Aliases for MLXIP Gene
Aliases for MLXIP Gene
External Ids for MLXIP Gene
- HGNC: 17055
- Entrez Gene: 22877
- Ensembl: ENSG00000175727
- OMIM: 608090
- UniProtKB: Q9HAP2
Previous GeneCards Identifiers for MLXIP Gene
- GC12P121137
- GC12P121002
- GC12P122516
- GC12P119572
Summaries for MLXIP Gene
-
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
GeneCards Summary for MLXIP Gene
MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Insulin resistance and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MLXIPL.
UniProtKB/Swiss-Prot for MLXIP Gene
-
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLXIP Gene
Genomics for MLXIP Gene
GeneHancer (GH) Regulatory Elements for MLXIP Gene
Promoters and enhancers for MLXIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MLXIP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MLXIP Gene
Genomic Locations for MLXIP Gene
- chr12:122,078,722-122,147,347
- (GRCh38/hg38)
- Size:
- 68,626 bases
- Orientation:
- Plus strand
- chr12:122,516,628-122,631,894
- (GRCh37/hg19)
Genomic View for MLXIP Gene
Genes around MLXIP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q21.31 by HGNC
MLXIP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLXIP Gene
Proteins for MLXIP Gene
-
Protein details for MLXIP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HAP2-MLXIP_HUMAN
- Recommended name:
- MLX-interacting protein
- Protein Accession:
- Q9HAP2
- A7MBN0
- O94945
- Q7LC47
- Q8IXP1
- Q8TAH9
- Q8WVQ0
- Q8WYA5
Protein attributes for MLXIP Gene
- Size:
- 919 amino acids
- Molecular mass:
- 101185 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.
- SequenceCaution:
-
- Sequence=BAA74890.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MLXIP Gene
Post-translational modifications for MLXIP Gene
Other Protein References for MLXIP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MLXIP
- Novus Biologicals Antibodies for MLXIP
-
Abcam antibodies for MLXIP
- Invitrogen Antibodies for MLXIP
- Search GeneTex for Antibodies for MLXIP
-
Custom Antibody ServicesProSci Antibodies for MLXIP
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLXIP
Protein Products
-
OriGene Purified Proteins for MLXIP
- Search Origene for MassSpec and Protein Over-expression Lysates for MLXIP
- Origene Custom Protein Services for MLXIP
- Novus Biologicals proteins for MLXIP
- antibodies-online: Search results for 7 available MLXIP Proteins ranked by validation data
- Compare Top MLXIP Proteins
-
Quality Products:
- Search GeneTex for Proteins for MLXIP
-
Abcam proteins for MLXIP
Assay Products
- antibodies-online: Search results for 2 available MLXIP Elisa Kits ranked by validation data
- Compare Top MLXIP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for MLXIP Gene
Domains & Families for MLXIP Gene
Gene Families for MLXIP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
- Transcription factors
Protein Domains for MLXIP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MLXIP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MLXIP Gene
Function for MLXIP Gene
Molecular function for MLXIP Gene
- UniProtKB/Swiss-Prot Function:
- Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5-CACGTG-3. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.
Phenotypes From GWAS Catalog for MLXIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 11073985 |
| GO:0000989 | transcription factor activity, transcription factor binding | IEA | -- |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 11073985 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IBA | -- |
Phenotypes for MLXIP Gene
- GenomeRNAi human phenotypes for MLXIP:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MLXIP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MLXIP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLXIP gene
- Search ViGene Biosciences for MLXIP
CRISPR Products
-
OriGene CRISPR knockouts for MLXIP
- genomics-online: gRNA clones - Search results for available MLXIP gene related products
- Applied Biological Materials CRISPR for MLXIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLXIP
- GenScript: Design CRISPR guide RNA sequences for MLXIP
miRNA for MLXIP Gene
- miRTarBase miRNAs that target MLXIP
-
- hsa-mir-335-5p (MIRT017115)
- hsa-mir-98-5p (MIRT027490)
- hsa-mir-26b-5p (MIRT029021)
- hsa-mir-877-5p (MIRT037318)
- hsa-mir-421 (MIRT039408)
- hsa-mir-20a-5p (MIRT050538)
- hsa-mir-106b-5p (MIRT440227)
- hsa-mir-6858-5p (MIRT473089)
- hsa-mir-4689 (MIRT473090)
- hsa-mir-4710 (MIRT473091)
- hsa-mir-6883-5p (MIRT473092)
- hsa-mir-6785-5p (MIRT473093)
- hsa-mir-4728-5p (MIRT473094)
- hsa-mir-4763-3p (MIRT473095)
- hsa-mir-149-3p (MIRT473096)
- hsa-mir-1207-5p (MIRT473097)
- hsa-mir-6077 (MIRT473098)
- hsa-mir-6799-3p (MIRT473099)
- hsa-mir-3173-5p (MIRT473100)
- hsa-mir-4722-5p (MIRT473101)
- hsa-mir-1286 (MIRT473102)
- hsa-mir-873-5p (MIRT473103)
- hsa-mir-6804-5p (MIRT473104)
- hsa-mir-6133 (MIRT473105)
- hsa-mir-6130 (MIRT473106)
- hsa-mir-6129 (MIRT473107)
- hsa-mir-6127 (MIRT473108)
- hsa-mir-4510 (MIRT473109)
- hsa-mir-4419a (MIRT473110)
- hsa-mir-4784 (MIRT473111)
- hsa-mir-1827 (MIRT473112)
- hsa-mir-4756-5p (MIRT473113)
- hsa-mir-3150b-3p (MIRT473114)
- hsa-mir-4739 (MIRT473115)
- hsa-mir-1321 (MIRT473116)
- hsa-mir-940 (MIRT473117)
- hsa-mir-6893-5p (MIRT473118)
- hsa-mir-6808-5p (MIRT473119)
- hsa-mir-6873-5p (MIRT473120)
- hsa-mir-6856-5p (MIRT473121)
- hsa-mir-6758-5p (MIRT473122)
- hsa-mir-6816-3p (MIRT535870)
- hsa-mir-3941 (MIRT612764)
- hsa-mir-5689 (MIRT612765)
- hsa-mir-8064 (MIRT612766)
- hsa-mir-362-3p (MIRT612767)
- hsa-mir-329-3p (MIRT612768)
- hsa-mir-8485 (MIRT612769)
- hsa-mir-4298 (MIRT612770)
- hsa-mir-1302 (MIRT612771)
- hsa-mir-561-5p (MIRT612772)
- hsa-mir-216b-3p (MIRT612773)
- hsa-mir-3922-5p (MIRT612774)
- hsa-mir-603 (MIRT612775)
- hsa-mir-5581-5p (MIRT656201)
- hsa-mir-4297 (MIRT656202)
- hsa-mir-5695 (MIRT656203)
- hsa-mir-662 (MIRT656204)
- hsa-mir-3614-3p (MIRT656205)
- hsa-mir-483-5p (MIRT656206)
- hsa-mir-6801-5p (MIRT701914)
- hsa-mir-1914-5p (MIRT701915)
- hsa-mir-4793-5p (MIRT701916)
- hsa-mir-383-3p (MIRT701917)
- hsa-mir-3065-3p (MIRT701918)
- hsa-mir-6871-3p (MIRT701919)
- hsa-mir-377-3p (MIRT725376)
- hsa-mir-4284 (MIRT725377)
- hsa-mir-342-3p (MIRT725378)
- hsa-mir-4714-3p (MIRT725379)
- hsa-mir-30e-5p (MIRT727165)
- hsa-mir-30d-5p (MIRT727166)
- hsa-mir-30c-5p (MIRT727167)
- hsa-mir-30b-5p (MIRT727168)
- hsa-mir-30a-5p (MIRT727169)
- hsa-mir-519d-3p (MIRT727170)
- hsa-mir-93-5p (MIRT727171)
- hsa-mir-20b-5p (MIRT727172)
- hsa-mir-17-5p (MIRT727173)
- hsa-mir-195-5p (MIRT727174)
- hsa-mir-16-5p (MIRT727175)
- hsa-mir-15a-5p (MIRT727176)
- hsa-mir-15b-5p (MIRT727177)
- hsa-mir-122-5p (MIRT761339)
- hsa-mir-1299 (MIRT762395)
- hsa-mir-1304-3p (MIRT762420)
- hsa-mir-140-3p (MIRT762631)
- hsa-mir-143-5p (MIRT762688)
- hsa-mir-150-3p (MIRT762856)
- hsa-mir-216a-5p (MIRT763880)
- hsa-mir-3135b (MIRT764935)
- hsa-mir-3652 (MIRT766294)
- hsa-mir-4430 (MIRT768929)
- hsa-mir-4476 (MIRT769486)
- hsa-mir-500b-3p (MIRT772993)
- hsa-mir-504-3p (MIRT773058)
- hsa-mir-5698 (MIRT775153)
- hsa-mir-6128 (MIRT775816)
- hsa-mir-6499-3p (MIRT776309)
- hsa-mir-6736-3p (MIRT778041)
- hsa-mir-6787-3p (MIRT779197)
- hsa-mir-6802-3p (MIRT779502)
- hsa-mir-6876-5p (MIRT780752)
- hsa-mir-6890-3p (MIRT781142)
- hsa-mir-875-3p (MIRT782520)
- hsa-mir-1182 (MIRT783097)
- hsa-mir-129-5p (MIRT783537)
- hsa-mir-193a-5p (MIRT784043)
- hsa-mir-3674 (MIRT785180)
- hsa-mir-4524a-3p (MIRT786121)
- hsa-mir-4524b-3p (MIRT786152)
- hsa-mir-4732-5p (MIRT786562)
- hsa-mir-6832-5p (MIRT789003)
miRNA Products
- Search ViGene Biosciences for MLXIP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MLXIP
- Browse OriGene Inhibitory RNA Products For MLXIP
- genomics-online: shRNA clones - Search results for available MLXIP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MLXIP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MLXIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLXIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MLXIP gene related products
- orf clones - Search results for available MLXIP gene related products
- Applied Biological Materials Clones for MLXIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MLXIP
-
ViGene Biosciences adenoviral particle packaged cDNA for MLXIP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MLXIP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MLXIP gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MLXIP Gene
Localization for MLXIP Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLXIP Gene
- Cytoplasm. Nucleus. Mitochondrion outer membrane. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250 UniProtKB:Q2VPU4, ECO:0000269 PubMed:12446771, ECO:0000269 PubMed:16782875}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MLXIP Gene
Pathways & Interactions for MLXIP Gene
Pathways by source for MLXIP Gene
2 KEGG pathways for MLXIP Gene
Interacting Proteins for MLXIP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 11073985 |
| GO:1900402 | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | IMP | 16782875 |
No data available for SIGNOR curated interactions for MLXIP Gene
Transcripts for MLXIP Gene
mRNA/cDNA for MLXIP Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (519) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MLXIP Gene
CRISPR Products
-
OriGene CRISPR knockouts for MLXIP
- genomics-online: gRNA clones - Search results for available MLXIP gene related products
- Applied Biological Materials CRISPR for MLXIP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLXIP
- GenScript: Design CRISPR guide RNA sequences for MLXIP
miRNA Products
- Search ViGene Biosciences for MLXIP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MLXIP
- Browse OriGene Inhibitory RNA Products For MLXIP
- genomics-online: shRNA clones - Search results for available MLXIP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MLXIP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for MLXIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLXIP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MLXIP gene related products
- orf clones - Search results for available MLXIP gene related products
- Applied Biological Materials Clones for MLXIP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
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| SP6: | - |
Expression for MLXIP Gene
mRNA differential expression in normal tissues according to GTEx for MLXIP Gene
This gene is overexpressed in Muscle - Skeletal (x5.6).
This gene is overexpressed in Islet of Langerhans (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MLXIP Gene
NURSA nuclear receptor signaling pathways regulating expression of MLXIP Gene:
MLXIPSOURCE GeneReport for Unigene cluster for MLXIP Gene:
Hs.721711mRNA Expression by UniProt/SwissProt for MLXIP Gene:
Q9HAP2-MLXIP_HUMAN
Tissue specificity:
Widely expressed in adult tissues. Most abundant in skeletal muscle.
Evidence on tissue expression from TISSUES for MLXIP Gene
- Nervous system(4.6)
- Eye(3.5)
- Muscle(3.1)
- Intestine(2.7)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for MLXIP
- genomics-online: primer clones - Search results for available MLXIP gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLXIP Gene
Orthologs for MLXIP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MLXIP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MLXIP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MLXIP 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mlxip 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mlxip 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MLXIP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MLXIP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MLXIP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MLXIP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mlxip 33 |
|
||
| Str.4943 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mlxip 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6592 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Mio 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mml-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for MLXIP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MLXIP Gene
(1) SIMAP similar genes for MLXIP Gene using alignment to 6 proteins:
Variants for MLXIP Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021681 | -- | 122,096,923(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000050326 | -- | 122,117,712(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000069578 | -- | 122,142,990(+) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000079049 | -- | 122,142,819(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000135783 | -- | 122,121,659(+) | G/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3n35 | CNV | novel sequence insertion | 20440878 |
| nsv1038827 | CNV | loss | 25217958 |
| nsv1126326 | CNV | deletion | 24896259 |
| nsv1145634 | CNV | deletion | 24896259 |
| nsv472322 | CNV | novel sequence insertion | 20440878 |
| nsv478155 | CNV | novel sequence insertion | 20440878 |
| nsv478681 | CNV | novel sequence insertion | 20440878 |
| nsv479428 | CNV | novel sequence insertion | 20440878 |
| nsv479769 | CNV | novel sequence insertion | 20440878 |
| nsv479827 | CNV | novel sequence insertion | 20440878 |
| nsv479940 | CNV | novel sequence insertion | 20440878 |
| nsv480531 | CNV | novel sequence insertion | 20440878 |
| nsv480768 | CNV | novel sequence insertion | 20440878 |
| nsv952496 | CNV | deletion | 24416366 |
Gene Damage Index Score:
6.65;
78.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MLXIP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MLXIP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLXIP Gene
Disorders for MLXIP Gene
Additional Disease Information for MLXIP
No disorders were found for MLXIP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MLXIP Gene
Publications for MLXIP Gene
- MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. (PMID: 11073985) Billin AN … Ayer DE (Molecular and cellular biology 2000) 2 3 4 58
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
- Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. (PMID: 19706488) Kaadige MR … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 58
- Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. (PMID: 18458340) Stoltzman CA … Ayer DE (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22 58
- MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. (PMID: 16782875) Sans CL … Ayer DE (Molecular and cellular biology 2006) 3 4 58
Products for MLXIP Gene
- Browse R&D Systems for Antibodies
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for MLXIP
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- Custom Assay Services
- OriGene Purified Proteins for MLXIP
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- CloneReady with Over 120,000 Genes
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MLXIP
- VectorBuilder custom plasmid, inducible vectors for MLXIP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MLXIP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 31 available MLXIP Antibodies ranked by validation data
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- antibodies-online: Search results for 2 available MLXIP Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 7 available MLXIP Proteins ranked by validation data
- Compare Top MLXIP Proteins
- Quality Products:
- Search GeneTex for Antibodies for MLXIP
- Search GeneTex for Proteins for MLXIP
- ViGene Biosciences adenoviral particle packaged cDNA for MLXIP gene
- ViGene Biosciences lentiviral particle packaged cDNA for MLXIP gene
- ViGene Biosciences ready-to-package AAV shRNAs for MLXIP gene
- Search ViGene Biosciences for MLXIP
- Santa Cruz Biotechnology (SCBT) Antibodies for MLXIP
- Search Santa Cruz Biotechnology (SCBT) for MLXIP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MLXIP
- Custom Antibody ServicesProSci Antibodies for MLXIP
- Search for MLXIP Proteins at ProSci
- Horizon Cell Lines for MLXIP
- genomics-online: cdna clones - Search results for available MLXIP gene related products
- orf clones - Search results for available MLXIP gene related products
- genomics-online: gRNA clones - Search results for available MLXIP gene related products
- genomics-online: primer clones - Search results for available MLXIP gene related products
- genomics-online: shRNA clones - Search results for available MLXIP gene related products
Sources for MLXIP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems