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Aliases for MKX Gene

Aliases for MKX Gene

  • Mohawk Homeobox 2 3 5
  • Iroquois Homeobox Protein-Like 1 2 3
  • C10orf48 3 4
  • IRXL1 3 4
  • Iroquois Family Related Homeodomain Protein 3
  • Chromosome 10 Open Reading Frame 48 2
  • Homeobox Protein Mohawk 3
  • IFRX 3

External Ids for MKX Gene

Previous HGNC Symbols for MKX Gene

  • C10orf48
  • IRXL1

Previous GeneCards Identifiers for MKX Gene

  • GC10M028003
  • GC10M027961

Summaries for MKX Gene

Entrez Gene Summary for MKX Gene

  • The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for MKX Gene

MKX (Mohawk Homeobox) is a Protein Coding gene. Diseases associated with MKX include Smallpox. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is IRX4.

UniProtKB/Swiss-Prot for MKX Gene

  • May act as a morphogenetic regulator of cell adhesion.

Gene Wiki entry for MKX Gene

Additional gene information for MKX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MKX Gene

Genomics for MKX Gene

GeneHancer (GH) Regulatory Elements for MKX Gene

Promoters and enhancers for MKX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I027745 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.2 165 0.2 MXI1 L3MBTL2 ZNF449 ZNF10 ZNF76 SP1 KLF16 TARDBP FOS ZNF600 MKX MKX-AS1
GH10I027746 Enhancer 0.3 ENCODE 550.8 -0.3 -307 0.2 EZH2 MKX-AS1 MKX GC10P027778
GH10I028177 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -432.6 -432572 1.9 CTCF IRF2 ZNF654 ZBTB6 TRIM22 REST RAD21 IRF9 ZNF335 GATA3 MKX MKX-AS1 LRRC37A6P MIR8086 MPP7 MRPS21P5
GH10I028364 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.2 -621.3 -621261 5.2 ELF3 FOXA2 ZFP64 ARID4B RAD21 RARA YY1 ZNF366 ETV6 FOS MPP7 MKX MKX-AS1 WAC ZNF101P1 ENSG00000222666
GH10I028241 Enhancer 0.9 ENCODE dbSUPER 11 -495.9 -495877 0.2 GATAD2A CTCF ZNF654 CBFB TRIM22 REST RAD21 RFX5 KLF16 CREB1 MKX MKX-AS1 MPP7 MIR8086 MRPS21P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MKX on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MKX gene promoter:

Genomic Locations for MKX Gene

Genomic Locations for MKX Gene
73,187 bases
Minus strand

Genomic View for MKX Gene

Genes around MKX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKX Gene

Proteins for MKX Gene

  • Protein details for MKX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Mohawk
    Protein Accession:
    Secondary Accessions:
    • B3KWM5

    Protein attributes for MKX Gene

    352 amino acids
    Molecular mass:
    39331 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MKX Gene

Post-translational modifications for MKX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MKX Gene

Domains & Families for MKX Gene

Gene Families for MKX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MKX Gene

Suggested Antigen Peptide Sequences for MKX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TALE/IRO homeobox family.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with MKX: view

Function for MKX Gene

Molecular function for MKX Gene

UniProtKB/Swiss-Prot Function:
May act as a morphogenetic regulator of cell adhesion.

Phenotypes From GWAS Catalog for MKX Gene

Gene Ontology (GO) - Molecular Function for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MKX: view
genes like me logo Genes that share phenotypes with MKX: view

Animal Models for MKX Gene

MGI Knock Outs for MKX:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKX Gene

Localization for MKX Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MKX gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MKX: view

Pathways & Interactions for MKX Gene

No Data Available

Gene Ontology (GO) - Biological Process for MKX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007517 muscle organ development ISS 16408284
genes like me logo Genes that share ontologies with MKX: view

No data available for Pathways by source and SIGNOR curated interactions for MKX Gene

Drugs & Compounds for MKX Gene

No Compound Related Data Available

Transcripts for MKX Gene

Unigene Clusters for MKX Gene

Mohawk homeobox:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MKX Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for MKX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MKX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MKX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKX Gene

This gene is overexpressed in Prostate (x4.5).

Protein differential expression in normal tissues from HIPED for MKX Gene

This gene is overexpressed in Tlymphocyte (37.7) and Heart (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MKX Gene

Protein tissue co-expression partners for MKX Gene

NURSA nuclear receptor signaling pathways regulating expression of MKX Gene:


SOURCE GeneReport for Unigene cluster for MKX Gene:


Evidence on tissue expression from TISSUES for MKX Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MKX: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MKX Gene

Orthologs for MKX Gene

This gene was present in the common ancestor of animals.

Orthologs for MKX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MKX 33 34
  • 99.43 (n)
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
-- 34
  • 94 (a)
MKX 33
  • 91.1 (n)
-- 34
  • 81 (a)
(Monodelphis domestica)
Mammalia MKX 34
  • 90 (a)
(Bos Taurus)
Mammalia MKX 33 34
  • 89.68 (n)
(Rattus norvegicus)
Mammalia Mkx 33
  • 86.09 (n)
(Mus musculus)
Mammalia Mkx 33 16 34
  • 85.51 (n)
(Ornithorhynchus anatinus)
Mammalia MKX 34
  • 82 (a)
(Gallus gallus)
Aves MKX 33 34
  • 84.24 (n)
(Anolis carolinensis)
Reptilia MKX 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mkx 33
  • 74.88 (n)
(Danio rerio)
Actinopterygii mkxb 34
  • 73 (a)
mkxa 33 34
  • 66.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11617 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea irx-1 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
Species where no ortholog for MKX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MKX Gene

Gene Tree for MKX (if available)
Gene Tree for MKX (if available)

Paralogs for MKX Gene

Paralogs for MKX Gene

(2) SIMAP similar genes for MKX Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MKX: view

Variants for MKX Gene

Sequence variations from dbSNP and Humsavar for MKX Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000009169 -- 27,685,827(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000072147 -- 27,729,080(-) A/C intron_variant
rs1000098702 -- 27,711,115(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000137441 -- 27,722,740(-) A/C intron_variant
rs1000151138 -- 27,710,791(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MKX Gene

Variant ID Type Subtype PubMed ID
esv2677848 CNV deletion 23128226
esv2734606 CNV deletion 23290073
esv2734639 CNV deletion 23290073
esv2734650 CNV deletion 23290073
esv2734661 CNV deletion 23290073
esv3622708 CNV gain 21293372
esv3622728 CNV gain 21293372
esv3622732 CNV loss 21293372
esv4953 CNV loss 18987735
esv7833 CNV loss 19470904
nsv550241 CNV gain 21841781
nsv831813 CNV loss 17160897

Variation tolerance for MKX Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MKX Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKX Gene

Disorders for MKX Gene

MalaCards: The human disease database

(1) MalaCards diseases for MKX Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • ordinary smallpox
- elite association - COSMIC cancer census association via MalaCards
Search MKX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MKX

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MKX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MKX Gene

Publications for MKX Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  2. Mohawk is a novel homeobox gene expressed in the developing mouse embryo. (PMID: 16408284) Anderson DM … Rawls A (Developmental dynamics : an official publication of the American Association of Anatomists 2006) 2 3 58
  3. In silico characterization of an Iroquois family-related homeodomain protein. (PMID: 16077953) Weinmann A … Teufel A (International journal of molecular medicine 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for MKX Gene

Sources for MKX Gene

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