Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular prot... See more...

Aliases for MMP11 Gene

Aliases for MMP11 Gene

  • Matrix Metallopeptidase 11 2 3 5
  • Stromelysin-3 3 4
  • STMY3 3 4
  • SL-3 3 4
  • ST3 3 4
  • Matrix Metalloproteinase 11 (Stromelysin 3) 2
  • Matrix Metallopeptidase 11 (Stromelysin 3) 3
  • Matrix Metalloproteinase-11 4
  • Stromelysin III 3
  • Stromelysin 3 2
  • EC 3.4.24.24 51
  • EC 3.4.24.- 4
  • EC 3.4.24 51
  • MMP-11 4
  • MMP11 5

External Ids for MMP11 Gene

Previous HGNC Symbols for MMP11 Gene

  • STMY3

Previous GeneCards Identifiers for MMP11 Gene

  • GC22P020811
  • GC22P022439
  • GC22P024110
  • GC22P007103

Summaries for MMP11 Gene

Entrez Gene Summary for MMP11 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP11 Gene

MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Dermatofibrosarcoma Protuberans and Cutaneous Fibrous Histiocytoma. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.

UniProtKB/Swiss-Prot Summary for MMP11 Gene

  • May play an important role in the progression of epithelial malignancies.

Tocris Summary for MMP11 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP11 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMP11 Gene

Genomics for MMP11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MMP11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MMP11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMP11

Top Transcription factor binding sites by QIAGEN in the MMP11 gene promoter:
  • ARP-1
  • Egr-3
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA5
  • MZF-1
  • p300
  • p53
  • Pax-4a

Genomic Locations for MMP11 Gene

Genomic Locations for MMP11 Gene
chr22:23,768,226-23,784,316
(GRCh38/hg38)
Size:
16,091 bases
Orientation:
Plus strand
chr22:24,110,413-24,126,503
(GRCh37/hg19)
Size:
16,091 bases
Orientation:
Plus strand

Genomic View for MMP11 Gene

Genes around MMP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP11 Gene

Proteins for MMP11 Gene

  • Protein details for MMP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24347-MMP11_HUMAN
    Recommended name:
    Stromelysin-3
    Protein Accession:
    P24347
    Secondary Accessions:
    • Q5FX24
    • Q6PEZ6
    • Q9UC26

    Protein attributes for MMP11 Gene

    Size:
    488 amino acids
    Molecular mass:
    54590 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP11 Gene

Selected DME Specific Peptides for MMP11 Gene

P24347:
  • PRCGVPD
  • VWSDVTPL
  • GYPALASRHW
  • VAAHEFGH
  • FDAVSTIRGELFFFK
  • KVWSDVTPL
  • RNRQKRFVLSGGRW

Post-translational modifications for MMP11 Gene

Other Protein References for MMP11 Gene

Domains & Families for MMP11 Gene

Gene Families for MMP11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP11 Gene

GenScript: Design optimal peptide antigens:
  • Matrix metalloproteinase 11 (A5GZ71_HUMAN)
  • cDNA PSEC0140 fis, clone PLACE1005783, highly similar to STROMELYSIN-3 (EC 3.4.24.-) (B3KQS8_HUMAN)
  • Matrix metalloproteinase-11 (MMP11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24347

UniProtKB/Swiss-Prot:

MMP11_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP11: view

Function for MMP11 Gene

Molecular function for MMP11 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the progression of epithelial malignancies.
GENATLAS Biochemistry:
matrix metalloproteinase 11,regulator in matrix remodeling,overexpressed in stromal and epithelial cells of pancreatic carcinoma

Enzyme Numbers (IUBMB) for MMP11 Gene

Phenotypes From GWAS Catalog for MMP11 Gene

Gene Ontology (GO) - Molecular Function for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,IBA 21873635
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MMP11: view
genes like me logo Genes that share phenotypes with MMP11: view

Animal Models for MMP11 Gene

MGI Knock Outs for MMP11:
  • Mmp11 Mmp11<tm1Mrio>
  • Mmp11 Mmp11<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP11

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP11 Gene

Localization for MMP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP11 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP11 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 3
mitochondrion 3
cytoskeleton 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix IEA,IDA 18622425
genes like me logo Genes that share ontologies with MMP11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMP11 Gene

Pathways & Interactions for MMP11 Gene

PathCards logo

SuperPathways for MMP11 Gene

SuperPathway Contained pathways
1 Matrix Metalloproteinases
.69
2 Degradation of the extracellular matrix
3 Integrin Pathway
.56
.38
4 Colorectal Cancer Metastasis
-
5 GPCR Pathway
.59
genes like me logo Genes that share pathways with MMP11: view

Pathways by source for MMP11 Gene

5 Qiagen pathways for MMP11 Gene
  • Colorectal Cancer Metastasis
  • Inhibition of Matrix Metalloproteinases
  • Pancreatic Adenocarcinoma
  • Transendothelial Migration of Leukocytes
  • UPA-UPAR Pathway

Gene Ontology (GO) - Biological Process for MMP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organism development IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization IEA,IBA 21873635
GO:0030199 collagen fibril organization IEA --
genes like me logo Genes that share ontologies with MMP11: view

No data available for SIGNOR curated interactions for MMP11 Gene

Drugs & Compounds for MMP11 Gene

(12) Drugs for MMP11 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nα-[(2S)-2-{[(S)-[(1S)-1-{[(Benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]methyl}-5-phenylpentanoyl]-L-tryptophanamide Experimental Pharma Target 0
Marimastat Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
Calcium Nutra 6556
ARP 100 Pharma Selective MMP-2 inhibitor, Selective inhibitor of MMP-2 0
ARP 101 Pharma MMP inhibitor,potent and selective, Inhibitor of MMP-2 0

(6) Additional Compounds for MMP11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP11 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP11: view

Transcripts for MMP11 Gene

mRNA/cDNA for MMP11 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMP11

Alternative Splicing Database (ASD) splice patterns (SP) for MMP11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for MMP11 Gene

GeneLoc Exon Structure for
MMP11

Expression for MMP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MMP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP11 Gene

This gene is overexpressed in Uterus (x8.9), Cervix - Endocervix (x6.1), and Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for MMP11 Gene

This gene is overexpressed in Breast (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MMP11 Gene



Protein tissue co-expression partners for MMP11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMP11

SOURCE GeneReport for Unigene cluster for MMP11 Gene:

Hs.143751

mRNA Expression by UniProt/SwissProt for MMP11 Gene:

P24347-MMP11_HUMAN
Tissue specificity: Specifically expressed in stromal cells of breast carcinomas.

Evidence on tissue expression from TISSUES for MMP11 Gene

  • Intestine(2.9)
  • Skin(2.3)
  • Blood(2.3)
  • Lymph node(2.2)
  • Muscle(2.2)
  • Heart(2.2)
  • Pancreas(2.1)
  • Liver(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with MMP11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP11 Gene

Orthologs for MMP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MMP11 30 31
  • 99.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MMP11 30 31
  • 86.39 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MMP11 30 31
  • 85.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mmp11 30 17 31
  • 83.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mmp11 30
  • 82.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia MMP11 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC101751203 30
  • 68.42 (n)
MMP11 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mmp11 30
  • 64.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64247 30
Zebrafish
(Danio rerio)
Actinopterygii mmp11a 30 31
  • 62.04 (n)
OneToMany
mmp11b 31
  • 49 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Mmp1 32
  • 39 (a)
Mmp2 31 32
  • 22 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
ManyToMany
Species where no ortholog for MMP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MMP11 Gene

ENSEMBL:
Gene Tree for MMP11 (if available)
TreeFam:
Gene Tree for MMP11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MMP11: view image

Paralogs for MMP11 Gene

(16) SIMAP similar genes for MMP11 Gene using alignment to 6 proteins:

  • MMP11_HUMAN
  • A5GZ71_HUMAN
  • B3KQS8_HUMAN
  • E9PED7_HUMAN
  • F8WDI7_HUMAN
  • H7C3I7_HUMAN
genes like me logo Genes that share paralogs with MMP11: view

Variants for MMP11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMP11 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
710387 Benign: not provided 23,782,284(+) C/A SYNONYMOUS_VARIANT
743973 Benign: not provided 23,780,998(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
VAR_036140 A colorectal cancer sample p.Asp166Asn
rs17854940 - p.Phe182Ser
rs28363646 - p.Glu44Lys

Additional dbSNP identifiers (rs#s) for MMP11 Gene

Structural Variations from Database of Genomic Variants (DGV) for MMP11 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for MMP11 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP11 Gene

Human Gene Mutation Database (HGMD)
MMP11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP11 Gene

Disorders for MMP11 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MMP11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dermatofibrosarcoma protuberans
  • dfsp
cutaneous fibrous histiocytoma
  • benign cutaneous fibrous histiocytoma
space motion sickness
aleutian mink disease
  • aleutian disease
basal cell carcinoma
  • basal cell cancer
- elite association - COSMIC cancer census association via MalaCards
Search MMP11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MMP11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP11 Gene

Publications for MMP11 Gene

  1. Structure and promoter characterization of the human stromelysin-3 gene. (PMID: 7657606) Anglard P … Basset P (The Journal of biological chemistry 1995) 2 3 4 23
  2. Furin-dependent intracellular activation of the human stromelysin-3 zymogen. (PMID: 7746327) Pei D … Weiss SJ (Nature 1995) 3 4 23
  3. Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22. (PMID: 1639418) Levy A … Basset P (Genomics 1992) 2 3 23
  4. The clinical implications of MMP-11 and CK-20 expression in human breast cancer. (PMID: 19914229) Cheng CW … Shen CY (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23
  5. Overexpression of matrix metalloproteinase 11 in human gastric carcinoma and its clinicopathologic significance. (PMID: 20060156) Zhao ZS … Tao HQ (Human pathology 2010) 3 23

Products for MMP11 Gene

Sources for MMP11 Gene