Aliases for MLLT10 Gene
External Ids for MLLT10 Gene
Previous GeneCards Identifiers for MLLT10 Gene
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for MLLT10 Gene
MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor) is a Protein Coding gene. Diseases associated with MLLT10 include Leukemia, Acute Myeloid and Precursor T-Cell Acute Lymphoblastic Leukemia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is MLLT6.
UniProtKB/Swiss-Prot Summary for MLLT10 Gene
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).