This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation facto... See more...

Aliases for MKNK2 Gene

Aliases for MKNK2 Gene

  • MAPK Interacting Serine/Threonine Kinase 2 2 3 5
  • MNK2 2 3 4
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 3 4
  • MAP Kinase Interacting Serine/Threonine Kinase 2 2 3
  • MAP Kinase Signal-Integrating Kinase 2 3 4
  • G Protein-Coupled Receptor Kinase 7 2 3
  • MAPK Signal-Integrating Kinase 2 3 4
  • EC 2.7.11.1 4 51
  • GPRK7 3 4
  • Putative Map Kinase Interacting Kinase 2
  • EC 2.7.11 51
  • MKNK2 5
  • Mnk2 4

External Ids for MKNK2 Gene

Previous HGNC Symbols for MKNK2 Gene

  • GPRK7

Previous GeneCards Identifiers for MKNK2 Gene

  • GC19M002100
  • GC19M001977
  • GC19M001988
  • GC19M001809

Summaries for MKNK2 Gene

Entrez Gene Summary for MKNK2 Gene

  • This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

GeneCards Summary for MKNK2 Gene

MKNK2 (MAPK Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK1.

UniProtKB/Swiss-Prot Summary for MKNK2 Gene

  • Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

Tocris Summary for MKNK2 Gene

  • Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression

Gene Wiki entry for MKNK2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MKNK2 Gene

Genomics for MKNK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MKNK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MKNK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MKNK2

Top Transcription factor binding sites by QIAGEN in the MKNK2 gene promoter:
  • E2F
  • E2F-1
  • HSF1 (long)
  • HSF1short
  • HSF2
  • HTF
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • SREBP-1c

Genomic Locations for MKNK2 Gene

Genomic Locations for MKNK2 Gene
chr19:2,037,465-2,051,278
(GRCh38/hg38)
Size:
13,814 bases
Orientation:
Minus strand
chr19:2,037,470-2,051,243
(GRCh37/hg19)
Size:
13,774 bases
Orientation:
Minus strand

Genomic View for MKNK2 Gene

Genes around MKNK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKNK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKNK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK2 Gene

Proteins for MKNK2 Gene

  • Protein details for MKNK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBH9-MKNK2_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 2
    Protein Accession:
    Q9HBH9
    Secondary Accessions:
    • Q6GPI3
    • Q9HBH8
    • Q9UHR0
    • Q9Y2N6

    Protein attributes for MKNK2 Gene

    Size:
    465 amino acids
    Molecular mass:
    51875 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.

    Three dimensional structures from OCA and Proteopedia for MKNK2 Gene

    Alternative splice isoforms for MKNK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK2 Gene

Selected DME Specific Peptides for MKNK2 Gene

Q9HBH9:
  • SIQEGKYEFP
  • GFHRSFKGQNPF
  • GVILYIL
  • KDWAHIS
  • HFNELEAS
  • DCGWDRGE
  • DLWSLGV
  • GGSILSHI
  • PIDIPDAKKR
  • VSPVKICDFDLGSG
  • WSLGVILY
  • LELIEFFE
  • GIAHRDLKPENILCE
  • EYMAPEVV
  • RDLKPEN
  • RSRVFREVE
  • FEDVYQL
  • QVLQHPW
  • GIAHRDLKP
  • AKDLISKLLVRDAK
  • AKDLTSFAAEAIAMNRQL

Post-translational modifications for MKNK2 Gene

  • Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MKNK2 Gene

Gene Families for MKNK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MKNK2 Gene

Suggested Antigen Peptide Sequences for MKNK2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53467, highly similar to MAP kinase-interactingserine/threonine-protein kinase 2 (EC 2.7.11.1) (B4DEQ4_HUMAN)
  • MAP kinase signal-integrating kinase 2 (MKNK2_HUMAN)
  • cDNA FLJ10868 fis, clone NT2RP4001644, weakly similar to MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117) (Q9NV89_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HBH9

UniProtKB/Swiss-Prot:

MKNK2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MKNK2: view

Function for MKNK2 Gene

Molecular function for MKNK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11463832};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11463832};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by CGP57380 and staurosporine. Activated by phosphorylation in a negative-feedback regulatory manner in response to chemotherapy (e.g. cytarabine) and thus impairs the generation of antileukemic responses.

Enzyme Numbers (IUBMB) for MKNK2 Gene

Phenotypes From GWAS Catalog for MKNK2 Gene

Gene Ontology (GO) - Molecular Function for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 11463832
GO:0004683 calmodulin-dependent protein kinase activity IBA 21873635
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with MKNK2: view
genes like me logo Genes that share phenotypes with MKNK2: view

Animal Models for MKNK2 Gene

MGI Knock Outs for MKNK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MKNK2

CRISPR Products

miRNA for MKNK2 Gene

miRTarBase miRNAs that target MKNK2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MKNK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKNK2 Gene

Localization for MKNK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK2 Gene

[Isoform 2]: Nucleus, PML body.
[Isoform 1]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MKNK2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0016604 nuclear body IDA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with MKNK2: view

Pathways & Interactions for MKNK2 Gene

PathCards logo

SuperPathways for MKNK2 Gene

SuperPathway Contained pathways
1 Regulation of lipid metabolism Insulin signaling-generic cascades
.51
2 ERK Signaling
.61
.58
3 HIF-1 signaling pathway
4 MAPK signaling pathway
5 MAPK Erk Pathway
genes like me logo Genes that share pathways with MKNK2: view

