Aliases for MMP11 Gene
External Ids for MMP11 Gene
Previous HGNC Symbols for MMP11 Gene
Previous GeneCards Identifiers for MMP11 Gene
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP11 Gene
MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Dermatofibrosarcoma Protuberans and Cutaneous Fibrous Histiocytoma. Among its related pathways are Degradation of the extracellular matrix and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP25.
UniProtKB/Swiss-Prot Summary for MMP11 Gene
May play an important role in the progression of epithelial malignancies.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.