Aliases for MLLT1 Gene
External Ids for MLLT1 Gene
Previous GeneCards Identifiers for MLLT1 Gene
GeneCards Summary for MLLT1 Gene
MLLT1 (MLLT1 Super Elongation Complex Subunit) is a Protein Coding gene. Diseases associated with MLLT1 include Acute Leukemia and Leukemia. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. An important paralog of this gene is MLLT3.
UniProtKB/Swiss-Prot Summary for MLLT1 Gene
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114).
Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.