Pathways by source for MKNK2 Gene

1 GeneGo (Thomson Reuters) pathway for MKNK2 Gene
  • Transcription Receptor-mediated HIF regulation
4 Qiagen pathways for MKNK2 Gene
  • ERK Signaling
  • MAPK Family Pathway
  • MAPK Signaling
  • p38 Signaling

SIGNOR curated interactions for MKNK2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MKNK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IDA 11463832
GO:0006915 apoptotic process IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8415712
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MKNK2: view

Drugs & Compounds for MKNK2 Gene

(6) Drugs for MKNK2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
Cercosporamide Pharma Mnk2 and JAK3 inhibitor, Potent Mnk2 inhibitor 0
MNK1 INHIBITOR Pharma 0

(2) Additional Compounds for MKNK2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
ETP 45835 dihydrochloride

(3) Tocris Compounds for MKNK2 Gene

Compound Action Cas Number
Cercosporamide Potent Mnk2 inhibitor 131436-22-1
CGP 57380 Selective inhibitor of Mnk1 522629-08-9
ETP 45835 dihydrochloride Mnk1 and Mnk2 inhibitor

(1) ApexBio Compounds for MKNK2 Gene

Compound Action Cas Number
Cercosporamide Mnk2 and JAK3 inhibitor 131436-22-1
genes like me logo Genes that share compounds with MKNK2: view

Drug Products

Transcripts for MKNK2 Gene

mRNA/cDNA for MKNK2 Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MKNK2

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10:

Relevant External Links for MKNK2 Gene

GeneLoc Exon Structure for
MKNK2

Expression for MKNK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MKNK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK2 Gene

This gene is overexpressed in Muscle - Skeletal (x13.1).

Protein differential expression in normal tissues from HIPED for MKNK2 Gene

This gene is overexpressed in Blymphocyte (55.1) and Placenta (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MKNK2 Gene



Protein tissue co-expression partners for MKNK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MKNK2

SOURCE GeneReport for Unigene cluster for MKNK2 Gene:

Hs.515032

mRNA Expression by UniProt/SwissProt for MKNK2 Gene:

Q9HBH9-MKNK2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.

Evidence on tissue expression from TISSUES for MKNK2 Gene

  • Nervous system(4.7)
  • Blood(4.6)
  • Adrenal gland(4.3)
  • Muscle(4)
  • Lung(3.2)
  • Intestine(3.1)
  • Liver(2.8)
  • Heart(2.8)
  • Kidney(2.7)
  • Skin(2.6)
  • Pancreas(2.5)
  • Eye(2.4)
  • Bone marrow(2.3)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with MKNK2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MKNK2 Gene

Orthologs for MKNK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MKNK2 30 31
  • 95.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MKNK2 30 31
  • 90.88 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MKNK2 30 31
  • 89.31 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mknk2 30 17 31
  • 88.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mknk2 30
  • 88.11 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MKNK2 31
  • 84 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MKNK2 31
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MKNK2 30 31
  • 83.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MKNK2 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mknk2 30
  • 71.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68447 30
Zebrafish
(Danio rerio)
Actinopterygii mknk2a 31
  • 74 (a)
OneToMany
mknk2b 30 31
  • 72.5 (n)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta Lk6 31 32
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mnk-1 30 31
  • 53.89 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 31
  • 22 (a)
ManyToMany
RCK2 31
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11342 31
  • 58 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15288 30
Species where no ortholog for MKNK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MKNK2 Gene

ENSEMBL:
Gene Tree for MKNK2 (if available)
TreeFam:
Gene Tree for MKNK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MKNK2: view image

Paralogs for MKNK2 Gene

Paralogs for MKNK2 Gene

(30) SIMAP similar genes for MKNK2 Gene using alignment to 8 proteins:

  • MKNK2_HUMAN
  • B4DEQ4_HUMAN
  • K7EIN7_HUMAN
  • K7EK27_HUMAN
  • K7ELG3_HUMAN
  • K7ELN0_HUMAN
  • K7EMP5_HUMAN
  • Q9NV89_HUMAN

Pseudogenes.org Pseudogenes for MKNK2 Gene

genes like me logo Genes that share paralogs with MKNK2: view

Variants for MKNK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MKNK2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
770281 Benign: not provided 2,042,041(-) G/A INTRON_VARIANT
rs34475638 - p.Arg428Gln
rs3746101 - p.Gln10Lys
rs56158214 - p.Asp73Asn

Additional dbSNP identifiers (rs#s) for MKNK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MKNK2 Gene

Variant ID Type Subtype PubMed ID
esv3419044 CNV insertion 20981092
esv3583202 CNV loss 25503493
esv3583203 CNV loss 25503493
esv3643414 CNV gain 21293372
esv3893156 CNV loss 25118596
nsv458325 CNV loss 19166990
nsv470107 CNV loss 18288195
nsv578380 CNV loss 21841781
nsv953942 CNV deletion 24416366

Variation tolerance for MKNK2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MKNK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MKNK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKNK2 Gene

Disorders for MKNK2 Gene

Additional Disease Information for MKNK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for MKNK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKNK2 Gene

Publications for MKNK2 Gene

  1. Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. (PMID: 11013076) Slentz-Kesler K … Weiner MP (Genomics 2000) 2 3 4 23
  2. Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2. (PMID: 18299328) Dolniak B … Platanias LC (The Journal of biological chemistry 2008) 3 4 23
  3. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. (PMID: 11154262) Scheper GC … Proud CG (Molecular and cellular biology 2001) 3 4 23
  4. Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis. (PMID: 21149447) Joshi S … Platanias LC (The Journal of biological chemistry 2011) 3 4
  5. The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). (PMID: 18508592) Buxade M … Proud CG (Frontiers in bioscience : a journal and virtual library 2008) 3 4

Products for MKNK2 Gene