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Aliases for MLST8 Gene

Aliases for MLST8 Gene

  • MTOR Associated Protein, LST8 Homolog 2 3 5
  • Mammalian Lethal With SEC13 Protein 8 3 4
  • TORC Subunit LST8 3 4
  • Protein GbetaL 3 4
  • Gable 3 4
  • LST8 3 4
  • GBL 3 4
  • MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) 2
  • Target Of Rapamycin Complex Subunit LST8 3
  • G Protein Beta Subunit-Like 4
  • G Protein Beta Subunit Like 2
  • GbetaL 3
  • MLST8 4
  • POP3 3
  • WAT1 3

External Ids for MLST8 Gene

Previous GeneCards Identifiers for MLST8 Gene

  • GC16P002196
  • GC16P002255
  • GC16P002182
  • GC16P002254

Summaries for MLST8 Gene

GeneCards Summary for MLST8 Gene

MLST8 (MTOR Associated Protein, LST8 Homolog) is a Protein Coding gene. Diseases associated with MLST8 include Benign Familial Neonatal Epilepsy and Childhood Absence Epilepsy. Among its related pathways are Gene Expression and LKB1 signaling events.

UniProtKB/Swiss-Prot for MLST8 Gene

  • Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.

Gene Wiki entry for MLST8 Gene

Additional gene information for MLST8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLST8 Gene

Genomics for MLST8 Gene

GeneHancer (GH) Regulatory Elements for MLST8 Gene

Promoters and enhancers for MLST8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J002204 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 671.8 +1.5 1494 2.5 HDGF CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MLST8 CRAMP1 E4F1 ZNF213-AS1 UNKL TBL3 UBE2I TSC2 TELO2 NME3
GH16J002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23 -48.5 -48458 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002156 GC16M002158 RAB26 ENSG00000261505 CRAMP1 ENSG00000260051
GH16J003156 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +954.5 954546 3.8 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D SSRP1 ZNF610 GLIS1 NBN GC16M003157 TRK-CTT3-1 TRP-TGG3-3 ZNF75A E4F1 ZNF213-AS1 ZNF205 ENSG00000261938 CREBBP ZNF263
GH16J002211 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.5 +10.1 10072 5.1 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A PGP BRICD5 TBL3 AMDHD2 CRAMP1 ENSG00000261207 SRRM2 ZNF598 ENSG00000260051 MLST8
GH16J003182 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.4 +979.2 979223 2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF213 E2F8 FOS KLF13 ENSG00000262521 TRP-AGG2-7 TRP-TGG3-4 ZNF75A ZNF213-AS1 ENSG00000261938 E4F1 CREBBP RNPS1 PDPK2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MLST8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MLST8 Gene

Genomic Locations for MLST8 Gene
chr16:2,204,248-2,209,417
(GRCh38/hg38)
Size:
5,170 bases
Orientation:
Plus strand
chr16:2,254,249-2,259,418
(GRCh37/hg19)
Size:
5,170 bases
Orientation:
Plus strand

Genomic View for MLST8 Gene

Genes around MLST8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLST8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLST8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLST8 Gene

Proteins for MLST8 Gene

  • Protein details for MLST8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC4-LST8_HUMAN
    Recommended name:
    Target of rapamycin complex subunit LST8
    Protein Accession:
    Q9BVC4
    Secondary Accessions:
    • B3KMM4
    • B4DY00
    • D3DU88
    • Q5M800
    • Q86Y18
    • Q8WUI5
    • Q9HA66
    • Q9UJV6

    Protein attributes for MLST8 Gene

    Size:
    326 amino acids
    Molecular mass:
    35876 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB.
    SequenceCaution:
    • Sequence=EAW85539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MLST8 Gene

    Alternative splice isoforms for MLST8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLST8 Gene

Post-translational modifications for MLST8 Gene

  • Ubiquitination at isoforms=3, 5305, Lys245, and isoforms=3, 4, 586
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MLST8 Gene

Domains & Families for MLST8 Gene

Gene Families for MLST8 Gene

Suggested Antigen Peptide Sequences for MLST8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVC4

UniProtKB/Swiss-Prot:

LST8_HUMAN :
  • Belongs to the WD repeat LST8 family.
Family:
  • Belongs to the WD repeat LST8 family.
genes like me logo Genes that share domains with MLST8: view

Function for MLST8 Gene

Molecular function for MLST8 Gene

UniProtKB/Swiss-Prot Function:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.

Phenotypes From GWAS Catalog for MLST8 Gene

Gene Ontology (GO) - Molecular Function for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12408816
GO:0043539 protein serine/threonine kinase activator activity IDA 12718876
genes like me logo Genes that share ontologies with MLST8: view
genes like me logo Genes that share phenotypes with MLST8: view

Animal Models for MLST8 Gene

MGI Knock Outs for MLST8:

Animal Model Products

  • Taconic Biosciences Mouse Models for MLST8

miRNA for MLST8 Gene

miRTarBase miRNAs that target MLST8

Clone Products

  • Addgene plasmids for MLST8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLST8 Gene

Localization for MLST8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLST8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLST8 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0031931 TORC1 complex IDA 12718876
GO:0031932 TORC2 complex IDA 24036451
genes like me logo Genes that share ontologies with MLST8: view

Pathways & Interactions for MLST8 Gene

genes like me logo Genes that share pathways with MLST8: view

Gene Ontology (GO) - Biological Process for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0016241 regulation of macroautophagy TAS --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0031929 TOR signaling IBA,IEA --
GO:0032008 positive regulation of TOR signaling IMP 15467718
genes like me logo Genes that share ontologies with MLST8: view

No data available for SIGNOR curated interactions for MLST8 Gene

Drugs & Compounds for MLST8 Gene

(7) Drugs for MLST8 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OSI-027 Investigational Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0

(2) Additional Compounds for MLST8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MLST8: view

Transcripts for MLST8 Gene

Unigene Clusters for MLST8 Gene

MTOR associated protein, LST8 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for MLST8

Alternative Splicing Database (ASD) splice patterns (SP) for MLST8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - -
SP14: - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - -
SP19: - - - - -
SP20:
SP21: - - - -

ExUns: 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for MLST8 Gene

GeneLoc Exon Structure for
MLST8
ECgene alternative splicing isoforms for
MLST8

Expression for MLST8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLST8 Gene

Protein differential expression in normal tissues from HIPED for MLST8 Gene

This gene is overexpressed in Bone (52.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLST8 Gene



Protein tissue co-expression partners for MLST8 Gene

NURSA nuclear receptor signaling pathways regulating expression of MLST8 Gene:

MLST8

SOURCE GeneReport for Unigene cluster for MLST8 Gene:

Hs.29203

mRNA Expression by UniProt/SwissProt for MLST8 Gene:

Q9BVC4-LST8_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, heart and kidney.

Evidence on tissue expression from TISSUES for MLST8 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with MLST8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLST8 Gene

Orthologs for MLST8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MLST8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLST8 34 33
  • 99.69 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLST8 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLST8 34 33
  • 91.46 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MLST8 34 33
  • 90.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlst8 33
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Mlst8 16 34 33
  • 87.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MLST8 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLST8 34 33
  • 84.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLST8 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mlst8 33
  • 79.96 (n)
Str.15148 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68713 33
zebrafish
(Danio rerio)
Actinopterygii mlst8 34 33
  • 78.22 (n)
OneToOne
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001036 33
  • 61.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lst8 34 33
  • 58.25 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C10H11.8 34
  • 22 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL009C 33
  • 53.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04840g 33
  • 51.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LST8 36 34 33
  • 50.78 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18140 33
  • 51.39 (n)
rice
(Oryza sativa)
Liliopsida Os03g0681700 33
  • 52.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04281 33
  • 52.94 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pop3 33
  • 51.33 (n)
Species where no ortholog for MLST8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLST8 Gene

ENSEMBL:
Gene Tree for MLST8 (if available)
TreeFam:
Gene Tree for MLST8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MLST8: view image

Paralogs for MLST8 Gene

(1) SIMAP similar genes for MLST8 Gene using alignment to 10 proteins:

  • LST8_HUMAN
  • H3BM50_HUMAN
  • H3BN58_HUMAN
  • H3BPT1_HUMAN
  • H3BPU5_HUMAN
  • H3BQ74_HUMAN
  • H3BR25_HUMAN
  • H3BR38_HUMAN
  • H3BSZ4_HUMAN
  • I3L2E7_HUMAN
genes like me logo Genes that share paralogs with MLST8: view

No data available for Paralogs for MLST8 Gene

Variants for MLST8 Gene

Sequence variations from dbSNP and Humsavar for MLST8 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000516908 -- 2,207,452(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1001099862 -- 2,203,628(+) A/C/G upstream_transcript_variant
rs1001207212 -- 2,207,513(+) G/A genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1001269088 -- 2,207,665(+) C/G/T genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1001393965 -- 2,207,641(+) CACTC/CACTCACTC genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MLST8 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1711 CNV insertion 18451855
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571200 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for MLST8 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MLST8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLST8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLST8 Gene

Disorders for MLST8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MLST8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign familial neonatal epilepsy
  • benign familial neonatal seizures
childhood absence epilepsy
  • absence seizure
- elite association - COSMIC cancer census association via MalaCards
Search MLST8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MLST8

genes like me logo Genes that share disorders with MLST8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLST8 Gene

Publications for MLST8 Gene

  1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 3 4 58
  2. Rheb binds and regulates the mTOR kinase. (PMID: 15854902) Long X … Avruch J (Current biology : CB 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PMID: 15467718) Jacinto E … Hall MN (Nature cell biology 2004) 3 4 58
  5. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim DH … Sabatini DM (Molecular cell 2003) 3 4 58

Products for MLST8 Gene