This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have... See more...

Aliases for MKNK1 Gene

Aliases for MKNK1 Gene

  • MAPK Interacting Serine/Threonine Kinase 1 2 3 5
  • MNK1 2 3 4
  • MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 3 4
  • MAP Kinase Interacting Serine/Threonine Kinase 1 2 3
  • MAP Kinase Signal-Integrating Kinase 1 3 4
  • MAPK Signal-Integrating Kinase 1 3 4
  • EC 2.7.11.1 4 50
  • EC 2.7.11 50
  • MKNK1 5
  • Mnk1 4

External Ids for MKNK1 Gene

Previous GeneCards Identifiers for MKNK1 Gene

  • GC01M046717
  • GC01M045980
  • GC01M046409
  • GC01M046393
  • GC01M046735
  • GC01M046795
  • GC01M047023
  • GC01M045139

Summaries for MKNK1 Gene

Entrez Gene Summary for MKNK1 Gene

  • This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for MKNK1 Gene

MKNK1 (MAPK Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot Summary for MKNK1 Gene

  • May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

Tocris Summary for MKNK1 Gene

  • Mitogen-activated protein kinase (MAPK) interacting protein kinases (Mnks) are a family of serine/threonine kinases. Mnks are downstream effectors of MAPK signaling, and have been implicated in oncogenic transformation and progression

Gene Wiki entry for MKNK1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MKNK1 Gene

Genomics for MKNK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MKNK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046603 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 274.7 +12.8 12793 3.3 SP1 MYC IKZF1 KLF9 POLR2A NFIC YY1 NONO CTCF KLF11 MKNK1 lnc-TEX38-3 lnc-MOB3C-3 EFCAB14 TEX38 ATPAF1 EFCAB14-AS1 HSALNG0003345 KNCN
GH01J046610 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 25.5 +2.3 2328 7.4 SP1 ZNF600 MYC IKZF1 ZNF592 POLR2A ZIC2 MXD4 SIN3A ELK1 MOB3C MKNK1 HSALNG0003347 lnc-TEX38-3 KNCN
GH01J046580 Enhancer 0.9 Ensembl ENCODE 27.9 +32.7 32742 10.6 MYC IKZF1 JUND MBD2 GABPA FOXA2 TAL1 FOSL2 SPI1 MAX MKNK1 GPBP1L1 RPL7AP16 LRRC41 RPS15AP10 EFCAB14-AS1 MKNK1-AS1 HSALNG0003343 HSALNG0003345 piR-35674-018
GH01J046622 Enhancer 0.9 Ensembl ENCODE 18.1 -6.2 -6158 3.2 ZNF654 ZNF600 IKZF1 ZIC2 REST CTCF RAD21 SMC3 HDAC2 ZNF143 HSALNG0003347 MKNK1 EFCAB14 TEX38 ATPAF1 EFCAB14-AS1 LOC105378697 MOB3C
GH01J046489 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 9 +126.8 126842 1.2 EZH2 ZNF600 ZBTB10 FEZF1 ZNF639 TBP KLF9 SP2 GABPB1 DDX20 DMBX1 MKNK1 piR-41525-022 TMEM275
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MKNK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MKNK1

Top Transcription factor binding sites by QIAGEN in the MKNK1 gene promoter:
  • AP-1
  • ATF
  • ATF-2
  • c-Jun
  • Nkx2-5
  • PPAR-alpha
  • SRF (504 AA)

Genomic Locations for MKNK1 Gene

Latest Assembly
chr1:46,557,407-46,616,843
(GRCh38/hg38)
Size:
59,437 bases
Orientation:
Minus strand

Previous Assembly
chr1:47,023,079-47,069,940
(GRCh37/hg19 by Entrez Gene)
Size:
46,862 bases
Orientation:
Minus strand

chr1:47,023,090-47,082,515
(GRCh37/hg19 by Ensembl)
Size:
59,426 bases
Orientation:
Minus strand

Genomic View for MKNK1 Gene

Genes around MKNK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MKNK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MKNK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MKNK1 Gene

Proteins for MKNK1 Gene

  • Protein details for MKNK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUB5-MKNK1_HUMAN
    Recommended name:
    MAP kinase-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Q9BUB5
    Secondary Accessions:
    • D3DQ20
    • D3DQ21
    • O00312
    • Q5TC06
    • Q5TC07
    • Q6V0N6

    Protein attributes for MKNK1 Gene

    Size:
    465 amino acids
    Molecular mass:
    51342 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.

    Three dimensional structures from OCA and Proteopedia for MKNK1 Gene

    Alternative splice isoforms for MKNK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MKNK1 Gene

Selected DME Specific Peptides for MKNK1 Gene

Q9BUB5:
  • SIQEGKYEFP
  • KDWAHIS
  • DCGWDRGE
  • DLWSLGV
  • VSPVKICDFDLGSG
  • HFNEREAS
  • LGEGAYAKVQ
  • LELIEFFE
  • GIAHRDLKPENILCE
  • EYMAPEVV
  • RDLKPEN
  • RSRVFREVE
  • QVLQHPW
  • GIAHRDLKP
  • AKDLISKLLVRDAK
  • RATDSLPGKFED

Post-translational modifications for MKNK1 Gene

  • Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MKNK1 Gene

Gene Families for MKNK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MKNK1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59008, highly similar to MAP kinase-interactingserine/threonine-protein kinase 1 (EC 2.7.11.1) (B4E1V9_HUMAN)
  • MAP kinase interacting serine/threonine kinase 1 (B5BU64_HUMAN)
  • MAP kinase interacting serine/threonine kinase 1 (B5BUJ6_HUMAN)
  • MAP kinase signal-integrating kinase 1 (MKNK1_HUMAN)
  • MAP kinase interacting serine/threonine kinase 1, isoform CRA_c (Q5TC08_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BUB5

UniProtKB/Swiss-Prot:

MKNK1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MKNK1: view

Function for MKNK1 Gene

Molecular function for MKNK1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:9155018};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:9155018};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.

Enzyme Numbers (IUBMB) for MKNK1 Gene

Phenotypes From GWAS Catalog for MKNK1 Gene

Gene Ontology (GO) - Molecular Function for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004683 calmodulin-dependent protein kinase activity IBA 21873635
GO:0005515 protein binding IPI 20936779
genes like me logo Genes that share ontologies with MKNK1: view
genes like me logo Genes that share phenotypes with MKNK1: view

Animal Models for MKNK1 Gene

MGI Knock Outs for MKNK1:

Animal Models for research

  • Taconic Biosciences Mouse Models for MKNK1

miRNA for MKNK1 Gene

miRTarBase miRNAs that target MKNK1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MKNK1

Clone products for research

  • Addgene plasmids for MKNK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MKNK1 Gene

Localization for MKNK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MKNK1 Gene

[Isoform 2]: Cytoplasm.
[Isoform 3]: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MKNK1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MKNK1: view

Pathways & Interactions for MKNK1 Gene

genes like me logo Genes that share pathways with MKNK1: view

Pathways by source for MKNK1 Gene

2 GeneGo (Thomson Reuters) pathways for MKNK1 Gene
  • Transcription Receptor-mediated HIF regulation
  • Translation Regulation of EIF4F activity
5 Qiagen pathways for MKNK1 Gene
  • ERK Signaling
  • MAPK Family Pathway
  • MAPK Signaling
  • p38 Signaling
  • Regulation of eIF4 and p70S6K
1 Cell Signaling Technology pathway for MKNK1 Gene

SIGNOR curated interactions for MKNK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MKNK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IEA,IDA 9155018
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 17130135
GO:0035556 intracellular signal transduction IDA 9155018
genes like me logo Genes that share ontologies with MKNK1: view

Drugs & Compounds for MKNK1 Gene

(10) Drugs for MKNK1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra 0
Cercosporamide Pharma Mnk2 and JAK3 inhibitor, Potent Mnk2 inhibitor 0
CGP 57380 Pharma Selective inhibitor of Mnk1 0

(3) Additional Compounds for MKNK1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
ETP 45835 dihydrochloride

(3) Tocris Compounds for MKNK1 Gene

Compound Action Cas Number
Cercosporamide Potent Mnk2 inhibitor 131436-22-1
CGP 57380 Selective inhibitor of Mnk1 522629-08-9
ETP 45835 dihydrochloride Mnk1 and Mnk2 inhibitor

(2) ApexBio Compounds for MKNK1 Gene

Compound Action Cas Number
Cercosporamide Mnk2 and JAK3 inhibitor 131436-22-1
CGP 57380 522629-08-9
genes like me logo Genes that share compounds with MKNK1: view

Drug products for research

Transcripts for MKNK1 Gene

mRNA/cDNA for MKNK1 Gene

11 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MKNK1

Clone products for research

  • Addgene plasmids for MKNK1

Alternative Splicing Database (ASD) splice patterns (SP) for MKNK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:

ExUns: 17b ^ 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MKNK1 Gene

GeneLoc Exon Structure for
MKNK1

Expression for MKNK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MKNK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MKNK1 Gene

This gene is overexpressed in Whole Blood (x11.0) and Pancreas (x4.4).

