This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] See more...

Aliases for MLF1 Gene

Aliases for MLF1 Gene

  • Myeloid Leukemia Factor 1 2 3 4 5
  • Myelodysplasia-Myeloid Leukemia Factor 1 3 4
  • Testis Tissue Sperm-Binding Protein Li 49e 3
  • Myeloid Leukemia Factor 1 Variant 1 2
  • Myeloid Leukemia Factor 1 Variant 2 2
  • Myeloid Leukemia Factor 1 Variant 3 2

External Ids for MLF1 Gene

Previous GeneCards Identifiers for MLF1 Gene

  • GC03P155550
  • GC03P159236
  • GC03P159570
  • GC03P159609
  • GC03P159771
  • GC03P158288
  • GC03P155686

Summaries for MLF1 Gene

Entrez Gene Summary for MLF1 Gene

  • This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for MLF1 Gene

MLF1 (Myeloid Leukemia Factor 1) is a Protein Coding gene. Diseases associated with MLF1 include Thyroid Carcinoma and Myeloid Leukemia. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is MLF2.

UniProtKB/Swiss-Prot Summary for MLF1 Gene

  • Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Gene Wiki entry for MLF1 Gene

Additional gene information for MLF1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLF1 Gene

Genomics for MLF1 Gene

GeneHancer (GH) Regulatory Elements for MLF1 Gene

Promoters and enhancers for MLF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MLF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MLF1

Top Transcription factor binding sites by QIAGEN in the MLF1 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • NCX
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU6F1 (c2)

Genomic Locations for MLF1 Gene

Genomic Locations for MLF1 Gene
chr3:158,571,163-158,607,252
(GRCh38/hg38)
Size:
36,090 bases
Orientation:
Plus strand
chr3:158,288,952-158,325,041
(GRCh37/hg19)
Size:
36,090 bases
Orientation:
Plus strand

Genomic View for MLF1 Gene

Genes around MLF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MLF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MLF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLF1 Gene

Proteins for MLF1 Gene

  • Protein details for MLF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58340-MLF1_HUMAN
    Recommended name:
    Myeloid leukemia factor 1
    Protein Accession:
    P58340
    Secondary Accessions:
    • E9PEU9
    • Q2TLE3
    • Q2TLE5
    • Q8N8F8
    • Q96MH1

    Protein attributes for MLF1 Gene

    Size:
    268 amino acids
    Molecular mass:
    30627 Da
    Quaternary structure:
    • Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of COP1 and activation of p53.

    Three dimensional structures from OCA and Proteopedia for MLF1 Gene

    Alternative splice isoforms for MLF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLF1 Gene

Post-translational modifications for MLF1 Gene

No data available for DME Specific Peptides for MLF1 Gene

Domains & Families for MLF1 Gene

Gene Families for MLF1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for MLF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MLF1 Gene

GenScript: Design optimal peptide antigens:
  • Myelodysplasia-myeloid leukemia factor 1 (MLF1_HUMAN)
  • cDNA FLJ52995, highly similar to Myeloid leukemia factor 1 (Q2TLE3_HUMAN)
  • Myeloid leukemia factor 1 variant 2 (Q2TLE4_HUMAN)
  • cDNA FLJ39570 fis, clone SKMUS2001850, highly similar to Homo sapiens t(3 (Q8N8F8_HUMAN)
  • cDNA FLJ32386 fis, clone SKMUS1000118, highly similar to Homo sapiens t(3 (Q96MH1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58340

UniProtKB/Swiss-Prot:

MLF1_HUMAN :
  • Belongs to the MLF family.
Family:
  • Belongs to the MLF family.
genes like me logo Genes that share domains with MLF1: view

Function for MLF1 Gene

Molecular function for MLF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
GENATLAS Biochemistry:
myelodysplasia/myeloid leukemia factor 1.31kDa,fused with NPM1 in myelodysplastic syndrome with translocation t(3;5)(q25.1;q34),cytoplasmic protein expressed in a variety of tissues,homolog to murine hemopoietic lineage switch HLS7

Phenotypes From GWAS Catalog for MLF1 Gene

Gene Ontology (GO) - Molecular Function for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS,IBA --
GO:0005515 protein binding IPI 12176995
GO:0019904 protein domain specific binding IDA 12176995
genes like me logo Genes that share ontologies with MLF1: view
genes like me logo Genes that share phenotypes with MLF1: view

Human Phenotype Ontology for MLF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MLF1 Gene

MGI Knock Outs for MLF1:

Animal Model Products

miRNA for MLF1 Gene

miRTarBase miRNAs that target MLF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MLF1 Gene

Localization for MLF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLF1 Gene

Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250 UniProtKB:Q9QWV4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MLF1 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium ISS --
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with MLF1: view

Pathways & Interactions for MLF1 Gene

PathCards logo

SuperPathways for MLF1 Gene

genes like me logo Genes that share pathways with MLF1: view

Pathways by source for MLF1 Gene

1 KEGG pathway for MLF1 Gene

SIGNOR curated interactions for MLF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for MLF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002318 myeloid progenitor cell differentiation ISS --
GO:0006351 transcription, DNA-templated ISS --
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 15861129
genes like me logo Genes that share ontologies with MLF1: view

Drugs & Compounds for MLF1 Gene

(1) Drugs for MLF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MLF1: view

Transcripts for MLF1 Gene

mRNA/cDNA for MLF1 Gene

11 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products