Aliases for MMP14 Gene
Aliases for MMP14 Gene
External Ids for MMP14 Gene
- HGNC: 7160
- Entrez Gene: 4323
- Ensembl: ENSG00000157227
- OMIM: 600754
- UniProtKB: P50281
Previous GeneCards Identifiers for MMP14 Gene
- GC14P020678
- GC14P017093
- GC14P021295
- GC14P022375
- GC14P023305
- GC14P003422
- GC14P022837
- GC14P022839
- GC14P023827
- GC14P023920
- GC14P024028
- GC14P024145
Summaries for MMP14 Gene
-
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP14 Gene
MMP14 (Matrix Metallopeptidase 14) is a Protein Coding gene. Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Cell adhesion_ECM remodeling and Signaling events mediated by focal adhesion kinase. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and metalloendopeptidase activity. An important paralog of this gene is MMP15.
UniProtKB/Swiss-Prot for MMP14 Gene
-
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
-
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.
Additional gene information for MMP14 Gene
- Monarch Initiative
- Search for MMP14 at DataMed
- Search for MMP14 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP14 Gene
Genomics for MMP14 Gene
GeneHancer (GH) Regulatory Elements for MMP14 Gene
Promoters and enhancers for MMP14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MMP14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MMP14 gene promoter:
-
- AP-1
- AP-2alphaA
- AP-2alpha isoform 4
- AP-2alpha isoform 3
- AP-2alpha isoform 2
- AP-2alpha
- c-Jun
- ATF-2
- AREB6
- AP-4
Regulatory Element Products
Genomic Locations for MMP14 Gene
Genomic Locations for MMP14 Gene
- chr14:22,836,533-22,849,027
- (GRCh38/hg38)
- Size:
- 12,495 bases
- Orientation:
- Plus strand
- chr14:23,305,766-23,318,236
- (GRCh37/hg19)
- Size:
- 12,471 bases
- Orientation:
- Plus strand
Genomic View for MMP14 Gene
Genes around MMP14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
- 14q11.2 by Ensembl
MMP14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MMP14 Gene
Proteins for MMP14 Gene
-
Protein details for MMP14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50281-MMP14_HUMAN
- Recommended name:
- Matrix metalloproteinase-14
- Protein Accession:
- P50281
- A8K5L0
- Q6GSF3
- Q92678
Protein attributes for MMP14 Gene
- Size:
- 582 amino acids
- Molecular mass:
- 65894 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Interacts (via C-terminal cytoplasmic tail) with BST2. Interacts with DLL1; inhibits DLL1-induced Notch signaling (PubMed:21572390).
Protein Expression for MMP14 Gene
Post-translational modifications for MMP14 Gene
- The precursor is cleaved by a furin endopeptidase.
- Tyrosine phosphorylated by PKDCC/VLK.
- Glycosylation at isoforms=304, isoforms=301, Thr300, Thr299, isoforms=291, and Thr77
- Modification sites at PhosphoSitePlus
Other Protein References for MMP14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MMP14 (MMP-14/MT1-MMP)
-
Custom Antibody ServicesOriGene Antibodies for MMP14
- Novus Biologicals Antibodies for MMP14
-
Abcam antibodies for MMP14
- Invitrogen Antibodies for MMP14
- antibodies-online: Search results for 266 available MMP14 Antibodies ranked by validation data
- Compare Top MMP14 Antibodies
-
Recommended
- 216 WB Antibodies (anti-human)
- 17 FACS Antibodies (anti-human)
- 9 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 54 WB Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 51 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- GeneTex MMP14 Antibody for MMP14
-
Santa Cruz Biotechnology (SCBT) Antibodies for MMP14
Protein Products
- R&D Systems Proteins and Enzymes for MMP14 (MMP-14/MT1-MMP)
-
OriGene Purified Proteins for MMP14
- Search Origene for MassSpec and Protein Over-expression Lysates for MMP14
- Origene Custom Protein Services for MMP14
- ProSpec Recombinant Proteins for MMP14
- Search GeneTex for Proteins for MMP14
-
Abcam proteins for MMP14
Assay Products
- R&D Systems ELISAs and other biochemical assays for MMP14 (MMP-14/MT1-MMP)
-
Boster Bio ELISA Kits for MMP14
No data available for DME Specific Peptides for MMP14 Gene
Domains & Families for MMP14 Gene
Gene Families for MMP14 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for MMP14 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MMP14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P50281UniProtKB/Swiss-Prot:
MMP14_HUMAN :- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- Belongs to the peptidase M10A family.
- Domain:
-
- The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
- Family:
-
- Belongs to the peptidase M10A family.
Function for MMP14 Gene
Molecular function for MMP14 Gene
- UniProtKB/Swiss-Prot Function:
- Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn- -Leu-38. Other bonds hydrolyzed include 35-Gly- -Ile-36 in the propeptide of collagenase 3, and 341-Asn- -Phe-342, 441-Asp- -Leu-442 and 354-Gln- -Thr-355 in the aggrecan interglobular domain.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by NANOS1.
- GENATLAS Biochemistry:
- matrix metalloproteinase 14,regulator in matrix remodeling in the MMP cluster,membrane-type,involved in pathophysiology of malignant gliomas by glial invasion and angiogenesis,required for the activation of MMP2 in the stronal cancer cells
Enzyme Numbers (IUBMB) for MMP14 Gene
Phenotypes From GWAS Catalog for MMP14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA,TAS | -- |
| GO:0004252 | serine-type endopeptidase activity | TAS | -- |
| GO:0005178 | integrin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12220632 |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for MMP14 Gene
- MGI mutant phenotypes for MMP14:
-
inferred from 9 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for MMP14:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
Animal Models for MMP14 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MMP14
-
CRISPR Products
-
OriGene CRISPR knockouts for MMP14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMP14
- genomics-online: gRNA clones - Search results for 114 available MMP14 gene related products
- Overview of 114 available MMP14 gene related products
- Applied Biological Materials CRISPR for MMP14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMP14
- GenScript: Design CRISPR guide RNA sequences for MMP14
miRNA for MMP14 Gene
- miRTarBase miRNAs that target MMP14
-
- hsa-mir-335-5p (MIRT016970)
- hsa-mir-145-5p (MIRT021533)
- hsa-mir-181a-5p (MIRT053694)
- hsa-mir-133a-3p (MIRT437400)
- hsa-mir-24-3p (MIRT437500)
- hsa-mir-22-3p (MIRT732074)
- hsa-mir-10a-5p (MIRT734252)
- hsa-mir-193a-3p (MIRT734596)
- hsa-mir-150-5p (MIRT734650)
- hsa-mir-143-3p (MIRT734787)
- hsa-mir-133b (MIRT735376)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMP14
- Browse OriGene Inhibitory RNA Products For MMP14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP14
- genomics-online: shRNA clones - Search results for 114 available MMP14 gene related products
- Overview of 114 available MMP14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MMP14
- VectorBuilder custom plasmid, inducible vectors for MMP14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MMP14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MMP14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMP14
- Applied Biological Materials Clones for MMP14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MMP14
No data available for Transcription Factor Targets and HOMER Transcription for MMP14 Gene
Localization for MMP14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MMP14 Gene
- Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| nucleus | 4 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Intermediate filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IMP | 24784232 |
| GO:0005634 | nucleus | IMP | 24784232 |
| GO:0005737 | colocalizes_with cytoplasm | IEA,IDA | 22065321 |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MMP14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Matrix Metalloproteinases | ||
| 2 | Degradation of the extracellular matrix | ||
| 3 | Development Endothelin-1/EDNRA signaling | ||
| 4 | Parathyroid hormone synthesis, secretion and action | ||
| 5 | TNF signaling pathway | ||
Pathways by source for MMP14 Gene
5 BioSystems pathways for MMP14 Gene
4 Reactome pathways for MMP14 Gene
3 KEGG pathways for MMP14 Gene
1 GeneGo (Thomson Reuters) pathway for MMP14 Gene
2 Qiagen pathways for MMP14 Gene
1 Cell Signaling Technology pathway for MMP14 Gene
Interacting Proteins for MMP14 Gene
Selected Interacting proteins:
P50281-MMP14_HUMAN
ENSP00000308208
for MMP14 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MMP14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001935 | endothelial cell proliferation | IEA | -- |
| GO:0001958 | endochondral ossification | IEA | -- |
Drugs & Compounds for MMP14 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Marimastat | Approved, Investigational | Pharma | Target, inhibitor | MMPs inhibitor,board spectrum | 4 | |
| calcium | Approved | Nutra | 0 | |||
| Prinomastat | Investigational | Pharma | inhibitor, Vaccine | Vaccines | 3 | |
| NSC 405020 | Pharma | MT1-MMP inhibitor | 0 | |||
| Ro 32-3555 | Pharma | MMP inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) Tocris Compounds for MMP14 Gene
(3) ApexBio Compounds for MMP14 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Marimastat | MMPs inhibitor,board spectrum | 154039-60-8 |
| NSC 405020 | MT1-MMP inhibitor | 7497-07-6 |
| Ro 32-3555 | MMP inhibitor | 190648-49-8 |
Transcripts for MMP14 Gene
mRNA/cDNA for MMP14 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (178) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000311852 3732 bps (uc001whc.5)
- ENST00000547074 560 bps (uc058zjt.1)
- ENST00000548162 1740 bps (uc058zju.1)
- ENST00000547279 412 bps (uc058zjv.1)
- ENST00000548761 582 bps (uc058zjw.1)
Unigene Clusters for MMP14 Gene
- Matrix metallopeptidase 14 (membrane-inserted):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MMP14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMP14
- genomics-online: gRNA clones - Search results for 114 available MMP14 gene related products
- Overview of 114 available MMP14 gene related products
- Applied Biological Materials CRISPR for MMP14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMP14
- GenScript: Design CRISPR guide RNA sequences for MMP14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMP14
- Browse OriGene Inhibitory RNA Products For MMP14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP14
- genomics-online: shRNA clones - Search results for 114 available MMP14 gene related products
- Overview of 114 available MMP14 gene related products
Clone Products
- Sino Biological Human cDNA Clone for MMP14
- VectorBuilder custom plasmid, inducible vectors for MMP14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MMP14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MMP14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMP14
- Applied Biological Materials Clones for MMP14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MMP14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Terminal Chondrocytes Caudal Facial Endochondral Bones
- Terminal Chondrocytes Mandibular Condyle
- Terminal Chondrocytes Rib
- Terminal Chondrocytes Stylopod Growth Plate
- Hypertrophic Chondrocytes Mandibular Condyle
-
Cartilage (Muscoskeletal System)
- Terminal Chondrocytes Caudal Facial Endochondral Bones
- Terminal Chondrocytes Mandibular Condyle
- Terminal Chondrocytes Rib
- Terminal Chondrocytes Stylopod Growth Plate
- Hypertrophic Chondrocytes Mandibular Condyle
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Odontoblasts Dentin
- Inner Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Early Ameloblasts Dental Enamel
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
- Smooth Muscle (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Ovary (Reproductive System)
This gene is overexpressed in Amniocyte (42.1), Bone (8.3), and Liver (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP14 Gene
NURSA nuclear receptor signaling pathways regulating expression of MMP14 Gene:
MMP14SOURCE GeneReport for Unigene cluster for MMP14 Gene:
Hs.2399mRNA Expression by UniProt/SwissProt for MMP14 Gene:
P50281-MMP14_HUMAN
Tissue specificity:
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
Evidence on tissue expression from TISSUES for MMP14 Gene
- Lung(4.7)
- Skin(4.6)
- Heart(2.8)
- Nervous system(2.8)
- Muscle(2.5)
- Intestine(2.4)
- Lymph node(2.4)
- Kidney(2.3)
- Eye(2)
- Gall bladder(2)
- Stomach(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP14 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- chin
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- skull
- tooth
Thorax:
- chest wall
- clavicle
- lung
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for MMP14
-
OriGene qPCR primer pairs for MMP14
- genomics-online: primer clones - Search results for 114 available MMP14 gene related products
- Overview of 114 available MMP14 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for MMP14 Gene
Orthologs for MMP14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MMP14 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MMP-14 34 |
|
OneToOne | |
| MMP14 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | MMP14 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mmp14 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mmp14 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MMP14 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MMP14 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MMP14 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mmp14 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23718 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mmp14b 34 33 33 |
|
OneToMany | |
| mmp14a 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Mmp1 35 33 |
|
||
| Mmp2 34 35 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006904 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | H36L18.1 33 |
|
||
| H19M22.3a 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for MMP14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MMP14 Gene
- ENSEMBL:
- Gene Tree for MMP14 (if available)
- TreeFam:
- Gene Tree for MMP14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MMP14: view image
Paralogs for MMP14 Gene
Paralogs for MMP14 Gene
(18) SIMAP similar genes for MMP14 Gene using alignment to 4 proteins:
- MMP14_HUMAN
- F8VP90_HUMAN
- F8W1B7_HUMAN
- K4RH61_HUMAN
Variants for MMP14 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs587777039 | pathogenic, Winchester syndrome, Winchester syndrome (WNCHRS) [MIM:277950] | 22,836,867(+) | C/G | coding_sequence_variant, missense_variant | |
| rs757044765 | uncertain-significance, Winchester syndrome | 22,843,420(+) | C/T | splice_donor_variant | |
| rs1000465730 | -- | 22,843,993(+) | C/T | intron_variant | |
| rs1000492144 | -- | 22,841,856(+) | A/G | intron_variant | |
| rs1000553192 | -- | 22,836,248(+) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3633763 | CNV | gain | 21293372 |
| nsv1070211 | CNV | deletion | 25765185 |
| nsv1143607 | CNV | deletion | 24896259 |
| nsv563998 | CNV | gain | 21841781 |
| nsv952816 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.83;
79.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MMP14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP14 Gene
Disorders for MMP14 Gene
(19) MalaCards diseases for MMP14 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| winchester syndrome |
|
|
| multicentric osteolysis, nodulosis, and arthropathy |
|
|
| fibrosarcoma |
|
|
| light chain deposition disease |
|
|
| klatskin's tumor |
|
|
Search MMP14 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MMP14_HUMAN- Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. {ECO:0000269 PubMed:22922033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MMP14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MMP14 Gene
Publications for MMP14 Gene
- Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. (PMID: 8706726) Lohi J … Keski-Oja J (European journal of biochemistry 1996) 3 4 22 58
- A matrix metalloproteinase expressed on the surface of invasive tumour cells. (PMID: 8015608) Sato H … Seiki M (Nature 1994) 2 3 4 58
- Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. (PMID: 22922033) Evans BR … Martignetti JA (American journal of human genetics 2012) 3 4 58
- A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1. (PMID: 22330140) Cork SM … Van Meir EG (Oncogene 2012) 3 4 58
- BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. (PMID: 22065321) Gu G … Liu P (Journal of cellular biochemistry 2012) 3 4 58
Products for MMP14 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MMP14
- antibodies-online: Search results for 266 available MMP14 Antibodies ranked by validation data
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- 216 WB Antibodies (anti-human)
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- 3 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 54 WB Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 51 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- antibodies-online: Search results for 28 available MMP14 Elisa Kits ranked by validation data
- Compare Top MMP14 Elisa Kits
- antibodies-online: Search results for 27 available MMP14 Proteins ranked by validation data
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- GeneTex MMP14 Antibody for MMP14
- Search GeneTex for Proteins for MMP14
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