Aliases for MLX Gene
External Ids for MLX Gene
Previous HGNC Symbols for MLX Gene
Previous GeneCards Identifiers for MLX Gene
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MLX Gene
MLX (MAX Dimerization Protein MLX) is a Protein Coding gene. Diseases associated with MLX include Takayasu Arteritis and Pontocerebellar Hypoplasia, Type 12. Among its related pathways are Apoptosis and Autophagy and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is MLXIPL.
UniProtKB/Swiss-Prot Summary for MLX Gene
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.