Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mai... See more...
Aliases for MMEL1 Gene
Aliases for MMEL1 Gene
External Ids for MMEL1 Gene
- HGNC: 14668
- Entrez Gene: 79258
- Ensembl: ENSG00000142606
- OMIM: 618104
- UniProtKB: Q495T6
Previous HGNC Symbols for MMEL1 Gene
- MMEL2
Previous GeneCards Identifiers for MMEL1 Gene
- GC00U990694
- GC01M002557
- GC01M001803
Summaries for MMEL1 Gene
-
The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMEL1 Gene
MMEL1 (Membrane Metalloendopeptidase Like 1) is a Protein Coding gene. Diseases associated with MMEL1 include Primary Biliary Cirrhosis and Schwartz-Jampel Syndrome, Type 1. Among its related pathways are A-beta Uptake and Degradation and A-beta Plaque Formation and APP Metabolism. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is MME.
UniProtKB/Swiss-Prot Summary for MMEL1 Gene
-
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
Additional gene information for MMEL1 Gene
- HGNC(14668)
- Entrez Gene(79258)
- Ensembl(ENSG00000142606)
- OMIM(618104)
- UniProtKB(Q495T6)
- Open Targets Platform(ENSG00000142606)
- Monarch Initiative
- Search for MMEL1 at DataMed
- Search for MMEL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MMEL1 Gene
Genomics for MMEL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MMEL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MMEL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MMEL1
- Top Transcription factor binding sites by QIAGEN in the MMEL1 gene promoter:
-
- AREB6
- GR
- GR-alpha
- GR-beta
- ZID
Genomic Locations for MMEL1 Gene
Genomic Locations for MMEL1 Gene
- chr1:2,590,639-2,633,042
- (GRCh38/hg38)
- Size:
- 42,404 bases
- Orientation:
- Minus strand
- chr1:2,522,078-2,564,481
- (GRCh37/hg19)
- Size:
- 42,404 bases
- Orientation:
- Minus strand
Genomic View for MMEL1 Gene
Genes around MMEL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.32 by HGNC
- 1p36.32 by Entrez Gene
- 1p36.32 by Ensembl
MMEL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MMEL1 Gene
Proteins for MMEL1 Gene
-
Protein details for MMEL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q495T6-MMEL1_HUMAN
- Recommended name:
- Membrane metallo-endopeptidase-like 1
- Protein Accession:
- Q495T6
- B9DI79
- Q495T7
- Q495T8
- Q5SZS6
- Q96PH9
Protein attributes for MMEL1 Gene
- Size:
- 779 amino acids
- Molecular mass:
- 89367 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI01028.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI01031.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAL08942.1; Type=Frameshift; Evidence={ECO:0000305};
Selected DME Specific Peptides for MMEL1 Gene
- Q495T6:
-
- SIKTDVHSP
- AVVNAFYS
- FACGGWLRRH
- VIGHEITHGFDD
- FPAGILQ
- TLGENIADNGG
- FPAGILQPPFFS
Post-translational modifications for MMEL1 Gene
- N-glycosylated.
-
Glycosylation at Asn177, Asn350, Asn207, Asn530, and Asn657
- NX_Q495T6 (NX_Q495T6-1)
- Modification sites at PhosphoSitePlus
Other Protein References for MMEL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- HUABIO Anti-MMEL1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for MMEL1
- Novus Biologicals Antibodies for MMEL1
-
Abcam antibodies for MMEL1
- Invitrogen Antibodies for MMEL1 (AFLGC-MMEL1)
-
Boster Bio Antibodies for MMEL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for MMEL1
Protein Products
-
OriGene Purified Proteins for MMEL1
- Search Origene for MassSpec and Protein Over-expression Lysates for MMEL1
- Origene Custom Protein Services for MMEL1
- antibodies-online: Show 7 available MMEL1 Proteins ranked by validation data
- Compare Top MMEL1 Proteins
-
Quality Products:
-
Signalway Proteins for MMEL1
-
Abcam proteins for MMEL1
Assay Products
- RayBiotech Custom Human Neprilysin-2 ELISA
- antibodies-online: Show 9 available MMEL1 Elisa Kits ranked by validation data
- Compare Top MMEL1 Elisa Kits
-
Quality Products:
Domains & Families for MMEL1 Gene
Gene Families for MMEL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for MMEL1 Gene
- InterPro:
- Blocks:
-
- Neprilysin metalloprotease (M13) family signature
- Peptidase M13
- ProtoNet:
Suggested Antigen Peptide Sequences for MMEL1 Gene
- GenScript: Design optimal peptide antigens:
-
- Neprilysin-2 (MMEL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q495T6- Family:
-
- Belongs to the peptidase M13 family.
Function for MMEL1 Gene
Molecular function for MMEL1 Gene
- UniProtKB/Swiss-Prot Function:
- Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.; EC=3.4.24.11;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by thiorphan and phosphoramidon.
Enzyme Numbers (IUBMB) for MMEL1 Gene
Phenotypes From GWAS Catalog for MMEL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IDA | 18539150 |
| GO:0004222 | metalloendopeptidase activity | IEA | -- |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for MMEL1 Gene
- MGI mutant phenotypes for MMEL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MMEL1:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Negative genetic interaction between BLM-/- and BLM+/+
- Synthetic lethal with Ras
- Increased IL-8 secretion
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Decreased viability
- Increased NF-kappaB reporter expression
- Decreased shRNA abundance
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased epidermal growth factor (EGF) endocytosis
Animal Models for MMEL1 Gene
- MGI Knock Outs for MMEL1:
-
- Mmel1 Mmel1<tm1Ldg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MMEL1 - Select products 50% OFF >
- * MMEL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MMEL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMEL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMEL1
miRNA for MMEL1 Gene
- miRTarBase miRNAs that target MMEL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMEL1
- Browse OriGene Inhibitory RNA Products For MMEL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMEL1
Clone Products
- Applied Biological Materials (abm): Clones for MMEL1 - Select products 50% OFF >
- * MMEL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMEL1
Cell Line Products
-
Horizon Cell Lines for MMEL1
No data available for Transcription Factor Targets and HOMER Transcription for MMEL1 Gene
Localization for MMEL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MMEL1 Gene
- Membrane. Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 18539150 |
| GO:0016020 | membrane | IDA | 18539150 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MMEL1 Gene
Pathways & Interactions for MMEL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | A-beta Plaque Formation and APP Metabolism | ||
| 2 | A-beta Uptake and Degradation | ||
Pathways by source for MMEL1 Gene
2 R&D Systems pathways for MMEL1 Gene
Interacting Proteins for MMEL1 Gene
GPS-Prot Interaction Network for MMEL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IDA | 18539150 |
No data available for SIGNOR curated interactions for MMEL1 Gene
Drugs & Compounds for MMEL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Racecadotril | Investigational | Pharma | 8 |
(1) ApexBio Compounds for MMEL1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Racecadotril | 81110-73-8 |
Transcripts for MMEL1 Gene
mRNA/cDNA for MMEL1 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378412 2879 nts (view in UCSC)
- ENST00000464195 559 nts (view in UCSC)
- ENST00000469962 460 nts (view in UCSC)
- ENST00000471840 552 nts (view in UCSC)
- ENST00000491941 482 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MMEL1 - Select products 50% OFF >
- * MMEL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MMEL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMEL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MMEL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMEL1
- Browse OriGene Inhibitory RNA Products For MMEL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMEL1
Clone Products
- Applied Biological Materials (abm): Clones for MMEL1 - Select products 50% OFF >
- * MMEL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMEL1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | |||||||||||||||
| SP4: | - |
Relevant External Links for MMEL1 Gene
- GeneLoc Exon Structure for
- MMEL1
Expression for MMEL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Granulosa Cells Primary Follicle
mRNA differential expression in normal tissues according to GTEx for MMEL1 Gene
This gene is overexpressed in Testis (x23.0).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MMEL1
SOURCE GeneReport for Unigene cluster for MMEL1 Gene:
Hs.591453mRNA Expression by UniProt/SwissProt for MMEL1 Gene:
Q495T6-MMEL1_HUMAN
Tissue specificity:
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.
Evidence on tissue expression from TISSUES for MMEL1 Gene
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for MMEL1
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMEL1 Gene
Orthologs for MMEL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MMEL1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MMEL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MMEL1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mmel1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mmel1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MMEL1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MMEL1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MMEL1 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mmel1 30 |
|
||
| Str.13545 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | mmel1 30 |
|
||
| MMEL1 31 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003106 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Nep4 30 31 |
|
ManyToMany | |
| Nep1 31 |
|
ManyToMany | |||
| Nep2 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | nep-2 30 31 |
|
ManyToMany | |
| nep-1 31 |
|
ManyToMany | |||
| nep-11 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MMEL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MMEL1 Gene
- ENSEMBL:
- Gene Tree for MMEL1 (if available)
- TreeFam:
- Gene Tree for MMEL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MMEL1: view image
Paralogs for MMEL1 Gene
Variants for MMEL1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MMEL1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708734 | Likely Benign: not provided | 2,592,689(-) | A/G | MISSENSE_VARIANT | |
| 712823 | Benign: not provided | 2,604,193(-) | T/C | MISSENSE_VARIANT | |
| 719695 | Benign: not provided | 2,592,725(-) | G/A | INTRON_VARIANT | |
| 719696 | Benign: not provided | 2,593,833(-) | C/T | SYNONYMOUS_VARIANT | |
| 719937 | Benign: not provided | 2,591,922(-) | C/T | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv19e59 | CNV | duplication | 20981092 |
| esv3582248 | CNV | gain | 25503493 |
| esv3585029 | CNV | loss | 21293372 |
| nsv1136059 | CNV | deletion | 24896259 |
| nsv1144338 | CNV | deletion | 24896259 |
| nsv428399 | CNV | gain | 18775914 |
| nsv470684 | CNV | loss | 18288195 |
| nsv545077 | CNV | gain | 21841781 |
| nsv545082 | CNV | loss | 21841781 |
| nsv545083 | CNV | gain | 21841781 |
| nsv7171 | OTHER | inversion | 18451855 |
| nsv829648 | CNV | loss | 17160897 |
| nsv951592 | CNV | deletion | 24416366 |
| nsv951593 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.06;
50.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MMEL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMEL1 Gene
Disorders for MMEL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary biliary cirrhosis |
|
|
| schwartz-jampel syndrome, type 1 |
|
|
| nemaline myopathy 2 |
|
|
| celiac disease 1 |
|
|
Search MMEL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MMEL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MMEL1 Gene
Publications for MMEL1 Gene
- Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family. (PMID: 11560781) Bonvouloir N … DesGroseillers L (DNA and cell biology 2001) 2 3 4 23
- Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PMID: 19674979) Hinks A … Thomson W (Annals of the rheumatic diseases 2010) 3 41
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
- Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 41
- Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois PC … van Heel DA (Nature genetics 2010) 3 41
ExternalLinks
Products for MMEL1 Gene
- Custom Antibody ServicesOriGene Antibodies for MMEL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MMEL1
- Search Origene for MassSpec and Protein Over-expression Lysates for MMEL1
- Origene Custom Protein Services for MMEL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MMEL1
- Browse OriGene Inhibitory RNA Products For MMEL1
- OriGene qPCR primer pairs for MMEL1
- OriGene CRISPR knockouts for MMEL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MMEL1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MMEL1
- Novus Biologicals proteins and lysates for MMEL1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for MMEL1
- Abcam proteins for MMEL1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for MMEL1 (AFLGC-MMEL1)
- ApexBio compounds for MMEL1
- VectorBuilder Custom and pre-made DNA vectors for MMEL1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MMEL1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MMEL1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MMEL1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MMEL1
- antibodies-online: Show 14 available MMEL1 Antibodies ranked by validation data
- Compare Top MMEL1 Antibodies
- antibodies-online: Show 9 available MMEL1 Elisa Kits ranked by validation data
- Compare Top MMEL1 Elisa Kits
- Quality Products:
- antibodies-online: Show 7 available MMEL1 Proteins ranked by validation data
- Compare Top MMEL1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MMEL1
- Search Santa Cruz Biotechnology (SCBT) for MMEL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MMEL1
- Horizon Cell Lines for MMEL1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MMEL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MMEL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MMEL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MMEL1
- Boster Bio Antibodies for MMEL1
- Browse Boster Bio ELISA Kits
- Signalway Proteins for MMEL1
Sources for MMEL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB