Aliases for MMP10 Gene
External Ids for MMP10 Gene
Previous HGNC Symbols for MMP10 Gene
Previous GeneCards Identifiers for MMP10 Gene
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
GeneCards Summary for MMP10 Gene
MMP10 (Matrix Metallopeptidase 10) is a Protein Coding gene. Diseases associated with MMP10 include Epidermolysis Bullosa Dystrophica and Pyoderma Gangrenosum. Among its related pathways are Cell adhesion_ECM remodeling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP3.
UniProtKB/Swiss-Prot for MMP10 Gene
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.