Aliases for MKNK1 Gene
External Ids for MKNK1 Gene
Previous GeneCards Identifiers for MKNK1 Gene
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for MKNK1 Gene
MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression and Negative regulation of FGFR1 signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK2.
UniProtKB/Swiss-Prot Summary for MKNK1 Gene
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression