Aliases for MLH3 Gene
External Ids for MLH3 Gene
Previous GeneCards Identifiers for MLH3 Gene
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for MLH3 Gene
MLH3 (MutL Homolog 3) is a Protein Coding gene. Diseases associated with MLH3 include Colorectal Cancer, Hereditary Nonpolyposis, Type 7 and Endometrial Cancer. Among its related pathways are Meiosis and Mismatch repair. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded DNA binding. An important paralog of this gene is PMS1.
UniProtKB/Swiss-Prot Summary for MLH3 Gene
Probably involved in the repair of mismatches in DNA.