Aliases for MME Gene
Aliases for MME Gene
- Membrane Metalloendopeptidase 2 3 5
- Common Acute Lymphocytic Leukemia Antigen 3 4
- Neutral Endopeptidase 24.11 3 4
- Skin Fibroblast Elastase 3 4
- Neutral Endopeptidase 2 4
- Atriopeptidase 3 4
- Enkephalinase 2 4
- Neprilysin 2 3
- CALLA 3 4
- NEP 3 4
- SFE 3 4
- Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10) 3
External Ids for MME Gene
- HGNC: 7154
- Entrez Gene: 4311
- Ensembl: ENSG00000196549
- OMIM: 120520
- UniProtKB: P08473
Previous GeneCards Identifiers for MME Gene
- GC03P151792
- GC03P155641
- GC03P156079
- GC03P156118
- GC03P156280
- GC03P154741
- GC03P152191
Summaries for MME Gene
-
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]
GeneCards Summary for MME Gene
MME (Membrane Metalloendopeptidase) is a Protein Coding gene. Diseases associated with MME include Charcot-Marie-Tooth Disease, Axonal, Type 2T and Spinocerebellar Ataxia 43. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include peptidase activity and endopeptidase activity. An important paralog of this gene is MMEL1.
UniProtKB/Swiss-Prot for MME Gene
-
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Additional gene information for MME Gene
- Monarch Initiative
- Search for MME at DataMed
- Search for MME at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MME Gene
Genomics for MME Gene
GeneHancer (GH) Regulatory Elements for MME Gene
Promoters and enhancers for MME Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J155077 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 667.6 | +56.7 | 56723 | 5.8 | RB1 ZSCAN4 SIN3A RAD21 YY1 ZNF335 GLIS2 ZNF366 SP3 PHF21A | MME MME-AS1 | |
| GH03J155022 | Enhancer | 0.7 | ENCODE | 655.5 | -0.7 | -670 | 2 | MEIS2 PKNOX1 JUN NEUROD1 ZNF384 FEZF1 ZBTB40 CTBP1 GATA3 POLR2A | MME LOC105374171 | |
| GH03J155068 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 16.2 | +46.5 | 46473 | 3.9 | JUN MAX CHAMP1 FOSL1 DIDO1 POLR2A TRIM24 FOS ZNF639 L3MBTL2 | MME MME-AS1 | |
| GH03J154969 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 18.7 | -53.0 | -52977 | 2.9 | CEBPB CBFA2T3 CEBPG EP300 ATF4 JUND GATA3 HMBOX1 NFE2 TRIM24 | LOC105374171 MME MME-AS1 | |
| GH03J155000 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 13.6 | -22.6 | -22648 | 1.1 | ZNF217 CTBP1 GATA3 HLF CEBPB | MME LOC105374171 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MME on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MME gene promoter:
-
- AP-1
Regulatory Element Products
Genomic Locations for MME Gene
Genomic Locations for MME Gene
- chr3:155,024,124-155,183,729
- (GRCh38/hg38)
- Size:
- 159,606 bases
- Orientation:
- Plus strand
- chr3:154,741,913-154,901,518
- (GRCh37/hg19)
- Size:
- 159,606 bases
- Orientation:
- Plus strand
Genomic View for MME Gene
Genes around MME on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q25.2 by Entrez Gene
- 3q25.2 by HGNC
- 3q25.2 by Ensembl
MME Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MME Gene
Proteins for MME Gene
-
Protein details for MME Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08473-NEP_HUMAN
- Recommended name:
- Neprilysin
- Protein Accession:
- P08473
- A8K6U6
- D3DNJ9
- Q3MIX4
Protein attributes for MME Gene
- Size:
- 750 amino acids
- Molecular mass:
- 85514 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.
- SequenceCaution:
-
- Sequence=CAA30157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for MME Gene
Post-translational modifications for MME Gene
- Myristoylation is a determinant of membrane targeting.
- Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Glycosylation at isoforms=628, isoforms=325, isoforms=285, and Asn145
- Modification sites at PhosphoSitePlus
Other Protein References for MME Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MME (Neprilysin/CD10)
-
Custom Antibody ServicesOriGene Antibodies for MME
- AM05174FC-N
- AM05174PU-N
- AM06014PU-N
- AM06091PU-N
- AM31220AF-N
- AM31220PU-N
- AM31220PU-S
- AM31220RP-N
- AM33192PU-N
- AM33192PU-S
- DM240
- DM240-05
- DMP107
- SM1525A
- SM1525APC
- SM1525APCT
- SM1525B
- SM1525F
- SM1525FT
- SM1525P
- SM1525PS
- SM1525PT
- SM1525RT
- SM3006APC
- SM3006F
- SM3006P
- SM3006PP
- SM3006R
- SM3139F
- SM3139P
- SM3139R
- TA320422
- TA321228
- TA321229
- TA324359
- TA324923
- TA324924
- TA327616
- TA332826
- TA353334
- TA353646
- TA353647
- TA353648
- TA504507
- CF504507
- TA590055
- TA808300
- CF808300
- TA810605
- CF810605
- TA810614
- CF810614
- Novus Biologicals Antibodies for MME
-
Abcam antibodies for MME
- Invitrogen Antibodies for MME
- antibodies-online: Search results for 645 available MME Antibodies ranked by validation data
- Compare Top MME Antibodies
-
Recommended
- 290 WB Antibodies (anti-human)
- 150 FACS Antibodies (anti-human)
- 55 IHC (p) Antibodies (anti-human)
- 28 IP Antibodies (anti-human)
- 27 IF Antibodies (anti-human)
- 25 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IF/ICC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 IA Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 63 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- GeneTex Mme Antibody for MME
-
Boster Bio Antibodies for MME
-
Santa Cruz Biotechnology (SCBT) Antibodies for MME
- Sino Biological Antibodies for MME
Protein Products
- R&D Systems Proteins and Enzymes for MME (Neprilysin/CD10)
- Search Origene for MassSpec and Protein Over-expression Lysates for MME
- Origene Custom Protein Services for MME
- Sino Biological Recombinant Proteins for MME
- Sino Biological Cell Lysates for MME
- ProSpec Recombinant Proteins for MME
- Search GeneTex for Proteins for MME
-
ProSci Proteins for MME
-
Abcam proteins for MME
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MME (Neprilysin/CD10)
- Novus Biologicals ELISA Kits for MME
No data available for DME Specific Peptides for MME Gene
Domains & Families for MME Gene
Gene Families for MME Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MME Gene
Suggested Antigen Peptide Sequences for MME Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08473- Family:
-
- Belongs to the peptidase M13 family.
Function for MME Gene
Molecular function for MME Gene
- UniProtKB/Swiss-Prot Function:
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited in a dose dependent manner by opiorphin.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=55.1 uM for angiotensin-1 {ECO:0000269 PubMed:15283675}; KM=179 uM for angiotensin-2 {ECO:0000269 PubMed:15283675}; KM=111.4 uM for angiotensin 1-9 {ECO:0000269 PubMed:15283675};
- GENATLAS Biochemistry:
- zinc metallopeptidase,membrane (neutral endopeptidase 24.11,enkephalinase),constitutively expressed in various tissues,developmentally regulated in other cell types,i.e. lymphocytes
Enzyme Numbers (IUBMB) for MME Gene
Phenotypes From GWAS Catalog for MME Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004175 | endopeptidase activity | IMP | 2531377 |
| GO:0004222 | metalloendopeptidase activity | IMP,IEA | 2521388 |
| GO:0005515 | protein binding | IPI | 17342744 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008237 | metallopeptidase activity | EXP | 15283675 |
Phenotypes for MME Gene
- MGI mutant phenotypes for MME:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MME:
Animal Models for MME Gene
- MGI Knock Outs for MME:
-
- Mme Mme<tm1Cge>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MME
-
CRISPR Products
-
OriGene CRISPR knockouts for MME
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MME
- genomics-online: gRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- Applied Biological Materials CRISPR for MME
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MME
- GenScript: Design CRISPR guide RNA sequences for MME
miRNA for MME Gene
- miRTarBase miRNAs that target MME
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MME
- Browse OriGene Inhibitory RNA Products For MME
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MME
- genomics-online: shRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
Clone Products
- Sino Biological Human cDNA Clone for MME
- VectorBuilder custom plasmid, inducible vectors for MME
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MME
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MME
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MME
- Applied Biological Materials Clones for MME
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MME
No data available for Transcription Factor Targets and HOMER Transcription for MME Gene
Localization for MME Gene
Subcellular locations from UniProtKB/Swiss-Prot for MME Gene
- Cell membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | 20876573 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 2521388 |
| GO:0005903 | brush border | IDA | 22272689 |
| GO:0005925 | focal adhesion | HDA | 21423176 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MME Gene
Pathways & Interactions for MME Gene
Pathways by source for MME Gene
2 BioSystems pathways for MME Gene
6 Reactome pathways for MME Gene
2 PharmGKB pathways for MME Gene
4 KEGG pathways for MME Gene
Interacting Proteins for MME Gene
Selected Interacting proteins:
ENSP00000353679
P08473-NEP_HUMAN
for MME Gene via
STRING
IID
MINT
UniProtKB
GPS-Prot Interaction Network for MME
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001822 | kidney development | IEP | 22272689 |
| GO:0002003 | angiotensin maturation | TAS | -- |
| GO:0006508 | proteolysis | IDA,IEA | 8168535 |
| GO:0006518 | peptide metabolic process | ISS | -- |
| GO:0019233 | sensory perception of pain | ISS | -- |
Drugs & Compounds for MME Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | 2430 | |||
| Liraglutide | Approved | Pharma | Full agonist, Agonist, Enzyme, substrate | 347 | ||
| Sacubitril | Approved | Pharma | Target, antagonist, inhibitor | 0 | ||
| Semaglutide | Approved, Investigational | Pharma | Enzyme, substrate | 0 | ||
| Candoxatril | Experimental | Pharma | inhibitor, Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) ApexBio Compounds for MME Gene
| Compound | Action | Cas Number |
|---|---|---|
| AHU-377 hemicalcium salt | Potent neprilysin inhibitor | 1369773-39-6 |
| AHU-377(Sacubitril) | Neprilysin inhibitor | 149709-62-6 |
| Phosphoramidon Disodium Salt | 164204-38-0 | |
| Racecadotril | 81110-73-8 |
Transcripts for MME Gene
mRNA/cDNA for MME Gene
- (10) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (145) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000492661 2854 bps (uc010hvr.2)
- ENST00000491597 951 bps (uc062peo.1)
- ENST00000460393 5622 bps (uc003fab.2)
- ENST00000481828 856 bps (uc062peq.1)
- ENST00000382989 1319 bps (uc062pes.1)
Unigene Clusters for MME Gene
- Membrane metallo-endopeptidase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MME
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MME
- genomics-online: gRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- Applied Biological Materials CRISPR for MME
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MME
- GenScript: Design CRISPR guide RNA sequences for MME
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MME
- Browse OriGene Inhibitory RNA Products For MME
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MME
- genomics-online: shRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
Clone Products
- Sino Biological Human cDNA Clone for MME
- VectorBuilder custom plasmid, inducible vectors for MME
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MME
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MME
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MME
- Applied Biological Materials Clones for MME
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MME Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Adventitial Reticular Cells Bone Marrow
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Bone Marrow Stromal Cells Bone Marrow
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Pro B-Cells Hematopoietic Bone Marrow
- Granulocytes Peripheral Blood
- B-cell Progenitor Cells Peripheral Blood
- Large Pre B-Cells Hematopoietic Bone Marrow
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Body Subcutaneous White Adipose
- Adipose-derived stem cells (Adipoplus)
- Adipose tissue-derived stem cells
- Tooth (Integumentary System)
- Umbilical Cord (Extraembryonic Tissues)
-
Bone (Muscoskeletal System)
- Adventitial Reticular Cells Bone Marrow
- Bone Marrow Stromal Cells Bone Marrow
- HyStem+BMP4-induced MEL2 cells
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
- Duct Cells Pancreatic Ducts
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Testicular Interstitial Cells Testis Interstitium
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
-
Placenta (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
- Placenta-derived cells
- Inner Cell Mass (Early Embryonic Tissues)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesenchymal Stromal Cells Chorionic Villus
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Eye (Sensory Organs)
- Dermis (Integumentary System)
- Fibroblasts
- Neural Crest (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for MME Gene
This gene is overexpressed in Whole Blood (x5.4).
This gene is overexpressed in Urine (32.3), Pancreatic juice (19.6), and Kidney (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MME Gene
NURSA nuclear receptor signaling pathways regulating expression of MME Gene:
MMESOURCE GeneReport for Unigene cluster for MME Gene:
Hs.307734Evidence on tissue expression from TISSUES for MME Gene
- Kidney(4.9)
- Nervous system(4.6)
- Liver(4.5)
- Blood(3.4)
- Bone marrow(3.3)
- Lymph node(3.2)
- Lung(3)
- Muscle(2.9)
- Skin(2.8)
- Intestine(2.7)
- Heart(2.6)
- Stomach(2.5)
- Bone(2.4)
- Spleen(2.3)
Primer Products
-
OriGene qPCR primer pairs for MME
- genomics-online: primer clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MME Gene
Orthologs for MME Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MME 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MME 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mme 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mme 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | MME 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | MME 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MME 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MME 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG6265 35 |
|
|
|
| Nep1 34 35 |
|
ManyToMany | |||
| Nep2 34 35 |
|
ManyToMany | |||
| CG8358 35 |
|
|
|||
| Nep4 34 35 |
|
ManyToMany | |||
| CG14527 35 |
|
|
|||
| BcDNA:GH07188 35 |
|
|
|||
| CG5527 35 |
|
|
|||
| CG14528 35 |
|
|
|||
| CG4721 35 |
|
|
|||
| CG14529 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | nep-2 34 |
|
ManyToMany | |
| T05A8.4 35 |
|
|
|||
| nep-1 34 |
|
ManyToMany | |||
| T16A9.4 35 |
|
|
|||
| nep-11 34 |
|
ManyToMany | |||
| F26G1.6 35 |
|
|
|||
| F54F11.2 35 |
|
|
|||
| T25B6.2 35 |
|
|
|||
| F18A12.1 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MME was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for MME Gene
- ENSEMBL:
- Gene Tree for MME (if available)
- TreeFam:
- Gene Tree for MME (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MME: view image
Paralogs for MME Gene
(5) SIMAP similar genes for MME Gene using alignment to 11 proteins:
- NEP_HUMAN
- B7ZKY6_HUMAN
- C9IYX7_HUMAN
- C9J7X4_HUMAN
- C9J9X7_HUMAN
- C9JDZ3_HUMAN
- C9JR96_HUMAN
- L7Z660_HUMAN
- L7ZC27_HUMAN
- L8E8E1_HUMAN
- Q3KQS6_HUMAN
Variants for MME Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519023 | pathogenic, Charcot-Marie-Tooth disease, axonal, type 2T | 155,116,987(+) | G/A | splice_donor_variant | |
| rs1057519024 | pathogenic, Charcot-Marie-Tooth disease, axonal, type 2T | 155,116,561(+) | T/A | splice_donor_variant | |
| rs1060499935 | uncertain-significance, Charcot-Marie-Tooth disease, axonal, type 2T | 155,143,523(+) | GGGG/GGG | coding_sequence_variant, frameshift | |
| rs138218277 | Charcot-Marie-Tooth disease 2T (CMT2T) [MIM:617017] | 155,142,073(+) | A/G | coding_sequence_variant, missense_variant | |
| rs151302020 | uncertain-significance, Charcot-Marie-Tooth disease, axonal, type 2T | 155,168,615(+) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3598262 | CNV | loss | 21293372 |
| esv3598264 | CNV | loss | 21293372 |
| nsv1000140 | CNV | loss | 25217958 |
| nsv474350 | CNV | novel sequence insertion | 20440878 |
| nsv829762 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.59;
44.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MME Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MME Gene
Disorders for MME Gene
(122) MalaCards diseases for MME Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| charcot-marie-tooth disease, axonal, type 2t |
|
|
| spinocerebellar ataxia 43 |
|
|
| membranous nephropathy |
|
|
| adenosarcoma |
|
|
| charcot-marie-tooth disease, axonal, type 2e |
|
|
Search MME in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NEP_HUMAN- Charcot-Marie-Tooth disease 2T (CMT2T) [MIM:617017]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269 PubMed:26991897, ECO:0000269 PubMed:27588448}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Spinocerebellar ataxia 43 (SCA43) [MIM:617018]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA43 is a slowly progressive, autosomal dominant form. {ECO:0000269 PubMed:27583304}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MME
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for MME Gene
Publications for MME Gene
- [Association of the neprilysin and apolipoprotein E gene polymorphisms with Alzheimer's disease in Xinjiang Uygur population]. (PMID: 20376800) Zhou XH … Luo XM (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2010) 3 22 44 58
- Lack of association of neprilysin gene polymorphisms with Alzheimer's disease in a southern Chinese community. (PMID: 19250583) Fu Y … Zhao ZH (International psychogeriatrics 2009) 3 22 44 58
- Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. (PMID: 10669592) Oefner C … Dale GE (Journal of molecular biology 2000) 3 4 22 58
- Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. (PMID: 8168535) Le Moual H … Boileau G (European journal of biochemistry 1994) 3 4 22 58
- Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. (PMID: 27588448) Auer-Grumbach M … Senderek J (American journal of human genetics 2016) 3 4 58
Products for MME Gene
- R&D Systems Antibodies for MME (Neprilysin/CD10)
- R&D Systems Proteins and Enzymes for MME (Neprilysin/CD10)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MME (Neprilysin/CD10)
- Browse Human Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for MME
- AM05174FC-N
- AM05174PU-N
- AM06014PU-N
- AM06091PU-N
- AM31220AF-N
- AM31220PU-N
- AM31220PU-S
- AM31220RP-N
- AM33192PU-N
- AM33192PU-S
- DM240
- DM240-05
- DMP107
- SM1525A
- SM1525APC
- SM1525APCT
- SM1525B
- SM1525F
- SM1525FT
- SM1525P
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- SM1525PT
- SM1525RT
- SM3006APC
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- SM3006P
- SM3006PP
- SM3006R
- SM3139F
- SM3139P
- SM3139R
- TA320422
- TA321228
- TA321229
- TA324359
- TA324923
- TA324924
- TA327616
- TA332826
- TA353334
- TA353646
- TA353647
- TA353648
- TA504507
- CF504507
- TA590055
- TA808300
- CF808300
- TA810605
- CF810605
- TA810614
- CF810614
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MME
- Origene Custom Protein Services for MME
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MME
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- OriGene qPCR primer pairs for MME
- OriGene CRISPR knockouts for MME
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MME
- GenScript: Next-day shipping of latest version cDNA ORF clones for MME in any vector
- GenScript Custom Purified and Recombinant Proteins Services for MME
- GenScript Custom Assay Services for MME
- GenScript Custom overexpressing Cell Line Services for MME
- GenScript: Design CRISPR guide RNA sequences for MME
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
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- Plasmid Preparation
- GenScript Custom Peptide Services for MME
- Sino Biological Human cDNA Clone for MME
- Sino Biological Recombinant Proteins for MME
- Sino Biological Cell Lysates for MME
- Sino Biological Antibodies for MME
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MME
- Novus Biologicals lysates and proteins for MME
- Novus Biologicals ELISA Kits for MME
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam proteins for MME
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for MME
- Cyagen custom Knockout/knockin (KOKI) mouse models for MME
- VectorBuilder custom plasmid, inducible vectors for MME
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MME
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MME
- antibodies-online: Search results for 645 available MME Antibodies ranked by validation data
- Compare Top MME Antibodies
- Recommended
- 290 WB Antibodies (anti-human)
- 150 FACS Antibodies (anti-human)
- 55 IHC (p) Antibodies (anti-human)
- 28 IP Antibodies (anti-human)
- 27 IF Antibodies (anti-human)
- 25 IHC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IF/ICC Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 IA Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 63 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Search results for 43 available MME Elisa Kits ranked by validation data
- Compare Top MME Elisa Kits
- antibodies-online: Search results for 39 available MME Proteins ranked by validation data
- Compare Top MME Proteins
- GeneTex Mme Antibody for MME
- Search GeneTex for Proteins for MME
- Santa Cruz Biotechnology (SCBT) Antibodies for MME
- Search Santa Cruz Biotechnology (SCBT) for MME siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MME
- Horizon Cell Lines for MME
- genomics-online: cdna clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- orf clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- genomics-online: gRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- genomics-online: primer clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- genomics-online: shRNA clones - Search results for 153 available MME gene related products
- Overview of 153 available MME gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MME
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MME
- GeneCopoeia miRNA 3'UTR Target clone products for MME
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MME
- Boster Bio Antibodies for MME
Sources for MME Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt