MLST8 Gene (Protein Coding)

MTOR Associated Protein, LST8 Homolog

GC16P002204
GIFtS:
43
See more...

Aliases for MLST8 Gene

Aliases for MLST8 Gene

  • MTOR Associated Protein, LST8 Homolog 2 3 5
  • GBL 2 3 4
  • Target Of Rapamycin Complex Subunit LST8 3 4
  • Mammalian Lethal With SEC13 Protein 8 3 4
  • TORC Subunit LST8 3 4
  • Protein GbetaL 3 4
  • GbetaL 2 3
  • Gable 3 4
  • MLST8 4 5
  • LST8 3 4
  • MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) 2
  • G Protein Beta Subunit Like 2
  • G Protein Beta Subunit-Like 4
  • POP3 3
  • WAT1 3
  • Lst8 2
  • Pop3 2

External Ids for MLST8 Gene

Previous GeneCards Identifiers for MLST8 Gene

  • GC16P002196
  • GC16P002255
  • GC16P002182
  • GC16P002254

Summaries for MLST8 Gene

GeneCards Summary for MLST8 Gene

MLST8 (MTOR Associated Protein, LST8 Homolog) is a Protein Coding gene. Diseases associated with MLST8 include Tuberous Sclerosis 1 and Subependymal Glioma. Among its related pathways are RET signaling and Development HGF signaling pathway.

UniProtKB/Swiss-Prot Summary for MLST8 Gene

  • Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

Gene Wiki entry for MLST8 Gene

Additional gene information for MLST8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLST8 Gene

Genomics for MLST8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MLST8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MLST8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MLST8

Genomic Locations for MLST8 Gene

Latest Assembly
chr16:2,204,248-2,209,453
(GRCh38/hg38)
Size:
5,206 bases
Orientation:
Plus strand

Previous Assembly
chr16:2,255,455-2,259,454
(GRCh37/hg19 by Entrez Gene)
Size:
4,000 bases
Orientation:
Plus strand

chr16:2,254,249-2,259,417
(GRCh37/hg19 by Ensembl)
Size:
5,169 bases
Orientation:
Plus strand

Genomic View for MLST8 Gene

Genes around MLST8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLST8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLST8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MLST8 Gene

Proteins for MLST8 Gene

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  • Protein details for MLST8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC4-LST8_HUMAN
    Recommended name:
    Target of rapamycin complex subunit LST8
    Protein Accession:
    Q9BVC4
    Secondary Accessions:
    • B3KMM4
    • B4DY00
    • D3DU88
    • Q5M800
    • Q86Y18
    • Q8WUI5
    • Q9HA66
    • Q9UJV6

    Protein attributes for MLST8 Gene

    Size:
    326 amino acids
    Molecular mass:
    35876 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7 (PubMed:29750193). Interacts with SIK3 (PubMed:30232230).
    SequenceCaution:
    • Sequence=EAW85539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MLST8 Gene

    Alternative splice isoforms for MLST8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLST8 Gene

Protein Expression for MLST8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MLST8 Gene

  • Ubiquitination at Lys86, Lys245, and Lys305
  • Modification sites at PhosphoSitePlus

Other Protein References for MLST8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MLST8 Gene

Domains & Families for MLST8 Gene

Gene Families for MLST8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MLST8 Gene

InterPro:

Suggested Antigen Peptide Sequences for MLST8 Gene

GenScript: Design optimal peptide antigens:
  • Mammalian lethal with SEC13 protein 8 (LST8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BVC4

UniProtKB/Swiss-Prot:

LST8_HUMAN :
  • Belongs to the WD repeat LST8 family.
Family:
  • Belongs to the WD repeat LST8 family.
genes like me logo Genes that share domains with MLST8: view

Function for MLST8 Gene

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  6. Cell Lines for research

Molecular function for MLST8 Gene

UniProtKB/Swiss-Prot Function:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.

Phenotypes From GWAS Catalog for MLST8 Gene

Gene Ontology (GO) - Molecular Function for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12408816
GO:0043539 protein serine/threonine kinase activator activity IDA 12718876
genes like me logo Genes that share ontologies with MLST8: view
genes like me logo Genes that share phenotypes with MLST8: view

Animal Models for MLST8 Gene

MGI Knock Outs for MLST8:

Animal Models for research

  • Taconic Biosciences Mouse Models for MLST8

miRNA for MLST8 Gene

miRTarBase miRNAs that target MLST8

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLST8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLST8 Gene

Localization for MLST8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLST8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLST8 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
cytoskeleton 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0031931 TORC1 complex IDA 12718876
GO:0031932 TORC2 complex IDA 24036451
genes like me logo Genes that share ontologies with MLST8: view

Pathways & Interactions for MLST8 Gene

genes like me logo Genes that share pathways with MLST8: view

Gene Ontology (GO) - Biological Process for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0016241 regulation of macroautophagy TAS --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0031929 TOR signaling IBA 21873635
GO:0032008 positive regulation of TOR signaling IMP 15467718
genes like me logo Genes that share ontologies with MLST8: view

No data available for SIGNOR curated interactions for MLST8 Gene

Drugs & Compounds for MLST8 Gene

Products:

  1. Drug products for research

(7) Drugs for MLST8 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OSI-027 Investigational Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0

(2) Additional Compounds for MLST8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MLST8: view

Transcripts for MLST8 Gene

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mRNA/cDNA for MLST8 Gene

7 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
35 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLST8

Alternative Splicing Database (ASD) splice patterns (SP) for MLST8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - -
SP14: - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - -
SP19: - - - - -
SP20:
SP21: - - - -

ExUns: 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for MLST8 Gene

GeneLoc Exon Structure for
MLST8

Expression for MLST8 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MLST8 Gene

mRNA expression in normal human tissues for MLST8 Gene
mRNA expression by GTEx for MLST8 GenemRNA expression by BioGPS for MLST8 Gene

Protein differential expression in normal tissues from HIPED for MLST8 Gene

This gene is overexpressed in Bone (52.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLST8 Gene



Protein tissue co-expression partners for MLST8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MLST8

SOURCE GeneReport for Unigene cluster for MLST8 Gene:

Hs.29203

mRNA Expression by UniProt/SwissProt for MLST8 Gene:

Q9BVC4-LST8_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, heart and kidney.

Evidence on tissue expression from TISSUES for MLST8 Gene

  • Nervous system(4.6)
  • Skin(4.5)
  • Muscle(2.6)
  • Kidney(2.6)
  • Heart(2.5)
  • Liver(2.4)
  • Pancreas(2.3)
  • Intestine(2.3)
  • Lung(2.3)
  • Eye(2.2)
  • Blood(2.2)
  • Thyroid gland(2.2)
  • Spleen(2.1)
  • Lymph node(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with MLST8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLST8 Gene

Orthologs for MLST8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MLST8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MLST8 29 30
  • 99.69 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MLST8 30
  • 95 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MLST8 29 30
  • 91.46 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MLST8 29 30
  • 90.39 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mlst8 29
  • 88.96 (n)
Mouse
(Mus musculus)
 Mammalia Mlst8 29 16 30
  • 87.63 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia MLST8 30
  • 54 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MLST8 29 30
  • 84.66 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MLST8 30
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mlst8 29
  • 79.96 (n)
Str.15148 29
African clawed frog
(Xenopus laevis)
 Amphibia MGC68713 29
Zebrafish
(Danio rerio)
 Actinopterygii mlst8 29 30
  • 78.22 (n)
 OneToOne
-- 29
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001036 29
  • 61.43 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Lst8 29 30
  • 58.25 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea C10H11.8 30
  • 22 (a)
 OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AAL009C 29
  • 53.69 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0D04840g 29
  • 51.45 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes LST8 29 30 32
  • 50.78 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT3G18140 29
  • 51.39 (n)
Rice
(Oryza sativa)
 Liliopsida Os03g0681700 29
  • 52.51 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 63 (a)
 OneToOne
Bread mold
(Neurospora crassa)
 Ascomycetes NCU04281 29
  • 52.94 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes pop3 29
  • 51.33 (n)
Species where no ortholog for MLST8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MLST8 Gene

ENSEMBL:
Gene Tree for MLST8 (if available)
TreeFam:
Gene Tree for MLST8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MLST8: view image
Alliance of Genome Resources:
Additional Orthologs for MLST8

Paralogs for MLST8 Gene

(1) SIMAP similar genes for MLST8 Gene using alignment to 10 proteins:

  • LST8_HUMAN
  • H3BM50_HUMAN
  • H3BN58_HUMAN
  • H3BPT1_HUMAN
  • H3BPU5_HUMAN
  • H3BQ74_HUMAN
  • H3BR25_HUMAN
  • H3BR38_HUMAN
  • H3BSZ4_HUMAN
  • I3L2E7_HUMAN
genes like me logo Genes that share paralogs with MLST8: view

No data available for Paralogs for MLST8 Gene

Variants for MLST8 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MLST8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MLST8 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv1711 CNV insertion 18451855
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571200 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for MLST8 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MLST8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MLST8
Leiden Open Variation Database (LOVD)
MLST8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MLST8 Gene

Disorders for MLST8 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MLST8 Gene - From: COP

Disorder Aliases PubMed IDs
tuberous sclerosis 1
  • tsc1
subependymal glioma
  • mixed subependymoma-ependymoma
kidney angiomyolipoma
  • angiomyolipoma of kidney
benign ependymoma
  • epithelial ependymoma
cowden syndrome 1
  • cws1
- elite association - COSMIC cancer census association via MalaCards
Search MLST8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MLST8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MLST8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MLST8 Gene

Publications for MLST8 Gene

  1. The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. (PMID: 30232230) Csukasi F … Krakow D (Science translational medicine 2018) 3 4
  2. Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. (PMID: 29750193) Nguyen JT … Krebsbach PH (Science advances 2018) 3 4
  3. mLST8 Promotes mTOR-Mediated Tumor Progression. (PMID: 25906254) Kakumoto K … Oneyama C (PloS one 2015) 2 3
  4. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 3 4
  5. Rheb binds and regulates the mTOR kinase. (PMID: 15854902) Long X … Avruch J (Current biology : CB 2005) 3 4

ExternalLinks

View latest publications for MLST8 gene in Mastermind

Products for MLST8 Gene

  • Addgene plasmids for MLST8

Sources for MLST8 Gene