Protein differential expression in normal tissues from HIPED for MKNK1 Gene

This gene is overexpressed in Pancreas (51.1) and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MKNK1 Gene



Protein tissue co-expression partners for MKNK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MKNK1

SOURCE GeneReport for Unigene cluster for MKNK1 Gene:

Hs.371594

mRNA Expression by UniProt/SwissProt for MKNK1 Gene:

Q9BUB5-MKNK1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MKNK1 Gene

  • Blood(4.4)
  • Nervous system(3.7)
  • Intestine(2.3)
  • Pancreas(2.2)
  • Liver(2.2)
  • Muscle(2.2)
  • Skin(2.1)
  • Lung(2.1)
  • Heart(2.1)
  • Spleen(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with MKNK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MKNK1 Gene

Orthologs for MKNK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MKNK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MKNK1 29
  • 99.26 (n)
Cow
(Bos Taurus)
Mammalia MKNK1 29 30
  • 91.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MKNK1 29
  • 90.61 (n)
-- 30
  • 84 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Mknk1 29
  • 88.64 (n)
Mouse
(Mus musculus)
Mammalia Mknk1 29 16 30
  • 88.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MKNK1 30
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MKNK1 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MKNK1 29 30
  • 75.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MKNK1 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mknk1 29
  • 73.96 (n)
Str.15197 29
African clawed frog
(Xenopus laevis)
Amphibia mnk1 29
Zebrafish
(Danio rerio)
Actinopterygii mknk1 29 30
  • 72.12 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Lk6 29 30 31
  • 60.32 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mnk-1 30
  • 27 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 30
  • 23 (a)
ManyToMany
RCK2 30
  • 19 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11342 30
  • 58 (a)
OneToMany
Species where no ortholog for MKNK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MKNK1 Gene

ENSEMBL:
Gene Tree for MKNK1 (if available)
TreeFam:
Gene Tree for MKNK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MKNK1: view image
Alliance of Genome Resources:
Additional Orthologs for MKNK1

Paralogs for MKNK1 Gene

Paralogs for MKNK1 Gene

(48) SIMAP similar genes for MKNK1 Gene using alignment to 17 proteins:

  • MKNK1_HUMAN
  • B4E1V9_HUMAN
  • B5BU64_HUMAN
  • B5BUJ6_HUMAN
  • E9PIA0_HUMAN
  • E9PII5_HUMAN
  • E9PJH1_HUMAN
  • E9PLE7_HUMAN
  • E9PMF1_HUMAN
  • E9PMM8_HUMAN
  • E9PN34_HUMAN
  • E9PPI6_HUMAN
  • E9PQ23_HUMAN
  • E9PQ26_HUMAN
  • E9PSC9_HUMAN
  • E9PSE0_HUMAN
  • H0YE67_HUMAN
genes like me logo Genes that share paralogs with MKNK1: view

Variants for MKNK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MKNK1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs34881418 -- p.Arg446Gln
rs55791614 -- p.Asp308Asn
rs56351860 -- p.Lys49Gln
rs56408722 -- p.Leu158Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MKNK1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MKNK1 Gene

Variant ID Type Subtype PubMed ID
esv2761743 CNV gain 21179565
esv3329869 CNV duplication 20981092
nsv1008246 CNV loss 25217958
nsv1009193 CNV gain 25217958
nsv755 CNV insertion 18451855

Variation tolerance for MKNK1 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MKNK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MKNK1
Leiden Open Variation Database (LOVD)
MKNK1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MKNK1 Gene

Disorders for MKNK1 Gene

Additional Disease Information for MKNK1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MKNK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MKNK1 Gene

Publications for MKNK1 Gene

  1. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. (PMID: 15234964) Orton KC … Traugh JA (The Journal of biological chemistry 2004) 3 4 22
  2. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. (PMID: 9878069) Pyronnet S … Sonenberg N (The EMBO journal 1999) 3 4 22
  3. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PMID: 9155018) Fukunaga R … Hunter T (The EMBO journal 1997) 2 3 4
  4. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard LR … McDermott MF (Annals of the rheumatic diseases 2011) 3 40
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for MKNK1 Gene

Sources for MKNK1 Gene