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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
MMP14 (Matrix Metallopeptidase 14) is a Protein Coding gene. Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum. Among its related pathways are Degradation of the extracellular matrix and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and metalloendopeptidase activity. An important paralog of this gene is MMP15.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004175 | endopeptidase activity | IDA | 20666777 |
GO:0004222 | metalloendopeptidase activity | IEA,ISS | -- |
GO:0005178 | integrin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 14718544 |
GO:0008233 | peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IMP | 24784232 |
GO:0005634 | nucleus | IMP | 24784232 |
GO:0005737 | colocalizes_with cytoplasm | IEA,IDA | 22065321 |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Matrix Metalloproteinases |
Inhibition of Matrix Metalloproteinases
.69
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2 | Degradation of the extracellular matrix | ||
3 | Adhesion |
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4 | Development Endothelin-1/EDNRA signaling | ||
5 | Parathyroid hormone synthesis, secretion and action |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IBA | 21873635 |
GO:0001503 | ossification | IEA | -- |
GO:0001525 | angiogenesis | IEA | -- |
GO:0001541 | ovarian follicle development | IEA | -- |
GO:0001666 | response to hypoxia | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Marimastat | Investigational | Pharma | Target, inhibitor | MMPs inhibitor,board spectrum | 4 | |
Prinomastat | Investigational | Pharma | inhibitor, Vaccine | Vaccines | 3 | |
Calcium | Nutra | 6556 | ||||
NSC 405020 | Pharma | MT1-MMP inhibitor | 0 | |||
ARP 100 | Pharma | Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Marimastat | MMPs inhibitor,board spectrum | 154039-60-8 |
NSC 405020 | MT1-MMP inhibitor | 7497-07-6 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MMP14 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MMP-14 31 |
|
OneToOne | |
MMP14 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | MMP14 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mmp14 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mmp14 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MMP14 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MMP14 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MMP14 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mmp14 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23718 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mmp14b 30 30 31 |
|
OneToMany | |
mmp14a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mmp1 30 32 |
|
||
Mmp2 31 32 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006904 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | H36L18.1 30 |
|
||
H19M22.3a 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710218 | Benign: not provided | 22,844,475(+) | C/T | SYNONYMOUS_VARIANT | |
717373 | Benign: not provided | 22,844,771(+) | G/A | MISSENSE_VARIANT | |
729027 | Likely Benign: not provided | 22,841,491(+) | G/C | MISSENSE_VARIANT | |
729815 | Likely Benign: not provided | 22,844,373(+) | G/A | SYNONYMOUS_VARIANT | |
752764 | Likely Benign: not provided | 22,845,724(+) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3633763 | CNV | gain | 21293372 |
nsv1070211 | CNV | deletion | 25765185 |
nsv1143607 | CNV | deletion | 24896259 |
nsv563998 | CNV | gain | 21841781 |
nsv952816 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
winchester syndrome |
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multicentric osteolysis-nodulosis-arthropathy spectrum |
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fibrosarcoma |
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lymph node disease |
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cervical squamous cell carcinoma |
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