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Aliases for MLIP Gene

Aliases for MLIP Gene

  • Muscular LMNA Interacting Protein 2 3 5
  • Muscular-Enriched A-Type Laminin-Interacting Protein 3 4
  • Muscle-Enriched A-Type Lamin Interacting Protein 2 3
  • Cardiac ISL1-Interacting Protein 2 3
  • C6orf142 3 4
  • CIP 3 4
  • Chromosome 6 Open Reading Frame 142 2
  • Muscular LMNA-Interacting Protein 3
  • Cardiac Isl1-Interacting Protein 4
  • Cip 4

External Ids for MLIP Gene

Previous HGNC Symbols for MLIP Gene

  • C6orf142

Previous GeneCards Identifiers for MLIP Gene

  • GC06P053796

Summaries for MLIP Gene

GeneCards Summary for MLIP Gene

MLIP (Muscular LMNA Interacting Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcriptional repressor activity, RNA polymerase II transcription factor binding.

UniProtKB/Swiss-Prot for MLIP Gene

  • Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.

Gene Wiki entry for MLIP Gene

Additional gene information for MLIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLIP Gene

Genomics for MLIP Gene

GeneHancer (GH) Regulatory Elements for MLIP Gene

Promoters and enhancers for MLIP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J053926 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.7 -1.5 -1450 4.2 PKNOX1 NFIB MZF1 SIN3A ZBTB7B ZBTB40 ZNF366 E2F8 FOS RCOR1 ENSG00000236740 LOC101927189 MLIP MLIP-IT1 FAM83B ENSG00000271218
GH06J054018 Promoter 0.5 EPDnew 650.2 +89.0 88969 0.1 MLIP MLIP-AS1 ERHP2 GC06P053984
GH06J054111 Promoter 0.5 EPDnew 650.1 +181.4 181446 0.1 MLIP MLIP-AS1 GC06P054160
GH06J053982 Enhancer 0.8 Ensembl ENCODE 23.1 +53.7 53658 3 JUND POLR2A JUN STAT3 CEBPB FOSL2 FOS EP300 GC06P053984 MLIP MLIP-IT1 ENSG00000236740 MLIP-AS1 KLHL31 PIR57668 LOC101927189
GH06J054074 Enhancer 0.8 Ensembl ENCODE 18 +144.7 144670 1.2 SP1 JUND RXRA ATF3 HNF4G HNF4A RAD21 YY1 MLIP MLIP-AS1 ERHP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MLIP on UCSC Golden Path with GeneCards custom track

Genomic Locations for MLIP Gene

Genomic Locations for MLIP Gene
336,299 bases
Plus strand
336,299 bases
Plus strand

Genomic View for MLIP Gene

Genes around MLIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLIP Gene

Proteins for MLIP Gene

  • Protein details for MLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Muscular LMNA-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B7Z2N0
    • D6RE05
    • Q96H08
    • Q96NF7

    Protein attributes for MLIP Gene

    458 amino acids
    Molecular mass:
    50429 Da
    Quaternary structure:
    • Interacts with LMNA (PubMed:21498514). Interacts with ISL1 (via N-terminal domain); the interaction represses ISL1 transactivator activity (By similarity).
    • Sequence=CAI13927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MLIP Gene


neXtProt entry for MLIP Gene

Post-translational modifications for MLIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MLIP Gene

Domains & Families for MLIP Gene

Gene Families for MLIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MLIP Gene


Suggested Antigen Peptide Sequences for MLIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MLIP: view

No data available for UniProtKB/Swiss-Prot for MLIP Gene

Function for MLIP Gene

Molecular function for MLIP Gene

UniProtKB/Swiss-Prot Function:
Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.

Phenotypes From GWAS Catalog for MLIP Gene

genes like me logo Genes that share phenotypes with MLIP: view

Animal Models for MLIP Gene

MGI Knock Outs for MLIP:
  • Mlip Mlip<tm1.1(cre)Dzw>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MLIP Gene

Localization for MLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLIP Gene

Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLIP gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005635 nuclear envelope ISS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016605 PML body ISS --
genes like me logo Genes that share ontologies with MLIP: view

Pathways & Interactions for MLIP Gene

No Data Available

Interacting Proteins for MLIP Gene

Gene Ontology (GO) - Biological Process for MLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0010614 negative regulation of cardiac muscle hypertrophy ISS --
GO:0045944 positive regulation of transcription by RNA polymerase II ISS --
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress ISS --
genes like me logo Genes that share ontologies with MLIP: view

No data available for Pathways by source and SIGNOR curated interactions for MLIP Gene

Drugs & Compounds for MLIP Gene

No Compound Related Data Available

Transcripts for MLIP Gene

Unigene Clusters for MLIP Gene

Muscular LMNA-interacting protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MLIP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - -
SP2: - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: -

Relevant External Links for MLIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MLIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MLIP Gene

This gene is overexpressed in Muscle - Skeletal (x18.0), Heart - Left Ventricle (x14.7), Nerve - Tibial (x7.3), and Heart - Atrial Appendage (x7.2).

Protein differential expression in normal tissues from HIPED for MLIP Gene

This gene is overexpressed in Heart (51.3) and Fetal heart (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MLIP Gene

Protein tissue co-expression partners for MLIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MLIP Gene:


SOURCE GeneReport for Unigene cluster for MLIP Gene:


mRNA Expression by UniProt/SwissProt for MLIP Gene:

Tissue specificity: Primarily expressed in heart and skeletal muscle. Also detected in liver.

Evidence on tissue expression from TISSUES for MLIP Gene

  • Heart(4.5)
  • Nervous system(4.4)
  • Muscle(2.9)
  • Liver(2)
genes like me logo Genes that share expression patterns with MLIP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MLIP Gene

Orthologs for MLIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MLIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MLIP 34 33
  • 95.26 (n)
(Canis familiaris)
Mammalia LOC474943 33
  • 85.44 (n)
  • 38 (a)
(Mus musculus)
Mammalia Mlip 16 34 33
  • 81.67 (n)
(Bos Taurus)
Mammalia MLIP 34 33
  • 80 (n)
(Rattus norvegicus)
Mammalia Mlip 33
  • 78.88 (n)
(Monodelphis domestica)
Mammalia MLIP 34
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia MLIP 34
  • 24 (a)
(Gallus gallus)
Aves MLIP 34
  • 46 (a)
(Anolis carolinensis)
Reptilia MLIP 34
  • 21 (a)
(Danio rerio)
Actinopterygii CU571255.1 34
  • 9 (a)
Species where no ortholog for MLIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MLIP Gene

Gene Tree for MLIP (if available)
Gene Tree for MLIP (if available)
Evolutionary constrained regions (ECRs) for MLIP: view image

Paralogs for MLIP Gene

No data available for Paralogs for MLIP Gene

Variants for MLIP Gene

Sequence variations from dbSNP and Humsavar for MLIP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000013336 -- 54,195,298(+) G/C intron_variant
rs1000019974 -- 54,260,688(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000025085 -- 54,237,007(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000060016 -- 54,178,007(+) A/G intron_variant
rs1000065132 -- 54,086,890(+) T/A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MLIP Gene

Variant ID Type Subtype PubMed ID
dgv1045n67 CNV loss 20364138
dgv1046n67 CNV gain 20364138
dgv10662n54 CNV gain+loss 21841781
dgv10663n54 CNV gain 21841781
dgv10664n54 CNV gain 21841781
dgv10665n54 CNV gain 21841781
dgv1116e199 CNV deletion 23128226
dgv1117e199 CNV deletion 23128226
dgv119n17 CNV loss 16327808
dgv1774e212 CNV gain 25503493
dgv1775e212 CNV loss 25503493
dgv1776e212 CNV loss 25503493
dgv3317n106 CNV deletion 24896259
dgv390e215 CNV deletion 23714750
dgv53n50 CNV loss 21212237
esv2421881 CNV deletion 20811451
esv26113 CNV gain 19812545
esv2732099 CNV deletion 23290073
esv2759431 CNV gain+loss 17122850
esv2762593 CNV loss 21179565
esv2763985 CNV gain 21179565
esv34853 CNV gain 17911159
esv3539747 CNV deletion 23714750
esv3571069 CNV loss 25503493
esv3609040 CNV gain 21293372
esv3609041 CNV gain 21293372
esv3609042 CNV loss 21293372
esv3609043 CNV gain 21293372
esv3609045 CNV loss 21293372
esv3609046 CNV loss 21293372
esv5312 CNV loss 18987735
esv5367 OTHER complex 18987735
esv990236 CNV deletion 20482838
nsv1017633 CNV gain 25217958
nsv1018062 CNV gain 25217958
nsv1020329 CNV loss 25217958
nsv1025090 CNV loss 25217958
nsv1027036 CNV loss 25217958
nsv1030908 CNV loss 25217958
nsv1034955 CNV gain 25217958
nsv1073558 CNV deletion 25765185
nsv1074575 CNV deletion 25765185
nsv1112125 CNV deletion 24896259
nsv1142463 CNV tandem duplication 24896259
nsv473642 CNV novel sequence insertion 20440878
nsv507330 OTHER sequence alteration 20534489
nsv508407 CNV deletion 20534489
nsv514360 CNV loss 21397061
nsv517189 CNV loss 19592680
nsv523301 CNV loss 19592680
nsv526401 CNV loss 19592680
nsv5307 CNV deletion 18451855
nsv603110 CNV gain 21841781
nsv603111 CNV loss 21841781
nsv603112 CNV gain 21841781
nsv603113 CNV loss 21841781
nsv7901 CNV gain 18304495
nsv820018 CNV gain 19587683
nsv821284 CNV deletion 20802225
nsv823690 CNV gain 20364138
nsv823691 CNV gain 20364138
nsv823699 CNV gain 20364138
nsv970716 CNV deletion 23825009
nsv981145 CNV duplication 23825009

Variation tolerance for MLIP Gene

Gene Damage Index Score: 7.52; 82.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MLIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MLIP Gene

Disorders for MLIP Gene


  • Note=Expression is reduced in patients with dilated cardiomyocytes. In murine cardiomyopathy models, deletion of the encoding gene accelerates progress from hypertrophy to heart failure. {ECO:0000269 PubMed:26436652}.

Additional Disease Information for MLIP

No disorders were found for MLIP Gene.

No data available for MalaCards and Genatlas for MLIP Gene

Publications for MLIP Gene

  1. Identification of a novel muscle A-type lamin-interacting protein (MLIP). (PMID: 21498514) Ahmady E … Burgon PG (The Journal of biological chemistry 2011) 2 3 4 58
  2. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. (PMID: 26436652) Huang ZP … Wang DZ (The Journal of clinical investigation 2015) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for MLIP Gene

Sources for MLIP Gene

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