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This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradati... See more...
Aliases for MLEC Gene
Aliases for MLEC Gene
External Ids for MLEC Gene
- HGNC: 28973
- Entrez Gene: 9761
- Ensembl: ENSG00000110917
- OMIM: 613802
- UniProtKB: Q14165
Previous HGNC Symbols for MLEC Gene
- KIAA0152
Previous GeneCards Identifiers for MLEC Gene
- GC12P119611
- GC12P121124
- GC12P118134
Summaries for MLEC Gene
-
This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for MLEC Gene
MLEC (Malectin) is a Protein Coding gene. Diseases associated with MLEC include Advanced Sleep Phase Syndrome, Familial, 1 and Congenital Disorder Of Glycosylation, Type Iib. Among its related pathways are Calnexin/calreticulin cycle and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include enzyme binding and carbohydrate binding.
UniProtKB/Swiss-Prot Summary for MLEC Gene
-
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).
Additional gene information for MLEC Gene
- HGNC(28973)
- Entrez Gene(9761)
- Ensembl(ENSG00000110917)
- OMIM(613802)
- UniProtKB(Q14165)
- Open Targets Platform(ENSG00000110917)
- Search for MLEC at DataMed
- Search for MLEC at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MLEC Gene
Genomics for MLEC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MLEC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MLEC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MLEC
- Top Transcription factor binding sites by QIAGEN in the MLEC gene promoter:
-
- Brachyury
- CBF-C
- CP1A
- CP1C
- Elk-1
- GATA-3
- LCR-F1
- NF-Y
- Pax-4a
- XBP-1
Genomic Locations for MLEC Gene
Genomic Locations for MLEC Gene
- chr12:120,687,149-120,701,864
- (GRCh38/hg38)
- Size:
- 14,716 bases
- Orientation:
- Plus strand
- chr12:121,124,672-121,139,667
- (GRCh37/hg19)
- Size:
- 14,996 bases
- Orientation:
- Plus strand
Genomic View for MLEC Gene
Genes around MLEC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
MLEC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MLEC Gene
Proteins for MLEC Gene
-
Protein details for MLEC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14165-MLEC_HUMAN
- Recommended name:
- Malectin
- Protein Accession:
- Q14165
Protein attributes for MLEC Gene
- Size:
- 292 amino acids
- Molecular mass:
- 32234 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA09773.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MLEC Gene
Post-translational modifications for MLEC Gene
Other Protein References for MLEC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences KIAA0152 / MLEC Antibody (LS-A9847) and KIAA0152 / MLEC Antibody (LS-A9848)
- Novus Biologicals Antibodies for MLEC
-
Abcam antibodies for MLEC
- Invitrogen Antibodies for MLEC (AFLGC-Mlec)
Protein Products
-
OriGene Purified Proteins for MLEC
- Search Origene for MassSpec and Protein Over-expression Lysates for MLEC
- Origene Custom Protein Services for MLEC
- ProSpec Recombinant Proteins for MLEC
- antibodies-online: Show 9 available MLEC Proteins ranked by validation data
- Compare Top MLEC Proteins
-
Quality Products:
-
Abcam proteins for MLEC
Assay Products
- antibodies-online: Search results for available MLEC related products ranked by validation data
-
Signalway ELISA kits for MLEC
No data available for DME Specific Peptides for MLEC Gene
Domains & Families for MLEC Gene
Gene Families for MLEC Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MLEC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MLEC Gene
- GenScript: Design optimal peptide antigens:
-
- Malectin (MLEC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14165- Family:
-
- Belongs to the malectin family.
Function for MLEC Gene
Molecular function for MLEC Gene
- UniProtKB/Swiss-Prot Function:
- Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).
Phenotypes From GWAS Catalog for MLEC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 30021884 |
| GO:0019899 | enzyme binding | IPI | 22988243 |
| GO:0030246 | carbohydrate binding | IEA,ISS | -- |
Phenotypes for MLEC Gene
- MGI mutant phenotypes for MLEC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MLEC:
Animal Models for MLEC Gene
- MGI Knock Outs for MLEC:
-
- Mlec Mlec<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MLEC - Select products 50% OFF >
- * MLEC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MLEC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLEC
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLEC
miRNA for MLEC Gene
- miRTarBase miRNAs that target MLEC
-
- hsa-miR-24-3p (MIRT003889)
- mmu-miR-541-5p (MIRT008093)
- mmu-miR-425-5p (MIRT008546)
- mmu-miR-362-5p (MIRT008933)
- hsa-miR-375 (MIRT019896)
- hsa-miR-124-3p (MIRT022943)
- hsa-miR-296-3p (MIRT038439)
- hsa-miR-25-3p (MIRT050275)
- hsa-miR-19a-3p (MIRT062706)
- hsa-miR-19b-3p (MIRT062707)
- hsa-miR-148a-3p (MIRT062708)
- hsa-miR-130a-3p (MIRT062709)
- hsa-miR-152-3p (MIRT062710)
- hsa-miR-301a-3p (MIRT062711)
- hsa-miR-130b-3p (MIRT062712)
- hsa-miR-148b-3p (MIRT062713)
- hsa-miR-495-3p (MIRT062714)
- hsa-miR-454-3p (MIRT062715)
- hsa-miR-301b-3p (MIRT062716)
- hsa-miR-548e-5p (MIRT062717)
- hsa-miR-548f-5p (MIRT062718)
- hsa-miR-548g-5p (MIRT062719)
- hsa-miR-548p (MIRT062720)
- hsa-miR-548x-5p (MIRT062721)
- hsa-miR-4295 (MIRT062722)
- hsa-miR-3666 (MIRT062723)
- hsa-miR-3925-5p (MIRT062724)
- hsa-miR-548aj-5p (MIRT062725)
- hsa-miR-548aw (MIRT062726)
- hsa-miR-5688 (MIRT062727)
- hsa-miR-101-3p (MIRT112563)
- hsa-miR-6840-3p (MIRT112574)
- hsa-miR-4797-5p (MIRT133303)
- hsa-miR-5571-5p (MIRT133304)
- hsa-miR-485-5p (MIRT440231)
- hsa-miR-1226-5p (MIRT473173)
- hsa-miR-1257 (MIRT473174)
- hsa-miR-6829-5p (MIRT473175)
- hsa-miR-6762-3p (MIRT473176)
- hsa-miR-3649 (MIRT473177)
- hsa-miR-4721 (MIRT473178)
- hsa-miR-3616-3p (MIRT473179)
- hsa-miR-4446-3p (MIRT473180)
- hsa-miR-4764-3p (MIRT513557)
- hsa-miR-151a-3p (MIRT535884)
- hsa-miR-3194-3p (MIRT535885)
- hsa-miR-298 (MIRT535886)
- hsa-miR-4680-5p (MIRT535887)
- hsa-miR-3158-5p (MIRT535888)
- hsa-miR-6787-3p (MIRT535889)
- hsa-miR-4267 (MIRT535890)
- hsa-miR-5685 (MIRT535891)
- hsa-miR-4690-3p (MIRT535892)
- hsa-miR-6501-3p (MIRT535893)
- hsa-miR-4463 (MIRT535894)
- hsa-miR-4499 (MIRT535895)
- hsa-miR-509-5p (MIRT535896)
- hsa-miR-509-3-5p (MIRT535897)
- hsa-miR-4418 (MIRT535898)
- hsa-miR-526b-5p (MIRT556115)
- hsa-miR-1468-3p (MIRT556116)
- mmu-miR-669n (MIRT593209)
- mmu-miR-592-5p (MIRT593210)
- mmu-miR-466n-5p (MIRT593211)
- mmu-miR-466l-5p (MIRT593212)
- mmu-miR-466i-5p (MIRT593213)
- mmu-miR-466d-5p (MIRT593214)
- mmu-miR-466k (MIRT593215)
- hsa-miR-133a-3p (MIRT687546)
- hsa-miR-323a-5p (MIRT687547)
- hsa-miR-4281 (MIRT687548)
- hsa-miR-548v (MIRT687549)
- hsa-miR-3665 (MIRT687550)
- hsa-miR-139-5p (MIRT687551)
- hsa-miR-4673 (MIRT687552)
- hsa-miR-4645-5p (MIRT687553)
- hsa-miR-4692 (MIRT687554)
- hsa-miR-4514 (MIRT687555)
- hsa-miR-940 (MIRT687556)
- hsa-miR-6893-5p (MIRT687557)
- hsa-miR-6808-5p (MIRT687558)
- hsa-miR-144-3p (MIRT687559)
- hsa-miR-1249-5p (MIRT736441)
- hsa-miR-149-3p (MIRT737751)
- hsa-miR-3202 (MIRT741153)
- hsa-miR-4475 (MIRT745019)
- hsa-miR-4728-5p (MIRT747847)
- hsa-miR-4747-5p (MIRT748251)
- hsa-miR-5196-5p (MIRT750035)
- hsa-miR-545-3p (MIRT750453)
- hsa-miR-6785-5p (MIRT755842)
- hsa-miR-6797-5p (MIRT756201)
- hsa-miR-6825-5p (MIRT756995)
- hsa-miR-6828-5p (MIRT757077)
- hsa-miR-6883-5p (MIRT758427)
- hsa-miR-7515 (MIRT759385)
- hsa-miR-7845-5p (MIRT759801)
- hsa-miR-9500 (MIRT760890)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLEC
- Browse OriGene Inhibitory RNA Products For MLEC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLEC
Clone Products
- Applied Biological Materials (abm): Clones for MLEC - Select products 50% OFF >
- * MLEC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MLEC
- Addgene plasmids for MLEC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLEC
Cell Line Products
-
Horizon Cell Lines for MLEC
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MLEC Gene
Localization for MLEC Gene
Subcellular locations from UniProtKB/Swiss-Prot for MLEC Gene
- Endoplasmic reticulum membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 4 |
| extracellular | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | ISS | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for MLEC Gene
Pathways & Interactions for MLEC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Metabolism of proteins | ||
| 3 | Transport to the Golgi and subsequent modification | ||
| 4 | Calnexin/calreticulin cycle | ||
Pathways by source for MLEC Gene
7 Reactome pathways for MLEC Gene
Interacting Proteins for MLEC Gene
Selected Interacting proteins:
Q14165-MLEC_HUMAN
ENSP00000228506
for MLEC Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MLEC
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006457 | protein folding | TAS | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for MLEC Gene
Transcripts for MLEC Gene
mRNA/cDNA for MLEC Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000228506 6341 nts (view in UCSC)
- ENST00000412616 841 nts (view in UCSC)
- ENST00000535413 617 nts (view in UCSC)
- ENST00000535656 543 nts (view in UCSC)
- ENST00000545525 549 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MLEC - Select products 50% OFF >
- * MLEC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MLEC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLEC
-
Santa Cruz Biotechnology (SCBT) CRISPR for MLEC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLEC
- Browse OriGene Inhibitory RNA Products For MLEC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLEC
Clone Products
- Applied Biological Materials (abm): Clones for MLEC - Select products 50% OFF >
- * MLEC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for MLEC
- Addgene plasmids for MLEC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLEC
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | - |
Relevant External Links for MLEC Gene
- GeneLoc Exon Structure for
- MLEC
Expression for MLEC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Pancreas (Endocrine System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MLEC Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MLEC
SOURCE GeneReport for Unigene cluster for MLEC Gene:
Hs.744910Evidence on tissue expression from TISSUES for MLEC Gene
- Skin(4.8)
- Lung(4.8)
- Liver(4.6)
- Nervous system(4.4)
- Bone marrow(4.4)
- Intestine(4.2)
- Kidney(3.7)
- Heart(3)
- Eye(2.8)
- Pancreas(2.8)
- Muscle(2.5)
- Blood(2.4)
- Spleen(2.3)
Primer Products
-
OriGene qPCR primer pairs for MLEC
-
OriGene qPCR primer pairs and template standards for MLEC
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MLEC Gene
Orthologs for MLEC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MLEC 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MLEC 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MLEC 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MLEC 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mlec 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mlec 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MLEC 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MLEC 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mlec 30 |
|
||
| Str.6941 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | kiaa0152-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mlec 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007950 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9257 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | F44E2.10 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8086 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1179 30 |
|
- Species where no ortholog for MLEC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for MLEC Gene
- ENSEMBL:
- Gene Tree for MLEC (if available)
- TreeFam:
- Gene Tree for MLEC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MLEC: view image
Paralogs for MLEC Gene
Pseudogenes.org Pseudogenes for MLEC Gene
No data available for Paralogs for MLEC Gene
Variants for MLEC Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2659790 | CNV | deletion | 23128226 |
| esv3630929 | CNV | loss | 21293372 |
| nsv1045923 | CNV | gain | 25217958 |
| nsv521928 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MLEC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MLEC
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MLEC Gene
Disorders for MLEC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| advanced sleep phase syndrome, familial, 1 |
|
|
| congenital disorder of glycosylation, type iib |
|
|
| cerebral palsy |
|
|
| spinal muscular atrophy, type i |
|
|
| autosomal recessive non-syndromic intellectual disability |
|
|
Search MLEC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MLEC
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MLEC Gene
Publications for MLEC Gene
- Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. (PMID: 22988243) Qin SY … Yamamoto K (The Journal of biological chemistry 2012) 2 3
- MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 41
- Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. (PMID: 18524852) Schallus T … Muhle-Goll C (Molecular biology of the cell 2008) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 3 4
ExternalLinks
Products for MLEC Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for MLEC
- Search Origene for MassSpec and Protein Over-expression Lysates for MLEC
- Origene Custom Protein Services for MLEC
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MLEC
- Browse OriGene Inhibitory RNA Products For MLEC
- OriGene qPCR primer pairs for MLEC
- OriGene qPCR primer pairs and template standards for MLEC
- OriGene CRISPR knockouts for MLEC
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MLEC
- Sino Biological Human cDNA Clone for MLEC
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for MLEC
- Novus Biologicals proteins and lysates for MLEC
- Browse Antibodies
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- Abcam antibodies for MLEC
- Abcam proteins for MLEC
- Find your target
- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for MLEC (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MLEC (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MLEC (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MLEC CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MLEC
- Addgene plasmids for MLEC
- antibodies-online: Show 12 available MLEC Antibodies ranked by validation data
- Compare Top MLEC Antibodies
- antibodies-online: Search results for available MLEC related products ranked by validation data
- antibodies-online: Show 9 available MLEC Proteins ranked by validation data
- Compare Top MLEC Proteins
- Quality Products:
- Horizon Cell Lines for MLEC
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MLEC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MLEC
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MLEC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MLEC
- Signalway ELISA kits for MLEC
Sources for MLEC Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB