Aliases for MMP15 Gene
External Ids for MMP15 Gene
Previous GeneCards Identifiers for MMP15 Gene
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
GeneCards Summary for MMP15 Gene
MMP15 (Matrix Metallopeptidase 15) is a Protein Coding gene. Diseases associated with MMP15 include Supraglottis Cancer and Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency. Among its related pathways are Cell adhesion_ECM remodeling and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP24.
UniProtKB/Swiss-Prot Summary for MMP15 Gene
Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.