID Type Subtype PubMed ID
esv1991117 CNV deletion 18987734
esv2188156 CNV deletion 18987734
esv23361 CNV loss 19812545
esv2669999 CNV deletion 23128226
esv2671281 CNV deletion 23128226
esv2737272 CNV deletion 23290073
esv2737273 CNV deletion 23290073
esv2737275 CNV deletion 23290073
esv2737276 CNV deletion 23290073
esv2759625 CNV loss 17122850
esv3247 CNV loss 18987735
esv3543804 CNV deletion 23714750
esv3617938 CNV gain 21293372
esv3617939 CNV loss 21293372
esv3617940 CNV loss 21293372
esv3617942 CNV loss 21293372
nsv1124359 CNV deletion 24896259
nsv1139939 CNV duplication 24896259
nsv396473 CNV deletion 16902084
nsv474154 CNV novel sequence insertion 20440878
nsv527243 CNV loss 19592680
nsv831386 CNV gain 17160897

Variation tolerance for MMP16 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 21.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP16 Gene

Disorders for MMP16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MMP16 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
seminoma
  • seminoma, pure
osteochondrosis
  • juvenile osteochondrosis of tibial tubercle
- elite association - COSMIC cancer census association via MalaCards
Search MMP16 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP16 Gene

Publications for MMP16 Gene

  1. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. (PMID: 7559440) Takino T … Seiki M (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development. (PMID: 18784838) Hadchouel A … Delacourt C (PloS one 2008) 3 22 44 58
  3. Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PMID: 11278606) Iida J … McCarthy JB (The Journal of biological chemistry 2001) 3 4 22 58
  4. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. (PMID: 9092507) Shofuda K … Miyazaki K (The Journal of biological chemistry 1997) 3 4 22 58
  5. Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA. (PMID: 9396633) Matsumoto S … Masuho Y (Biochimica et biophysica acta 1997) 3 4 22 58

Products for MMP16 Gene

Sources for MMP16 Gene

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