This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014] See more...

Aliases for MLXIP Gene

Aliases for MLXIP Gene

  • MLX Interacting Protein 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 36 3 4
  • Transcriptional Activator MondoA 3 4
  • MLX-Interacting Protein 3 4
  • BHLHe36 3 4
  • MONDOA 3 4
  • MIR 3 4
  • Mlx Interactor 3
  • KIAA0867 4
  • BHLHE36 4

External Ids for MLXIP Gene

Previous GeneCards Identifiers for MLXIP Gene

  • GC12P121137
  • GC12P121002
  • GC12P122516
  • GC12P119572

Summaries for MLXIP Gene

Entrez Gene Summary for MLXIP Gene

  • This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]

GeneCards Summary for MLXIP Gene

MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Insulin resistance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MLXIPL.

UniProtKB/Swiss-Prot Summary for MLXIP Gene

  • Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Additional gene information for MLXIP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLXIP Gene

Genomics for MLXIP Gene

GeneHancer (GH) Regulatory Elements for MLXIP Gene

Promoters and enhancers for MLXIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MLXIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MLXIP gene promoter:
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • RSRFC4
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3
  • ZID

Genomic Locations for MLXIP Gene

Genomic Locations for MLXIP Gene
chr12:122,078,728-122,147,347
(GRCh38/hg38)
Size:
68,620 bases
Orientation:
Plus strand
chr12:122,516,628-122,631,894
(GRCh37/hg19)
Size:
115,267 bases
Orientation:
Plus strand

Genomic View for MLXIP Gene

Genes around MLXIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLXIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLXIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLXIP Gene

Proteins for MLXIP Gene

  • Protein details for MLXIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAP2-MLXIP_HUMAN
    Recommended name:
    MLX-interacting protein
    Protein Accession:
    Q9HAP2
    Secondary Accessions:
    • A7MBN0
    • O94945
    • Q7LC47
    • Q8IXP1
    • Q8TAH9
    • Q8WVQ0
    • Q8WYA5

    Protein attributes for MLXIP Gene

    Size:
    919 amino acids
    Molecular mass:
    101185 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.
    SequenceCaution:
    • Sequence=BAA74890.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MLXIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLXIP Gene

Post-translational modifications for MLXIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MLXIP

No data available for DME Specific Peptides for MLXIP Gene

Domains & Families for MLXIP Gene

Gene Families for MLXIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for MLXIP Gene

Suggested Antigen Peptide Sequences for MLXIP Gene

GenScript: Design optimal peptide antigens:
  • Transcriptional activator MondoA (MLXIP_HUMAN)
genes like me logo Genes that share domains with MLXIP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MLXIP Gene

Function for MLXIP Gene

Molecular function for MLXIP Gene

UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.

Phenotypes From GWAS Catalog for MLXIP Gene

Gene Ontology (GO) - Molecular Function for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 11073985
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11073985
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with MLXIP: view
genes like me logo Genes that share phenotypes with MLXIP: view

Animal Models for MLXIP Gene

MGI Knock Outs for MLXIP:
  • Mlxip Mlxip<tm1.2Lchan>

Animal Model Products

CRISPR Products

miRNA for MLXIP Gene

miRTarBase miRNAs that target MLXIP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLXIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLXIP Gene

Localization for MLXIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLXIP Gene

Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250 UniProtKB:Q2VPU4, ECO:0000269 PubMed:12446771, ECO:0000269 PubMed:16782875}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLXIP gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 0

Gene Ontology (GO) - Cellular Components for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MLXIP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MLXIP Gene

Pathways & Interactions for MLXIP Gene

genes like me logo Genes that share pathways with MLXIP: view

Pathways by source for MLXIP Gene

Gene Ontology (GO) - Biological Process for MLXIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 11073985
GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter IMP 16782875
genes like me logo Genes that share ontologies with MLXIP: view

No data available for SIGNOR curated interactions for MLXIP Gene

Drugs & Compounds for MLXIP Gene

No Compound Related Data Available

Transcripts for MLXIP Gene

mRNA/cDNA for MLXIP Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLXIP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLXIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for MLXIP Gene

GeneLoc Exon Structure for
MLXIP
ECgene alternative splicing isoforms for
MLXIP

Expression for MLXIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLXIP Gene

mRNA differential expression in normal tissues according to GTEx for MLXIP Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for MLXIP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLXIP Gene



Protein tissue co-expression partners for MLXIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MLXIP Gene:

MLXIP

SOURCE GeneReport for Unigene cluster for MLXIP Gene:

Hs.721711

mRNA Expression by UniProt/SwissProt for MLXIP Gene:

Q9HAP2-MLXIP_HUMAN
Tissue specificity: Widely expressed in adult tissues. Most abundant in skeletal muscle.

Evidence on tissue expression from TISSUES for MLXIP Gene

  • Nervous system(4.6)
  • Eye(3.5)
  • Muscle(3.1)
  • Intestine(2.7)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with MLXIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLXIP Gene

Orthologs for MLXIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MLXIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLXIP 33 32
  • 99.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MLXIP 33 32
  • 87.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MLXIP 33 32
  • 87.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlxip 32
  • 85.33 (n)
mouse
(Mus musculus)
Mammalia Mlxip 17 33 32
  • 85.24 (n)
oppossum
(Monodelphis domestica)
Mammalia MLXIP 33
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLXIP 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLXIP 33 32
  • 66.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLXIP 33
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlxip 32
  • 64.56 (n)
Str.4943 32
zebrafish
(Danio rerio)
Actinopterygii mlxip 33 32
  • 61.94 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6592 32
fruit fly
(Drosophila melanogaster)
Insecta Mio 33
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mml-1 33
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
OneToMany
Species where no ortholog for MLXIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLXIP Gene

ENSEMBL:
Gene Tree for MLXIP (if available)
TreeFam:
Gene Tree for MLXIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MLXIP: view image

Paralogs for MLXIP Gene

Paralogs for MLXIP Gene

(1) SIMAP similar genes for MLXIP Gene using alignment to 6 proteins:

  • MLXIP_HUMAN
  • C9JBQ4_HUMAN
  • F5H0V4_HUMAN
  • F5H321_HUMAN
  • H0YGR9_HUMAN
  • L8EAR3_HUMAN
genes like me logo Genes that share paralogs with MLXIP: view

Variants for MLXIP Gene

Sequence variations from dbSNP and Humsavar for MLXIP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000021681 -- 122,096,923(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000050326 -- 122,117,712(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000069578 -- 122,142,990(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000079049 -- 122,142,819(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000135783 -- 122,121,659(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MLXIP Gene

Variant ID Type Subtype PubMed ID
dgv3n35 CNV novel sequence insertion 20440878
nsv1038827 CNV loss 25217958
nsv1126326 CNV deletion 24896259
nsv1145634 CNV deletion 24896259
nsv472322 CNV novel sequence insertion 20440878
nsv478155 CNV novel sequence insertion 20440878
nsv478681 CNV novel sequence insertion 20440878
nsv479428 CNV novel sequence insertion 20440878
nsv479769 CNV novel sequence insertion 20440878
nsv479827 CNV novel sequence insertion 20440878
nsv479940 CNV novel sequence insertion 20440878
nsv480531 CNV novel sequence insertion 20440878
nsv480768 CNV novel sequence insertion 20440878
nsv952496 CNV deletion 24416366

Variation tolerance for MLXIP Gene

Gene Damage Index Score: 6.65; 78.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MLXIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLXIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLXIP Gene

Disorders for MLXIP Gene

Additional Disease Information for MLXIP

No disorders were found for MLXIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLXIP Gene

Publications for MLXIP Gene

  1. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin AN … Ayer DE (Molecular and cellular biology 2000) 2 3 4 56
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 56
  3. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PMID: 19706488) Kaadige MR … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 56
  4. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PMID: 18458340) Stoltzman CA … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23 56
  5. MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PMID: 16782875) Sans CL … Ayer DE (Molecular and cellular biology 2006) 3 4 56

Products for MLXIP Gene

Sources for MLXIP Gene