Aliases for MLNR Gene
External Ids for MLNR Gene
Previous HGNC Symbols for MLNR Gene
Previous GeneCards Identifiers for MLNR Gene
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
GeneCards Summary for MLNR Gene
MLNR (Motilin Receptor) is a Protein Coding gene. Diseases associated with MLNR include Gastroparesis and Diabetic Autonomic Neuropathy. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and growth hormone-releasing hormone receptor activity. An important paralog of this gene is GHSR.
UniProtKB/Swiss-Prot Summary for MLNR Gene
Receptor for motilin.
The motilin receptor is a Gq/11-protein-coupled receptor that mediates progastrokinetic effects. It is found at its highest concentrations in the nerves of the antral wall of the stomach and is also found at significant levels throughout the smooth muscle of the upper GI tract.