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Aliases for MLLT1 Gene
Aliases for MLLT1 Gene
External Ids for MLLT1 Gene
- HGNC: 7134
- Entrez Gene: 4298
- Ensembl: ENSG00000130382
- OMIM: 159556
- UniProtKB: Q03111
Previous GeneCards Identifiers for MLLT1 Gene
- GC19M006305
- GC19M006152
- GC19M006163
- GC19M005969
Summaries for MLLT1 Gene
GeneCards Summary for MLLT1 Gene
MLLT1 (MLLT1 Super Elongation Complex Subunit) is a Protein Coding gene. Diseases associated with MLLT1 include Acute Leukemia and Leukemia. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. An important paralog of this gene is MLLT3.
UniProtKB/Swiss-Prot Summary for MLLT1 Gene
-
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114).
-
Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
Additional gene information for MLLT1 Gene
- HGNC(7134)
- Entrez Gene(4298)
- Ensembl(ENSG00000130382)
- OMIM(159556)
- UniProtKB(Q03111)
- Open Targets Platform(ENSG00000130382)
- Monarch Initiative
- Search for MLLT1 at DataMed
- Search for MLLT1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLLT1 Gene
Genomics for MLLT1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MLLT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MLLT1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MLLT1
- Top Transcription factor binding sites by QIAGEN in the MLLT1 gene promoter:
-
- AML1a
Genomic Locations for MLLT1 Gene
Genomic Locations for MLLT1 Gene
- chr19:6,210,381-6,279,975
- (GRCh38/hg38)
- Size:
- 69,595 bases
- Orientation:
- Minus strand
- chr19:6,210,392-6,279,959
- (GRCh37/hg19)
- Size:
- 69,568 bases
- Orientation:
- Minus strand
Genomic View for MLLT1 Gene
Genes around MLLT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by HGNC
- 19p13.3 by Entrez Gene
- 19p13.3 by Ensembl
MLLT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLLT1 Gene
Proteins for MLLT1 Gene
-
Protein details for MLLT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03111-ENL_HUMAN
- Recommended name:
- Protein ENL
- Protein Accession:
- Q03111
- Q14768
Protein attributes for MLLT1 Gene
- Size:
- 559 amino acids
- Molecular mass:
- 62056 Da
- Quaternary structure:
-
- Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3) (PubMed:20159561, PubMed:20471948, PubMed:22195968). Interacts with ALKBH4 (PubMed:23145062). Component of a SWI/SNF-like EBAFb complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, SMARCC1/BAF155, SMARCC2/BAF170, ARID1B/BAF250B, MLLT1/ENL and actin (PubMed:12665591).
Protein Expression for MLLT1 Gene
Post-translational modifications for MLLT1 Gene
Other Protein References for MLLT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-MLLT1 monoclonal antibody, clone EML514
-
Custom Antibody ServicesOriGene Antibodies for MLLT1
- Novus Biologicals Antibodies for MLLT1
- Invitrogen Antibodies for MLLT1 (AFLGC-MLLT1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MLLT1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for MLLT1
- Origene Custom Protein Services for MLLT1
- antibodies-online: Show 3 available MLLT1 Proteins ranked by validation data
- Compare Top MLLT1 Proteins
-
Quality Products:
-
Abcam proteins for MLLT1
No data available for DME Specific Peptides for MLLT1 Gene
Domains & Families for MLLT1 Gene
Gene Families for MLLT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for MLLT1 Gene
Suggested Antigen Peptide Sequences for MLLT1 Gene
- GenScript: Design optimal peptide antigens:
-
- YEATS domain-containing protein 1 (ENL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03111UniProtKB/Swiss-Prot:
ENL_HUMAN :- The YEATS domain specifically recognizes and binds acylated histones, with a preference for histones that are crotonylated.
- Domain:
-
- The YEATS domain specifically recognizes and binds acylated histones, with a preference for histones that are crotonylated.
Function for MLLT1 Gene
Molecular function for MLLT1 Gene
- UniProtKB/Swiss-Prot Function:
- Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114).
- UniProtKB/Swiss-Prot Function:
- Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Acylated lysine-binding is specifically inhibited by the tripeptide XL-13m, carrying a 2-furancarbonyl side chain, preventing recruitment to chromatin.
- GENATLAS Biochemistry:
- serine/proline rich nuclear protein,fused with HRX (MLL) in acute lymphoblastic leukemia with translocation t(11;19)(q23;p13)
Phenotypes From GWAS Catalog for MLLT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003677 | DNA binding | TAS | 7991593 |
| GO:0005515 | protein binding | IPI | 20153263 |
Phenotypes for MLLT1 Gene
- MGI mutant phenotypes for MLLT1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MLLT1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased IL-8 secretion
- Decreased Salmonella enterica Typhimurium invasion
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Lamellipodia cells
Animal Models for MLLT1 Gene
- MGI Knock Outs for MLLT1:
-
- Mllt1 Mllt1<tm1Dw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MLLT1 - Select products 50% OFF >
- * MLLT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MLLT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLLT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLLT1
miRNA for MLLT1 Gene
- miRTarBase miRNAs that target MLLT1
-
- hsa-miR-16-5p (MIRT001442)
- hsa-let-7b-5p (MIRT001617)
- hsa-miR-484 (MIRT041863)
- hsa-miR-6730-5p (MIRT447856)
- hsa-miR-488-3p (MIRT447857)
- hsa-miR-5681a (MIRT447858)
- hsa-miR-8083 (MIRT447859)
- hsa-miR-147b (MIRT473140)
- hsa-miR-3944-5p (MIRT473141)
- hsa-miR-3175 (MIRT473142)
- hsa-miR-4741 (MIRT473143)
- hsa-miR-4675 (MIRT473144)
- hsa-miR-6721-5p (MIRT473145)
- hsa-miR-8085 (MIRT473146)
- hsa-miR-6731-5p (MIRT473147)
- hsa-miR-7974 (MIRT473148)
- hsa-miR-4763-3p (MIRT473149)
- hsa-miR-1207-5p (MIRT473150)
- hsa-miR-5192 (MIRT473151)
- hsa-miR-4749-5p (MIRT473152)
- hsa-miR-4706 (MIRT473153)
- hsa-miR-4767 (MIRT473154)
- hsa-miR-4745-5p (MIRT473155)
- hsa-miR-4481 (MIRT473156)
- hsa-miR-4693-3p (MIRT473157)
- hsa-miR-6889-5p (MIRT473158)
- hsa-miR-6777-5p (MIRT473159)
- hsa-miR-6746-3p (MIRT473160)
- hsa-miR-4781-5p (MIRT473161)
- hsa-miR-519c-3p (MIRT473162)
- hsa-miR-519b-3p (MIRT473163)
- hsa-miR-519a-3p (MIRT473164)
- hsa-miR-106a-5p (MIRT473165)
- hsa-miR-93-5p (MIRT473166)
- hsa-miR-20a-5p (MIRT473167)
- hsa-miR-519d-3p (MIRT473168)
- hsa-miR-17-5p (MIRT473169)
- hsa-miR-20b-5p (MIRT473170)
- hsa-miR-526b-3p (MIRT473171)
- hsa-miR-106b-5p (MIRT473172)
- hsa-miR-6780a-5p (MIRT491192)
- hsa-miR-6779-5p (MIRT491194)
- hsa-miR-3689c (MIRT491195)
- hsa-miR-3689b-3p (MIRT491196)
- hsa-miR-3689a-3p (MIRT491197)
- hsa-miR-30b-3p (MIRT491198)
- hsa-miR-1273h-5p (MIRT491199)
- hsa-miR-4726-5p (MIRT491200)
- hsa-miR-4640-5p (MIRT491201)
- hsa-miR-6799-5p (MIRT491202)
- hsa-miR-6883-5p (MIRT491203)
- hsa-miR-6785-5p (MIRT491204)
- hsa-miR-149-3p (MIRT491205)
- hsa-miR-4728-5p (MIRT491206)
- hsa-miR-7106-5p (MIRT491207)
- hsa-miR-661 (MIRT491208)
- hsa-miR-3194-5p (MIRT491209)
- hsa-miR-5189-3p (MIRT491210)
- hsa-miR-3192-5p (MIRT491211)
- hsa-miR-6895-5p (MIRT491212)
- hsa-miR-3940-3p (MIRT491213)
- hsa-miR-181d-3p (MIRT570209)
- mmu-miR-669e-5p (MIRT592977)
- mmu-miR-669d-5p (MIRT592978)
- mmu-miR-331-5p (MIRT592979)
- mmu-miR-450b-5p (MIRT592980)
- mmu-miR-3061-3p (MIRT592981)
- hsa-miR-6887-5p (MIRT701920)
- hsa-miR-6797-5p (MIRT701921)
- hsa-miR-1249-5p (MIRT701922)
- hsa-miR-505-5p (MIRT701923)
- hsa-miR-4534 (MIRT701924)
- hsa-miR-8082 (MIRT701925)
- hsa-miR-6875-5p (MIRT701926)
- hsa-miR-3126-5p (MIRT701927)
- hsa-miR-1225-3p (MIRT701928)
- hsa-miR-4518 (MIRT701929)
- hsa-miR-4680-5p (MIRT701930)
- hsa-miR-1266-5p (MIRT701931)
- hsa-miR-3691-3p (MIRT701932)
- hsa-miR-6754-5p (MIRT701933)
- hsa-miR-4441 (MIRT701934)
- hsa-miR-4270 (MIRT701935)
- hsa-miR-211-3p (MIRT701936)
- hsa-miR-4756-5p (MIRT701937)
- hsa-miR-4739 (MIRT701938)
- hsa-miR-1321 (MIRT701939)
- hsa-miR-7845-5p (MIRT701940)
- hsa-miR-3943 (MIRT701941)
- hsa-miR-5683 (MIRT701942)
- hsa-miR-4482-3p (MIRT711793)
- hsa-miR-7159-3p (MIRT711794)
- hsa-miR-205-3p (MIRT711795)
- hsa-miR-3163 (MIRT711796)
- hsa-miR-5582-3p (MIRT711797)
- hsa-miR-548f-3p (MIRT711798)
- hsa-miR-548e-3p (MIRT711799)
- hsa-miR-548az-3p (MIRT711800)
- hsa-miR-548ar-3p (MIRT711801)
- hsa-miR-548a-3p (MIRT711802)
- hsa-miR-1207-3p (MIRT735998)
- hsa-miR-1233-5p (MIRT736249)
- hsa-miR-1237-3p (MIRT736297)
- hsa-miR-124-3p (MIRT736343)
- hsa-miR-2278 (MIRT739134)
- hsa-miR-2682-5p (MIRT739419)
- hsa-miR-30c-1-3p (MIRT739825)
- hsa-miR-30c-2-3p (MIRT739868)
- hsa-miR-3166 (MIRT740576)
- hsa-miR-342-5p (MIRT741398)
- hsa-miR-34a-5p (MIRT741437)
- hsa-miR-34b-5p (MIRT741460)
- hsa-miR-34c-5p (MIRT741480)
- hsa-miR-3616-3p (MIRT741672)
- hsa-miR-3714 (MIRT742562)
- hsa-miR-3910 (MIRT742834)
- hsa-miR-3918 (MIRT742932)
- hsa-miR-4303 (MIRT743879)
- hsa-miR-4436b-3p (MIRT744462)
- hsa-miR-4450 (MIRT744692)
- hsa-miR-4463 (MIRT744877)
- hsa-miR-449a (MIRT745404)
- hsa-miR-449b-5p (MIRT745436)
- hsa-miR-449c-5p (MIRT745458)
- hsa-miR-4512 (MIRT745681)
- hsa-miR-4514 (MIRT745706)
- hsa-miR-4632-5p (MIRT746272)
- hsa-miR-4649-3p (MIRT746484)
- hsa-miR-4651 (MIRT746558)
- hsa-miR-4664-5p (MIRT746733)
- hsa-miR-4667-5p (MIRT746800)
- hsa-miR-4692 (MIRT747113)
- hsa-miR-4700-5p (MIRT747277)
- hsa-miR-4731-5p (MIRT747938)
- hsa-miR-4734 (MIRT747977)
- hsa-miR-4779 (MIRT748745)
- hsa-miR-483-5p (MIRT749036)
- hsa-miR-506-3p (MIRT749591)
- hsa-miR-512-3p (MIRT749745)
- hsa-miR-602 (MIRT751629)
- hsa-miR-608 (MIRT751995)
- hsa-miR-6132 (MIRT752320)
- hsa-miR-646 (MIRT752755)
- hsa-miR-6735-5p (MIRT754175)
- hsa-miR-6737-5p (MIRT754240)
- hsa-miR-6742-5p (MIRT754387)
- hsa-miR-6746-5p (MIRT754492)
- hsa-miR-6747-5p (MIRT754524)
- hsa-miR-6756-5p (MIRT754804)
- hsa-miR-6766-5p (MIRT755112)
- hsa-miR-6767-5p (MIRT755145)
- hsa-miR-6768-5p (MIRT755165)
- hsa-miR-6778-5p (MIRT755445)
- hsa-miR-6788-5p (MIRT755977)
- hsa-miR-6808-5p (MIRT756577)
- hsa-miR-6812-5p (MIRT756709)
- hsa-miR-6819-5p (MIRT756856)
- hsa-miR-6836-5p (MIRT757214)
- hsa-miR-6857-5p (MIRT757762)
- hsa-miR-6878-5p (MIRT758215)
- hsa-miR-6879-5p (MIRT758262)
- hsa-miR-6882-3p (MIRT758356)
- hsa-miR-6893-5p (MIRT758721)
- hsa-miR-7112-5p (MIRT759084)
- hsa-miR-7154-3p (MIRT759228)
- hsa-miR-7155-5p (MIRT759260)
- hsa-miR-7162-3p (MIRT759343)
- hsa-miR-7843-5p (MIRT759764)
- hsa-miR-8089 (MIRT760272)
- hsa-miR-8485 (MIRT760286)
- hsa-miR-92a-2-5p (MIRT760568)
- hsa-miR-940 (MIRT760818)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLLT1
- Browse OriGene Inhibitory RNA Products For MLLT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLLT1
Clone Products
- Applied Biological Materials (abm): Clones for MLLT1 - Select products 50% OFF >
- * MLLT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MLLT1
- Addgene plasmids for MLLT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLLT1
Cell Line Products
-
Horizon Cell Lines for MLLT1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLLT1 Gene
Localization for MLLT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLLT1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | TAS | 8080983 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0008023 | transcription elongation factor complex | IDA | 22195968 |
Pathways & Interactions for MLLT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Transcription Elongation | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | Transcriptional misregulation in cancer | ||
| 4 | Gene Expression |
.48
|
|
Pathways by source for MLLT1 Gene
5 Reactome pathways for MLLT1 Gene
1 KEGG pathway for MLLT1 Gene
1 Cell Signaling Technology pathway for MLLT1 Gene
Interacting Proteins for MLLT1 Gene
Selected Interacting proteins:
Q03111-ENL_HUMAN
ENSP00000252674
for MLLT1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MLLT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | -- |
| GO:0006368 | transcription elongation from RNA polymerase II promoter | TAS | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
No data available for SIGNOR curated interactions for MLLT1 Gene
Transcripts for MLLT1 Gene
mRNA/cDNA for MLLT1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000252674 4532 nts (view in UCSC)
- ENST00000585588 637 nts (view in UCSC)
- ENST00000587473 556 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MLLT1 - Select products 50% OFF >
- * MLLT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MLLT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLLT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLLT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLLT1
- Browse OriGene Inhibitory RNA Products For MLLT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLLT1
Clone Products
- Applied Biological Materials (abm): Clones for MLLT1 - Select products 50% OFF >
- * MLLT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MLLT1
- Addgene plasmids for MLLT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLLT1
Relevant External Links for MLLT1 Gene
- GeneLoc Exon Structure for
- MLLT1
Expression for MLLT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Placenta (Extraembryonic Tissues)
This gene is overexpressed in Lung (16.4) and Blymphocyte (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLLT1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MLLT1
SOURCE GeneReport for Unigene cluster for MLLT1 Gene:
Hs.10095Evidence on tissue expression from TISSUES for MLLT1 Gene
- Nervous system(2.8)
- Blood(2.7)
- Bone marrow(2.6)
- Skin(2.5)
- Kidney(2.3)
- Liver(2.3)
- Spleen(2.3)
- Muscle(2.3)
- Intestine(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for MLLT1
-
OriGene qPCR primer pairs and template standards for MLLT1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLLT1 Gene
Orthologs for MLLT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MLLT1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MLLT1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MLLT1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mllt1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mllt1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MLLT1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MLLT1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MLLT1 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mllt1 30 |
|
||
| Str.6223 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | mllt1 30 31 |
|
OneToMany | |
| MLLT1 (1 of 2) 31 |
|
OneToMany | |||
| Dr.29084 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | ear 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2675 31 |
|
OneToMany |
- Species where no ortholog for MLLT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MLLT1 Gene
- ENSEMBL:
- Gene Tree for MLLT1 (if available)
- TreeFam:
- Gene Tree for MLLT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MLLT1: view image
Paralogs for MLLT1 Gene
(3) SIMAP similar genes for MLLT1 Gene using alignment to 1 proteins:
- ENL_HUMAN
Variants for MLLT1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MLLT1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718642 | Benign: not provided | 6,222,542(-) | G/A | MISSENSE_VARIANT | |
| rs749203329 | Likely Pathogenic: Hypertelorism; Muscular hypotonia; Global developmental delay; Cerebral atrophy; Abnormal cortical gyration; Short nose; Infantile spasms | 6,213,787(-) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2662795 | CNV | deletion | 23128226 |
| esv2666707 | CNV | deletion | 23128226 |
| esv2718063 | CNV | deletion | 23290073 |
| esv2718064 | CNV | deletion | 23290073 |
| esv3643548 | CNV | loss | 21293372 |
| esv3643549 | CNV | loss | 21293372 |
| esv991625 | CNV | deletion | 20482838 |
| nsv1055913 | CNV | gain | 25217958 |
| nsv1059525 | CNV | gain | 25217958 |
| nsv1134748 | CNV | deletion | 24896259 |
| nsv2396 | CNV | insertion | 18451855 |
| nsv953953 | CNV | deletion | 24416366 |
| nsv953954 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.81;
47.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MLLT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLLT1 Gene
Disorders for MLLT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute leukemia |
|
|
| leukemia |
|
|
| borderline leprosy |
|
|
| childhood leukemia |
|
|
| leprosy 3 |
|
|
Search MLLT1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ENL_HUMAN- Note=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
Additional Disease Information for MLLT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for MLLT1 Gene
Publications for MLLT1 Gene
- Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. (PMID: 8378076) Yamamoto K … Takahashi T (Oncogene 1993) 3 4 23
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. (PMID: 1423624) Tkachuk DC … Cleary ML (Cell 1992) 3 4 23
- ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia. (PMID: 28241141) Wan L … Shi X (Nature 2017) 3 4
- Human ALKBH4 interacts with proteins associated with transcription. (PMID: 23145062) Bjørnstad LG … Falnes PØ (PloS one 2012) 3 4
- The little elongation complex regulates small nuclear RNA transcription. (PMID: 22195968) Smith ER … Shilatifard A (Molecular cell 2011) 3 4
ExternalLinks
Products for MLLT1 Gene
- Custom Antibody ServicesOriGene Antibodies for MLLT1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for MLLT1
- Origene Custom Protein Services for MLLT1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLLT1
- Browse OriGene Inhibitory RNA Products For MLLT1
- OriGene qPCR primer pairs for MLLT1
- OriGene qPCR primer pairs and template standards for MLLT1
- OriGene CRISPR knockouts for MLLT1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MLLT1
- Sino Biological Human cDNA Clone for MLLT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MLLT1
- Novus Biologicals proteins and lysates for MLLT1
- Browse Antibodies
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- Browse Primary Antibodies
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- Invitrogen Antibodies for MLLT1 (AFLGC-MLLT1)
- VectorBuilder Custom and pre-made DNA vectors for MLLT1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MLLT1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MLLT1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MLLT1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MLLT1
- Addgene plasmids for MLLT1
- antibodies-online: Show 15 available MLLT1 Antibodies ranked by validation data
- Compare Top MLLT1 Antibodies
- Quality Products:
- antibodies-online: Search results for available MLLT1 related products ranked by validation data
- antibodies-online: Show 3 available MLLT1 Proteins ranked by validation data
- Compare Top MLLT1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MLLT1
- Search Santa Cruz Biotechnology (SCBT) for MLLT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MLLT1
- Horizon Cell Lines for MLLT1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLLT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLLT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MLLT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLLT1
Sources for MLLT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB