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This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014] See more...
Aliases for MLXIP Gene
Aliases for MLXIP Gene
External Ids for MLXIP Gene
- HGNC: 17055
- NCBI Entrez Gene: 22877
- Ensembl: ENSG00000175727
- OMIM®: 608090
- UniProtKB/Swiss-Prot: Q9HAP2
Previous GeneCards Identifiers for MLXIP Gene
- GC12P121137
- GC12P121002
- GC12P122516
- GC12P119572
Summaries for MLXIP Gene
-
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
GeneCards Summary for MLXIP Gene
MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Insulin resistance and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MLXIPL.
UniProtKB/Swiss-Prot Summary for MLXIP Gene
-
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Additional gene information for MLXIP Gene
- HGNC (17055)
- NCBI Entrez Gene (22877)
- Ensembl (ENSG00000175727)
- OMIM® (608090)
- UniProtKB/Swiss-Prot (Q9HAP2)
- Open Targets Platform(ENSG00000175727)
- Search for MLXIP at DataMed
- Search for MLXIP at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLXIP Gene
Genomics for MLXIP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MLXIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MLXIP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MLXIP
- Top Transcription factor binding sites by QIAGEN in the MLXIP gene promoter:
-
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- RSRFC4
- STAT1
- STAT1alpha
- STAT1beta
- STAT3
- ZID
Genomic Locations for MLXIP Gene
Latest Assembly
- chr12:122,078,744-122,147,344
- (GRCh38/hg38)
- Size:
- 68,601 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:122,516,662-122,631,891
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 115,230 bases
- Orientation:
- Plus strand
- chr12:122,516,628-122,631,894
- (GRCh37/hg19 by Ensembl)
- Size:
- 115,267 bases
- Orientation:
- Plus strand
Genomic View for MLXIP Gene
Genes around MLXIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q21.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
MLXIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLXIP Gene
Proteins for MLXIP Gene
-
Protein details for MLXIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HAP2-MLXIP_HUMAN
- Recommended name:
- MLX-interacting protein
- Protein Accession:
- Q9HAP2
- A7MBN0
- O94945
- Q7LC47
- Q8IXP1
- Q8TAH9
- Q8WVQ0
- Q8WYA5
Protein attributes for MLXIP Gene
- Size:
- 919 amino acids
- Molecular mass:
- 101185 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.
- SequenceCaution:
-
- Sequence=BAA74890.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MLXIP Gene
Post-translational modifications for MLXIP Gene
Other Protein References for MLXIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences MLXIP / MONDOA Antibody (LS-B12245) and MLXIP / MONDOA Antibody (LS-B16013)
- G Biosciences Immunotag™ MLXIP Antibody
-
Custom Antibody ServicesOriGene Antibodies for MLXIP
- Novus Biologicals Antibodies for MLXIP
-
Abcam antibodies for MLXIP
- Invitrogen Antibodies for MLXIP (AFLGC-MLXIP)
-
Boster Bio Antibodies for MLXIP
-
Custom Antibody ServicesProSci Antibodies for MLXIP
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLXIP
Protein products for research
-
OriGene Purified Proteins for MLXIP
- Search Origene for MassSpec and Protein Over-expression Lysates for MLXIP
- Origene Custom Protein Services for MLXIP
- Novus Biologicals proteins for MLXIP
- antibodies-online: Show 4 available MLXIP Proteins ranked by validation data
- Compare Top MLXIP Proteins
-
Quality Products:
-
Abcam proteins for MLXIP
Assay products for research
- antibodies-online: Show 4 available MLXIP Elisa Kits ranked by validation data
- Compare Top MLXIP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MLXIP Gene
Domains & Families for MLXIP Gene
Gene Families for MLXIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MLXIP Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
- ProtoNet:
Suggested Antigen Peptide Sequences for MLXIP Gene
- GenScript: Design optimal peptide antigens:
-
- Transcriptional activator MondoA (MLXIP_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MLXIP Gene
Function for MLXIP Gene
Molecular function for MLXIP Gene
- UniProtKB/Swiss-Prot Function:
- Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Phenotypes From GWAS Catalog for MLXIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 11073985 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11073985 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for MLXIP Gene
- MGI mutant phenotypes for MLXIP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MLXIP:
Animal Models for MLXIP Gene
- MGI Knock Outs for MLXIP:
-
- Mlxip Mlxip<tm1.2Lchan>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MLXIP - Starting at $85 >
- * MLXIP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MLXIP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLXIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLXIP
miRNA for MLXIP Gene
- miRTarBase miRNAs that target MLXIP
-
- mmu-miR-7b-5p (MIRT009330)
- mmu-miR-17-5p (MIRT009996)
- mmu-miR-136-5p (MIRT014978)
- hsa-miR-335-5p (MIRT017115)
- hsa-miR-98-5p (MIRT027490)
- hsa-miR-26b-5p (MIRT029021)
- hsa-miR-877-5p (MIRT037318)
- hsa-miR-421 (MIRT039408)
- hsa-miR-20a-5p (MIRT050538)
- hsa-miR-106b-5p (MIRT440227)
- hsa-miR-6858-5p (MIRT473089)
- hsa-miR-4689 (MIRT473090)
- hsa-miR-4710 (MIRT473091)
- hsa-miR-6883-5p (MIRT473092)
- hsa-miR-6785-5p (MIRT473093)
- hsa-miR-4728-5p (MIRT473094)
- hsa-miR-4763-3p (MIRT473095)
- hsa-miR-149-3p (MIRT473096)
- hsa-miR-1207-5p (MIRT473097)
- hsa-miR-6077 (MIRT473098)
- hsa-miR-6799-3p (MIRT473099)
- hsa-miR-3173-5p (MIRT473100)
- hsa-miR-4722-5p (MIRT473101)
- hsa-miR-1286 (MIRT473102)
- hsa-miR-873-5p (MIRT473103)
- hsa-miR-6804-5p (MIRT473104)
- hsa-miR-6133 (MIRT473105)
- hsa-miR-6130 (MIRT473106)
- hsa-miR-6129 (MIRT473107)
- hsa-miR-6127 (MIRT473108)
- hsa-miR-4510 (MIRT473109)
- hsa-miR-4419a (MIRT473110)
- hsa-miR-4784 (MIRT473111)
- hsa-miR-1827 (MIRT473112)
- hsa-miR-4756-5p (MIRT473113)
- hsa-miR-3150b-3p (MIRT473114)
- hsa-miR-4739 (MIRT473115)
- hsa-miR-1321 (MIRT473116)
- hsa-miR-940 (MIRT473117)
- hsa-miR-6893-5p (MIRT473118)
- hsa-miR-6808-5p (MIRT473119)
- hsa-miR-6873-5p (MIRT473120)
- hsa-miR-6856-5p (MIRT473121)
- hsa-miR-6758-5p (MIRT473122)
- hsa-miR-6816-3p (MIRT535870)
- mmu-miR-3473c (MIRT600629)
- mmu-miR-1894-5p (MIRT600630)
- mmu-miR-3097-3p (MIRT605624)
- mmu-miR-717 (MIRT605625)
- mmu-miR-329-3p (MIRT605626)
- mmu-miR-362-3p (MIRT605627)
- hsa-miR-3941 (MIRT612764)
- hsa-miR-5689 (MIRT612765)
- hsa-miR-8064 (MIRT612766)
- hsa-miR-362-3p (MIRT612767)
- hsa-miR-329-3p (MIRT612768)
- hsa-miR-8485 (MIRT612769)
- hsa-miR-4298 (MIRT612770)
- hsa-miR-1302 (MIRT612771)
- hsa-miR-561-5p (MIRT612772)
- hsa-miR-216b-3p (MIRT612773)
- hsa-miR-3922-5p (MIRT612774)
- hsa-miR-603 (MIRT612775)
- hsa-miR-5581-5p (MIRT656201)
- hsa-miR-4297 (MIRT656202)
- hsa-miR-5695 (MIRT656203)
- hsa-miR-662 (MIRT656204)
- hsa-miR-3614-3p (MIRT656205)
- hsa-miR-483-5p (MIRT656206)
- hsa-miR-6801-5p (MIRT701914)
- hsa-miR-1914-5p (MIRT701915)
- hsa-miR-4793-5p (MIRT701916)
- hsa-miR-383-3p (MIRT701917)
- hsa-miR-3065-3p (MIRT701918)
- hsa-miR-6871-3p (MIRT701919)
- hsa-miR-377-3p (MIRT725376)
- hsa-miR-4284 (MIRT725377)
- hsa-miR-342-3p (MIRT725378)
- hsa-miR-4714-3p (MIRT725379)
- hsa-miR-30e-5p (MIRT727165)
- hsa-miR-30d-5p (MIRT727166)
- hsa-miR-30c-5p (MIRT727167)
- hsa-miR-30b-5p (MIRT727168)
- hsa-miR-30a-5p (MIRT727169)
- hsa-miR-519d-3p (MIRT727170)
- hsa-miR-93-5p (MIRT727171)
- hsa-miR-20b-5p (MIRT727172)
- hsa-miR-17-5p (MIRT727173)
- hsa-miR-195-5p (MIRT727174)
- hsa-miR-16-5p (MIRT727175)
- hsa-miR-15a-5p (MIRT727176)
- hsa-miR-15b-5p (MIRT727177)
- hsa-miR-122-5p (MIRT761339)
- hsa-miR-1299 (MIRT762395)
- hsa-miR-1304-3p (MIRT762420)
- hsa-miR-140-3p (MIRT762631)
- hsa-miR-143-5p (MIRT762688)
- hsa-miR-150-3p (MIRT762856)
- hsa-miR-216a-5p (MIRT763880)
- hsa-miR-3135b (MIRT764935)
- hsa-miR-3652 (MIRT766294)
- hsa-miR-4430 (MIRT768929)
- hsa-miR-4476 (MIRT769486)
- hsa-miR-500b-3p (MIRT772993)
- hsa-miR-504-3p (MIRT773058)
- hsa-miR-5698 (MIRT775153)
- hsa-miR-6128 (MIRT775816)
- hsa-miR-6499-3p (MIRT776309)
- hsa-miR-6736-3p (MIRT778041)
- hsa-miR-6787-3p (MIRT779197)
- hsa-miR-6802-3p (MIRT779502)
- hsa-miR-6876-5p (MIRT780752)
- hsa-miR-6890-3p (MIRT781142)
- hsa-miR-875-3p (MIRT782520)
- hsa-miR-1182 (MIRT783097)
- hsa-miR-129-5p (MIRT783537)
- hsa-miR-193a-5p (MIRT784043)
- hsa-miR-3674 (MIRT785180)
- hsa-miR-4524a-3p (MIRT786121)
- hsa-miR-4524b-3p (MIRT786152)
- hsa-miR-4732-5p (MIRT786562)
- hsa-miR-6832-5p (MIRT789003)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLXIP
- Browse OriGene Inhibitory RNA Products For MLXIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLXIP
Clone products for research
- Applied Biological Materials (abm): Clones for MLXIP - Starting at $45 >
- * MLXIP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MLXIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLXIP
Cell Lines for research
-
Horizon Cell Lines for MLXIP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLXIP Gene
Localization for MLXIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLXIP Gene
- Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250 UniProtKB:Q2VPU4, ECO:0000269 PubMed:12446771, ECO:0000269 PubMed:16782875}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 4 |
| nucleus | 4 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MLXIP Gene
Pathways & Interactions for MLXIP Gene
Pathways by source for MLXIP Gene
2 KEGG pathways for MLXIP Gene
Interacting Proteins for MLXIP Gene
GPS-Prot Interaction Network for MLXIP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA,IMP | 16782875 |
No data available for SIGNOR curated interactions for MLXIP Gene
Transcripts for MLXIP Gene
mRNA/cDNA for MLXIP Gene
- 1 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000319080 8390 nts (view in UCSC)
- ENST00000366272 1682 nts (view in UCSC)
- ENST00000377037 805 nts (view in UCSC)
- ENST00000535430 1619 nts (view in UCSC)
- ENST00000535876 465 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MLXIP - Starting at $85 >
- * MLXIP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MLXIP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLXIP
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLXIP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLXIP
- Browse OriGene Inhibitory RNA Products For MLXIP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLXIP
Clone products for research
- Applied Biological Materials (abm): Clones for MLXIP - Starting at $45 >
- * MLXIP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MLXIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLXIP
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
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| SP6: | - |
Relevant External Links for MLXIP Gene
- GeneLoc Exon Structure for
- MLXIP
Expression for MLXIP Gene
mRNA differential expression in normal tissues according to GTEx for MLXIP Gene
This gene is overexpressed in Muscle - Skeletal (x5.6).
This gene is overexpressed in Islet of Langerhans (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLXIP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MLXIP
SOURCE GeneReport for Unigene cluster for MLXIP Gene:
Hs.721711mRNA Expression by UniProt/SwissProt for MLXIP Gene:
Q9HAP2-MLXIP_HUMAN
Tissue specificity:
Widely expressed in adult tissues. Most abundant in skeletal muscle.
Evidence on tissue expression from TISSUES for MLXIP Gene
- Nervous system(4.6)
- Eye(3.7)
- Muscle(3.4)
- Intestine(3.2)
- Lung(2.5)
- Blood(2.4)
- Liver(2.3)
- Pancreas(2.3)
- Skin(2.1)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for MLXIP
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLXIP Gene
Orthologs for MLXIP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mlxip 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mlxip 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MLXIP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MLXIP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MLXIP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MLXIP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mlxip 30 |
|
||
| Str.4943 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | mlxip 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6592 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Mio 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | mml-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for MLXIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MLXIP Gene
- ENSEMBL:
- Gene Tree for MLXIP (if available)
- TreeFam:
- Gene Tree for MLXIP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MLXIP: view image
Paralogs for MLXIP Gene
Variants for MLXIP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MLXIP Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34702867 | - |
p.Val539Leu |
|||
| rs7978353 | - |
p.Glu396Gly |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3n35 | CNV | novel sequence insertion | 20440878 |
| nsv1038827 | CNV | loss | 25217958 |
| nsv1126326 | CNV | deletion | 24896259 |
| nsv1145634 | CNV | deletion | 24896259 |
| nsv472322 | CNV | novel sequence insertion | 20440878 |
| nsv478155 | CNV | novel sequence insertion | 20440878 |
| nsv478681 | CNV | novel sequence insertion | 20440878 |
| nsv479428 | CNV | novel sequence insertion | 20440878 |
| nsv479769 | CNV | novel sequence insertion | 20440878 |
| nsv479827 | CNV | novel sequence insertion | 20440878 |
| nsv479940 | CNV | novel sequence insertion | 20440878 |
| nsv480531 | CNV | novel sequence insertion | 20440878 |
| nsv480768 | CNV | novel sequence insertion | 20440878 |
| nsv952496 | CNV | deletion | 24416366 |
Gene Damage Index Score:
6.65;
78.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MLXIP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MLXIP
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLXIP Gene
Disorders for MLXIP Gene
Additional Disease Information for MLXIP
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for MLXIP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLXIP Gene
Publications for MLXIP Gene
- MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin AN … Ayer DE (Molecular and cellular biology 2000) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PMID: 19706488) Kaadige MR … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23
- Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PMID: 18458340) Stoltzman CA … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 23
- MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PMID: 16782875) Sans CL … Ayer DE (Molecular and cellular biology 2006) 3 4
ExternalLinks
Products for MLXIP Gene
- Custom Antibody ServicesOriGene Antibodies for MLXIP
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- Sino Biological Human cDNA Clone for MLXIP
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for MLXIP
- Novus Biologicals proteins for MLXIP
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for MLXIP (AFLGC-MLXIP)
- VectorBuilder Custom and pre-made DNA vectors for MLXIP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MLXIP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MLXIP (ie. knockout, knockin, CRISPRa, CRISPRi)
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- VectorBuilder Stable cell line generation for MLXIP
- antibodies-online: Show 13 available MLXIP Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for MLXIP
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- Search for MLXIP Proteins at ProSci
- Horizon Cell Lines for MLXIP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLXIP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLXIP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MLXIP
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- Boster Bio Antibodies for MLXIP
- Browse Boster Bio ELISA Kits
Sources for MLXIP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB