Aliases for MLST8 Gene
Aliases for MLST8 Gene
External Ids for MLST8 Gene
- HGNC: 24825
- Entrez Gene: 64223
- Ensembl: ENSG00000167965
- OMIM: 612190
- UniProtKB: Q9BVC4
Previous GeneCards Identifiers for MLST8 Gene
- GC16P002196
- GC16P002255
- GC16P002182
- GC16P002254
Summaries for MLST8 Gene
GeneCards Summary for MLST8 Gene
MLST8 (MTOR Associated Protein, LST8 Homolog) is a Protein Coding gene. Diseases associated with MLST8 include Benign Familial Neonatal Epilepsy and Childhood Absence Epilepsy. Among its related pathways are Gene Expression and LKB1 signaling events.
UniProtKB/Swiss-Prot for MLST8 Gene
-
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLST8 Gene
Genomics for MLST8 Gene
GeneHancer (GH) Regulatory Elements for MLST8 Gene
Promoters and enhancers for MLST8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MLST8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MLST8 Gene
Genomic Locations for MLST8 Gene
- chr16:2,204,248-2,209,417
- (GRCh38/hg38)
- Size:
- 5,170 bases
- Orientation:
- Plus strand
- chr16:2,254,249-2,259,418
- (GRCh37/hg19)
- Size:
- 5,170 bases
- Orientation:
- Plus strand
Genomic View for MLST8 Gene
Genes around MLST8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
- 16p13.3 by Ensembl
MLST8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLST8 Gene
Proteins for MLST8 Gene
-
Protein details for MLST8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BVC4-LST8_HUMAN
- Recommended name:
- Target of rapamycin complex subunit LST8
- Protein Accession:
- Q9BVC4
- B3KMM4
- B4DY00
- D3DU88
- Q5M800
- Q86Y18
- Q8WUI5
- Q9HA66
- Q9UJV6
Protein attributes for MLST8 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 35876 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB.
- SequenceCaution:
-
- Sequence=EAW85539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MLST8 Gene
Protein Expression for MLST8 Gene
Post-translational modifications for MLST8 Gene
Other Protein References for MLST8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for MLST8 (GBL)
-
Custom Antibody ServicesOriGene Antibodies for MLST8
- Novus Biologicals Antibodies for MLST8
-
Abcam antibodies for MLST8
- Invitrogen Antibodies for MLST8 (AFLGC-MLST8)
- antibodies-online: Search results for 132 available MLST8 Antibodies ranked by validation data
- Compare Top MLST8 Antibodies
-
Recommended
- 99 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 PLA Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 47 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 1 PLA Antibody (anti-mouse)
- 31 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 PLA Antibody (anti-rat)
- GeneTex MLST8 Antibody for MLST8
-
Boster Bio Antibodies for MLST8
-
Custom Antibody ServicesProSci Antibodies for MLST8
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLST8
Protein Products
-
OriGene Purified Proteins for MLST8
- Search Origene for MassSpec and Protein Over-expression Lysates for MLST8
- Origene Custom Protein Services for MLST8
- GeneTex Proteins for MLST8
-
Abcam proteins for MLST8
Assay Products
No data available for DME Specific Peptides for MLST8 Gene
Domains & Families for MLST8 Gene
Gene Families for MLST8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MLST8 Gene
Suggested Antigen Peptide Sequences for MLST8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BVC4- Family:
-
- Belongs to the WD repeat LST8 family.
Function for MLST8 Gene
Molecular function for MLST8 Gene
- UniProtKB/Swiss-Prot Function:
- Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.
Phenotypes From GWAS Catalog for MLST8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12408816 |
| GO:0043539 | protein serine/threonine kinase activator activity | IDA | 12718876 |
Phenotypes for MLST8 Gene
- MGI mutant phenotypes for MLST8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MLST8:
Animal Models for MLST8 Gene
- MGI Knock Outs for MLST8:
-
- Mlst8 Mlst8<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for MLST8
- Cyagen custom Knockout/knockin (KOKI) mouse models for MLST8
-
CRISPR Products
-
OriGene CRISPR knockouts for MLST8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLST8
- genomics-online: gRNA clones - Search results for 130 available MLST8 gene related products
- Overview of 130 available MLST8 gene related products
- Applied Biological Materials CRISPR for MLST8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLST8
- GenScript: Design CRISPR guide RNA sequences for MLST8
miRNA for MLST8 Gene
- miRTarBase miRNAs that target MLST8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLST8
- Browse OriGene Inhibitory RNA Products For MLST8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLST8
- genomics-online: shRNA clones - Search results for 130 available MLST8 gene related products
- Overview of 130 available MLST8 gene related products
Clone Products
-
OriGene ORF clones in human for MLST8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MLST8
- Addgene plasmids for MLST8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLST8
- Applied Biological Materials Clones for MLST8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MLST8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLST8 Gene
Localization for MLST8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLST8 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| extracellular | 1 |
- Cell Junctions (2)
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031931 | TORC1 complex | IDA | 12718876 |
| GO:0031932 | TORC2 complex | IDA | 24036451 |
Pathways & Interactions for MLST8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | mTOR signalling |
.70
|
.51
|
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | CD28 co-stimulation | ||
| 5 | Autophagy Pathway |
.34
|
|
Pathways by source for MLST8 Gene
12 BioSystems pathways for MLST8 Gene
51 Reactome pathways for MLST8 Gene
1 PharmGKB pathway for MLST8 Gene
5 KEGG pathways for MLST8 Gene
3 R&D Systems pathways for MLST8 Gene
1 Qiagen pathway for MLST8 Gene
1 Cell Signaling Technology pathway for MLST8 Gene
Interacting Proteins for MLST8 Gene
Selected Interacting proteins:
ENSP00000380313
Q9BVC4-LST8_HUMAN
for MLST8 Gene via
STRING
UniProtKB
MINT
IID
GPS-Prot Interaction Network for MLST8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007050 | cell cycle arrest | TAS | -- |
| GO:0016241 | regulation of macroautophagy | TAS | -- |
| GO:0030838 | positive regulation of actin filament polymerization | IEA | -- |
| GO:0031929 | TOR signaling | IBA,IEA | -- |
| GO:0032008 | positive regulation of TOR signaling | IMP | 15467718 |
No data available for SIGNOR curated interactions for MLST8 Gene
Drugs & Compounds for MLST8 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for MLST8 Gene
mRNA/cDNA for MLST8 Gene
- (16) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (393) Selected AceView cDNA sequences:
- (35) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000562043 512 bps (uc059piu.1)
- ENST00000563179 564 bps (uc059piv.1)
- ENST00000565926 577 bps (uc059piw.1)
- ENST00000569457 792 bps (uc059pix.1)
- ENST00000564088 1861 bps (uc002cpc.4)
Unigene Clusters for MLST8 Gene
- MTOR associated protein, LST8 homolog (S. cerevisiae):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MLST8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLST8
- genomics-online: gRNA clones - Search results for 130 available MLST8 gene related products
- Overview of 130 available MLST8 gene related products
- Applied Biological Materials CRISPR for MLST8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLST8
- GenScript: Design CRISPR guide RNA sequences for MLST8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLST8
- Browse OriGene Inhibitory RNA Products For MLST8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLST8
- genomics-online: shRNA clones - Search results for 130 available MLST8 gene related products
- Overview of 130 available MLST8 gene related products
Clone Products
-
OriGene ORF clones in human for MLST8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MLST8
- Addgene plasmids for MLST8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLST8
- Applied Biological Materials Clones for MLST8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - |
| ExUns: | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: | |||||||||
| SP15: | |||||||||
| SP16: | |||||||||
| SP17: | |||||||||
| SP18: | |||||||||
| SP19: | |||||||||
| SP20: | |||||||||
| SP21: |
Expression for MLST8 Gene
This gene is overexpressed in Bone (52.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLST8 Gene
NURSA nuclear receptor signaling pathways regulating expression of MLST8 Gene:
MLST8SOURCE GeneReport for Unigene cluster for MLST8 Gene:
Hs.29203mRNA Expression by UniProt/SwissProt for MLST8 Gene:
Q9BVC4-LST8_HUMAN
Tissue specificity:
Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
Evidence on tissue expression from TISSUES for MLST8 Gene
- Nervous system(4.6)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for MLST8
-
OriGene qPCR primer pairs and template standards for MLST8
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLST8 Gene
Orthologs for MLST8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MLST8 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MLST8 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MLST8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MLST8 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mlst8 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mlst8 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | MLST8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MLST8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MLST8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mlst8 33 |
|
||
| Str.15148 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68713 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mlst8 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001036 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Lst8 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C10H11.8 34 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL009C 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D04840g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LST8 36 34 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18140 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0681700 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04281 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pop3 33 |
|
- Species where no ortholog for MLST8 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MLST8 Gene
- ENSEMBL:
- Gene Tree for MLST8 (if available)
- TreeFam:
- Gene Tree for MLST8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MLST8: view image
Paralogs for MLST8 Gene
(1) SIMAP similar genes for MLST8 Gene using alignment to 10 proteins:
- LST8_HUMAN
- H3BM50_HUMAN
- H3BN58_HUMAN
- H3BPT1_HUMAN
- H3BPU5_HUMAN
- H3BQ74_HUMAN
- H3BR25_HUMAN
- H3BR38_HUMAN
- H3BSZ4_HUMAN
- I3L2E7_HUMAN
No data available for Paralogs for MLST8 Gene
Variants for MLST8 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000516908 | -- | 2,207,452(+) | C/T | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
| rs1001099862 | -- | 2,203,628(+) | A/C/G | upstream_transcript_variant | |
| rs1001207212 | -- | 2,207,513(+) | G/A | genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
| rs1001269088 | -- | 2,207,665(+) | C/G/T | genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
| rs1001393965 | -- | 2,207,641(+) | CACTC/CACTCACTC | genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4859n54 | CNV | loss | 21841781 |
| dgv4861n54 | CNV | loss | 21841781 |
| dgv4863n54 | CNV | loss | 21841781 |
| esv2422427 | CNV | duplication | 17116639 |
| nsv1052260 | CNV | gain | 25217958 |
| nsv1711 | CNV | insertion | 18451855 |
| nsv457351 | CNV | loss | 19166990 |
| nsv471072 | CNV | loss | 18288195 |
| nsv571200 | CNV | loss | 21841781 |
| nsv952902 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MLST8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MLST8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLST8 Gene
Disorders for MLST8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| benign familial neonatal epilepsy |
|
|
| childhood absence epilepsy |
|
|
Search MLST8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MLST8
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MLST8 Gene
Publications for MLST8 Gene
- Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 3 4 58
- Rheb binds and regulates the mTOR kinase. (PMID: 15854902) Long X … Avruch J (Current biology : CB 2005) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PMID: 15467718) Jacinto E … Hall MN (Nature cell biology 2004) 3 4 58
- GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim DH … Sabatini DM (Molecular cell 2003) 3 4 58
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