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This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
MLXIP (MLX Interacting Protein) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Insulin resistance. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MLXIPL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 11073985 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11073985 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005741 | mitochondrial outer membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA,IMP | 16782875 |
GO:1900402 | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MLXIP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mlxip 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mlxip 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MLXIP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MLXIP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MLXIP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MLXIP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mlxip 30 |
|
||
Str.4943 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | mlxip 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6592 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mio 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mml-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs34702867 | - | p.Val539Leu | |||
rs7978353 | - | p.Glu396Gly |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3n35 | CNV | novel sequence insertion | 20440878 |
nsv1038827 | CNV | loss | 25217958 |
nsv1126326 | CNV | deletion | 24896259 |
nsv1145634 | CNV | deletion | 24896259 |
nsv472322 | CNV | novel sequence insertion | 20440878 |
nsv478155 | CNV | novel sequence insertion | 20440878 |
nsv478681 | CNV | novel sequence insertion | 20440878 |
nsv479428 | CNV | novel sequence insertion | 20440878 |
nsv479769 | CNV | novel sequence insertion | 20440878 |
nsv479827 | CNV | novel sequence insertion | 20440878 |
nsv479940 | CNV | novel sequence insertion | 20440878 |
nsv480531 | CNV | novel sequence insertion | 20440878 |
nsv480768 | CNV | novel sequence insertion | 20440878 |
nsv952496 | CNV | deletion | 24416366 |
No disorders were found for MLXIP Gene.